Details of the Target

General Information of Target

Target ID LDTP07255
Target Name Proteasome adapter and scaffold protein ECM29 (ECPAS)
Gene Name ECPAS
Gene ID 23392
Synonyms
ECM29; KIAA0368; Proteasome adapter and scaffold protein ECM29; Ecm29 proteasome adapter and scaffold; Proteasome-associated protein ECM29 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAASASQDELNQLERVFLRLGHAETDEQLQNIISKFLPPVLLKLSSTQEGVRKKVME
LLVHLNKRIKSRPKIQLPVETLLVQYQDPAAVSFVTNFTIIYVKMGYPRLPVEKQCELAP
TLLTAMEGKPQPQQDSLMHLLIPTLFHMKYPVESSKSASPFNLAEKPKTVQLLLDFMLDV
LLMPYGYVLNESQSRQNSSSAQGSSSNSGGGSGIPQPPPGMSFYAAKRVIGDNPWTPEQL
EQCKLGIVKFIEAEQVPELEAVLHLVIASSDTRHSVATAADLELKSKQSLIDWNNPAIIN
KMYKVYLGDIPLKTKEGAVLKPELKRDPVSTRVKLKIVPHLLRSRQAAETFPANIQVVYD
GLFGTNTNSKLRTLSLQFVHHICITCPEIKIKPLGPMLLNGLTKLINEYKEDPKLLSMAY
SAVGKLSSRMPHLFTKDIALVQQLFEALCKEEPETRLAIQEALSMMVGAYSTLEGAQRTL
MEALVASYLIKPEVQVRQVAVKFASTVFPSDHIPSRYLLLLAAGDPREEVHGEAQRVLRC
LPGRNRKESTSEQMPSFPEMVYYIQEKASHRMKTPVKYMTGTTVLPFNPAAFGEIVLYLR
MCLAHSAGVVPTSQSLADMQDHAPAIGRYIRTLMSSGQMAPSSSNKSGETNPVQIYIGLL
QQLLAGVGGLPVMYCLLEAVSVYPEKLATKFVDKTEWIKSLMNNSKEEMRELAALFYSVV
VSTVSGNELKSMIEQLIKTTKDNHSPEIQHGSLLALGFTVGRYLAKKKMRMSEQQDLERN
ADTLPDQEELIQSATETIGSFLDSTSPLLAIAACTALGEIGRNGPLPIPSEGSGFTKLHL
VESLLSRIPSSKETNKMKERAIQTLGYFPVGDGDFPHQKLLLQGLMDSVEAKQIELQFTI
GEAITSAAIGTSSVAARDAWQMTEEEYTPPAGAKVNDVVPWVLDVILNKHIISPNPHVRQ
AACIWLLSLVRKLSTHKEVKSHLKEIQSAFVSVLSENDELSQDVASKGLGLVYELGNEQD
QQELVSTLVETLMTGKRVKHEVSGETVVFQGGALGKTPDGQGLSTYKELCSLASDLSQPD
LVYKFMNLANHHAMWNSRKGAAFGFNVIATRAGEQLAPFLPQLVPRLYRYQFDPNLGIRQ
AMTSIWNALVTDKSMVDKYLKEILQDLVKNLTSNMWRVRESSCLALNDLLRGRPLDDIID
KLPEIWETLFRVQDDIKESVRKAAELALKTLSKVCVKMCDPAKGAAGQRTIAALLPCLLD
KGMMSTVTEVRALSINTLVKISKSAGAMLKPHAPKLIPALLESLSVLEPQVLNYLSLRAT
EQEKAAMDSARLSAAKSSPMMETINMCLQYLDVSVLGELVPRLCELIRSGVGLGTKGGCA
SVIVSLTTQCPQDLTPYSGKLMSALLSGLTDRNSVIQKSCAFAMGHLVRTSRDSSTEKLL
QKLNGWYMEKEEPIYKTSCALTIHAIGRYSPDVLKNHAKEVLPLAFLGMHEIADEEKSEK
EECNLWTEVWQENVPGSFGGIRLYLQELITITQKALQSQSWKMKAQGAIAMASIAKQTSS
LVPPYLGMILTALLQGLAGRTWAGKEELLKAIACVVTACSAELEKSVPNQPSTNEILQAV
LKECSKENVKYKIVAISCAADILKATKEDRFQEFSNIVIPLIKKNSLESSGVRTTKNEEE
NEKEKELQLEYLLGAFESLGKAWPRNAETQRCYRQELCKLMCERLKLSTWKVQLGVLQSM
NAFFQGLMLLEEEHADPEALAEILLETCKSITYSLENKTYSSVRTEALSVIELLLKKLEE
SKQWECLTSECRVLLIESLATMEPDSRPELQEKAALLKKTLENLE
Target Bioclass
Other
Family
ECM29 family
Subcellular location
Endoplasmic reticulum
Function
Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress.
