Details of the Target

General Information of Target

Target ID LDTP03348
Target Name Probable ATP-dependent RNA helicase DDX6 (DDX6)
Gene Name DDX6
Gene ID 1656
Synonyms
HLR2; RCK; Probable ATP-dependent RNA helicase DDX6; EC 3.6.4.13; ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ
SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS
PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV
SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV
QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL
MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS
CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH
RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED
EKP
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX6/DHH1 subfamily
Subcellular location
Cytoplasm, P-body
Function
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Uniprot ID
P26196
Ensemble ID
ENST00000526070.2
HGNC ID
HGNC:2747
ChEMBL ID
CHEMBL4105783

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.60  LDD0402  [1]
A-EBA
 Probe Info  		3.52  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y440(10.73)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K141(10.00); K162(7.06); K26(1.67); K94(0.90)  LDD0277  [6]
Probe 1
 Probe Info  		Y101(55.15); Y312(31.06); Y313(22.43); Y315(18.19)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C102(2.16)  LDD0169  [8]
HHS-475
 Probe Info  		Y473(0.85)  LDD0264  [9]
HHS-465
 Probe Info  		Y440(10.00); Y473(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C102(1.14); C324(0.97)  LDD0078  [11]
ATP probe
 Probe Info  		K86(0.00); K94(0.00); K236(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C184(0.00); C102(0.00); C361(0.00); C341(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C102(0.00); C390(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C184(0.00); C102(0.00); C361(0.00); C341(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
BTD
 Probe Info  		N.A.  LDD0004  [17]
IPM
 Probe Info  		N.A.  LDD0025  [18]
TFBX
 Probe Info  		C324(0.00); C390(0.00); C102(0.00)  LDD0027  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
Compound 10
 Probe Info  		C102(0.00); C390(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
OSF
 Probe Info  		N.A.  LDD0029  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
SF
 Probe Info  		N.A.  LDD0028  [21]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K26(0.00); K67(0.00); K94(0.00); K73(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C390(0.00); C102(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		C102(0.00); C390(0.00)  LDD0218  [24]
W1
 Probe Info  		C102(0.00); C324(0.00)  LDD0236  [25]
AOyne
 Probe Info  		4.20  LDD0443  [26]
NAIA_5
 Probe Info  		C184(0.00); C102(0.00); C361(0.00); C341(0.00)  LDD2223  [27]
HHS-482
 Probe Info  		Y363(1.82); Y473(1.04)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		10.99  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C390(0.69)  LDD2142  [30]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C102(0.81)  LDD2112  [30]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C102(1.29); C324(0.94)  LDD2117  [30]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C102(0.69)  LDD2132  [30]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C102(0.79)  LDD2131  [30]
 LDCM0026  4SU-RNA+native RNA HEK-293T C102(2.16)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C102(0.95); C184(1.28); C324(0.89); C341(0.78)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C102(1.27); C184(0.94); C324(1.06); C341(0.81)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C102(1.09); C324(1.00); C341(0.91); C390(1.20)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C102(0.91); C324(0.89); C341(0.66); C390(0.89)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C102(1.01); C324(0.83); C341(0.91); C390(0.94)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C102(1.19); C324(0.89); C341(0.63); C390(0.89)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C102(1.00); C324(0.86); C341(0.76); C390(0.99)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C102(1.19); C324(0.84); C341(0.70); C390(0.98)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C102(1.22); C324(0.82); C341(0.66); C390(0.98)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C102(1.04); C324(1.01); C341(0.65); C390(1.08)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C102(1.22); C324(0.97); C341(0.79); C390(0.95)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C102(0.95); C324(0.89); C341(0.86); C390(1.08)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C102(1.30); C184(1.21); C324(1.13); C341(0.77)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C102(1.01); C324(0.88); C341(0.85); C390(0.87)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C102(1.11); C324(0.86); C341(0.73); C390(0.85)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C102(1.04); C324(0.91); C341(0.78); C390(0.81)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C102(0.99); C324(1.00); C341(0.91); C361(0.99)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C102(1.08); C324(0.98); C341(0.71); C361(0.90)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C102(1.18); C324(0.97); C341(0.72); C361(0.82)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C102(1.15); C324(0.96); C341(0.85); C361(0.86)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C102(1.13); C324(0.91); C341(0.78); C361(0.95)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C102(1.07); C324(1.02); C341(0.83); C361(0.95)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C102(1.11); C324(0.89); C341(0.75); C361(0.81)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C102(1.21); C184(1.01); C324(1.09); C341(0.82)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C102(1.10); C324(0.88); C341(0.77); C361(1.22)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C102(1.09); C324(0.96); C341(0.97); C361(1.17)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C102(1.13); C324(0.93); C341(0.69); C361(0.87)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C102(1.00); C324(1.12); C341(0.91); C361(0.95)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C102(0.92); C324(0.95); C341(0.91); C361(0.87)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C102(1.04); C324(0.93); C341(0.91); C361(1.00)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C102(1.10); C324(0.99); C341(0.79); C361(1.07)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C102(1.13); C324(1.04); C341(0.86); C361(0.93)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C102(0.87); C324(1.12); C341(1.22); C390(1.84)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C102(0.77); C324(1.22); C341(1.56); C390(1.63)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C102(0.96); C324(1.05); C341(1.06); C390(1.48)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C102(0.74); C324(1.06); C341(1.07); C390(1.28)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C102(0.74); C324(1.10); C341(1.55); C390(1.22)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C102(0.89); C324(1.05); C341(1.01); C390(1.31)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C102(0.89); C324(1.10); C341(1.11); C390(1.19)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C102(0.81); C324(1.23); C341(1.14); C390(1.66)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C102(0.80); C324(1.19); C341(1.14); C390(1.28)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C102(0.71); C324(1.23); C341(1.10); C390(1.38)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C102(0.93); C324(1.31); C341(1.28); C390(1.33)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C102(0.82); C324(1.23); C341(1.04); C390(1.19)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C102(1.19); C184(1.03); C324(1.14); C341(0.80)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C102(0.90); C324(1.35); C341(1.20); C390(1.15)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C102(0.87); C324(1.22); C341(1.29); C390(1.22)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C102(0.77); C324(1.07); C341(1.01); C390(1.27)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C102(1.13); C184(0.75); C324(1.03); C341(0.93)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C184(0.83); C341(0.83); C324(0.99); C390(1.16)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C341(0.82); C324(1.02); C184(1.14); C102(1.19)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C184(0.64); C324(0.93); C390(0.95); C341(0.95)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C341(0.81); C184(0.91); C324(1.00); C390(1.03)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C184(0.67); C341(0.72); C390(0.97); C324(1.11)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C184(0.59); C341(0.81); C390(0.94); C324(1.03)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C184(0.93); C341(0.96); C102(1.11); C390(1.13)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C184(0.73); C390(0.96); C341(0.99); C324(1.08)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C184(0.70); C390(0.87); C341(0.93); C324(1.08)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C184(0.72); C390(0.92); C341(1.00); C324(1.11)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C184(0.53); C341(0.88); C390(0.90); C324(1.23)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C102(1.32); C184(0.68); C324(1.08); C341(0.87)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C102(1.36); C184(0.54); C324(1.04); C341(0.93)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C102(1.11); C184(0.83); C324(0.97); C341(1.07)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C102(0.91); C184(0.82); C324(1.02); C341(1.02)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C184(0.89); C102(1.08); C341(1.11); C390(1.12)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C184(0.68); C324(0.99); C341(0.99); C390(1.00)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C184(0.84); C102(1.12); C390(1.12); C324(1.21)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C341(0.83); C102(0.97); C390(1.04); C184(1.05)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C184(0.83); C102(0.96); C341(1.02); C390(1.15)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C184(0.73); C341(0.96); C390(1.05); C102(1.14)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C102(0.89); C341(0.91); C184(0.92); C390(1.11)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C184(0.90); C102(1.02); C341(1.07); C324(1.11)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C102(0.95); C184(1.04); C361(1.11); C390(1.20)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C102(0.75); C341(0.85); C324(0.93); C390(1.06)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C102(0.62); C341(0.82); C390(0.94); C324(0.95)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C102(0.77); C341(0.84); C390(0.89); C324(0.97)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C102(0.41); C341(0.87); C324(0.93); C184(0.98