Details of the Target

General Information of Target

Target ID LDTP13314
Target Name Enolase-phosphatase E1 (ENOPH1)
Gene Name ENOPH1
Gene ID 58478
Synonyms
MASA; Enolase-phosphatase E1; EC 3.1.3.77; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; MASA homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESP
CGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDN
LIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRW
CTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNL
HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQ
REFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNM
DTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEV
TSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDL
MPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS
Target Bioclass
Enzyme
Family
HAD-like hydrolase superfamily, MasA/MtnC family
Subcellular location
Cytoplasm
Function
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). {|HAMAP-Rule:MF_03117}.
Uniprot ID
Q9UHY7
Ensemble ID
ENST00000273920.8
HGNC ID
HGNC:24599

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.A236T IA-alkyne    Probe Info 
NCIH1155 SNV: p.M117I .
RKO SNV: p.C52Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K111(2.41)  LDD0277  [1]
Probe 1
 Probe Info  		Y193(15.03)  LDD3495  [2]
m-APA
 Probe Info  		13.64  LDD0403  [3]
DBIA
 Probe Info  		C56(1.61)  LDD3327  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C52(0.00); C202(0.00); C98(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C52(0.00); C202(0.00); C98(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		14.00  LDD0443  [10]
NAIA_5
 Probe Info  		C202(0.00); C98(0.00)  LDD2223  [11]
HHS-465
 Probe Info  		K106(0.00); K111(0.00)  LDD2240  [12]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.63  LDD1728  [13]
C100
 Probe Info  		6.28  LDD1789  [13]
C158
 Probe Info  		28.84  LDD1838  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
JN0003
 Probe Info  		20.00  LDD0469  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C52(1.02); C202(1.04)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C52(1.01); C202(1.16)  LDD1508  [16]
 LDCM0226  AC11 HEK-293T C52(1.08); C202(0.95)  LDD1509  [16]
 LDCM0237  AC12 HEK-293T C52(0.96); C202(1.05)  LDD1510  [16]
 LDCM0246  AC128 PaTu 8988t C202(1.19)  LDD1125  [17]
 LDCM0247  AC129 PaTu 8988t C202(0.92)  LDD1126  [17]
 LDCM0249  AC130 PaTu 8988t C202(1.35)  LDD1128  [17]
 LDCM0250  AC131 PaTu 8988t C202(0.84)  LDD1129  [17]
 LDCM0251  AC132 PaTu 8988t C202(1.12)  LDD1130  [17]
 LDCM0252  AC133 PaTu 8988t C202(0.35)  LDD1131  [17]
 LDCM0253  AC134 PaTu 8988t C202(0.44)  LDD1132  [17]
 LDCM0254  AC135 PaTu 8988t C202(0.44)  LDD1133  [17]
 LDCM0255  AC136 PaTu 8988t C202(0.46)  LDD1134  [17]
 LDCM0256  AC137 PaTu 8988t C202(0.37)  LDD1135  [17]
 LDCM0257  AC138 PaTu 8988t C202(1.01)  LDD1136  [17]
 LDCM0258  AC139 PaTu 8988t C202(0.83)  LDD1137  [17]
 LDCM0259  AC14 HEK-293T C52(1.06); C202(1.28)  LDD1512  [16]
 LDCM0260  AC140 PaTu 8988t C202(0.86)  LDD1139  [17]
 LDCM0261  AC141 PaTu 8988t C202(1.06)  LDD1140  [17]
 LDCM0262  AC142 PaTu 8988t C202(0.71)  LDD1141  [17]
 LDCM0270  AC15 HEK-293T C52(1.26); C202(1.07)  LDD1513  [16]
 LDCM0276  AC17 HEK-293T C52(0.85); C202(1.07)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C52(1.09); C202(0.99)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C52(1.13); C202(1.05)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C52(0.98); C202(1.03)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C52(1.09); C202(1.17)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C52(1.10); C202(0.98)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C52(1.16); C202(1.14)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C52(1.16); C202(1.07)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C52(1.04); C202(0.97)  LDD1523  [16]
