Details of the Target

General Information of Target

Target ID LDTP13478
Target Name Ergosterol biosynthetic protein 28 homolog (ERG28)
Gene Name ERG28
Gene ID 11161
Synonyms
C14orf1; Ergosterol biosynthetic protein 28 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLSIFLLLCVLGLSQAATPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTA
AHCSGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRV
TSSVQPLPLPNDCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPGRI
TSNMVCAGGVPGQDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYICKYVDW
IRMIMRNN
Target Bioclass
Other
Family
ERG28 family
Subcellular location
Endoplasmic reticulum membrane
Uniprot ID
Q9UKR5
Ensemble ID
ENST00000256319.7
HGNC ID
HGNC:1187

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y127(20.00)  LDD0260  [1]
IA-alkyne
 Probe Info  		1.37  LDD2182  [2]
DBIA
 Probe Info  		C65(0.96); C67(0.96)  LDD0531  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C65(0.00); C67(0.00)  LDD2156  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.00  LDD1728  [7]
C026
 Probe Info  		5.62  LDD1732  [7]
C362
 Probe Info  		26.54  LDD2023  [7]
OEA-DA
 Probe Info  		3.70  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C65(0.96); C67(0.96)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C65(1.01); C67(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C65(0.89); C67(0.89)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C65(0.95); C67(0.95)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C65(0.74); C67(0.74)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C65(0.86); C67(0.86)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C65(0.99); C67(0.99)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C65(0.79); C67(0.79)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C65(0.84); C67(0.84)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C65(0.80); C67(0.80)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C65(0.81); C67(0.81)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C65(0.88); C67(0.88)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C65(0.93); C67(0.93)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C65(0.89); C67(0.89)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C65(0.83); C67(0.83)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C65(0.90); C67(0.90)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C65(0.89); C67(0.89)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C65(0.88); C67(0.88)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C65(1.11); C67(1.11)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C65(0.98); C67(0.98)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C65(1.08); C67(1.08)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C65(1.12); C67(1.12)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C65(0.97); C67(0.97)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C65(0.96); C67(0.96)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C65(0.91); C67(0.91)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C65(1.13); C67(1.13)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C65(0.88); C67(0.88)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C65(1.04); C67(1.04)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C65(1.21); C67(1.21)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C65(0.94); C67(0.94)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C65(0.99); C67(0.99)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C65(1.00); C67(1.00)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C67(1.03)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C67(1.18)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C67(1.05)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C67(1.01)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C67(1.24)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C67(0.93)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C67(0.87)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C67(1.01)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C67(1.01)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C67(0.80)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C67(0.83)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C67(0.96)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C65(0.83); C67(0.83)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C67(0.98)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C67(0.97)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C67(0.99)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C65(0.88); C67(0.88)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C65(0.95); C67(0.95)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C65(0.89); C67(0.89)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C65(0.80); C67(0.80)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C65(0.87); C67(0.87)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C65(1.18); C67(1.18)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C65(0.70); C67(0.70)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C65(1.19); C67(1.19)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C65(0.73); C67(0.73)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C65(1.07); C67(1.07)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C65(0.82); C67(0.82)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C65(0.81); C67(0.81)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C65(0.85); C67(0.85)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C65(1.03); C67(1.03)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C65(0.83); C67(0.83)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C65(0.84); C67(0.84)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C65(0.78); C67(0.78)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C65(0.82); C67(0.82)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C65(0.79); C67(0.79)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C65(1.13); C67(1.13)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C65(0.79); C67(0.79)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C65(0.89); C67(0.89)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C65(0.79); C67(0.79)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C65(0.86); C67(0.86)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C65(0.82); C67(0.82)  LDD0882  [3]
 LDCM0285  AC25 HCT 116 C65(1.02); C67(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C65(0.87); C67(0.87)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C65(0.91); C67(0.91)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C65(1.03); C67(1.03)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C65(0.86); C67(0.86)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C65(1.23); C67(1.23)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C65(0.80); C67(0.80)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C65(1.10); C67(1.10)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C65(0.91); C67(0.91)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C65(1.06); C67(1.06)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C65(0.91); C67(0.91)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C67(0.98); C65(0.98)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C65(1.02); C67(1.08)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C65(0.97); C67(0.98)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C65(0.95); C67(1.01)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C65(0.90); C67(0.91)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C65(1.20); C67(1.20)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C65(0.96); C67(1.00)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C67(0.76); C65(0.79)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C65(0.88); C67(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C65(0.89); C67(0.92)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C67(0.85); C65(0.93)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C65(0.91); C67(0.92