Details of the Target

General Information of Target

Target ID LDTP19609
Target Name Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1)
Gene Name PTAR1
Gene ID 375743
Synonyms
Protein prenyltransferase alpha subunit repeat-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMHPVASSNPAFCGPGKPSCLNEDAMRAADQFDIYSSQQSKYSHTVNHKPMVCQRQDPLN
ETHLQTTSGRSIEIKDELKKKKNLNRSGKRGRPSGTTKSAGYRTSTGRPLGTTKAAGFKT
SPGRPLGTTKAAGYKVSPGRPPGSIKALSRLADLGYGCGTAAFPYPMMHGRAVHGVEETS
SEVKPPNE
Target Bioclass
Enzyme
Family
Protein prenyltransferase subunit alpha family
Uniprot ID
Q7Z6K3
Ensemble ID
ENST00000340434.5
HGNC ID
HGNC:30449

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K132(3.96)  LDD0277  [1]
NAIA_5
 Probe Info  		C381(20.00)  LDD2227  [2]
DBIA
 Probe Info  		C381(0.97)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C381(0.00); C60(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C373
 Probe Info  		10.56  LDD2033  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C381(0.95)  LDD1507  [12]
 LDCM0215  AC10 HCT 116 C381(0.76)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C381(0.90)  LDD0543  [3]
 LDCM0230  AC113 HCT 116 C381(0.86)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C381(1.28)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C381(0.94)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C381(0.82)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C381(1.04)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C381(1.07)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C381(0.93)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C381(0.85)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C381(1.06)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C381(1.13)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C381(0.94)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C381(0.98)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C381(0.90)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C381(1.00)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C381(1.19)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C381(1.24)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C381(0.86)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C381(0.92)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C381(0.94)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C381(0.88)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C381(0.97)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C381(0.92)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C381(0.83)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C381(0.84)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C381(0.86)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C381(0.86)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C381(0.90)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C381(0.97)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C381(0.89)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C381(0.89)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C381(0.91)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C381(0.90)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C381(1.06)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C381(0.84)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C381(0.71)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C381(0.98)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C381(0.94)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C381(0.62)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C381(0.97)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C381(0.87)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C381(1.18)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C381(0.85)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C381(0.95)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C381(0.73)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C381(0.89)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C381(0.92)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C381(1.03)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C381(0.77)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C381(0.69); C60(0.86)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C381(0.78); C60(1.03)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C381(0.57); C60(0.98)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C381(1.13); C37(0.83)  LDD1518  [12]
 LDCM0280  AC20 HCT 116 C381(0.59); C60(0.89)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C381(0.71); C60(0.88)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C381(0.58); C60(0.80)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C381(0.58); C60(0.80)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C381(0.63); C60(0.83)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C60(0.79)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C60(0.77)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C60(0.90)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C60(0.84)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C60(0.93)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C381(1.01)  LDD1529  [12]
 LDCM0291  AC30 HCT 116 C60(0.86)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C60(0.91)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C60(0.94)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C60(0.99)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C60(1.09)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C60(0.92)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C60(0.89)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C60(1.04)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C60(0.96)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C60(0.86)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C381(0.98)  LDD1540  [12]
 LDCM0302  AC40 PaTu 8988t C60(0.86)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C60(0.96)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C60(1.03)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C60(1.04)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C60(1.12)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C60(0.90)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C60(0.92)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C60(0.91)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C60(0.77)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C60(1.08)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C381(0.94)  LDD1551  [12]
 LDCM0313  AC50 HCT 116 C60(1.00)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C60(0.85)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C60(0.92)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C60(0.94)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C60(1.09)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C60(0.92)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C60(0.98)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C381(0.44); C60(1.50)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C381(0.44); C60(1.04)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C381(0.59); C60(1.27)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C381(0.76)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C381(0.40); C60(1.20)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C381(0.37); C60(0.84)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C381(0.54); C60(1.10)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C381(0.45); C60(1.37)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C381(0.46); C60(1.53)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C381(0.35); C60(1.55)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C381(0.34); C60(1.27)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C381(0.25); C60(1.21)  LDD0648  [3]
 LDCM0334  AC7 HCT 116 C381(0.77)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C381(0.72)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C381(1.08)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C381(1.07)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C381(0.99)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C381(1.13)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C381(1.02)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C381(1.08)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C381(1.09)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C381(1.04)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C381(1.22)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C381(1.14)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C381(1.01)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C381(1.16)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C381(0.95)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C381(1.05)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C381(1.10)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C381(0.85)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C381(0.99)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C381(0.84)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C381(0.97)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C381(20.00)  LDD2227  [2]
 LDCM0367  CL1 HCT 116 C381(1.05)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C381(1.04)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C381(0.83)  LDD1573  [12]