 LDCM0285  AC25 HEK-293T C52(0.86); C202(1.33)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C52(1.02); C202(0.98)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C52(1.13); C202(1.01)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C52(0.80); C202(1.13)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C52(1.04); C202(1.01)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C52(0.97); C202(1.08)  LDD1529  [16]
 LDCM0291  AC30 HEK-293T C52(1.17); C202(1.06)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C52(1.07); C202(1.01)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C52(1.08); C202(1.00)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C52(1.02); C202(1.02)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C52(1.02); C202(1.18)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C52(1.04); C202(0.97)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C52(0.90); C202(0.97)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C52(1.12); C202(1.06)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C52(0.99); C202(1.18)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C52(1.00); C202(1.01)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C52(0.94); C202(1.12)  LDD1540  [16]
 LDCM0302  AC40 HEK-293T C52(1.06); C202(0.96)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C52(1.09); C202(1.08)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C52(1.08); C202(1.06)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C52(1.03); C202(0.93)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C52(0.93); C202(0.99)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C52(1.05); C202(1.01)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C52(1.05); C202(1.19)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C52(1.14); C202(0.99)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C52(0.99); C202(1.04)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C52(0.91); C202(1.19)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C52(1.08); C202(0.96)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C52(1.03); C202(1.03)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C52(1.04); C202(1.04)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C52(1.01); C202(1.07)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C52(1.04); C202(1.05)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C52(1.13); C202(1.17)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C52(0.96); C202(1.11)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C52(1.02); C202(1.03)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C52(0.90); C202(1.08)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C52(1.24); C202(0.96)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C52(1.08); C202(0.98)  LDD1561  [16]
 LDCM0323  AC6 HEK-293T C52(0.94); C202(1.18)  LDD1562  [16]
 LDCM0324  AC60 HEK-293T C52(0.89); C202(1.19)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C52(1.18); C202(0.94)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C52(0.96); C202(1.12)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C52(1.17); C202(1.02)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C52(1.06); C202(1.00)  LDD1567  [16]
 LDCM0334  AC7 HEK-293T C52(1.11); C202(0.97)  LDD1568  [16]
 LDCM0345  AC8 HEK-293T C52(1.09); C202(1.01)  LDD1569  [16]
 LDCM0248  AKOS034007472 HEK-293T C52(1.03); C202(0.96)  LDD1511  [16]
 LDCM0356  AKOS034007680 HEK-293T C52(0.88); C202(1.08)  LDD1570  [16]
 LDCM0275  AKOS034007705 HEK-293T C52(0.93); C202(1.02)  LDD1514  [16]
 LDCM0156  Aniline NCI-H1299 13.64  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C52(0.87); C202(1.07)  LDD1571  [16]
 LDCM0368  CL10 HEK-293T C52(1.28); C202(0.81)  LDD1572  [16]
 LDCM0369  CL100 HEK-293T C52(1.06); C202(1.04)  LDD1573  [16]
 LDCM0370  CL101 HEK-293T C52(0.94); C202(1.04)  LDD1574  [16]
 LDCM0371  CL102 HEK-293T C52(1.04); C202(1.11)  LDD1575  [16]
 LDCM0372  CL103 HEK-293T C52(1.09); C202(1.38)  LDD1576  [16]
 LDCM0373  CL104 HEK-293T C52(1.09); C202(1.08)  LDD1577  [16]
 LDCM0374  CL105 HEK-293T C52(0.83); C202(1.13)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C52(0.97); C202(1.10)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C52(1.09); C202(1.24)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C52(1.02); C202(1.16)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C52(0.93); C202(1.05)  LDD1582  [16]