)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C390(0.72); C102(0.73); C341(0.77); C324(0.90)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C341(0.91); C102(0.93); C390(1.07); C324(1.26)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C390(0.70); C341(0.74); C102(0.84); C184(0.94)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C102(0.59); C341(0.89); C324(0.97); C390(1.10)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C102(0.56); C341(0.73); C390(0.81); C324(0.94)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C102(0.61); C341(0.76); C390(0.79); C184(0.94)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C390(0.74); C102(0.82); C341(0.86); C184(0.92)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C324(0.89); C184(0.98); C341(1.06); C102(1.08)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C324(0.90); C341(0.91); C390(1.03); C184(1.03)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C324(0.84); C102(0.85); C341(0.95); C184(0.97)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C324(0.88); C390(0.94); C102(1.01); C184(1.01)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C324(0.83); C341(0.90); C184(0.93); C102(1.03)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C341(0.85); C102(1.01); C390(1.11); C324(1.16)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C324(0.82); C102(0.85); C341(0.91); C184(0.97)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C390(0.82); C184(0.89); C102(0.89); C341(0.91)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C184(0.84); C390(0.90); C102(0.99); C324(1.06)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C102(0.75); C184(0.88); C341(0.90); C324(0.93)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C102(0.87); C184(0.96); C390(1.05); C324(1.06)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C184(0.90); C324(0.96); C102(1.03); C390(1.04)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C390(0.72); C102(0.88); C324(0.96); C184(1.00)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C102(0.80); C390(0.81); C341(0.98); C184(0.99)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C341(0.75); C102(0.77); C390(0.81); C184(0.85)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C390(0.72); C102(0.87); C184(0.89); C324(1.02)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C341(0.90); C102(1.02); C324(1.18); C390(1.27)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C390(0.79); C184(0.83); C341(0.87); C102(0.87)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C390(0.79); C102(0.83); C341(1.01); C324(1.09)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C390(0.76); C102(0.89); C184(0.99); C324(1.02)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C102(0.74); C390(0.78); C184(0.88); C341(0.94)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C102(0.83); C390(0.94); C184(0.94); C324(1.01)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C102(0.78); C184(0.88); C390(0.91); C341(0.93)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C390(0.65); C184(0.81); C341(0.89); C324(0.97)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C341(0.72); C324(0.87); C102(1.01); C184(1.05)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C341(0.64); C324(0.99); C102(1.03); C184(1.06)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C341(0.64); C324(0.95); C390(0.96); C102(1.10)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C341(0.75); C184(0.79); C390(0.84); C324(1.04)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C341(0.68); C102(0.94); C324(0.95); C390(0.99)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C341(0.56); C361(0.91); C324(0.93); C390(1.02)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C341(0.71); C361(0.95); C324(0.99); C102(1.00)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C341(0.86); C102(0.97); C324(1.00); C361(1.10)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C102(0.82); C341(0.89); C324(0.91); C361(0.98)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C341(0.55); C361(0.80); C390(0.88); C324(0.95)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C341(0.67); C361(0.85); C324(0.99); C102(1.02)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C341(0.62); C390(0.85); C324(0.88); C102(0.95)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C184(0.77); C390(0.93); C341(0.94); C324(0.98)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C184(0.72); C341(0.92); C390(0.98); C324(1.03)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C184(0.77); C341(0.83); C390(0.97); C324(1.03)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C341(0.70); C184(0.82); C390(0.93); C324(1.00)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C324(1.07); C390(1.08); C102(1.11); C184(1.12)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C341(0.94); C102(0.96); C184(1.00); C324(1.01)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C341(0.87); C184(0.91); C324(0.93); C390(0.97)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C184(0.86); C102(0.92); C390(0.98); C324(1.08)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C341(0.82); C102(0.88); C184(0.91); C390(0.95)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C102(0.88); C341(1.03); C324(1.03); C184(1.05)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C102(0.92); C341(0.93); C184(1.01); C390(1.04)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C102(0.81); C184(0.87); C390(0.90); C341(0.91)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