Details of the Target

General Information of Target

Target ID LDTP04148
Target Name Sodium- and chloride-dependent creatine transporter 1 (SLC6A8)
Gene Name SLC6A8
Gene ID 6535
Synonyms
Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMD
FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGS
INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
CVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLL
ACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
GSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVF
SILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV
GVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASG
TTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV
YYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG
LHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A8 subfamily
Subcellular location
Cell membrane
Function Creatine:sodium symporter which mediates the uptake of creatine . Plays an important role in supplying creatine to the brain via the blood-brain barrier.
TTD ID
T20741
Uniprot ID
P48029
DrugMap ID
TTYUHB5
Ensemble ID
ENST00000253122.10
HGNC ID
HGNC:11055
ChEMBL ID
CHEMBL5209634

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.K117N .
JURKAT SNV: p.K117E; p.R207Q .
KASUMI2 SNV: p.D189G .
KELLY SNV: p.F78L .
NCIH358 SNV: p.A285V .
RBE SNV: p.L433V .
REH SNV: p.T166M .
TOV21G SNV: p.G223R; p.V270M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.46  LDD0197  [1]
AHL-Pu-1
 Probe Info  		C127(3.24)  LDD0168  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C82(0.72)  LDD0531  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C127(3.24)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C127(3.33)  LDD0169  [2]
 LDCM0214  AC1 HCT 116 C82(0.72)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C82(0.87)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C82(0.73)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C82(0.71)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C82(0.90)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C82(0.85)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C82(0.68)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C82(0.61)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C82(0.78)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C82(0.73)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C82(0.43)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C82(0.80)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C82(0.86)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C82(0.80)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C82(0.76)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C82(0.70)  LDD0546  [4]
 LDCM0237  AC12 HCT 116 C82(1.04)  LDD0554  [4]
 LDCM0259  AC14 HCT 116 C82(0.96)  LDD0576  [4]
 LDCM0263  AC143 HCT 116 C82(0.94)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C82(0.67)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C82(0.85)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C82(0.64)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C82(0.69)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C82(0.62)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C82(0.61)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C82(0.88)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C82(0.87)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C82(0.85)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C82(0.69)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C82(0.51)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C82(0.72)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C82(0.71)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C82(0.88)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C82(0.94)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C82(1.08)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C82(1.02)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C82(0.96)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C82(1.06)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C82(0.98)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C82(0.97)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C82(1.02)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C82(0.96)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C82(1.04)  LDD0601  [4]
 LDCM0286  AC26 HEK-293T C82(1.00); C127(1.12)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C82(0.99); C127(0.88)  LDD1526  [5]
 LDCM0289  AC29 HEK-293T C82(0.92); C127(0.58)  LDD1528  [5]
 LDCM0290  AC3 HCT 116 C82(1.10)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C82(0.92); C127(1.03)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C82(0.97)  LDD1531  [5]
 LDCM0295  AC34 HEK-293T C82(0.95); C127(1.40)  LDD1534  [5]
 LDCM0296  AC35 PaTu 8988t C82(0.88)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C82(0.74)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C82(0.69)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C82(0.73)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C82(0.76)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C82(0.85)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C82(0.62)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C82(0.68)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C82(0.71)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C82(0.77)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C82(0.50)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C82(0.58)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C82(0.97); C127(1.25)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C82(1.12)  LDD1548  [5]
 LDCM0312  AC5 HCT 116 C82(0.84)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C82(0.87); C127(1.20)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C82(0.96); C127(0.87)  LDD1553  [5]
 LDCM0316  AC53 HEK-293T C82(0.98); C127(0.76)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C82(0.99); C127(0.99)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C82(1.02)  LDD1557  [5]
 LDCM0321  AC58 HEK-293T C82(1.04); C127(1.03)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C82(1.02); C127(1.02)  LDD1561  [5]
 LDCM0323  AC6 HCT 116 C82(0.82)  LDD0640  [4]
 LDCM0325  AC61 HEK-293T C82(1.00); C127(0.90)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C82(1.06); C127(1.02)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C82(1.06)  LDD1566  [5]
 LDCM0332  AC68 HCT 116 C82(0.94)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C82(0.98)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C82(0.88)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C82(0.97)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C82(1.32)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C82(0.90)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C82(0.93)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C82(0.71)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C82(0.74)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C82(0.87)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C82(0.85)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C82(1.01)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C82(0.77)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C82(1.05)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C82(1.02)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C82(0.76)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C82(0.74)  LDD0665  [4]
 LDCM0349  AC83 PaTu 8988t C82(0.98)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C82(0.97)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C82(1.02)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C82(1.08)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C82(1.09)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C82(1.12)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C82(1.17)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C82(1.10)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C82(1.00)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C82(0.96)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C82(1.20)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C82(1.06)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C82(1.00)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C82(1.04)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C82(1.03)  LDD1243  [4]