 LDCM0370  CL101 HCT 116 C381(0.73)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C381(1.05)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C381(0.78)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C381(0.75)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C381(0.64); C60(0.90)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C381(0.63); C60(0.88)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C381(0.57); C60(1.02)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C381(0.61); C60(1.17)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C381(0.65); C60(0.86)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C381(1.33)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C381(0.62); C60(0.94)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C381(0.55); C60(0.85)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C60(0.96)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C60(1.05)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C60(0.95)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C60(0.95)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C60(0.95)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C60(1.15)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C60(0.97)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C60(1.09)  LDD1268  [3]
 LDCM0390  CL12 HCT 116 C381(1.22)  LDD0707  [3]
 LDCM0391  CL120 PaTu 8988t C60(0.95)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C60(0.81)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C60(0.91)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C60(0.94)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C60(1.05)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C381(0.78); C60(1.09)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C381(0.51); C60(1.27)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C381(0.56); C60(1.17)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C381(0.53); C60(1.33)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C381(0.97)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C381(1.05)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C381(1.03)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C381(1.03)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C381(0.89)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C381(1.15)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C381(1.09)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C381(1.00)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C381(1.03)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C381(1.02)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C381(0.97)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C381(0.99)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C381(1.12)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C381(1.12)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C381(1.03)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C381(1.13)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C381(1.02)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C381(1.19)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C381(1.03)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C381(1.07)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C381(0.96)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C381(0.73)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C381(0.80)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C381(0.94)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C381(0.98)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C381(0.97)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C381(0.93)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C381(0.99)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C381(0.97)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C381(0.85)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C381(1.09)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C381(0.89)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C381(0.96)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C381(0.94)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C381(0.89)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C381(0.89); C60(0.88)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C381(0.96); C60(0.88)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C381(0.89); C60(0.85)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C381(0.91); C60(0.94)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C381(1.07)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C381(0.90); C60(0.88)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C381(0.89); C60(0.86)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C381(0.90); C60(0.88)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C381(1.05); C60(0.95)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C381(0.92); C60(0.82)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C381(0.86); C60(0.83)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C381(0.90); C60(0.86)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C381(1.01); C60(0.81)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C381(0.92); C60(0.90)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C381(0.89); C60(0.91)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C381(1.04)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C381(0.88); C60(0.90)  LDD0769  [3]
 LDCM0453  CL61 PaTu 8988t C381(1.00); C60(1.24)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C381(0.63); C60(0.92)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C381(0.75); C60(0.97)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C381(0.77); C60(1.09)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C381(0.89); C60(1.02)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C381(0.77); C60(1.12)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C381(0.72); C60(0.81)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C381(0.90); C60(1.10)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C381(0.76); C60(1.10)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C381(0.99)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C381(0.87); C60(0.79)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C381(0.85); C60(0.72)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C381(0.89); C60(0.86)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C381(0.56); C60(1.06)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C381(0.94); C60(1.04)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C381(0.73)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C381(0.99)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C381(0.84)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C381(0.88)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C381(1.11)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C381(0.80)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C381(0.82)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C381(0.74)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C381(0.97)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C381(0.97)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C381(1.17)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C381(0.68)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C381(0.85)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C381(0.73)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C381(0.79)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C381(1.18)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C381(1.05)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C381(1.14)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C381(1.27)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C381(1.08)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C381(1.08)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C381(0.98)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C381(1.07); C314(0.98)  LDD1694  [12]
 LDCM0493  CL98 HEK-293T C381(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C381(0.69); C60(0.94)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C381(0.95); C60(1.12)  LDD1698  [12]
 LDCM0625  F8 Ramos C381(0.77)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C381(0.71)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C381(1.55)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C381(0.55)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C381(0.89)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C381(0.78)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C381(2.45)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C381(1.02)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C381(1.29)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C381(0.88)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C381(1.30)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C381(1.05)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C381(0.99)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C381(0.72)  LDD2201  [13]
 LDCM0468  Fragment33 PaTu 8988t C381(0.86); C60(0.85)  LDD1347  [3]
 LDCM0596  Fragment38 Ramos C381(1.18)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C381(0.67)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C381(1.05)  LDD0744  [3]
 LDCM0610  Fragment52 Ramos C381(0.88)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C381(1.00)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C381(0.65)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C381(1.56)  LDD2188  [13]
 LDCM0022  KB02 Ramos C381(0.90)  LDD2182  [13]
 LDCM0023  KB03 Jurkat C92(18.51)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C381(2.48)  LDD3310  [15]
 LDCM0021  THZ1 HCT 116 C381(1.12)  LDD2173  [3]

References

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Mass spectrometry data entry: PXD028270
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840