C102(0.84); C184(1.01); C341(1.03); C390(1.05)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C184(0.76); C341(0.95); C390(1.02); C324(1.04)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C102(0.79); C184(0.90); C324(1.07); C390(1.09)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C102(0.90); C341(0.93); C184(0.96); C390(1.01)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C341(0.75); C102(0.78); C390(0.89); C184(0.95)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C341(0.39); C390(0.73); C324(0.94); C102(1.05)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C341(0.39); C390(0.87); C324(0.98); C102(1.10)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C341(0.45); C390(0.80); C324(0.88); C102(1.20)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C341(0.65); C390(0.73); C324(0.93); C102(0.99)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C341(0.60); C324(0.88); C102(0.93); C390(1.07)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C341(0.46); C324(0.98); C102(1.04); C390(1.05)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C341(0.49); C390(0.70); C324(0.94); C102(1.04)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C390(0.82); C324(0.94); C102(1.08); C341(1.18)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C341(0.60); C390(0.91); C324(0.94); C102(1.06)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C341(0.56); C390(0.87); C324(0.97); C102(1.07)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C341(0.53); C390(0.80); C324(0.97); C102(1.17)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C341(0.58); C324(0.97); C102(1.04); C390(1.36)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C341(0.41); C324(0.75); C390(0.97); C102(1.07)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C341(0.55); C324(0.88); C102(1.00); C390(1.27)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C341(0.58); C390(0.64); C324(0.91); C102(1.24)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C341(0.64); C324(0.78); C390(0.78); C102(1.52)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C341(0.76); C324(0.90); C390(0.94); C102(1.00)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C102(1.10); C184(0.99); C324(1.15); C341(0.80)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C341(0.72); C184(0.92); C390(1.01); C324(1.10)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C184(0.74); C341(0.75); C390(1.12); C324(1.14)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C102(1.14); C324(0.97)  LDD0078  [11]
 LDCM0108  Chloroacetamide HeLa C102(0.00); C390(0.00); H239(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C102(20.00); C102(1.75); C390(1.64); C102(1.19)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C324(0.89); C341(1.03); C102(1.19); C390(1.21)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C341(0.74); C184(0.76); C390(0.82); C324(0.97)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C341(0.84); C390(0.99); C102(1.00); C324(1.05)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C341(0.79); C184(0.85); C390(1.02); C324(1.09)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C341(0.82); C102(1.00); C390(1.05); C184(1.07)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C341(0.93); C184(0.98); C102(0.99); C324(1.08)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C341(0.85); C184(0.87); C390(0.99); C102(1.01)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C184(0.71); C341(1.00); C390(1.06); C102(1.07)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C184(0.58); C341(0.90); C390(1.08); C361(1.24)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C184(0.71); C341(0.94); C324(1.07); C390(1.08)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C184(0.72); C390(1.06); C102(1.12); C361(1.14)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C184(0.73); C341(0.88); C390(1.03); C324(1.08)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C184(0.72); C341(0.91); C324(0.94); C390(1.05)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C184(0.63); C341(0.82); C102(0.91); C390(1.03)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C184(0.72); C341(0.90); C390(1.00); C102(1.01)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C102(0.83); C341(0.97); C324(1.00); C390(1.02)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C102(0.66); C390(0.79); C341(0.81); C184(0.99)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C102(0.59); C390(0.67); C341(0.81); C324(0.87)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C102(0.66); C390(0.74); C341(0.80); C324(0.91)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C102(0.65); C341(0.75); C390(0.78); C324(0.89)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C324(0.87); C341(0.88); C184(0.88); C390(1.02)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C341(0.89); C102(0.95); C324(0.95); C184(0.98)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C324(0.85); C341(0.86); C184(0.92); C102(0.95)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C184(0.75); C341(0.84); C390(0.96); C324(1.01)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C102(0.69); C341(0.93); C184(0.94); C390(0.97)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C390(0.68); C102(0.83); C324(0.86); C184(0.89)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C390(0.70); C341(0.82); C184(0.85); C102(0.85)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C390(0.72); C102(0.76); C324(0.83); C184(0.85)