Details of the Target

General Information of Target

Target ID LDTP12667
Target Name Septin-11 (SEPTIN11)
Gene Name SEPTIN11
Gene ID 55752
Synonyms
11-Sep; Septin-11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIP
GIDIQLNRKYHTTRKLSTTKDSPQPVEEKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRM
YTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMW
EDVQQRGRVMGVNPYILKKNMILMTNHFYAAILGYDEGILSDDHGLAAALWRTFFNRKCE
DPRHLELLVEYVRKQIQYLDSMNGEDLLLTGEVSWRPLVEKNPQSILKPHSPTYNDEGL
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular location
Cytoplasm, cytoskeleton
Function
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {, }.
Uniprot ID
Q9NVA2
Ensemble ID
ENST00000264893.11
HGNC ID
HGNC:25589

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.Q213Ter DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.K357R DBIA    Probe Info 
JURKAT SNV: p.T227I .
KYM1 SNV: p.T289N DBIA    Probe Info 
NCIH1793 SNV: p.A426P DBIA    Probe Info 
TOV21G SNV: p.G238C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.39  LDD0402  [1]
A-EBA
 Probe Info  		4.87  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
TH211
 Probe Info  		Y255(20.00); Y323(7.28)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K190(1.61)  LDD0274  [6]
Probe 1
 Probe Info  		Y85(11.69)  LDD3495  [7]
DBIA
 Probe Info  		C293(1.98)  LDD3310  [8]
BTD
 Probe Info  		C46(0.59)  LDD2109  [9]
AHL-Pu-1
 Probe Info  		C268(3.03)  LDD0168  [10]
HHS-475
 Probe Info  		Y323(0.78)  LDD0264  [11]
HHS-465
 Probe Info  		Y297(10.00); Y323(10.00)  LDD2237  [12]
5E-2FA
 Probe Info  		H21(0.00); H143(0.00)  LDD2235  [13]
IA-alkyne
 Probe Info  		C150(0.00); C300(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C150(0.00); C268(0.00)  LDD0037  [16]
IPM
 Probe Info  		N.A.  LDD2156  [17]
NHS
 Probe Info  		N.A.  LDD0010  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
1c-yne
 Probe Info  		K272(0.00); K95(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C46(1.35)  LDD2117  [9]
 LDCM0025  4SU-RNA HEK-293T C268(3.03)  LDD0168  [10]
 LDCM0214  AC1 HEK-293T C150(1.41); C41(0.93)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C150(1.16); C41(0.98)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C150(0.97); C41(0.98)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C150(0.77); C41(0.95)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C150(0.95); C41(0.92)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C150(1.06); C41(0.98)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C150(0.92); C41(1.11)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C150(1.28); C41(1.01)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C150(0.90); C41(0.81)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C150(1.24); C41(1.01)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C150(1.02); C41(0.93)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C150(1.01); C41(0.93)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C150(0.96); C41(1.02)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C150(1.05); C41(0.93)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C150(1.37); C41(0.88)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C150(1.33); C41(1.11)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C150(1.23); C41(1.06)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C150(0.85); C41(0.94)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C150(1.00); C41(0.96)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C150(1.01); C41(0.92)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C150(0.82); C41(1.03)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C150(1.23); C41(0.91)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C150(1.16); C41(1.03)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C150(1.25); C41(1.02)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C150(1.04); C41(1.09)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C150(1.03); C41(0.94)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C150(1.03); C41(0.97)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C150(0.87); C41(0.93)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C150(1.11); C41(0.96)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C150(0.97); C41(1.02)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C150(1.09); C41(0.99)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C150(1.18); C41(0.95)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C150(1.13); C41(0.96)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C150(1.21); C41(0.98)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C150(1.04); C41(0.93)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C150(0.86); C41(0.89)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C150(0.87); C41(0.95)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C150(1.04); C41(0.92)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C150(1.06); C41(0.97)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C150(1.10); C41(0.89)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C150(1.20); C41(0.94)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C150(1.54); C41(0.98)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C150(1.23); C41(0.88)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C150(1.26); C41(0.98)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C150(0.92); C41(0.90)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C150(0.94); C41(0.90)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C150(1.05); C41(0.90)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C150(1.16); C41(0.98)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C150(1.06); C41(1.01)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C150(1.20); C41(0.97)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C150(1.21); C41(1.15)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C150(1.27); C41(1.06)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C150(1.33); C41(1.00)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C150(1.05); C41(0.98)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C150(0.99); C41(0.96)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C150(1.16); C41(0.97)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C150(1.46); C41(1.04)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C150(1.02); C41(1.03)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C150(1.39); C41(1.02)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C150(1.16); C41(0.96)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C150(1.30); C41(1.04)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C150(0.99); C41(0.92)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C150(1.51); C41(1.01)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C150(0.93); C41(0.98)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C150(0.94); C41(0.88)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C150(0.31); C41(0.61)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C150(1.35); C41(0.93)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C150(1.01); C41(0.97)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C150(0.91); C41(0.73)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C150(0.86); C41(0.92)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C150(1.38); C41(0.88)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C150(1.22); C41(0.89)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C150(0.86); C41(0.84)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C150(0.94); C41(0.91)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C150(1.07); C41(1.01)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C150(1.19); C41(0.92)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C150(0.56); C41(0.84)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C150(1.00); C41(0.72)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C150(0.93); C41(0.88)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C150(1.41); C41(0.97)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C150(1.31); C41(0.94)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C150(0.84); C41(0.91)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C150(0.97); C41(0.99)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C150(1.34); C41(0.94)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C150(1.28); C41(0.95)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C150(1.00); C41(0.84)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C150(1.02); C41(1.02)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C150(0.44); C41(0.85)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C150(1.15); C41(0.91)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C150(1.02); C41(1.06)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