Details of the Target

General Information of Target

Target ID LDTP10848
Target Name ATP-dependent zinc metalloprotease YME1L1 (YME1L1)
Gene Name YME1L1
Gene ID 10730
Synonyms
FTSH1; YME1L; ATP-dependent zinc metalloprotease YME1L1; EC 3.4.24.-; ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; PAMP; YME1-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSMRHEIEGTGLPQAQLLW
RKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYENKAAYERQVPPRAVINSA
GYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPLILWHPYARHYYFCMMTEAEQ
DKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQSKELYGTWEMLCGNEVQILSNL
VMEELGPELKAELGPRLKGKPQERQRQWIQISDAVYHMVYEQAKARFEEVLSKVQQVQPA
MQAVIRTDMDQIITSKEHLASKIRAFILPKAEVCVRNHVQPYIPSILEALMVPTSQGFTE
VRDVFFKEVTDMNLNVINEGGIDKLGEYMEKLSRLAYHPLKMQSCYEKMESLRLDGLQQR
FDVSSTSVFKQRAQIHMREQMDNAVYTFETLLHQELGKGPTKEELCKSIQRVLERVLKKY
DYDSSSVRKRFFREALLQISIPFLLKKLAPTCKSELPRFQELIFEDFARFILVENTYEEV
VLQTVMKDILQAVKEAAVQRKHNLYRDSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGG
SPSPSTPESATLSEKRRRAKQVVSVVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQG
LRPESPPPAGPLLNGAPAGESPQPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETG
EQVSSPSSHPALHTTTEDSAGVQTEF
Target Bioclass
Enzyme
Family
AAA ATPase family; Peptidase M41 family
Subcellular location
Mitochondrion inner membrane
Function
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
Uniprot ID
Q96TA2
Ensemble ID
ENST00000326799.7
HGNC ID
HGNC:12843