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C390(0.67); C184(0.82); C324(0.82); C341(0.84)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C341(0.76); C324(0.83); C361(0.87); C390(0.95)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C341(0.76); C390(0.78); C324(0.88); C361(0.98)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C341(0.69); C390(0.81); C361(0.87); C324(1.00)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C341(0.74); C324(1.02); C361(1.08); C184(1.09)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C390(0.81); C341(0.81); C184(0.91); C324(0.97)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C390(0.92); C341(0.93); C184(0.94); C324(0.99)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C184(0.69); C341(0.77); C390(0.83); C324(0.94)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C390(0.73); C341(0.85); C184(1.01); C102(1.01)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C341(0.81); C102(0.93); C324(0.94); C390(1.02)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C341(0.62); C324(0.87); C390(0.94); C184(0.96)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C341(0.81); C324(0.96); C102(0.97); C184(1.12)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C341(0.91); C390(0.93); C324(1.00); C184(1.01)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C341(0.83); C102(0.98); C184(1.05); C324(1.06)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C341(0.82); C102(0.87); C324(1.02); C184(1.02)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C102(0.73); C341(0.84); C184(0.91); C390(0.99)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C102(0.76); C390(0.78); C341(0.94); C184(0.96)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C341(0.79); C102(0.81); C390(0.94); C324(1.07)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C102(0.81); C184(1.02); C324(1.05); C341(0.73)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C102(0.74); C184(0.98); C324(1.07); C341(0.88)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C102(0.68); C184(1.13); C324(0.95); C341(0.89)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C102(0.97); C184(1.04); C324(0.95); C341(0.75)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C102(0.70); C184(1.24); C324(1.04); C341(0.84)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C102(1.15); C184(0.92); C324(0.93); C341(0.96)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C102(0.83); C184(1.04); C324(1.03); C341(0.89)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C102(0.98); C184(0.51); C324(0.96); C341(1.03)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C102(1.11); C184(0.42); C324(0.96); C341(0.73)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C102(1.08); C184(0.42); C324(0.94); C341(0.67)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C102(0.88); C184(0.40); C324(1.22); C341(0.81)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C102(1.10); C184(0.44); C324(1.00); C341(0.90)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C102(1.05); C184(0.51); C324(1.09); C341(1.01)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C102(1.05); C184(0.40); C324(0.94); C341(0.80)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C102(1.32); C184(0.44); C324(0.97); C341(0.83)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C102(1.03); C184(1.18); C324(0.95); C341(0.89)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C102(0.95); C184(0.44); C324(0.93); C341(0.80)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C102(1.03); C184(0.37); C324(1.18); C341(1.01)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C102(1.22); C184(0.39); C324(1.48); C341(0.93)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C102(0.97); C184(0.45); C324(1.00); C341(0.87)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C102(0.95); C184(0.34); C324(1.02); C341(0.78)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C102(0.98); C184(0.37); C324(1.00); C341(0.78)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C102(0.79); C324(0.86); C341(1.43); C361(0.37)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C102(0.82); C324(1.07); C341(1.31); C361(0.71)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C102(0.92); C324(0.93); C341(1.60); C361(0.59)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C102(1.08); C324(0.97); C341(1.19); C361(0.54)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C102(1.11); C184(1.15); C324(0.90); C341(0.88)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C102(0.88); C324(1.03); C341(1.28); C361(0.67)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C102(0.84); C324(0.88); C341(1.73); C361(0.46)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C102(0.95); C324(0.90); C341(1.52); C361(0.45)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C102(1.00); C324(0.99); C341(1.49); C361(1.03)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C102(0.89); C324(0.91); C341(1.85); C361(0.65)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C102(0.93); C324(0.93); C341(1.50); C361(0.67)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C102(0.91); C324(1.01); C341(1.43); C361(0.78)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C102(0.78); C324(0.94); C341(1.78); C361(0.79)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C102(0.81); C324(1.08); C341(1.71); C361(0.56)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C102(0.94); C324(0.96); C341(1.23); C361(0.71)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