Details of the Target

General Information of Target

Target ID LDTP00418
Target Name Protein arginine N-methyltransferase 5 (PRMT5)
Gene Name PRMT5
Gene ID 10419
Synonyms
HRMT1L5; IBP72; JBP1; SKB1; Protein arginine N-methyltransferase 5; PRMT5; EC 2.1.1.320; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
Subcellular location
Cytoplasm
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. May methylate the N-terminal region of MBD2. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter. Methylates GM130/GOLGA2, regulating Golgi ribbon formation. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner. Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression. Symmetrically methylates NCL. Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6.
TTD ID
T82665
Uniprot ID
O14744
DrugMap ID
TTR1D7X
Ensemble ID
ENST00000216350.12
HGNC ID
HGNC:10894
ChEMBL ID
CHEMBL1795116

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.R291H DBIA    Probe Info 
MOLT4 SNV: p.W189Ter IA-alkyne    Probe Info 
NCIH1155 SNV: p.S632L DBIA    Probe Info 
YSCCC SNV: p.R526T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.28  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y307(20.00); Y324(20.00); Y481(18.96); Y304(13.21)  LDD0257  [4]
TH216
 Probe Info  		Y389(20.00); Y502(20.00); Y307(16.03)  LDD0259  [4]
STPyne
 Probe Info  		K240(5.56); K380(8.33)  LDD0277  [5]
BTD
 Probe Info  		C196(0.21)  LDD1699  [6]
Probe 1
 Probe Info  		Y179(25.76); Y342(22.95); Y502(14.53)  LDD3495  [7]
THZ1-DTB
 Probe Info  		C22(1.11)  LDD0460  [8]
DA-P3
 Probe Info  		8.89  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C278(4.52); C449(2.59); C42(2.38)  LDD0168  [10]
HHS-482
 Probe Info  		Y468(0.67)  LDD0285  [11]
HHS-475
 Probe Info  		Y304(0.95); Y307(1.02)  LDD0264  [12]
DBIA
 Probe Info  		C42(1.09)  LDD0080  [13]
AMP probe
 Probe Info  		N.A.  LDD0200  [14]
ATP probe
 Probe Info  		K490(0.00); K241(0.00); K240(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C449(0.00); C344(0.00); C22(0.00); C278(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C42(0.00); C344(0.00)  LDD0032  [16]
IPIAA_L
 Probe Info  		C449(0.00); C42(0.00); C344(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C449(0.00); C344(0.00); C22(0.00); C278(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C22(0.00); C278(0.00)  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
IPM
 Probe Info  		C196(0.00); C22(0.00); C278(0.00)  LDD2156  [21]
NHS
 Probe Info  		N.A.  LDD0010  [22]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
VSF
 Probe Info  		N.A.  LDD0007  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K490(0.00); K227(0.00); K479(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
NAIA_5
 Probe Info  		C344(0.00); C22(0.00); C599(0.00); C449(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		K227(0.00); Y304(0.00); Y307(0.00)  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.68  LDD0475  [26]
FFF probe2
 Probe Info  		6.52  LDD0463  [26]
FFF probe3
 Probe Info  		6.89  LDD0465  [26]
JN0003
 Probe Info  		7.65  LDD0469  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
STS-1
 Probe Info  		N.A.  LDD0068  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C196(0.25)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C196(1.20)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C196(1.41)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C196(1.55); C599(1.18)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C278(4.52); C449(2.59); C42(2.38)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C278(2.19); C42(5.06); C22(2.04)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C196(1.73); C278(1.17); C42(0.90); C518(1.00)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C196(1.33); C278(1.30); C42(1.03); C518(0.83)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C278(0.87); C42(0.76); C599(2.62); C622(0.95)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C278(0.88); C42(0.83); C599(1.06); C622(1.31)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C278(0.98); C42(0.92); C599(1.37); C622(0.97)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C278(1.26); C42(0.75); C599(0.75); C622(0.92)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C278(1.16); C42(0.77); C599(1.04); C622(0.95)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C278(1.05); C42(0.88); C599(1.38); C622(1.05)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C278(1.11); C42(0.73); C599(0.92); C622(1.08)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C278(1.01); C42(0.82); C599(0.90); C622(0.92)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C278(0.86); C42(0.61); C599(1.17); C622(0.93)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C278(0.91); C42(0.72); C599(2.01); C622(0.98)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C196(1.69); C278(1.86); C42(0.94); C518(0.89)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C278(1.00); C42(0.71); C599(1.10); C622(0.99)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C278(0.93); C42(0.65); C599(1.01); C622(1.02)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C278(1.02); C42(0.77); C599(1.11); C622(0.85)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C196(1.62); C278(0.99); C42(0.95); C599(1.35)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C196(0.87); C278(1.22); C42(1.09); C599(1.19)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C196(