Uniprot ID
Q5VYK3
Ensemble ID
ENST00000684092.1
HGNC ID
HGNC:29020
ChEMBL ID
CHEMBL4295853

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.68  LDD0402  [1]
A-EBA
 Probe Info  		4.18  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y1469(5.00)  LDD0257  [4]
ONAyne
 Probe Info  		K1243(8.74)  LDD0275  [5]
Probe 1
 Probe Info  		Y1066(75.88); Y1130(15.17); Y1455(81.90); Y1469(9.71)  LDD3495  [6]
BTD
 Probe Info  		C1459(2.11)  LDD2096  [7]
AHL-Pu-1
 Probe Info  		C1503(2.98)  LDD0168  [8]
DBIA
 Probe Info  		C1594(2.33); C1599(2.33); C1420(1.87)  LDD0080  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
IA-alkyne
 Probe Info  		C1420(0.00); C963(0.00); C1183(0.00); C1459(0.00)  LDD0032  [11]
NAIA_4
 Probe Info  		C1459(0.00); C1503(0.00)  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		C1638(0.00); C1257(0.00); C1183(0.00); C1364(0.00)  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
ENE
 Probe Info  		C1364(0.00); C1239(0.00)  LDD0006  [14]
IPM
 Probe Info  		C1257(0.00); C1459(0.00); C1420(0.00); C1364(0.00)  LDD0005  [14]
NHS
 Probe Info  		K1229(0.00); K313(0.00)  LDD0010  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
STPyne
 Probe Info  		K1237(0.00); K46(0.00)  LDD0009  [14]
VSF
 Probe Info  		C1183(0.00); C1070(0.00); C1257(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
Acrolein
 Probe Info  		C1183(0.00); C243(0.00); C1459(0.00); C1257(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		C1183(0.00); C1257(0.00); C243(0.00)  LDD0218  [18]
W1
 Probe Info  		C1257(0.00); C1183(0.00); C1638(0.00); C1070(0.00)  LDD0236  [19]
AOyne
 Probe Info  		7.20  LDD0443  [20]
NAIA_5
 Probe Info  		C449(0.00); C1624(0.00); C1183(0.00); C1390(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [21]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		10.20  LDD1714  [22]
C091
 Probe Info  		13.74  LDD1782  [22]
C349
 Probe Info  		18.00  LDD2010  [22]
FFF probe11
 Probe Info  		17.00  LDD0471  [23]
FFF probe13
 Probe Info  		6.32  LDD0475  [23]
FFF probe14
 Probe Info  		20.00  LDD0477  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [24]
DA-2
 Probe Info  		N.A.  LDD0072  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1239(1.12)  LDD2130  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1239(0.67); C1420(0.55)  LDD2131  [7]
 LDCM0025  4SU-RNA HEK-293T C1503(2.98)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1503(2.17)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C1070(1.17); C1183(1.18); C1379(0.99); C1390(0.99)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C1070(0.80); C1183(0.98); C1257(0.94); C1379(0.88)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C1183(1.01); C1379(0.50); C1390(0.50); C1420(0.77)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C1183(1.12); C1379(0.51); C1390(0.51); C1420(0.89)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C1183(1.05); C1379(0.58); C1390(0.58); C1420(0.93)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C1183(1.11); C1379(0.59); C1390(0.59); C1420(0.78)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C1183(1.07); C1379(0.59); C1390(0.59); C1420(0.91)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C1183(1.01); C1379(0.55); C1390(0.55); C1420(0.71)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C1183(1.11); C1379(0.55); C1390(0.55); C1420(0.76)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C1183(1.00); C1379(0.78); C1390(0.78); C1420(0.85)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C1183(0.99); C1379(0.66); C1390(0.66); C1420(0.72)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C1183(1.04); C1379(0.84); C1390(0.84); C1420(0.82)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C1070(0.82); C1183(0.88); C1257(0.93); C1379(0.88)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C1183(0.99); C1379(0.74); C1390(0.74); C1420(0.71)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C1183(1.06); C1379(0.69); C1390(0.69); C1420(0.77)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C1183(1.02); C1379(0.74); C1390(0.74); C1420(0.77)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C1070(0.83); C1183(0.91); C1257(0.87); C1379(0.87)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C1070(0.92); C1183(0.92); C1257(0.76); C1379(0.85)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C1070(0.94); C1183(0.97); C1257(0.77); C1379(0.90)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C1070(0.88); C1183(0.94); C1257(0.80); C1379(0.82)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C1070(0.82); C1183(0.97); C1257(0.78); C1379(0.82)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C1070(0.88); C1183(0.94); C1257(0.80); C1379(0.87)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C1070(0.84); C1183(0.96); C1257(0.76); C1379(0.87)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C1070(0.94); C1183(0.95); C1257(0.91); C1379(0.96)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C1070(0.95); C1183(0.87); C1257(0.83); C1379(1.00)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C1070(1.29); C1183(1.10); C1257(0.85); C1379(0.76)