Details of the Target

General Information of Target

Target ID LDTP05159
Target Name Metallothionein-1X (MT1X)
Gene Name MT1X
Gene ID 4501
Synonyms
Metallothionein-1X; MT-1X; Metallothionein-IX; MT-IX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCC
A
Target Bioclass
Other
Family
Metallothionein superfamily, Type 1 family
Function
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling.
Uniprot ID
P80297
Ensemble ID
ENST00000394485.5
HGNC ID
HGNC:7405

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K43(3.96)  LDD2217  [3]
BTD
 Probe Info  		C50(1.59); C48(1.58); C26(0.63)  LDD1700  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Phosphinate-6
 Probe Info  		C60(0.00); C29(0.00); C21(0.00)  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C26(0.37)  LDD2112  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C50(0.92); C26(1.08); C48(1.17)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C50(1.04); C26(0.87); C48(0.95)  LDD2132  [4]
 LDCM0545  Acetamide MDA-MB-231 C50(0.94)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C50(1.01); C48(0.98)  LDD2113  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C26(0.85); C48(1.31)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C50(1.81); C48(1.65)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C26(0.53); C48(1.34)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C50(0.75); C48(0.66)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C50(1.36); C48(1.36)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C50(0.91); C48(0.86)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C50(1.03); C26(0.43)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C50(0.67)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C48(0.32)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C50(1.25); C26(1.25)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C48(0.35)  LDD2122  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C50(0.93); C26(0.38); C48(0.96)  LDD2125  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C50(0.73)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C50(0.79); C26(0.37)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C50(0.87); C48(0.80)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C50(0.73); C48(0.74)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C50(0.63); C26(0.42); C48(0.55)  LDD2135  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C50(1.59); C48(1.58); C26(0.63)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C50(1.77); C48(1.47)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C50(0.84); C48(0.40); C44(0.29)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C50(2.59)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C50(0.84); C26(0.41); C48(0.97); C44(0.98)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C50(1.76); C48(0.54)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C50(0.56); C48(0.57)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C48(0.35)  LDD2149  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein SIX6OS1 (SIX6OS1) . Q8N1H7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Copper . DB09130
Silver . DB12965

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004