Details of the Target

General Information of Target

Target ID LDTP09766
Target Name ATP-dependent RNA helicase DDX1 (DDX1)
Gene Name DDX1
Gene ID 1653
Synonyms
ATP-dependent RNA helicase DDX1; EC 3.6.4.13; DEAD box protein 1; DEAD box protein retinoblastoma; DBP-RB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF
VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPG
YATAEGNSSGSITCLQNGWSTQPICIKFCDMPVFENSRAKSNGMWFKLHDTLDYECYDGY
ESSYGNTTDSIVCGEDGWSHLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSRVEYQC
QSYYELQGSKYVTCSNGDWSEPPRCISMKPCEFPEIQHGHLYYENTRRPYFPVATGQSYS
YYCDQNFVTPSGSYWDYIHCTQDGWLPTVPCLRTCSKSDIEIENGFISESSSIYILNKEI
QYKCKPGYATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLD
YECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQ
SRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYA
KTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX1 subfamily
Subcellular location
Cytoplasm; Nucleus
Function
Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB: together with archease (ZBTB8OS), acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA.; (Microbial infection) Required for HIV-1 Rev function as well as for HIV-1 and coronavirus IBV replication. Binds to the RRE sequence of HIV-1 mRNAs.; (Microbial infection) Required for Coronavirus IBV replication.
Uniprot ID
Q92499
Ensemble ID
ENST00000233084.8
HGNC ID
HGNC:2734
ChEMBL ID
CHEMBL2010634

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.K502N DBIA    Probe Info 
NCIH446 SNV: p.H175R DBIA    Probe Info 
PATU8988T SNV: p.E245D DBIA    Probe Info 
RL952 SNV: p.Q529Ter DBIA    Probe Info 
TFK1 SNV: p.Y135F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		5.98  LDD0215  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y628(20.00); Y599(7.48)  LDD0257  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y96(20.23); Y265(13.39); Y496(42.95); Y525(7.67)  LDD3495  [5]
BTD
 Probe Info  		C638(2.34)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C122(6.60)  LDD0170  [7]
HHS-482
 Probe Info  		Y380(0.37)  LDD0286  [8]
HHS-475
 Probe Info  		Y701(0.65); Y265(0.79); Y628(0.90); Y380(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y265(6.80); Y628(7.60); Y96(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C631(1.11)  LDD0078  [11]
5E-2FA
 Probe Info  		H728(0.00); H704(0.00); H582(0.00); H140(0.00)  LDD2235  [12]
AMP probe
 Probe Info  		K234(0.00); K239(0.00)  LDD0200  [13]
ATP probe
 Probe Info  		K234(0.00); K239(0.00); K687(0.00); K82(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C631(0.00); C571(0.00); C145(0.00); C139(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C110(0.00); C519(0.00); C231(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		C519(0.00); C406(0.00); C571(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info  		C139(0.00); C571(0.00); C519(0.00); C542(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C631(0.00); C571(0.00); C110(0.00); C111(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
JW-RF-010
 Probe Info  		C231(0.00); C110(0.00)  LDD0026  [18]
TFBX
 Probe Info  		C231(0.00); C110(0.00); C571(0.00); C111(0.00)  LDD0027  [18]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
IPM
 Probe Info  		N.A.  LDD0005  [21]
NHS
 Probe Info  		K268(0.00); K260(0.00); K687(0.00); K307(0.00)  LDD0010  [21]
PF-06672131
 Probe Info  		N.A.  LDD0152  [22]
SF
 Probe Info  		Y701(0.00); Y265(0.00); Y586(0.00); K281(0.00)  LDD0028  [23]
STPyne
 Probe Info  		K281(0.00); K358(0.00)  LDD0009  [21]
VSF
 Probe Info  		N.A.  LDD0007  [21]
Phosphinate-6
 Probe Info  		C638(0.00); C631(0.00)  LDD0018  [24]
Ox-W18
 Probe Info  		N.A.  LDD2175  [25]
1c-yne
 Probe Info  		K490(0.00); K516(0.00); K421(0.00); K702(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C110(0.00); C139(0.00); H424(0.00); H704(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		C231(0.00); C513(0.00); C139(0.00); C631(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C139(0.00); C231(0.00); C571(0.00); C631(0.00)  LDD0218  [26]
W1
 Probe Info  		C571(0.00); C519(0.00); C513(0.00); C110(0.00)  LDD0236  [27]
m-APA
 Probe Info  		N.A.  LDD0404  [28]
NAIA_5
 Probe Info  		C513(0.00); C631(0.00); C122(0.00); C571(0.00)  LDD2223  [29]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C571(1.38); C638(0.73); C122(1.24); C542(1.47)  LDD2117  [6]
 LDCM0025  4SU-RNA DM93 C122(6.60)  LDD0170  [7]