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C1070(0.88); C1183(0.95); C1257(0.87); C1379(0.91)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C1070(1.02); C1183(1.04); C1257(0.82); C1379(0.85)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C1070(1.01); C1183(1.00); C1257(0.87); C1379(0.82)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C1070(0.97); C1183(0.94); C1257(0.79); C1379(1.02)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C1070(1.04); C1183(0.99); C1257(0.77); C1379(0.92)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C1070(0.96); C1183(0.90); C1257(0.73); C1379(0.88)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C1070(1.04); C1183(1.58); C1257(1.20); C1379(1.41)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C1070(1.16); C1183(1.56); C1257(0.83); C1379(1.21)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C1070(1.04); C1183(1.38); C1257(0.96); C1379(1.04)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C1070(1.28); C1183(1.41); C1257(0.97); C1379(1.16)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C1070(0.91); C1183(1.28); C1257(1.04); C1379(0.97)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C1070(0.83); C1183(1.56); C1257(0.99); C1379(1.03)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C1070(1.06); C1183(1.37); C1257(0.94); C1379(0.97)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C1070(0.95); C1183(1.31); C1257(1.01); C1379(1.08)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C1070(1.02); C1183(1.29); C1257(1.08); C1379(1.00)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C1070(0.86); C1183(1.25); C1257(1.06); C1379(1.04)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C1070(0.89); C1183(1.33); C1257(1.02); C1379(1.21)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C1070(0.93); C1183(1.22); C1257(0.98); C1379(0.99)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C1070(0.89); C1183(1.08); C1257(0.98); C1379(1.07)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C1070(0.93); C1183(1.35); C1257(1.07); C1379(1.06)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C1070(0.91); C1183(1.24); C1257(1.01); C1379(1.15)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C1070(0.80); C1183(1.32); C1257(1.03); C1379(1.05)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C1070(0.89); C1183(0.85); C1257(0.86); C1379(0.75)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C963(0.61); C383(0.65); C386(0.65); C1257(0.81)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C963(0.72); C383(0.74); C386(0.74); C1390(0.84)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C963(0.52); C383(0.67); C386(0.67); C1379(0.71)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C963(0.53); C383(0.73); C386(0.73); C1257(0.89)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C963(0.50); C383(0.75); C386(0.75); C1379(0.90)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C963(0.52); C1379(0.75); C383(0.75); C386(0.75)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C963(0.53); C1806(0.67); C243(0.70); C1638(0.81)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C1390(0.75); C1379(0.82); C1257(0.84); C383(0.85)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C963(0.71); C1257(0.79); C383(0.81); C386(0.81)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C963(0.64); C383(0.72); C386(0.72); C1257(0.81)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C963(0.56); C383(0.81); C386(0.81); C1183(0.94)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C1070(0.99); C1183(0.98); C1257(0.75); C1379(0.78)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C1070(1.09); C1183(0.84); C1257(0.73); C1379(0.71)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C1070(1.11); C1183(0.80); C1257(0.88); C1379(0.86)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C1070(1.30); C1183(0.76); C1257(0.78); C1379(0.76)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C1806(0.62); C243(0.68); C1811(0.71); C1257(0.81)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C1811(0.65); C1638(0.70); C243(0.79); C1594(0.81)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C1811(0.80); C1257(0.85); C1806(0.91); C243(0.92)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C963(0.83); C1379(0.95); C1390(0.95); C1420(0.97)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C1811(0.61); C1806(0.68); C1257(0.79); C1638(0.81)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C1806(0.56); C1638(0.70); C243(0.81); C1594(0.82)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C1806(0.71); C1638(0.77); C1257(0.78); C243(0.83)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C1638(0.71); C1811(0.74); C1806(0.74); C243(0.79)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C1806(0.59); C1811(0.74); C243(0.91); C1257(0.91)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C1806(0.77); C1811(0.77); C1420(0.78); C1594(0.78)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C1806(0.63); C1811(0.63); C1420(0.69); C1599(0.70)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C1806(0.56); C1811(0.56); C1599(0.71); C1594(0.71)