0.91); C278(1.28); C42(0.89); C599(1.19)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C196(0.88); C278(1.42); C42(0.81); C599(1.06)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C196(0.91); C278(1.17); C42(0.89); C599(1.50)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C196(0.86); C278(1.03); C42(0.92); C599(1.23)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C196(0.99); C278(1.14); C42(0.87); C599(1.20)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C196(1.59); C278(1.19); C42(1.04); C518(1.23)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C196(0.97); C278(1.77); C42(0.84); C599(1.06)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C196(1.01); C278(0.97); C42(0.78); C599(1.43)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C196(0.79); C278(1.18); C42(0.80); C599(0.95)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C196(0.79); C278(0.98); C42(0.94); C599(1.72)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C196(0.86); C278(1.03); C42(0.93); C599(1.10)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C196(0.85); C278(1.10); C42(1.05); C599(1.33)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C196(0.86); C278(1.40); C42(1.01); C599(1.04)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C196(0.84); C278(1.37); C42(0.87); C599(1.31)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C196(1.20); C518(0.80); C599(0.88); C622(0.47)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C196(1.05); C518(0.99); C599(0.82); C622(0.96)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C196(1.09); C518(0.89); C599(1.56); C622(0.71)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C196(0.94); C518(1.24); C599(0.81); C622(1.07)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C196(0.56); C518(1.08); C599(0.69); C622(0.86)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C196(0.84); C518(1.05); C599(0.87); C622(0.82)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C196(0.41); C518(1.02); C599(0.81); C622(0.73)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C196(0.59); C518(0.87); C599(0.63); C622(0.57)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C196(0.53); C518(0.95); C599(0.99); C622(0.59)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C196(0.53); C518(1.02); C599(0.74); C622(0.96)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C196(0.19); C518(0.98); C599(0.54); C622(0.61)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C196(0.27); C518(1.04); C599(0.60); C622(0.73)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C196(1.62); C278(1.11); C42(1.16); C518(1.62)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C196(0.22); C518(0.86); C599(0.56); C622(0.62)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C196(0.18); C518(0.96); C599(0.63); C622(0.81)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C196(0.51); C518(1.13); C599(0.92); C622(0.86)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C42(1.04); C278(1.10); C622(1.15)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C622(0.89); C42(1.03); C278(1.40)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C622(0.83); C42(1.05); C278(1.24)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C622(0.94); C42(1.06); C278(1.41)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C622(0.88); C42(1.04); C278(1.46)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C42(0.58); C622(0.74); C278(1.99)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C42(0.94); C622(0.95); C278(1.56)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C599(1.09); C622(1.13); C42(1.25); C278(1.32)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C42(0.98); C278(1.10); C622(1.28)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C278(1.04); C42(1.06); C622(1.25)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C622(0.97); C42(1.02); C278(1.78)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C42(0.49); C622(0.78); C278(2.36)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C278(1.40); C42(1.05); C622(0.90)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C278(1.44); C42(1.11); C622(1.00)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C278(1.00); C42(0.97); C622(1.15)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C278(0.91); C42(1.15); C622(1.06)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C518(0.87); C622(0.87); C42(0.96); C599(1.26)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C622(0.56); C42(0.84); C518(1.12); C599(1.18)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C622(0.79); C518(0.95); C42(1.00); C599(1.02)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C42(0.87); C622(0.87); C518(0.91); C278(1.03)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C622(0.87); C518(0.92); C42(0.93); C599(1.10)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C622(0.71); C599(0.91); C42(1.12); C518(1.26)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C622(0.68); C42(1.00); C518(1.02); C599(1.06)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C622(0.52); C42(0.77); C599(0.92); C518(1.11)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C518(0.89); C622(0.91); C42(1.03); C599(1.35)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C599(0.99); C278(1.01); C622(1.07); C42(1.08)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C622(0.80); C599(0.81); C196(0.96); C278(1.03)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C196(0