C102(1.15); C184(0.67); C324(0.83); C341(0.69)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C102(0.81); C324(0.92); C341(1.36); C361(0.46)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C102(1.01); C184(1.03); C324(1.03); C341(0.84)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C102(0.98); C184(0.89); C324(1.08); C341(0.86)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C102(1.05); C184(0.68); C324(1.01); C341(0.73)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C102(1.13); C184(0.74); C324(1.00); C341(0.84)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C102(1.03); C184(1.04); C324(1.13); C341(0.87)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C102(1.35); C184(0.81); C324(1.09); C341(0.79)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C102(1.25); C184(0.74); C324(1.13); C341(0.84)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C102(1.09); C184(0.71); C324(1.32); C341(0.70)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C102(0.92); C184(0.78); C324(0.99); C341(0.61)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C102(1.60); C184(0.85); C324(0.93); C341(0.81)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C102(1.10); C184(0.69); C324(1.17); C341(0.74)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C102(1.24); C184(0.76); C324(1.22); C341(0.86)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C102(0.95); C184(0.68); C324(1.14); C341(0.80)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C102(1.06); C184(0.77); C324(1.10); C341(1.25)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C102(1.08); C184(0.85); C324(1.23); C341(0.94)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C102(1.32); C184(0.67); C324(0.89); C341(0.91)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C102(1.29); C184(0.70); C324(1.08); C341(1.24)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C102(1.21); C184(0.83); C324(0.97); C341(1.02)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C102(1.41); C184(0.79); C324(0.99); C341(1.01)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C102(1.08); C184(0.92); C324(1.08); C341(0.91)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C102(1.10); C184(0.95); C324(0.93); C341(0.92)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C102(1.16); C184(0.82); C324(1.01); C341(1.13)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C102(1.57); C184(0.77); C324(1.07); C341(1.14)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C102(1.81); C184(0.77); C324(1.00); C341(1.08)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C102(2.03); C184(0.74); C324(1.09); C341(0.97)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C102(1.25); C184(0.84); C324(1.01); C341(1.02)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C102(1.16); C184(1.05); C324(1.05); C341(1.02)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C102(1.08); C184(0.87); C324(0.99); C341(1.03)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C102(1.58); C184(0.85); C324(0.98); C341(1.17)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C102(2.24); C184(0.78); C324(1.18); C341(1.06)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C102(1.35); C184(0.91); C324(0.94); C341(0.91)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C102(0.84); C184(1.21); C324(0.88); C341(1.07)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C102(1.16); C184(1.00); C324(1.16); C341(0.84)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C102(1.16); C184(0.98); C324(0.89); C341(0.97)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C102(1.01); C184(1.13); C324(0.86); C341(1.00)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C102(0.99); C184(1.43); C324(0.90); C341(0.86)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C102(1.19); C184(1.03); C324(1.01); C341(0.81)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C102(0.99); C184(1.02); C324(1.01); C341(0.75)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C102(0.98); C184(0.93); C324(0.85); C341(0.74)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C102(1.05); C184(1.03); C324(0.88); C341(0.66)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C102(1.05); C184(1.28); C324(0.91); C341(0.76)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C102(0.13)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C324(0.97); C102(0.92); C390(0.92); C341(1.00)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C102(1.08); C324(0.86)  LDD1702  [30]
 LDCM0625  F8 Ramos C102(1.54); C324(2.62); C390(0.64)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C102(0.90); C324(2.03); C390(0.52)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C102(0.26); C324(1.28); C390(0.03)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C102(0.76); C324(0.90); C390(0.44)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C102(1.05); C324(1.11); C390(0.89)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C102(0.77); C324(0.79); C390(0.66)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C102(0.68); C324(0.66); C390(0.50)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C102(0.85); C324(0.09); C390(0.91)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C102(1.08); C324(1.38); C390(0.55)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C102(1.11); C324(0.45); C390(0.87)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C102(1.02); C324(0.96); C390(0.40)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C102(1.21); C324(0.66); C390(0.91)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C102(0.91); C324(0.86); C390(1.25)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C102(0.88); C324(0.37); C390(0.22)  LDD2201  [32]