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C1806(0.56); C1811(0.56); C383(0.66); C386(0.66)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C1806(0.59); C1811(0.59); C1599(0.64); C1594(0.67)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C963(0.82); C1379(0.88); C1390(0.88); C243(1.02)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C243(0.54); C1806(0.66); C1811(0.66); C383(0.68)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C1806(0.58); C1811(0.58); C1594(0.72); C1599(0.73)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C1806(0.54); C1811(0.54); C243(0.58); C1599(0.62)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C1806(0.56); C1811(0.56); C383(0.63); C386(0.63)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C243(0.51); C1806(0.52); C1811(0.52); C1599(0.60)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C1459(0.83); C1257(0.90); C1070(0.94); C1638(1.01)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C1459(0.62); C1070(0.82); C1183(0.83); C1257(0.90)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C1459(0.68); C243(0.89); C1257(0.93); C1070(0.99)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C1459(0.71); C1806(0.89); C1811(0.89); C1070(0.94)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C963(0.71); C1459(0.73); C1257(0.87); C1379(0.91)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C963(0.66); C1379(0.90); C1390(0.90); C1594(0.91)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C1459(0.59); C963(0.79); C1806(0.93); C1811(0.93)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C1806(0.74); C1811(0.74); C1459(0.74); C963(0.81)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C963(0.74); C1806(0.93); C1811(0.93); C1070(0.94)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C1459(0.66); C963(0.87); C243(0.88); C1070(0.92)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C1459(0.69); C963(0.73); C243(0.87); C1070(0.97)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C1459(0.70); C963(0.74); C243(0.85); C1183(0.90)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C1459(0.77); C243(0.79); C1594(0.87); C1599(0.87)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C1459(0.81); C1379(0.85); C1390(0.85); C1594(0.89)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C1420(0.80); C383(0.82); C386(0.82); C1379(0.87)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C963(0.82); C383(0.84); C386(0.84); C1459(0.86)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C963(0.59); C1379(0.92); C1390(0.92); C1594(0.95)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C1594(0.79); C1599(0.79); C383(0.84); C386(0.84)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C1594(0.85); C1599(0.85); C1459(0.88); C1070(0.92)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C1594(0.76); C1599(0.76); C1459(0.78); C1379(0.87)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C1459(0.86); C383(0.90); C386(0.90); C1594(0.91)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C1459(0.82); C1594(0.85); C1599(0.85); C963(0.85)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C1459(0.80); C963(0.88); C1811(0.94); C383(0.97)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C1459(0.76); C383(0.96); C386(0.96); C1594(0.97)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C243(0.75); C1806(0.79); C1811(0.79); C1638(0.85)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C1806(0.63); C1811(0.63); C243(0.75); C1638(0.89)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C243(0.62); C1638(0.96); C1806(0.98); C1811(0.98)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C1806(0.62); C1638(0.74); C963(0.77); C243(0.78)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C243(0.68); C1638(0.81); C1806(0.82); C1811(0.82)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C1806(0.85); C1811(0.85); C1379(0.85); C1390(0.85)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C243(0.57); C1459(0.95); C1638(0.99); C1183(1.05)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C243(0.66); C1806(0.78); C1811(0.78); C1638(0.82)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C243(0.69); C1459(0.91); C1638(0.97); C1806(0.99)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C243(0.75); C1420(0.85); C1379(0.93); C1390(0.93)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C1806(0.82); C1811(0.82); C243(0.91); C1420(0.94)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C243(0.81); C1459(0.92); C1420(0.92); C1806(0.92)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C1183(0.63); C963(0.72); C1379(0.81); C1390(0.81)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C1811(0.69); C1806(0.69); C1183(0.76); C1459(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C1806(0.53); C963(0.69); C243(0.80); C1183(0.85)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C963(0.50); C383(0.72); C386(0.72); C1638(0.73)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C1183(0.78); C1806(0.80); C1379(0.85); C1390(0.85)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C1811(0.71); C1183(0.77); C1379(0.78); C1390(0.78)