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K237(5.86); K278(4.64)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C433(0.71)  LDD0580  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
Acrolein
 Probe Info  		C433(0.00); H669(0.00)  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.59  LDD1728  [9]
FFF probe11
 Probe Info  		20.00  LDD0471  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe14
 Probe Info  		6.21  LDD0477  [10]
FFF probe2
 Probe Info  		20.00  LDD0463  [10]
FFF probe3
 Probe Info  		6.17  LDD0464  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C433(0.08)  LDD1093  [3]
 LDCM0215  AC10 PaTu 8988t C433(0.30)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C433(0.28)  LDD1105  [3]
 LDCM0230  AC113 HEK-293T C433(0.97)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C433(0.79)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C433(0.97)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C433(0.76)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C433(0.65)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C433(0.54)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C433(0.59)  LDD0834  [3]
 LDCM0237  AC12 PaTu 8988t C433(0.32)  LDD1116  [3]
 LDCM0238  AC120 HEK-293T C433(0.62)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C433(0.56)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C433(0.72)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C433(0.74)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C433(0.67)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C433(0.78)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C433(0.68)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C433(0.72)  LDD0843  [3]
 LDCM0259  AC14 PaTu 8988t C433(0.34)  LDD1138  [3]
 LDCM0263  AC143 HCT 116 C433(0.71)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C433(0.29)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C433(0.52)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C433(0.33)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C433(0.28)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C433(0.23)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C433(0.27)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C433(0.32)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C433(0.68)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C433(0.57)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C433(0.24)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C433(0.22)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C433(0.33)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C433(0.38)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C433(0.81)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C433(0.89)  LDD2161  [3]
 LDCM0276  AC17 PaTu 8988t C433(0.82)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C433(0.43)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C433(0.70)  LDD1157  [3]
 LDCM0279  AC2 PaTu 8988t C433(0.18)  LDD1158  [3]
 LDCM0280  AC20 PaTu 8988t C433(0.54)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C433(0.69)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C433(0.42)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C433(0.34)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C433(0.41)  LDD1163  [3]
 LDCM0285  AC25 HCT 116 C433(0.54)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C433(0.41)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C433(0.41)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C433(0.44)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C433(0.41)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C433(0.08)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C433(0.44)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C433(0.36)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C433(0.26)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C433(0.31)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C433(0.27)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C433(1.70)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C433(1.43)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C433(1.29)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C433(1.25)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C433(1.05)  LDD0617  [3]
 LDCM0301  AC4 PaTu 8988t C433(0.13)  LDD1180  [3]
 LDCM0302  AC40 HCT 116 C433(0.78)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C433(1.22)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C433(1.01)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C433(0.97)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C433(0.97)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C433(0.82)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C433(1.06)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C433(0.95)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C433(1.09)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C433(0.77)  LDD0628  [3]
 LDCM0312  AC5 PaTu 8988t C433(0.10)  LDD1191  [3]
 LDCM0313  AC50 HCT 116 C433(0.61)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C433(1.61)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C433(1.01)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C433(0.73)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C433(0.83)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C433(0.73)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C433(0.78)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C433(0.93); C143(1.10)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C433(1.22)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C433(1.14); C143(0.99)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C433(0.54)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C433(1.45)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C433(1.08); C143(0.86)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C433(0.90)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C433(1.09)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C433(1.15); C143(0.92)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C433(0.89)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C433(0.65)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C433(1.04)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C433(0.58)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C433(0.88)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C433(0.63)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C433(0.63)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C433(0.56)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C433(0.61)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C433(0.58)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C433(0.62)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C433(0.95)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C433(0.91)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C433(0.58)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C433(0.73)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C433(0.84)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C433(0.71)  LDD0665  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C433(0.29)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C433(0.44)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C433(0.34)  LDD1154  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C433(1.77)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C433(0.55)  LDD0685  [3]
 LDCM0369  CL100 PaTu 8988t C433(0.14)  LDD1248  [3]
 LDCM0370  CL101 PaTu 8988t C433(0.65)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C433(0.48)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C433(0.32)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C433(0.38)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C433(0.68)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C433(0.60)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C433(0.79)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C433(0.62)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C433(0.56)  LDD1257  [3]
 LDCM0379  CL11 HCT 116 C433(0.53)  LDD0696  [3]
 LDCM0380  CL110 PaTu 8988t C433(0.44)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C433(0.33)  LDD1260  [3]
 LDCM0382  CL112 HCT 116 C433(0.76)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C433(0.28)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C433(0.50)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C433(0.44)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C433(0.41)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C433(0.74)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C433(1.04)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C433(0.88)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C433(0.53)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C433(1.20)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C433(0.85)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C433(0.91)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C433(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C433(0.74)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C433(0.97)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C433(1.02); C143(0.89)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C433(1.03)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C433(1.05)  LDD1603  [11]
 LDCM0400  CL13 HCT 116 C433(0.64)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C433(0.94)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C433(0.68)  LDD0719  [3]
 LDCM0403  CL16 PaTu 8988t C433(0.50)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C433(0.46)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C433(0.40)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C433(0.37)  LDD1285  [3]
 LDCM0407  CL2 HCT 116 C433(1.33)  LDD0724  [3]
 LDCM0408  CL20 PaTu 8988t C433(0.41)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C433(0.39)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C433(0.35)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C433(0.45)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C433(0.56)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C433(0.56)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C433(0.40)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C433(0.42)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C433(0.43)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C433(0.45)  LDD1296  [3]
 LDCM0418  CL3 HCT 116 C433(1.06)  LDD0735  [3]
 LDCM0419  CL30 PaTu 8988t C433(0.43)  LDD1298  [3]
 LDCM0420  CL31 HCT 116 C433(0.60)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C433(0.62)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C433(0.57)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C433(0.39)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C433(0.42)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C433(0.45)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C433(0.43)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C433(0.36)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C433(0.93)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C433(0.43)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C433(0.47)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C433(0.37)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C433(0.38)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C433(0.42)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C433(0.41)  LDD0752  [3]
 LDCM0436  CL46 PaTu 8988t C433(0.87)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C433(0.65)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C433(0.74)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C433(0.68)  LDD1318  [3]
 LDCM0440  CL5 HCT 116 C433(0.88)  LDD0757  [3]
 LDCM0441  CL50 PaTu 8988t C433(0.46)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C433(0.63)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C433(0.53)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C433(0.40)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C433(0.44)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C433(0.51)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C433(0.13)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C433(0.26)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C433(0.34)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C433(0.27)  LDD1329  [3]
 LDCM0451  CL6 HCT 116 C433(0.69)  LDD0768  [3]
 LDCM0452  CL60 PaTu 8988t C433(0.25)  LDD1331  [3]
 LDCM0453  CL61 HCT 116 C433(0.95)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C433(0.78)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C433(0.58)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C433(0.46)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C433(0.75)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C433(0.38)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C433(0.45)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C433(0.51)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C433(0.74)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C433(0.60)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C433(0.60)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C433(0.51)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C433(0.91)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C433(0.52)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C433(0.51)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C433(0.66)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C433(0.68)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C433(0.56)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C433(0.81)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C433(0.49)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C433(0.55)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C433(0.49)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C433(0.58)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C433(0.58)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C433(0.42)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C433(0.74)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C433(0.52)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C433(0.40)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C433(0.43)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C433(0.44)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C433(0.72)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C433(0.44)  LDD1364  [3]
 LDCM0486  CL91 PaTu 8988t C433(0.28)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C433(0.29)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C433(0.18)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C433(0.27)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C433(0.18)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C433(0.20)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C433(0.20)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C433(0.12)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C433(0.21)  LDD1373  [3]
 LDCM0495  E2913 HEK-293T C433(1.07)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C433(0.59)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C433(0.37)  LDD0744  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C433(1.07)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C433(0.96)  LDD1497  [11]
 LDCM0024  KB05 HMCB C433(2.38)  LDD3312  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

References

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Mass spectrometry data entry: PXD028270
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4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840