.87); C622(0.89); C599(1.04); C42(1.07)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C599(0.83); C622(0.88); C196(0.92); C42(0.96)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C196(0.72); C599(0.83); C622(0.98); C42(1.08)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C42(0.88); C622(0.88); C518(0.90); C278(1.07)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C196(0.68); C599(0.76); C622(0.85); C42(0.96)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C622(0.81); C599(0.86); C196(0.88); C42(1.16)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C196(0.68); C599(0.74); C622(0.77); C42(0.93)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C599(0.84); C622(0.85); C42(0.95); C196(0.96)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C599(0.67); C622(0.83); C196(1.00); C42(1.02)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C518(0.81); C599(1.04); C42(1.06); C196(1.27)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C599(0.85); C278(0.89); C518(0.94); C622(0.94)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C278(0.74); C42(0.91); C622(0.93); C518(0.97)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C196(0.85); C622(0.90); C278(0.95); C599(0.96)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C599(0.70); C518(0.80); C42(0.86); C278(0.86)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C622(0.81); C42(0.81); C518(0.99); C278(1.15)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C518(0.63); C622(0.66); C42(0.81); C599(0.84)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C518(0.75); C278(0.79); C622(0.84); C42(0.91)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C599(0.72); C622(0.78); C518(0.84); C196(0.88)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C196(0.61); C42(0.74); C599(0.78); C518(0.81)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C42(0.75); C518(0.76); C622(0.78); C278(0.98)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C518(0.65); C622(0.69); C42(0.72); C599(0.85)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C518(0.69); C196(0.80); C42(0.85); C622(0.97)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C518(0.75); C622(0.83); C599(0.84); C42(0.91)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C196(0.73); C518(0.74); C622(0.78); C42(0.82)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C42(0.58); C518(0.62); C599(0.76); C196(0.78)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C42(0.79); C622(0.95); C518(0.99); C278(1.22)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C518(0.56); C196(0.61); C42(0.67); C599(0.80)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C196(0.63); C278(0.78); C518(0.78); C599(0.86)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C196(0.70); C518(0.78); C622(0.84); C42(0.91)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C599(0.72); C622(0.73); C196(0.88); C42(0.91)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C196(0.71); C599(0.72); C518(0.82); C42(0.85)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C599(0.71); C518(0.83); C622(0.84); C42(0.88)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C42(0.45); C518(0.51); C599(0.54); C196(0.60)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C622(0.81); C42(0.91); C518(1.05); C196(1.30)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C42(0.81); C622(0.85); C196(0.86); C518(0.96)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C42(0.80); C622(0.83); C518(0.92); C196(1.35)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C518(0.77); C622(0.87); C196(0.89); C42(0.91)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C622(0.83); C42(0.84); C518(0.95); C278(1.38)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C42(0.70); C622(0.99); C518(1.00); C196(1.03)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C42(0.79); C622(0.79); C518(0.86); C196(1.20)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C622(0.81); C42(0.97); C518(1.08); C278(1.28)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C42(0.79); C622(0.82); C518(0.91); C196(1.23)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C42(0.65); C622(0.88); C196(0.88); C518(1.06)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C42(0.71); C622(0.99); C196(1.00); C518(1.15)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C518(0.35); C42(0.53); C622(0.62); C196(1.09)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C196(0.86); C518(0.96); C622(0.97); C599(1.17)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C42(0.77); C196(0.83); C518(0.86); C599(1.00)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C42(0.89); C622(1.00); C518(1.02); C196(1.05)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C196(0.58); C42(0.61); C622(0.63); C518(0.79)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C196(0.92); C42(0.96); C599(1.05); C278(1.14)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C196(0.68); C518(0.94); C622(1.04); C42(1.04)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C518(0.36); C42(0.43); C622(0.62); C196(0.69)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C518(0.38); C42(0.44); C622(0.68); C196(0.88)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C518(0.21); C42(0.26); C622(0.50); C196(0.62)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C196(0.76); C42(0.84); C622(0.89); C518(0.97)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C196(0.65); C518(0.79); C42(0.85); C622(0.92)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C196(0.59); C42(0.94); C518(1.08); C599(1.20)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C196(0.54); C42(0.94); C599(1.10); C518(1.12)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C518(0.90); C196(0.90); C622(0.90); C42(0.93)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C196(0.84); C42(0.91); C518(0.94); C622(1.15)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C42(0.48); C196(0.63); C622(0.99); C518(1.08)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C518(0.14); C42(0.16); C622(0.41); C196(0.76)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C196(0.99); C622(1.02)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C196(0.84); C622(1.01)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C196(0.81); C622(1.05)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C622(0.64); C196(0.94)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C622(0.59); C196(1.06)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C622(0.51); C196(1.05)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C622(0.73); C196(0.99)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C622(0.70); C196(1.07)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C622(0.82); C196(0.99)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C196(0.81); C622(1.37)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C196(0.87); C622(1.34)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C622(0.73); C196(1.06)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C622(0.61); C196(1.07)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C196(1.02); C622(1.66)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C622(0.69); C196(1.06)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C42(0.45); C599(0.56); C622(1.03); C278(1.70)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C42(0.73); C278(0.83); C622(0.95); C599(1.53)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C196(0.44)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C196(0.79)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C196(1.61); C278(1.08); C42(1.08); C518(0.96)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C42(0.95); C622(0.98); C518(1.13); C599(1.29)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C599(0.71); C518(0.72); C622(0.78); C42(0.81)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C22(1.04); C42(0.97)  LDD2171  [13]
 LDCM0498  BS-3668 MDA-MB-231 C196(0.95)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C278(1.06)  LDD2214  [30]
 LDCM0108  Chloroacetamide HeLa C22(0.00); C622(0.00); C196(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C42(1.17); C22(0.85)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C278(0.89); C196(0.97); C42(0.99); C599(1.12)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C518(0.71); C42(0.90); C196(1.01); C622(1.15)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C622(0.85); C42(0.86); C518(0.90); C278(1.07)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C622(0.90); C518(0.94); C599(1.04); C42(1.06)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C42(0.83); C278(0.97); C622(1.02); C518(1.11)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C518(0.83); C622(0.84); C42(0.90); C278(1.10)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C622(0.88); C518(1.06); C599(1.14); C42(1.18)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C42(0.76); C622(0.79); C599(0.83); C518(1.23)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C42(0.70); C599(0.73); C622(0.91); C518(1.22)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C42(0.80); C599(0.83); C622(0.87); C518(1.11)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C42(0.76); C599(0.81); C622(0.84); C518(0.88)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C622(0.69); C599(0.86); C42(0.88); C518(1.12)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C518(0.79); C622(0.86); C42(0.89); C196(1.05)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C622(0.67); C42(0.78); C599(0.80); C518(0.88)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C622(0.74); C518(0.78); C42(0.86); C599(0.87)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C42(0.82); C599(0.86); C622(0.91); C196(0.98)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C196(0.75); C599(0.81); C622(0.87); C42(0.90)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C196(0.61); C599(0.73); C42(0.89); C622(0.90)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C599(0.72); C196(0.83); C622(0.83); C42(0.97)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C622(0.84); C599(0.98); C196(1.02); C42(1.03)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C518(0.28); C42(0.44); C622(0.46); C599(0.60)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C518(0.79); C42(0.80); C622(0.83); C599(0.89)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C599(0.84); C42(0.90); C518(0.92); C196(0.96)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C518(0.75); C196(0.83); C42(0.89); C599(1.08)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C196(0.73); C599(0.82); C278(0.84); C622(0.85)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C599(0.74); C622(0.78); C278(0.79); C196(0.82)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C196(0.73); C599(0.75); C42(0.78); C622(0.86)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C196(0.74); C622(0.74); C599(0.77); C42(0