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C963(0.68); C1459(0.82); C1183(0.83); C1811(0.85)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C963(0.68); C1183(0.78); C1811(0.85); C383(0.87)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C963(0.69); C1459(0.70); C1183(0.76); C1811(0.89)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C1811(0.75); C1183(0.75); C963(0.84); C1806(0.87)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C963(0.61); C1811(0.65); C1183(0.69); C1806(0.76)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C1183(0.66); C1379(0.75); C1390(0.75); C383(0.77)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C963(0.67); C1811(0.74); C1806(0.77); C1379(0.77)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C1806(0.60); C963(0.67); C243(0.72); C1638(0.79)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C963(0.65); C1811(0.78); C383(0.87); C386(0.87)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C963(0.45); C1638(0.57); C1806(0.80); C383(0.89)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C963(0.48); C1183(0.83); C1459(0.90); C383(1.06)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C1594(0.71); C1599(0.71); C1379(0.89); C1390(0.89)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C1594(0.72); C1599(0.72); C1420(0.88); C1379(0.91)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C1594(0.69); C1599(0.69); C1379(0.71); C1390(0.71)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C1379(0.75); C1390(0.75); C1594(0.77); C1599(0.77)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C1379(0.78); C1390(0.78); C1420(0.83); C1594(0.87)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C1379(0.77); C1390(0.77); C1594(0.80); C1599(0.80)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C1594(0.74); C1599(0.74); C1420(0.78); C1379(0.81)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C1420(0.84); C1379(0.85); C1390(0.85); C1070(0.85)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C1594(0.83); C1599(0.83); C1379(0.88); C1390(0.88)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C1594(0.74); C1599(0.74); C1420(0.81); C1379(0.89)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C1594(0.74); C1599(0.74); C1379(0.81); C1390(0.81)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C1379(0.82); C1390(0.82); C1420(0.88); C1257(0.89)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C1379(0.70); C1390(0.70); C1420(0.75); C1257(0.78)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C1420(0.83); C1379(0.85); C1390(0.85); C1257(0.86)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C1594(0.65); C1599(0.65); C1379(0.80); C1390(0.80)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C243(0.51); C1379(0.61); C1390(0.61); C1420(0.77)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C243(0.55); C1379(0.57); C1390(0.57); C1420(0.80)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C1459(1.29)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C1070(0.85); C1183(0.95); C1257(0.99); C1379(0.94)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C963(0.65); C1070(0.80); C1638(0.81); C1806(0.82)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C963(0.54); C1806(0.69); C243(0.74); C1638(0.81)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C1806(1.27); C1811(1.27)  LDD2171  [9]
 LDCM0108  Chloroacetamide HeLa C243(0.00); C1070(0.00); C1183(0.00); C1257(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C1420(20.00); C602(6.08); C1183(4.16); C1638(1.48)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C1599(0.82); C1183(0.86); C1503(0.90); C243(0.91)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C383(0.75); C386(0.75); C243(0.88); C1503(0.91)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C963(0.70); C243(0.89); C1594(0.93); C1379(0.95)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C1806(0.56); C963(0.62); C243(0.69); C1638(0.74)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C963(0.64); C243(0.76); C1070(0.78); C1806(0.78)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C1806(0.74); C243(0.82); C1070(0.86); C1638(0.86)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C1806(0.66); C243(0.81); C1638(0.84); C1257(0.92)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C1806(0.75); C1257(0.79); C243(0.81); C1070(0.82)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C1811(0.59); C1638(0.73); C1806(0.84); C1594(0.90)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C1811(0.59); C1638(0.77); C1594(0.81); C1599(0.81)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C1638(0.91); C243(0.93); C1070(0.94); C1806(0.95)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C1811(0.59); C1638(0.76); C1806(0.78); C243(0.82)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C383(0.94); C386(0.94); C243(0.94); C1183(1.03)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C1638(0.75); C1257(0.80); C243(0.81); C1070(0.87)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C1638(0.74); C243(0.76); C1257(0.81); C1806(0.82)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C963(0.74); C243(0.76); C383(0.85); C386(0.