 LDCM0379  CL11 HEK-293T C52(1.08); C202(0.83)  LDD1583  [16]
 LDCM0380  CL110 HEK-293T C52(0.98); C202(1.07)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C52(0.99); C202(1.04)  LDD1585  [16]
 LDCM0382  CL112 HEK-293T C52(0.89); C202(0.98)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C52(1.01); C202(1.02)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C52(1.13); C202(0.94)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C52(1.08); C202(1.33)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C52(1.00); C202(1.07)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C52(1.11); C202(1.15)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C52(1.01); C202(1.04)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C52(1.18); C202(1.11)  LDD1593  [16]
 LDCM0390  CL12 HEK-293T C52(1.04); C202(0.88)  LDD1594  [16]
 LDCM0391  CL120 HEK-293T C52(1.10); C202(0.96)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C52(1.14); C202(1.08)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C52(1.07); C202(1.04)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C52(1.02); C202(1.14)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C52(1.00); C202(1.12)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C52(0.90); C202(1.34)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C52(1.05); C202(1.32)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C52(1.11); C202(1.21)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C52(0.99); C202(1.09)  LDD1603  [16]
 LDCM0400  CL13 HEK-293T C52(0.81); C202(0.96)  LDD1604  [16]
 LDCM0401  CL14 HEK-293T C52(1.09); C202(0.99)  LDD1605  [16]
 LDCM0402  CL15 HEK-293T C52(1.00); C202(1.02)  LDD1606  [16]
 LDCM0403  CL16 PaTu 8988t C202(0.78)  LDD1282  [17]
 LDCM0404  CL17 PaTu 8988t C202(0.45)  LDD1283  [17]
 LDCM0405  CL18 PaTu 8988t C202(0.34)  LDD1284  [17]
 LDCM0406  CL19 PaTu 8988t C202(0.23)  LDD1285  [17]
 LDCM0407  CL2 HEK-293T C52(1.02); C202(1.00)  LDD1611  [16]
 LDCM0408  CL20 PaTu 8988t C202(0.20)  LDD1287  [17]
 LDCM0409  CL21 PaTu 8988t C202(0.21)  LDD1288  [17]
 LDCM0410  CL22 PaTu 8988t C202(0.23)  LDD1289  [17]
 LDCM0411  CL23 PaTu 8988t C202(0.20)  LDD1290  [17]
 LDCM0412  CL24 PaTu 8988t C202(0.67)  LDD1291  [17]
 LDCM0413  CL25 PaTu 8988t C202(1.05)  LDD1292  [17]
 LDCM0414  CL26 PaTu 8988t C202(0.20)  LDD1293  [17]
 LDCM0415  CL27 PaTu 8988t C202(0.63)  LDD1294  [17]
 LDCM0416  CL28 PaTu 8988t C202(0.24)  LDD1295  [17]
 LDCM0417  CL29 PaTu 8988t C202(0.21)  LDD1296  [17]
 LDCM0418  CL3 HEK-293T C52(1.15); C202(1.15)  LDD1622  [16]
 LDCM0419  CL30 PaTu 8988t C202(0.70)  LDD1298  [17]
 LDCM0420  CL31 PaTu 8988t C202(1.03)  LDD1299  [17]
 LDCM0421  CL32 PaTu 8988t C202(1.03)  LDD1300  [17]
 LDCM0422  CL33 PaTu 8988t C202(0.74)  LDD1301  [17]
 LDCM0423  CL34 PaTu 8988t C202(0.78)  LDD1302  [17]
 LDCM0424  CL35 PaTu 8988t C202(0.75)  LDD1303  [17]
 LDCM0425  CL36 PaTu 8988t C202(0.85)  LDD1304  [17]
 LDCM0426  CL37 PaTu 8988t C202(0.31)  LDD1305  [17]
 LDCM0428  CL39 PaTu 8988t C202(1.14)  LDD1307  [17]
 LDCM0429  CL4 HEK-293T C52(0.92); C202(0.32)  LDD1633  [16]
 LDCM0430  CL40 PaTu 8988t C202(0.91)  LDD1309  [17]
 LDCM0431  CL41 PaTu 8988t C202(0.54)  LDD1310  [17]
 LDCM0432  CL42 PaTu 8988t C202(0.20)  LDD1311  [17]
 LDCM0433  CL43 PaTu 8988t C202(0.17)  LDD1312  [17]
 LDCM0434  CL44 PaTu 8988t C202(0.37)  LDD1313  [17]
 LDCM0435  CL45 PaTu 8988t C202(1.04)  LDD1314  [17]
 LDCM0436  CL46 HEK-293T C52(1.18); C202(0.94)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C52(1.14); C202(0.80)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C52(1.16); C202(0.91)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C52(0.86); C202(1.00)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C52(0.80); C202(1.09)  LDD1644  [16]