.78)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C196(0.60); C599(0.65); C42(0.67); C518(0.67)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C42(0.85); C622(0.92); C518(0.98); C196(1.00)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C42(0.77); C622(0.93); C196(1.05); C518(1.28)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C42(0.81); C622(0.92); C518(1.04); C196(1.22)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C622(0.75); C518(0.87); C42(0.89); C196(1.14)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C518(0.86); C42(1.02); C196(1.18); C278(1.21)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C278(0.96); C196(0.98); C518(1.02); C599(1.28)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C599(0.73); C518(0.79); C42(0.87); C196(1.10)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C622(0.60); C196(0.71); C518(0.86); C42(0.90)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C622(0.63); C196(0.71); C42(0.81); C518(0.85)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C518(0.87); C622(0.87); C196(0.90); C42(1.10)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C622(0.77); C518(0.79); C196(0.88); C42(1.07)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C278(0.79); C196(0.94); C518(1.12); C622(1.14)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C622(0.74); C518(0.79); C196(0.88); C42(1.04)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C622(0.59); C518(0.70); C196(0.81); C42(0.84)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C622(0.49); C518(0.65); C42(0.66); C196(0.82)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C622(0.79); C599(0.83); C196(0.86); C518(0.93)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C196(0.77); C42(0.93); C518(0.72); C599(1.73)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C196(0.75); C42(0.88); C518(0.64); C599(1.96)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C196(0.51); C42(1.00); C518(0.84); C599(3.12)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C196(0.96); C42(0.94); C518(0.81); C599(2.09)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C196(0.71); C42(0.88); C518(0.73); C599(1.63)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C196(0.99); C42(0.78); C518(0.80); C599(1.73)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C196(1.03); C278(0.92); C42(1.01); C518(1.00)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C196(0.82); C42(0.86); C518(0.93); C599(2.24)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C196(0.71); C278(1.35); C42(1.05); C518(0.88)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C196(0.93); C278(1.73); C42(1.04); C518(0.93)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C196(0.82); C278(1.39); C42(1.00); C518(0.96)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C196(0.66); C278(3.15); C42(0.84); C518(0.57)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C196(0.66); C278(1.50); C42(1.07); C518(0.65)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C196(0.54); C278(1.32); C42(0.97); C518(0.70)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C196(0.56); C278(2.16); C42(0.99); C518(0.48)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C196(0.50); C278(1.67); C42(0.96); C518(0.59)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C196(0.99); C278(0.89); C42(1.10); C518(0.99)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C196(0.49); C278(1.74); C42(1.06); C518(0.63)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C196(0.50); C278(1.36); C42(1.04); C518(0.69)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C196(0.40); C278(3.60); C42(0.61); C518(0.24)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C196(0.57); C278(1.61); C42(1.00); C518(0.67)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C196(0.46); C278(1.43); C42(1.02); C518(0.71)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C196(0.57); C278(1.87); C42(0.77); C518(0.37)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C196(1.11); C42(1.00)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C196(1.04); C42(1.02)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C196(1.07); C42(1.08)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C196(1.00); C42(1.14)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C196(1.23); C278(0.90); C42(1.29); C518(1.40)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C196(0.97); C42(1.07)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C196(1.12); C42(1.05)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C196(1.05); C42(1.03)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C196(0.96); C42(1.17)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C196(1.04); C42(1.06)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C196(1.12); C42(1.24)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C196(1.11); C42(0.90)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C196(1.01); C42(0.94)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C196(1.16); C42(1.21)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C196(1.09); C42(1.23)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C196(0.94); C278(1.15); C42(0.91); C518(1.06)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C196(1.07); C42(1.15)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C196(0.93); C42(0.84)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C196(0.86); C42(0.96)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