C150(1.19); C41(0.77)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C150(0.93); C41(0.80)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C150(1.48); C41(0.83)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C150(1.36); C41(1.07)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C150(1.30); C41(0.76)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C150(1.54); C41(0.93)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C150(1.48); C41(0.96)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C150(1.05); C41(0.89)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C150(0.94); C41(0.82)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C150(0.76); C41(0.75)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C150(0.92); C41(0.94)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C150(0.62); C41(0.96)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C150(0.55); C41(0.97)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C150(0.38); C41(0.86)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C150(0.74); C41(0.96)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C150(0.44); C41(0.85)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C150(0.32); C41(0.74)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C150(0.30); C41(0.83)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C150(0.54); C41(0.84)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C150(0.41); C41(0.90)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C150(1.20); C41(0.87)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C150(0.79); C41(0.88)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C150(0.82); C41(0.94)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C150(0.95); C41(0.86)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C150(0.67); C41(0.98)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C150(0.77); C41(0.93)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C150(0.61); C41(1.04)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C150(0.35); C41(0.79)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C150(0.48); C41(0.80)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C150(0.31); C41(0.61)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C150(0.38); C41(0.79)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C150(0.48); C41(0.82)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C150(0.42); C41(0.92)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C150(1.31); C41(0.91)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C150(0.82); C41(0.93)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C150(0.80); C41(0.85)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C150(0.81); C41(1.05)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C150(0.60); C41(0.99)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C150(0.93); C41(1.03)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C150(0.39); C41(0.86)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C150(0.46); C41(0.77)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C150(0.32); C41(0.68)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C150(0.41); C41(0.78)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C150(0.54); C41(0.81)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C150(0.47); C41(0.82)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C150(1.34); C41(1.01)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C150(0.85); C41(1.09)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C150(1.09); C41(0.80)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C150(0.76); C41(1.03)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C150(0.80); C41(1.01)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C150(0.61); C41(0.80)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C150(0.34); C41(0.83)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C150(0.45); C41(0.78)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C150(0.35); C41(0.65)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C150(0.38); C41(0.79)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C150(0.69); C41(0.83)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C150(0.68); C41(0.93)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C150(0.49); C41(0.85)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C150(1.24); C41(1.01)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C150(0.90); C41(0.79)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C150(1.03); C41(0.94)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C150(0.92); C41(0.92)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C150(1.01); C41(1.07)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C150(0.73); C41(0.95)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C150(0.48); C41(0.87)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C150(0.46); C41(0.81)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C150(0.40); C41(0.75)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C150(0.42); C41(0.81)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C150(0.44); C41(0.88)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C150(0.56); C41(0.81)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C150(0.46); C41(0.86)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C150(1.34); C41(0.94)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C150(1.14); C41(0.81)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C150(1.52); C41(0.94)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C150(1.00); C41(1.03)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C150(0.80); C41(1.00)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C150(0.68); C41(0.88)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C150(0.46); C41(0.56)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C150(0.55); C41(0.91)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C150(0.41); C41(0.81)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C150(0.56); C41(0.88)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C150(0.61); C41(0.76)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C150(0.54); C41(0.82)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C150(1.98); C41(1.12)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C150(1.15); C41(0.96)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C150(1.06); C41(1.03)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C150(1.19); C41(0.96)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C150(1.55); C41(1.05)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C150(0.38); C41(0.81)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C150(0.72); C41(0.72)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C150(0.74); C41(0.90)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C150(0.65); C41(0.75)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C150(0.44); C41(0.79)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C150(0.54); C41(0.84)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C150(0.76); C41(0.65)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C150(0.73); C41(0.82)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C150(1.37); C41(0.95)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C150(0.96); C41(0.83)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C150(1.14); C41(0.97)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C150(0.88); C41(0.96)  LDD1698  [22]
 LDCM0573  Fragment11 Ramos C150(2.82)  LDD2190  [23]
 LDCM0576  Fragment14 Ramos C150(0.59)  LDD2193  [23]
 LDCM0468  Fragment33 HEK-293T C150(1.05); C41(0.93)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C150(0.96); C41(0.92)  LDD1631  [22]
 LDCM0569  Fragment7 Ramos C150(0.39)  LDD2186  [23]
 LDCM0116  HHS-0101 DM93 Y323(0.78)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y323(0.56)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y323(0.78)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y323(0.70)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y323(0.81)  LDD0268  [11]
 LDCM0107  IAA HeLa H143(0.00); H73(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C41(1.05)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C41(1.08)  LDD1497  [22]
 LDCM0024  KB05 COLO792 C293(1.98)  LDD3310  [8]
 LDCM0109  NEM HeLa H143(0.00); H73(0.00)  LDD0223  [20]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C46(0.59)  LDD2109  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C46(1.00)  LDD2140  [9]
 LDCM0131  RA190 MM1.R C41(1.20)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Septin-5 (SEPTIN5) Septin GTPase family Q99719
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MORN repeat-containing protein 4 (MORN4) . Q8NDC4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.