85)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C1806(0.52); C1811(0.52); C1599(0.63); C1594(0.65)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C1806(0.67); C1811(0.67); C243(0.67); C1599(0.73)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C1599(0.64); C1806(0.66); C1811(0.66); C383(0.67)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C243(0.55); C383(0.68); C386(0.68); C1806(0.72)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C1459(0.55); C963(0.75); C1806(0.84); C1811(0.84)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C1459(0.80); C963(0.81); C243(0.94); C1638(0.96)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C1257(0.90); C1459(0.90); C963(0.97); C243(0.99)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C383(0.96); C386(0.96); C243(0.97); C1183(0.99)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C1459(0.77); C963(0.81); C1420(0.86); C1806(0.89)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C1503(0.82); C243(0.90); C1459(0.91); C1420(0.92)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C1594(0.84); C1599(0.84); C383(0.86); C386(0.86)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C963(0.82); C1594(0.83); C1599(0.83); C1459(0.84)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C1459(0.70); C963(0.79); C383(0.81); C386(0.81)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C243(0.61); C1070(0.95); C1379(0.97); C1390(0.97)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C1806(0.61); C1811(0.61); C243(0.70); C1638(0.89)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C243(0.61); C1420(0.95); C1806(0.96); C1811(0.96)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C243(0.88); C1638(0.92); C1420(1.01); C1459(1.03)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C1599(0.86); C1594(0.87); C243(0.97); C1183(0.99)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C1503(0.75); C243(0.81); C1599(0.83); C1594(0.87)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C243(0.88); C1183(0.91); C1503(0.92); C1599(0.92)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C243(0.81); C1811(0.85); C383(0.86); C386(0.86)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C383(0.81); C386(0.81); C1070(0.87); C1811(0.88)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C1811(0.54); C383(0.67); C386(0.67); C1806(0.81)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C1811(0.79); C383(0.81); C386(0.81); C1183(0.91)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C1599(0.74); C1183(0.78); C1594(0.80); C243(0.80)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C1183(0.82); C383(0.89); C386(0.89); C963(0.92)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C963(0.77); C1811(0.80); C383(0.82); C386(0.82)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C963(0.79); C1183(1.01); C243(1.04); C1806(1.04)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C243(0.69); C1183(0.77); C1811(0.81); C383(0.83)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C243(0.76); C383(0.82); C386(0.82); C963(0.88)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C1070(1.00); C1183(1.44); C1257(0.91); C1379(1.16)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C1070(1.03); C1183(1.12); C1257(0.89); C1379(1.25)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C1070(0.94); C1183(1.00); C1257(0.94); C1379(0.86)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C1070(0.97); C1183(0.90); C1257(0.89); C1379(1.22)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C1070(1.00); C1183(0.90); C1257(0.98); C1379(1.18)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C1070(1.14); C1183(0.91); C1257(0.96); C1379(1.13)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C1070(0.84); C1183(1.15); C1257(0.84); C1379(1.15)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C1070(1.07); C1183(0.98); C1257(0.94); C1379(1.14)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C1070(1.12); C1183(1.09); C1257(0.97); C1379(1.06)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C1070(1.12); C1183(0.88); C1257(0.87); C1379(1.15)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C1070(1.13); C1183(1.11); C1257(1.11); C1379(1.26)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C1070(1.39); C1183(1.12); C1257(1.07); C1379(1.24)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C1070(1.11); C1183(1.17); C1257(1.09); C1379(1.59)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C1070(1.32); C1183(1.06); C1257(1.08); C1379(1.24)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C1070(1.35); C1183(1.09); C1257(1.04); C1379(1.27)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C1070(1.19); C1183(0.82); C1257(0.97); C1379(1.07)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C1070(1.11); C1183(0.96); C1257(1.04); C1379(1.27)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C1070(1.03); C1183(1.38); C1257(1.01); C1379(1.13)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C1070(1.46); C1183(0.95); C1257(1.47); C1379(1.50)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C1070(1.43); C1183(0.99); C1257(1.20); C1379(1.60)