)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C65(0.74); C67(0.74)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C65(0.76); C67(0.76)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C65(0.83); C67(0.83)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C65(0.80); C67(0.80)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C65(1.27); C67(1.27)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C65(0.69); C67(0.69)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C65(0.83); C67(0.83)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C65(0.87); C67(0.87)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C65(0.88); C67(0.88)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C65(0.86); C67(0.86)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C65(0.75); C67(0.75)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C65(0.79); C67(0.79)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C65(1.21); C67(1.21)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C65(1.00); C67(1.00)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C65(0.84); C67(0.84)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C65(1.18); C67(1.18)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C65(0.80); C67(0.80)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C65(1.28); C67(1.28)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C65(0.94); C67(0.94)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C65(0.72); C67(0.72)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C65(0.79); C67(0.79)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C65(0.88); C67(0.88)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C65(0.80); C67(0.80)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C65(0.87); C67(0.87)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C65(1.15); C67(1.15)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C65(1.71); C67(1.71)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C65(1.04); C67(1.04)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C65(1.36); C67(1.36)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C65(1.08); C67(1.08)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C65(1.14); C67(1.14)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C65(0.97); C67(0.97)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C65(1.38); C67(1.38)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C65(1.08); C67(1.08)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C65(1.01); C67(1.01)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C65(1.04); C67(1.04)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C65(0.99); C67(0.99)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C65(1.06); C67(1.06)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C65(1.01); C67(1.01)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C65(0.93); C67(0.93)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C65(0.93); C67(0.93)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C65(1.25); C67(1.25)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C65(0.65); C67(0.65)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C65(0.53); C67(0.53)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C65(0.57); C67(0.57)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C65(0.64); C67(0.64)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C65(0.84); C67(0.84)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C65(0.82); C67(0.82)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C65(0.70); C67(0.70)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C65(0.95); C67(0.95)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C65(0.58); C67(0.58)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C65(0.67); C67(0.67)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C65(0.70); C67(0.70)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C65(0.58); C67(0.58)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C65(0.69); C67(0.69)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C65(0.68); C67(0.68)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C65(0.70); C67(0.70)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C65(0.97); C67(0.97)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C65(0.79); C67(0.79)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C65(1.03); C67(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C65(0.89); C67(0.89)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C65(1.05); C67(1.05)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C65(1.32); C67(1.32)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C65(1.80); C67(1.80)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C65(1.01); C67(1.01)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C65(0.97); C67(0.97)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C65(0.80); C67(0.80)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C65(0.97); C67(0.97)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C65(1.00); C67(1.00)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C65(0.93); C67(0.93)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C65(0.63); C67(0.63)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C65(0.65); C67(0.65)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C65(0.71); C67(0.71)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C65(0.57); C67(0.57)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C65(1.77); C67(1.77)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C65(0.66); C67(0.66)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C65(0.86); C67(0.86)  LDD0979  [3]
 LDCM0382  CL112 HCT 116 C65(0.94); C67(0.94)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C65(0.87); C67(0.87)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C65(0.72); C67(0.72)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C65(0.92); C67(0.92)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C65(0.99); C67(0.99)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C65(1.00); C67(1.11)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C67(0.85); C65(0.86)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C65(0.96); C67(1.01)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C65(2.07); C67(2.07)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C65(0.90); C67(0.91)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C65(0.96); C67(0.96)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C65(0.84); C67(0.84)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C65(0.80); C67(0.80)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C65(0.81); C67(0.81)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C65(0.85); C67(0.85)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C65(0.88); C67(0.88)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C65(0.85); C67(0.85)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C65(1.22); C67(1.22)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C65(1.71); C67(1.71)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C65(1.64); C67(1.64)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C65(1.60); C67(1.60)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C65(1.19); C67(1.19)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C65(0.98); C67(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C65(0.83); C67(0.83)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C65(0.92); C67(0.92)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C65(1.45); C67(1.45)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C65(0.97); C67(0.97)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C65(1.02); C67(1.02)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C65(1.07); C67(1.07)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C65(1.03); C67(1.03)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C65(1.14); C67(1.14)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C65(1.06); C67(1.06)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C65(0.94); C67(0.94)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