 LDCM0214  AC1 HCT 116 C110(1.03); C111(1.21); C231(1.18); C513(1.54)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C110(1.99); C111(1.30); C231(0.99); C542(0.95)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C110(0.93); C111(1.22); C231(1.14); C513(0.84)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C110(0.77); C111(0.62); C231(0.82); C513(0.56)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C110(0.77); C111(0.83); C231(0.87); C513(0.72)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C110(0.77); C111(0.48); C231(0.68); C513(0.43)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C110(0.87); C111(0.67); C231(0.66); C513(0.73)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C110(0.78); C111(0.60); C231(0.79); C513(0.51)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C110(0.69); C111(0.61); C231(0.81); C513(0.45)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C110(0.89); C111(0.53); C231(0.66); C513(0.46)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C110(0.72); C111(0.66); C231(0.87); C513(0.55)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C110(0.72); C111(0.83); C231(0.78); C513(0.88)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C110(2.22); C111(1.17); C231(1.00); C542(1.24)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C110(0.75); C111(0.76); C231(0.85); C513(0.57)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C110(0.77); C111(0.67); C231(0.66); C513(0.63)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C110(0.78); C111(0.54); C231(0.60); C513(0.46)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C110(1.06); C111(1.37); C231(1.24); C513(1.13)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C110(1.04); C111(1.30); C231(1.06); C513(1.42)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C110(1.08); C111(1.05); C231(0.80); C513(1.05)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C110(1.04); C111(1.40); C231(1.05); C513(1.10)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C110(0.99); C111(1.24); C231(0.99); C513(1.08)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C110(1.04); C111(1.63); C231(1.28); C513(0.91)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C110(0.96); C111(1.25); C231(0.94); C513(1.37)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C110(1.24); C111(1.42); C231(1.13); C542(1.48)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C110(1.28); C111(1.58); C231(1.13); C513(1.23)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C110(0.95); C111(1.84); C231(1.47); C513(0.92)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C110(0.82); C111(1.44); C231(1.18); C513(1.01)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C110(1.23); C111(2.19); C231(1.49); C513(0.70)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C110(1.07); C111(1.93); C231(1.32); C513(0.95)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C110(1.06); C111(1.51); C231(1.30); C513(0.93)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C110(0.89); C111(1.61); C231(1.27); C513(1.07)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C110(0.91); C111(1.81); C231(1.32); C513(0.97)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C110(0.77); C111(0.96); C231(0.89); C513(0.80)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C110(1.21); C111(1.30); C231(1.39); C513(1.39)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C110(0.93); C111(0.97); C231(1.05); C513(0.85)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C110(1.39); C111(1.51); C231(1.45); C513(1.35)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C110(1.47); C111(1.41); C231(1.33); C513(1.08)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C110(0.94); C111(1.00); C231(1.19); C513(0.91)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C110(0.79); C111(0.71); C231(0.90); C513(0.74)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C110(0.81); C111(0.78); C231(0.91); C513(0.75)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C110(1.04); C111(0.98); C231(1.04); C513(0.79)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C110(1.03); C111(0.92); C231(1.01); C513(0.77)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C110(0.95); C111(0.65); C231(0.85); C513(0.69)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C110(0.93); C111(0.75); C231(0.97); C513(0.74)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C110(1.64); C111(2.07); C231(1.44); C542(1.53)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C110(0.81); C111(0.57); C231(0.79); C513(0.61)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C110(0.91); C111(0.68); C231(0.90); C513(0.69)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C110(1.53); C111(1.42); C231(1.21); C513(0.97)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C110(0.87); C111(0.61); C231(0.78); C513(0.83)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C513(0.59); C231(0.64); C111(0.64); C631(0.76)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C111(0.69); C110(0.79); C631(0.82); C231(0.85)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C513(0.43); C111(0.56); C631(0.65); C231(0.73)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C513(0.53); C231(0.57); C111(0.70); C542(0.75)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C513(0.25); C231(0.26); C111(0.42); C631(0.60)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C111(0.41); C513(0.41); C231(0.47); C542(0.67)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C631(0.77); C542(0.96); C544(0.96); C231(1.10)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C111(0.75); C542