Details of the Target

General Information of Target

Target ID LDTP10491
Target Name Fatty acyl-CoA reductase 2 (FAR2)
Gene Name FAR2
Gene ID 55711
Synonyms
MLSTD1; Fatty acyl-CoA reductase 2; EC 1.2.1.84; Male sterility domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRV
SHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRREL
LTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNR
ITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRST
VISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCI
EVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
Target Bioclass
Enzyme
Family
Fatty acyl-CoA reductase family
Subcellular location
Peroxisome membrane
Function
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates.
Uniprot ID
Q96K12
Ensemble ID
ENST00000182377.8
HGNC ID
HGNC:25531

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.I329SfsTer49 DBIA    Probe Info 
JURKAT SNV: p.K514E .
SUPT1 SNV: p.R116C DBIA    Probe Info 
THP1 Deletion: p.N436RfsTer24 .
WM2664 Insertion: p.I483HfsTer20 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C72(1.12)  LDD3323  [1]
IA-alkyne
 Probe Info  		C170(0.00); C72(0.00)  LDD0165  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
IPM
 Probe Info  		C170(0.00); C366(0.00)  LDD2156  [4]
AOyne
 Probe Info  		14.40  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.50  LDD1714  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C366(1.21)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C366(1.17)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C366(1.00)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C366(1.23)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C366(1.19)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C366(1.03)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C366(1.05)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C366(0.97)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C366(0.93)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C366(1.01)  LDD0823  [7]
 LDCM0227  AC110 HEK-293T C366(1.28)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C366(0.96)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C366(0.93)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C366(0.78)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C366(0.65)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C366(0.86)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C366(1.18)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C366(0.68)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C366(0.87)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C366(0.84)  LDD0834  [7]
 LDCM0238  AC120 HEK-293T C366(0.85)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C366(0.76)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C366(0.78)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C366(0.96)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C366(0.78)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C366(0.85)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C366(0.76)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C366(0.66)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C366(0.99)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C366(1.03)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C366(1.08)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C366(1.28)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C366(1.02)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C366(1.23)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C366(1.04)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C366(1.14)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C366(1.07)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C366(1.02)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C366(1.01)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C366(1.03)  LDD0856  [7]
 LDCM0260  AC140 HEK-293T C366(1.06)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C366(0.94)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C366(1.02)  LDD0860  [7]
 LDCM0263  AC143 HEK-293T C366(1.30)  LDD0861  [7]
 LDCM0264  AC144 HEK-293T C366(1.30)  LDD0862  [7]
 LDCM0265  AC145 HEK-293T C366(1.32)  LDD0863  [7]
 LDCM0266  AC146 HEK-293T C366(1.30)  LDD0864  [7]
 LDCM0267  AC147 HEK-293T C366(1.27)  LDD0865  [7]
 LDCM0268  AC148 HEK-293T C366(1.48)  LDD0866  [7]
 LDCM0269  AC149 HEK-293T C366(1.19)  LDD0867  [7]
 LDCM0271  AC150 HEK-293T C366(1.32)  LDD0869  [7]
 LDCM0272  AC151 HEK-293T C366(1.29)  LDD0870  [7]
 LDCM0273  AC152 HEK-293T C366(1.00)  LDD0871  [7]
 LDCM0274  AC153 HEK-293T C366(1.12)  LDD0872  [7]
 LDCM0621  AC154 HEK-293T C366(1.19)  LDD2162  [7]
 LDCM0622  AC155 HEK-293T C366(1.19)  LDD2163  [7]
 LDCM0623  AC156 HEK-293T C366(1.21)  LDD2164  [7]
 LDCM0624  AC157 HEK-293T C366(1.08)  LDD2165  [7]
 LDCM0276  AC17 HEK-293T C366(1.02)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C366(1.02)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C366(0.88)  LDD0876  [7]
 LDCM0280  AC20 HEK-293T C366(1.19)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C366(0.89)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C366(1.06)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C366(0.85)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C366(0.82)  LDD0882  [7]
 LDCM0296  AC35 HEK-293T C366(0.96)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C366(0.90)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C366(1.10)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C366(1.02)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C366(1.03)  LDD0898  [7]
 LDCM0302  AC40 HEK-293T C366(1.03)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C366(1.00)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C366(0.85)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C366(0.85)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C366(0.97)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C366(1.01)  LDD0905  [7]
 LDCM0308  AC46 HEK-293T C366(0.67)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C366(0.75)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C366(0.85)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C366(0.86)  LDD0909  [7]