 LDCM0441  CL50 HEK-293T C52(0.99); C202(0.94)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C52(1.07); C202(1.24)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C52(0.90); C202(0.91)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C52(1.00); C202(0.84)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C52(1.07); C202(0.80)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C52(0.84); C202(0.91)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C52(1.08); C202(0.76)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C52(1.16); C202(0.97)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C52(1.14); C202(0.87)  LDD1653  [16]
 LDCM0451  CL6 HEK-293T C52(1.10); C202(1.06)  LDD1654  [16]
 LDCM0452  CL60 HEK-293T C52(1.02); C202(0.87)  LDD1655  [16]
 LDCM0453  CL61 PaTu 8988t C202(1.39)  LDD1332  [17]
 LDCM0454  CL62 PaTu 8988t C202(1.62)  LDD1333  [17]
 LDCM0455  CL63 PaTu 8988t C202(1.50)  LDD1334  [17]
 LDCM0456  CL64 PaTu 8988t C202(1.19)  LDD1335  [17]
 LDCM0457  CL65 PaTu 8988t C202(1.02)  LDD1336  [17]
 LDCM0458  CL66 PaTu 8988t C202(0.83)  LDD1337  [17]
 LDCM0459  CL67 PaTu 8988t C202(0.38)  LDD1338  [17]
 LDCM0460  CL68 PaTu 8988t C202(0.18)  LDD1339  [17]
 LDCM0461  CL69 PaTu 8988t C202(0.25)  LDD1340  [17]
 LDCM0462  CL7 HEK-293T C52(1.08); C202(0.82)  LDD1665  [16]
 LDCM0463  CL70 PaTu 8988t C202(0.52)  LDD1342  [17]
 LDCM0464  CL71 PaTu 8988t C202(1.70)  LDD1343  [17]
 LDCM0465  CL72 PaTu 8988t C202(1.11)  LDD1344  [17]
 LDCM0466  CL73 PaTu 8988t C202(0.38)  LDD1345  [17]
 LDCM0467  CL74 PaTu 8988t C202(1.42)  LDD1346  [17]
 LDCM0469  CL76 HEK-293T C52(1.05); C202(1.01)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C52(0.90); C202(0.56)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C52(1.18); C202(1.04)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C52(0.97); C202(0.87)  LDD1675  [16]
 LDCM0473  CL8 HEK-293T C52(0.91); C202(0.83)  LDD1676  [16]
 LDCM0474  CL80 HEK-293T C52(1.02); C202(0.99)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C52(1.21); C202(0.92)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C52(1.16); C202(1.03)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C52(1.19); C202(0.82)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C52(1.07); C202(0.85)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C52(0.90); C202(1.12)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C52(1.05); C202(1.08)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C52(1.20); C202(1.31)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C52(0.96); C202(1.29)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C52(0.87); C202(1.08)  LDD1686  [16]
 LDCM0484  CL9 HEK-293T C52(1.06); C202(0.74)  LDD1687  [16]
 LDCM0485  CL90 HEK-293T C52(0.92); C202(0.93)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C52(1.27); C202(0.92)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C52(0.85); C202(1.05)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C52(1.11); C202(0.97)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C52(1.09); C202(1.12)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C52(1.11); C202(0.82)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C52(0.99); C202(1.01)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C52(0.82); C202(1.21)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C52(0.99); C202(1.15)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C52(1.07); C202(1.09)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C52(1.10); C202(0.69)  LDD1698  [16]
 LDCM0468  Fragment33 PaTu 8988t C202(0.89)  LDD1347  [17]
 LDCM0427  Fragment51 PaTu 8988t C202(0.90)  LDD1306  [17]
 LDCM0569  Fragment7 Ramos C202(0.79)  LDD2186  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C52(0.98); C202(0.99)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C52(1.01); C202(1.02)  LDD1497  [16]
 LDCM0024  KB05 WM115 C56(1.61)  LDD3327  [4]
 LDCM0131  RA190 MM1.R C202(1.13)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 280A (ZNF280A) . P59817

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-oxoheptylphosphonic Acid . DB07912

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.