C196(0.81); C42(0.88)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C196(0.85); C42(0.92)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C196(0.95); C42(0.93)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C196(0.78); C42(0.76)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C196(0.86); C42(1.16)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C196(0.86); C42(0.83)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C196(0.95); C42(0.87)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C196(1.31); C278(1.36); C42(0.98); C518(1.08)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C196(0.89); C42(0.85)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C196(0.81); C42(0.97)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C196(0.93); C42(1.01)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C196(0.85); C42(0.83)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C196(0.81); C42(0.99)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C196(0.84); C42(1.02); C622(0.85)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C196(0.77); C42(0.53); C622(0.97)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C196(0.70); C42(0.94); C622(1.04)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C196(0.84); C42(1.07); C622(0.93)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C196(1.13); C278(2.10); C42(0.95); C518(0.83)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C196(1.21); C42(0.92); C622(1.29)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C196(0.71); C42(0.80); C622(0.75)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C196(0.59); C42(0.75); C622(0.68)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C196(0.77); C42(0.89); C622(0.80)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C196(0.43); C42(0.74); C622(0.48)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C196(0.84); C42(1.06); C622(1.18)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C196(0.96); C42(0.94); C622(1.21)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C196(0.91); C42(1.07); C622(1.06)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C196(0.68); C42(1.07); C622(1.02)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C196(0.30); C42(0.75); C622(0.62)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C196(0.99); C278(1.01); C42(0.98); C518(1.05)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C196(0.95); C42(0.71); C622(0.96)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C196(0.64); C278(0.86); C42(0.89); C518(0.78)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C196(0.79); C278(1.20); C42(0.76); C518(1.02)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C196(1.30); C278(1.40); C42(0.88); C518(0.97)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C196(1.30); C278(1.31); C42(0.89); C518(1.03)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C196(0.72); C278(1.16); C42(0.80); C518(0.91)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C196(0.88); C278(0.99); C42(0.77); C518(0.92)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C196(0.88); C278(1.20); C42(0.82); C518(0.90)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C196(1.34); C278(1.08); C42(0.80); C518(0.87)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C196(1.46); C278(1.24); C42(0.82); C518(0.93)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C22(0.66)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C196(0.87); C622(0.93); C42(0.87); C22(1.05)  LDD1698  [31]
 LDCM0031  Epigallocatechin gallate HEK-293T 8.89  LDD0183  [9]
 LDCM0625  F8 Ramos C22(0.50); C622(0.89)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C599(0.44); C22(0.79)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C599(0.11); C22(0.35); C622(0.52)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C599(0.42); C22(0.93)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C599(0.71); C22(1.05)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C22(2.16); C622(0.87)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C599(0.38); C22(0.92)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C599(0.69); C22(1.40)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C599(1.16); C22(1.75)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C599(0.88); C22(1.47)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C599(0.85)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C599(1.03); C22(1.38)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C599(1.00); C22(1.69)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C599(0.55); C22(0.78)  LDD2201  [32]
 LDCM0468  Fragment33 HCT 116 C196(0.88); C42(0.96)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C599(0.75); C22(1.09)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C22(0.60); C622(0.94)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C196(0.55); C278(2.31); C42(0.79); C518(0.31)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C599(1.20); C22(1.33)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C599(1.13); C22(1.23)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C22(0.52); C622(1.35)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C599(0.42); C22(0.76)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y304(0.95); Y307(1.02)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y304(0.80); Y307(0.86)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y304(0.85); Y307(0.86)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y304(1.08); Y307(1.14)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y307(1.08); Y304(1.15)  LDD0268  [12]