(0.83); C544(0.83); C110(0.96)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C513(0.71); C542(0.78); C544(0.78); C231(0.82)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C513(0.46); C111(0.48); C231(0.49); C542(0.65)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C513(0.22); C231(0.26); C111(0.35); C631(0.52)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C110(0.91); C111(0.62); C231(0.60); C513(0.59)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C110(0.72); C111(0.55); C231(0.64); C513(0.54)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C110(0.81); C111(0.67); C231(0.88); C513(0.82)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C110(1.07); C111(0.73); C231(1.02); C513(0.97)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C513(0.96); C542(0.98); C544(0.98); C111(1.02)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C513(0.54); C542(0.63); C544(0.63); C111(0.84)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C111(0.86); C542(0.88); C544(0.88); C513(0.91)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C631(0.84); C111(0.95); C110(1.05); C231(1.07)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C513(0.85); C542(0.91); C544(0.91); C231(0.95)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C513(0.60); C542(0.88); C544(0.88); C110(0.93)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C513(0.82); C631(1.01); C542(1.04); C544(1.04)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C542(0.83); C544(0.83); C231(0.84); C111(0.87)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C111(0.85); C513(0.88); C231(0.98); C542(1.06)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C544(0.73); C542(0.75); C231(0.92); C111(0.93)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C542(0.51); C544(0.59); C631(0.76); C231(0.78)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C542(0.49); C544(0.56); C231(0.78); C110(0.80)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C542(0.58); C544(0.67); C231(0.74); C111(0.86)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C542(0.47); C544(0.60); C111(0.67); C231(0.75)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C631(0.79); C110(0.95); C111(1.15); C231(1.28)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C542(0.37); C544(0.49); C231(0.61); C111(0.63)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C542(0.47); C544(0.58); C231(0.85); C631(0.95)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C542(0.31); C544(0.44); C231(0.54); C111(0.63)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C542(0.52); C544(0.57); C111(0.60); C231(0.61)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C231(0.48); C111(0.53); C542(0.56); C544(0.58)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C110(0.86); C111(1.19); C231(1.20); C542(1.28)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C631(0.91); C542(0.96); C544(0.96); C513(1.07)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C631(0.86); C110(0.91); C542(1.11); C544(1.11)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C513(0.70); C110(0.80); C631(0.89); C542(0.93)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C631(0.82); C110(0.83); C542(0.86); C544(0.86)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C631(0.81); C110(0.86); C111(0.88); C231(1.20)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C231(0.59); C110(0.66); C111(0.68); C542(0.73)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C231(0.85); C631(0.86); C542(0.87); C544(0.87)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C231(0.73); C111(0.75); C542(0.75); C544(0.75)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C542(0.59); C544(0.59); C513(0.59); C631(0.72)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C231(0.65); C631(0.80); C111(0.81); C542(0.91)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C231(0.44); C111(0.58); C631(0.69); C542(0.76)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C111(0.77); C631(0.83); C231(0.95); C110(1.00)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C631(0.81); C111(0.84); C110(0.90); C542(1.00)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C631(0.57); C111(0.79); C542(0.82); C544(0.82)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C111(0.36); C231(0.41); C110(0.76); C542(0.77)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C631(0.69); C110(0.98); C111(1.05); C231(1.16)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C111(0.38); C231(0.50); C542(0.62); C544(0.62)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C631(0.87); C111(1.07); C542(1.15); C544(1.15)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C111(0.76); C631(0.81); C110(0.97); C542(1.00)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C231(0.80); C631(0.81); C111(0.85); C542(0.86)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C111(0.63); C231(0.67); C542(0.81); C544(0.81)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C631(0.64); C542(0.76); C544(0.76); C231(0.79)