 LDCM0468  Fragment33 HCT 116 C102(1.06); C184(0.76); C324(1.24); C341(0.80)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C102(1.03); C324(0.11); C390(0.88)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C102(0.97); C324(0.83); C390(0.80)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C102(0.80); C184(0.37); C324(1.32); C341(0.86)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C102(1.23); C324(0.48); C390(0.86)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C102(1.14); C324(0.17); C390(0.80)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C102(1.03); C324(0.66); C390(0.44)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C102(0.95); C324(1.75); C390(0.46)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y473(0.85)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y473(0.74)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y473(0.66)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y473(0.84)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y473(0.82)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C324(1.10); C102(1.20)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C324(1.32); C102(1.23)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C324(2.87); C102(1.50)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C102(0.99)  LDD2102  [30]
 LDCM0109  NEM HeLa H217(0.00); H474(0.00)  LDD0223  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C102(1.05)  LDD2090  [30]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C102(0.52)  LDD2092  [30]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C102(2.20)  LDD2094  [30]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C102(1.40); C324(0.70)  LDD2098  [30]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C102(0.73)  LDD2099  [30]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C102(0.64); C390(0.38)  LDD2100  [30]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C102(0.36); C390(0.45)  LDD2104  [30]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C102(2.22); C324(2.67)  LDD2105  [30]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C102(0.98)  LDD2107  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C102(0.95)  LDD2109  [30]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C102(1.84)  LDD2110  [30]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C102(0.90)  LDD2114  [30]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C102(0.45)  LDD2116  [30]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C102(0.77)  LDD2118  [30]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C102(1.20)  LDD2122  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C324(1.16)  LDD2123  [30]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C102(0.80)  LDD2124  [30]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C102(1.36)  LDD2125  [30]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C102(0.74)  LDD2126  [30]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C102(1.09)  LDD2129  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C324(1.18)  LDD2137  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C102(1.02); C390(0.27)  LDD2141  [30]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C390(0.33)  LDD2145  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C102(1.03); C102(0.51)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C390(1.40); C102(1.14)  LDD0304  [34]
 LDCM0021  THZ1 HCT 116 C102(1.11); C324(0.85)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Baculoviral IAP repeat-containing protein 7 (BIRC7) IAP family Q96CA5
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Serine/threonine-protein kinase PAK 5 (PAK5) STE Ser/Thr protein kinase family Q9P286
Serine hydroxymethyltransferase, cytosolic (SHMT1) SHMT family P34896
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
pre-mRNA splicing regulator USH1G (USH1G) . Q495M9
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger and BTB domain-containing protein 43 (ZBTB43) Krueppel C2H2-type zinc-finger protein family O43298
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Transcription factor 4 (TCF4) . P15884
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-2 (ATXN2) Ataxin-2 family Q99700
Junction plakoglobin (JUP) Beta-catenin family P14923
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) CNKSR family Q6P9H4
Enhancer of mRNA-decapping protein 3 (EDC3) EDC3 family Q96F86
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
PAK4-inhibitor INKA1 (INKA1) INKA family Q96EL1
Desmin (DES) Intermediate filament family P17661
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Peripherin (PRPH) Intermediate filament family P41219
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
LRP chaperone MESD (MESD) MESD family Q14696
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
RUN domain-containing protein 3A (RUNDC3A) RUNDC3 family Q59EK9
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Dynein axonemal assembly factor 11 (DNAAF11) TilB family Q86X45
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
PRKCA-binding protein (PICK1) . Q9NRD5
Splicing regulator RBM11 (RBM11) . P57052
Vinexin (SORBS3) . O60504

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-tartaric Acid Small molecular drug DB01694

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.