 LDCM0107  IAA HeLa C22(0.00); H175(0.00); C599(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y468(0.67)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y468(0.84)  LDD0286  [11]
 LDCM0126  JWB150 DM93 Y468(0.96)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y468(0.74)  LDD0289  [11]
 LDCM0130  JWB211 DM93 Y468(0.85)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C42(1.09)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C42(1.36)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C42(1.66)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C196(0.90)  LDD2102  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C196(0.94)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C196(0.87)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C196(1.09); C599(0.95)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C196(0.72)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C196(1.28); C599(0.92)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C599(0.55)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C196(0.94)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C196(1.58)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C599(0.37)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C196(1.13); C599(1.25)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C196(0.84)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C196(0.59); C599(0.50)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C196(1.36); C599(0.81)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C196(0.67)  LDD2114  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C196(1.96)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C196(0.62); C599(0.70)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C196(1.53); C599(0.65)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C196(1.01)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C599(0.57)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C196(0.94)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C599(0.40)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C599(0.95)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C196(0.74); C599(0.76)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C196(1.65); C599(1.23)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C196(0.59)  LDD2133  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C196(1.84); C599(1.05)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C196(1.44); C599(0.93)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C599(0.86)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C196(1.01)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C196(0.57); C599(0.68)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C196(0.61); C599(0.68)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C196(2.30); C599(2.12)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C196(1.04); C599(1.01)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C196(1.37)  LDD2147  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C599(0.75)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C599(0.32)  LDD2150  [6]
 LDCM0021  THZ1 HeLa S3 C22(1.11)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipoprotein lipase (LPL) Lipase family P06858
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Cryptochrome-1 (CRY1) DNA photolyase class-1 family Q16526
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930
Plasma kallikrein (KLKB1) Peptidase S1 family P03952
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Serine/threonine-protein kinase RIO1 (RIOK1) RIO-type Ser/Thr kinase family Q9BRS2
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) Calcium channel beta subunit family Q08289
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A9 (HOXA9) Abd-B homeobox family P31269
Protein c-Fos (FOS) BZIP family P01100
Transcription factor E2F1 (E2F1) E2F/DP family Q01094
Grainyhead-like protein 3 homolog (GRHL3) Grh/CP2 family Q8TE85
Heat shock factor protein 1 (HSF1) HSF family Q00613
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Protein FAM47E (FAM47E) FAM47 family Q6ZV65
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) Histone H4 family P62805
Angiotensinogen (AGT) Serpin family P01019
Probable RNA-binding protein 23 (RBM23) Splicing factor SR family Q86U06
T-complex protein 1 subunit beta (CCT2) TCP-1 chaperonin family P78371
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Chromodomain Y-like protein 2 (CDYL2) . Q8N8U2
Coordinator of PRMT5 and differentiation stimulator (COPRS) . Q9NQ92
Elongin-A (ELOA) . Q14241
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Methylosome protein WDR77 (WDR77) . Q9BQA1
NudC domain-containing protein 2 (NUDCD2) . Q8WVJ2
SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) . O75044
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gsk3326595 . D0CR7L
Phase 1
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jnj-64619178 Small molecular drug DFZ0V3
Prt543 Small molecular drug DC6UG5
Prt811 Small molecular drug D1SL2W
Pf-06939999 . DM1VE5
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cmp5 Small molecular drug D04NZF
Ds-437 Small molecular drug D00QZA
Epz015666 Small molecular drug D05XQD

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
30 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578