 LDCM0365  AC98 HCT 116 C82(0.37)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C82(0.89)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C82(0.97)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C82(0.96)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C82(0.70)  LDD0592  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HCT 116 C82(1.18)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C82(0.82)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C82(0.80)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C82(0.84)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C82(0.93)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C82(0.83)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C82(0.85)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C82(0.83)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C82(0.67)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C82(0.94)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C82(0.96)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C82(0.88)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C82(0.85)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C82(0.74)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C82(0.91)  LDD0698  [4]
 LDCM0383  CL113 HEK-293T C82(0.96)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C82(1.06)  LDD1589  [5]
 LDCM0387  CL117 PaTu 8988t C82(0.66)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C82(0.68)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C82(0.74)  LDD1268  [4]
 LDCM0390  CL12 HCT 116 C82(1.01)  LDD0707  [4]
 LDCM0391  CL120 PaTu 8988t C82(0.76)  LDD1270  [4]
 LDCM0392  CL121 HEK-293T C82(1.03)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C82(1.49)  LDD1598  [5]
 LDCM0396  CL125 HEK-293T C82(1.06)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C82(1.09)  LDD1602  [5]
 LDCM0400  CL13 HCT 116 C82(0.78)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C82(1.16)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C82(1.19)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C82(0.73)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C82(0.65)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C82(0.62)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C82(0.59)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C82(2.18)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C82(0.57)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C82(0.55)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C82(0.54)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C82(0.65)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C82(0.64)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C82(0.69)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C82(0.73)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C82(0.75)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C82(0.61)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C82(0.63)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C82(1.40)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C82(0.76)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C82(1.12); C127(1.03)  LDD1624  [5]
 LDCM0422  CL33 HEK-293T C82(1.69); C127(0.96)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C82(1.01); C127(1.76)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C82(1.03)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C82(0.98)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C82(1.12)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C82(1.09)  LDD0746  [4]
 LDCM0432  CL42 HEK-293T C82(0.99); C127(1.24)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C82(1.06); C127(1.02)  LDD1637  [5]
 LDCM0435  CL45 HEK-293T C82(1.30); C127(0.83)  LDD1639  [5]
 LDCM0436  CL46 PaTu 8988t C82(0.78)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C82(0.91)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C82(0.75)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C82(0.76)  LDD1318  [4]
 LDCM0440  CL5 HCT 116 C82(0.98)  LDD0757  [4]
 LDCM0441  CL50 PaTu 8988t C82(0.83)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C82(0.81)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C82(0.74)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C82(0.70)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C82(0.82)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C82(0.75)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C82(0.85)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C82(0.77)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C82(0.75)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C82(0.79)  LDD1329  [4]
 LDCM0451  CL6 HCT 116 C82(0.99)  LDD0768  [4]
 LDCM0452  CL60 PaTu 8988t C82(0.87)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C82(1.14)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C82(0.89)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C82(1.12)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C82(1.03)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C82(1.42)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C82(0.95)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C82(0.88)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C82(0.95)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C82(1.11)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C82(1.06)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C82(0.96)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C82(1.18)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C82(1.04)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C82(0.84)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C82(1.18)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C82(0.77)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C82(0.89)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C82(0.78)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C82(0.77)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C82(1.00)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C82(0.77)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C82(0.87)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C82(0.68)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C82(0.71)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C82(0.63)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C82(0.95)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C82(1.01)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C82(0.90)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C82(0.73)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C82(0.64)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C82(1.17)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C82(1.33)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C82(0.80)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C82(0.93)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C82(0.79)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C82(0.83)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C82(0.85)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C82(0.88)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C82(0.83)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C82(0.88)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C82(0.92)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C82(1.14)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C82(0.87)  LDD0785  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Creatine Small molecular drug DB00148
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rgx-202 Small molecular drug D0UO9R
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphocreatine . DB13191

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402