C65(1.22); C67(1.22)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C65(0.97); C67(0.97)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C65(1.27); C67(1.27)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C65(1.37); C67(1.37)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C65(1.14); C67(1.14)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C65(0.82); C67(0.82)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C65(0.62); C67(0.62)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C65(0.60); C67(0.60)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C65(0.72); C67(0.72)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C65(0.81); C67(0.81)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C65(0.85); C67(0.85)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C65(0.84); C67(0.84)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C65(0.78); C67(0.78)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C65(1.56); C67(1.56)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C65(0.67); C67(0.67)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C65(0.80); C67(0.80)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C65(0.83); C67(0.83)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C65(0.71); C67(0.71)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C65(0.60); C67(0.60)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C65(0.61); C67(0.61)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C65(1.16); C67(1.16)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C65(1.13); C67(1.13)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C65(1.03); C67(1.03)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C65(1.07); C67(1.07)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C65(1.47); C67(1.47)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C65(0.98); C67(0.98)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C65(1.10); C67(1.10)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C65(1.09); C67(1.09)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C65(1.03); C67(1.03)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C65(1.10); C67(1.10)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C65(1.06); C67(1.06)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C65(1.18); C67(1.18)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C65(1.31); C67(1.31)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C65(1.15); C67(1.15)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C65(1.35); C67(1.35)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C65(1.34); C67(1.34)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C65(1.24); C67(1.24)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C65(0.80)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C65(0.81)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C65(0.97)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C65(0.97)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C65(0.67)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C65(0.87)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C65(1.13)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C65(0.98)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C65(1.11)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C65(2.27); C67(2.27)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C65(0.79)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C65(0.82)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C65(1.05)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C65(0.89)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C65(0.69)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C65(0.67); C67(0.67)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C65(0.72); C67(0.72)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C65(0.91); C67(0.91)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C65(0.78); C67(0.78)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C65(1.06); C67(1.06)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C65(0.64); C67(0.64)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C65(0.86); C67(0.86)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C65(0.78); C67(0.78)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C65(0.76); C67(0.76)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C65(0.83); C67(0.83)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C65(0.94); C67(0.94)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C65(1.10); C67(1.10)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C65(0.86); C67(0.86)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C65(0.76); C67(0.76)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C65(0.78); C67(0.78)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C65(1.29); C67(1.29)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C65(0.98); C67(0.98)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C65(1.08); C67(1.08)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C65(0.94); C67(0.94)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C65(0.94); C67(0.94)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C65(1.08); C67(1.08)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C65(0.92); C67(0.92)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C65(0.99); C67(0.99)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C65(0.96); C67(0.96)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C65(1.03); C67(1.03)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C65(1.15); C67(1.15)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C65(0.89)  LDD1698  [9]
 LDCM0625  F8 Ramos 0.96  LDD2187  [2]
 LDCM0572  Fragment10 Ramos 0.77  LDD2189  [2]
 LDCM0573  Fragment11 Ramos 2.03  LDD2190  [2]
 LDCM0574  Fragment12 Ramos 1.49  LDD2191  [2]
 LDCM0576  Fragment14 Ramos 1.23  LDD2193  [2]
 LDCM0579  Fragment20 Ramos 0.84  LDD2194  [2]
 LDCM0580  Fragment21 Ramos 0.79  LDD2195  [2]
 LDCM0578  Fragment27 Ramos 1.31  LDD2197  [2]
 LDCM0588  Fragment30 Ramos 1.11  LDD2199  [2]
 LDCM0589  Fragment31 Ramos 0.68  LDD2200  [2]
 LDCM0590  Fragment32 Ramos 0.70  LDD2201  [2]
 LDCM0468  Fragment33 HEK-293T C65(0.57)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos 0.91  LDD2203  [2]
 LDCM0566  Fragment4 Ramos 1.05  LDD2184  [2]
 LDCM0427  Fragment51 HCT 116 C65(0.93); C67(0.93)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos 0.81  LDD2205  [2]
 LDCM0569  Fragment7 Ramos 0.99  LDD2186  [2]
 LDCM0571  Fragment9 Ramos 1.59  LDD2188  [2]
 LDCM0022  KB02 HEK-293T C65(0.96); C65(0.98); C67(0.98)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C65(1.02); C65(1.06); C67(1.06)  LDD1497  [9]
 LDCM0024  KB05 HEK-293T C65(0.91); C65(0.93); C67(0.93)  LDD1502  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) Complex I NDUFA3 subunit family O95167
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Methylsterol monooxygenase 1 (MSMO1) Sterol desaturase family Q15800
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (PIGY) . Q3MUY2
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Claudin-5 (CLDN5) Claudin family O00501
Claudin-7 (CLDN7) Claudin family O95471
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) MS4A family Q96HJ5
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Syntaxin-1A (STX1A) Syntaxin family Q16623
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 106A (TMEM106A) TMEM106 family Q96A25
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Natural cytotoxicity triggering receptor 3 ligand 1 (NCR3LG1) . Q68D85
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Gap junction beta-5 protein (GJB5) Connexin family O95377
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Membrane protein FAM174A (FAM174A) FAM174 family Q8TBP5
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Ly6/PLAUR domain-containing protein 5 (LYPD5) . Q6UWN5
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Transmembrane protein 222 (TMEM222) . Q9H0R3

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402