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C1070(1.27); C1183(1.00); C1257(0.98); C1379(1.16)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C1070(1.23); C1183(1.01); C1257(1.14); C1379(1.11)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C1070(1.02); C1183(0.87); C1257(0.87); C1379(0.92)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C1070(1.04); C1183(0.92); C1257(0.86); C1379(0.81)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C1070(1.09); C1183(0.92); C1257(0.83); C1379(0.95)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C1070(1.22); C1183(0.92); C1257(0.92); C1379(1.06)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C1070(0.84); C1183(0.95); C1257(1.07); C1379(1.10)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C1070(1.05); C1183(1.05); C1257(0.85); C1379(0.78)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C1070(0.98); C1183(0.96); C1257(0.92); C1379(0.80)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C1070(0.98); C1183(0.90); C1257(0.88); C1379(0.89)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C1070(1.01); C1183(0.82); C1257(0.88); C1379(0.93)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C1070(1.01); C1183(0.81); C1257(0.78); C1379(0.81)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C1070(1.18); C1183(0.90); C1257(0.84); C1379(0.99)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C1070(0.98); C1183(0.89); C1257(0.92); C1379(0.86)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C1070(0.94); C1183(1.03); C1257(0.85); C1379(0.88)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C1070(1.14); C1183(0.88); C1257(0.87); C1379(0.96)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C1070(1.03); C1183(0.96); C1257(0.90); C1379(0.86)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C1070(0.92); C1183(0.85); C1257(1.08); C1379(0.95)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C1070(1.04); C1183(0.87); C1257(0.91); C1379(0.92)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C1070(0.92); C1257(1.02); C1379(0.91); C1390(0.91)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C1070(0.82); C1257(1.04); C1379(0.87); C1390(0.87)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C1070(0.78); C1257(0.98); C1379(0.81); C1390(0.81)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C1070(0.88); C1257(1.05); C1379(0.79); C1390(0.79)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C1070(0.84); C1257(1.01); C1379(0.87); C1390(0.87)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C1070(0.95); C1257(1.18); C1379(0.96); C1390(0.96)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C1070(0.92); C1257(1.07); C1379(0.98); C1390(0.98)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C1070(0.72); C1257(1.00); C1379(0.96); C1390(0.96)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C1070(0.90); C1257(0.88); C1379(1.02); C1390(1.02)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C1070(0.83); C1183(0.93); C1257(1.18); C1379(1.04)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C1070(0.83); C1257(1.05); C1379(0.84); C1390(0.84)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C1070(0.79); C1257(1.02); C1379(1.04); C1390(1.04)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C1070(0.75); C1257(0.98); C1379(0.94); C1390(0.94)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C1070(0.84); C1257(0.97); C1379(1.74); C1390(1.74)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C1070(0.81); C1257(1.02); C1379(1.10); C1390(1.10)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C1070(1.04); C1183(1.17); C1257(1.02); C1379(1.01)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C1070(1.01); C1183(1.29); C1257(0.98); C1379(2.42)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C1070(1.01); C1183(1.27); C1257(0.98); C1379(1.01)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C1070(1.17); C1183(1.24); C1257(1.14); C1379(1.02)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C1070(1.40); C1183(0.98); C1257(1.15); C1379(1.37)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C1070(1.05); C1183(1.17); C1257(0.98); C1379(1.04)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C1070(0.93); C1183(1.36); C1257(1.01); C1379(0.89)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C1070(1.24); C1183(1.61); C1257(1.27); C1379(1.26)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C1070(1.17); C1183(1.42); C1257(1.23); C1379(1.19)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C1070(1.22); C1183(1.33); C1257(1.50); C1379(1.34)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C1070(0.99); C1183(1.22); C1257(1.06); C1379(0.89)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C1070(1.10); C1183(1.21); C1257(1.06); C1379(0.96)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C1070(1.03); C1183(1.37); C1257(1.05); C1379(0.97)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C1070(1.12); C1183(1.51); C1257(1.12); C1379(1.15)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C1070(1.44); C1183(1.41); C1257(1.68); C1379(1.49)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C1070(0.95); C1183(0.89); C1257(1.01); C1379(1.47)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C1070(1.14); C1183(1.33); C1257(0.90); C1379(1.01)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C1070(1.06); C1183(1.00); C1379(0.88); C1390(0.88)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C1070(1.13); C1183(0.95); C1379(0.98); C1390(0.98)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C1070(1.10); C1183(1.05); C1379(1.18); C1390(1.18)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C1070(1.02); C1183(1.09); C1379(1.03); C1390(1.03)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C1070(0.96); C1183(0.96); C1379(0.94); C1390(0.94)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C1070(1.03); C1183(0.98); C1379(0.97); C1390(0.97)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C1070(1.13); C1183(1.13); C1379(1.01); C1390(1.01)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C1070(1.06); C1183(1.14); C1379(0.79); C1390(0.79)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C1070(1.07); C1183(1.08); C1379(0.91); C1390(0.91)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C1459(0.94); C1420(0.95); C602(0.90); C243(1.12)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1459(1.31); C1594(0.94)  LDD1702  [7]
 LDCM0625  F8 Ramos C1420(1.60); C1257(0.62); C1183(1.24); C1459(0.28)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C1420(1.80); C1257(2.47); C1459(4.44); C243(0.69)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C1420(0.45); C1183(0.14); C1459(3.46); C1624(1.33)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C243(0.60); C602(11.31)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C1420(1.07); C1257(0.59); C1183(1.37); C602(5.20)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C1420(4.60); C243(1.24); C602(2.98)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C1257(1.67); C243(0.73)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C1420(1.20); C1257(0.82); C1183(4.67); C243(1.81)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C1420(1.18); C1257(0.34); C1183(1.74); C1459(2.66)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C1420(0.74); C1257(0.16); C1183(0.89); C1459(0.60)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C1420(1.30); C1257(0.38); C1183(0.60); C1459(2.64)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C1420(1.28); C1257(0.50); C1183(2.48); C243(0.75)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C1420(1.71); C1257(0.23); C1183(1.50); C602(11.13)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C243(0.71); C602(5.96)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C1070(0.76); C1257(1.01); C1379(0.94); C1390(0.94)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C1420(1.57); C1257(1.48); C1183(4.15); C243(0.53)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C1420(4.46); C1257(2.42); C1459(0.56); C602(2.29)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C1070(1.36); C1183(1.01); C1257(1.29); C1379(1.46)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C1420(1.10); C1183(4.64); C1459(1.50); C602(3.09)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C1420(0.71); C1257(0.47); C1183(0.95); C1459(1.32)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C1420(3.70); C602(1.70)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C243(1.00); C602(13.56)  LDD2188  [27]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C1594(2.33); C1599(2.33); C1420(1.87)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C1594(1.16); C1599(1.16); C1420(1.67)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C1594(2.52); C1599(2.52); C1420(2.44)  LDD0082  [9]
 LDCM0109  NEM HeLa H340(0.00); H839(0.00); H25(0.00)  LDD0223  [18]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1459(2.11)  LDD2096  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1420(1.03)  LDD2107  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1459(1.63)  LDD2119  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1459(0.91)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1239(1.12)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1239(1.19)  LDD2127  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1459(0.92)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1459(1.04)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1239(0.80)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1239(1.33); C1420(1.67)  LDD2137  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1459(0.43)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C602(0.57)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C1183(0.92); C1459(0.87); C1420(0.84); C1239(0.68)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C1638(2.08); C1459(0.72); C1183(0.70); C1239(0.58)  LDD2207  [28]
 LDCM0021  THZ1 HCT 116 C1806(1.27); C1811(1.27)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Barttin (BSND) . Q8WZ55
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) Chemokine-like factor family Q9NX76
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein MAL2 (MAL2) MAL family Q969L2
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.