 LDCM0313  AC50 HEK-293T C366(0.84)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C366(1.10)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C366(0.98)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C366(0.89)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C366(0.99)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C366(0.92)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C366(0.67)  LDD0917  [7]
 LDCM0320  AC57 HEK-293T C366(1.23)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C366(1.06)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C366(1.09)  LDD0920  [7]
 LDCM0324  AC60 HEK-293T C366(1.72)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C366(1.09)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C366(1.15)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C366(1.18)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C366(1.23)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C366(1.12)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C366(1.06)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C366(1.07)  LDD0929  [7]
 LDCM0349  AC83 HEK-293T C366(0.77)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C366(0.92)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C366(0.91)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C366(0.99)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C366(0.95)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C366(1.26)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C366(0.98)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C366(0.99)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C366(0.73)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C366(0.96)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C366(0.86)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C366(0.93)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C366(0.85)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C366(0.74)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C366(0.75)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C366(1.03)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C366(1.04)  LDD0964  [7]
 LDCM0374  CL105 HEK-293T C366(0.78)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C366(0.76)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C366(0.91)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C366(1.02)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C366(0.99)  LDD0976  [7]
 LDCM0380  CL110 HEK-293T C366(0.98)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C366(0.89)  LDD0979  [7]
 LDCM0387  CL117 HEK-293T C366(0.93)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C366(0.97)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C366(0.78)  LDD0987  [7]
 LDCM0391  CL120 HEK-293T C366(0.92)  LDD0989  [7]
 LDCM0392  CL121 HEK-293T C366(0.80)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C366(0.91)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C366(0.69)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C366(0.65)  LDD0993  [7]
 LDCM0396  CL125 HEK-293T C366(0.99)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C366(1.29)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C366(1.21)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C366(1.21)  LDD0997  [7]
 LDCM0403  CL16 HEK-293T C366(0.92)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C366(1.07)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C366(1.01)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C366(0.98)  LDD1004  [7]
 LDCM0408  CL20 HEK-293T C366(0.98)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C366(1.07)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C366(1.07)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C366(0.93)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C366(1.05)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C366(1.01)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C366(1.05)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C366(1.01)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C366(1.05)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C366(1.08)  LDD1015  [7]
 LDCM0419  CL30 HEK-293T C366(0.95)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C366(0.96)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C366(1.40)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C366(1.18)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C366(1.16)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C366(1.35)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C366(1.38)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C366(1.43)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C366(1.26)  LDD1026  [7]
 LDCM0430  CL40 HEK-293T C366(1.67)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C366(1.80)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C366(1.28)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C366(1.44)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C366(1.37)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C366(1.16)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C366(0.76)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C366(0.70)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C366(0.87)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C366(0.75)  LDD1037  [7]
 LDCM0441  CL50 HEK-293T C366(0.50)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C366(0.61)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C366(0.45)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C366(0.78)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C366(0.62)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C366(1.04)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C366(0.97)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C366(0.67)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C366(0.86)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C366(0.74)  LDD1048  [7]
 LDCM0452  CL60 HEK-293T C366(0.99)  LDD1050  [7]
 LDCM0427  Fragment51 HEK-293T C366(1.13)  LDD1025  [7]
 LDCM0022  KB02 22RV1 C72(1.16)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C72(1.12)  LDD2660  [1]
 LDCM0024  KB05 SKMEL24 C72(1.12)  LDD3323  [1]
 LDCM0627  NUDT7-COV-1 HEK-293T C170(0.69)  LDD2206  [8]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.