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C542(0.45); C544(0.45); C111(0.46); C231(0.47)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C542(0.63); C544(0.63); C231(0.72); C111(0.75)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C542(0.49); C544(0.49); C231(0.57); C111(0.63)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C542(0.60); C544(0.60); C231(0.62); C111(0.70)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C542(0.60); C544(0.60); C231(0.69); C631(0.79)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C542(0.53); C544(0.53); C231(0.73); C631(0.77)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C542(0.55); C544(0.55); C631(0.67); C111(0.68)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C542(0.49); C544(0.49); C231(0.60); C631(0.62)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C542(0.63); C544(0.63); C111(0.70); C231(0.81)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C542(0.62); C544(0.62); C631(0.67); C231(0.75)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C542(0.49); C544(0.49); C111(0.57); C231(0.60)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C542(0.60); C544(0.60); C231(0.66); C111(0.66)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C542(0.37); C544(0.37); C231(0.38); C631(0.44)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C513(0.70); C231(0.71); C111(0.74); C110(0.81)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C513(0.55); C231(0.68); C111(0.70); C631(0.82)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C631(0.84); C231(0.96); C542(1.04); C544(1.04)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C513(0.38); C231(0.40); C111(0.43); C110(0.67)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C513(0.76); C631(0.89); C111(0.96); C231(1.01)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C111(0.62); C231(0.63); C513(0.68); C542(0.84)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C513(0.27); C111(0.35); C231(0.43); C542(0.46)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C513(0.27); C111(0.44); C231(0.50); C542(0.60)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C513(0.20); C231(0.40); C111(0.43); C542(0.46)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C513(0.56); C111(0.59); C231(0.72); C542(0.74)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C513(0.46); C111(0.48); C231(0.57); C542(0.68)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C513(0.58); C542(0.75); C631(0.89); C111(0.91)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C111(0.71); C513(0.77); C231(0.79); C631(0.85)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C231(0.79); C542(0.87); C544(0.87); C631(0.93)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C111(0.59); C513(0.66); C231(0.73); C110(0.77)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C231(0.64); C111(0.87); C631(0.93); C513(0.95)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C513(0.20); C111(0.42); C231(0.44); C542(0.54)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C231(0.33); C542(0.41); C544(0.41); C513(0.46)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C231(0.35); C542(0.42); C544(0.42); C111(0.48)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C542(0.50); C544(0.50); C513(0.62); C231(0.78)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C513(0.62); C111(0.65); C542(0.77); C544(0.77)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C513(0.67); C111(0.68); C110(0.87); C542(1.04)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C111(0.59); C513(0.65); C110(0.67); C542(0.90)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C111(0.52); C513(0.54); C542(0.56); C544(0.56)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C110(0.60); C513(0.86); C111(0.92); C631(1.00)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C231(0.33); C542(0.48); C544(0.48); C513(0.53)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C110(0.48); C111(0.48); C542(0.48); C544(0.48)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C110(0.58); C513(0.65); C111(0.69); C542(0.80)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C231(0.73); C513(0.77); C542(0.80); C544(0.80)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C513(0.61); C542(0.75); C544(0.75); C111(0.81)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C542(0.61); C544(0.61); C110(0.61); C513(0.68)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C111(0.39); C513(0.43); C542(0.49); C544(0.49)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C542(0.17); C544(0.17); C513(0.27); C111(0.36)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C111(0.63); C110(0.67); C631(0.77); C513(0.79)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C638(0.81)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C110(1.62); C111(1.30); C231(1.28); C542(1.13)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C631(0.77); C111(1.25); C542(1.25); C544(1.25)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C231(0.47); C542(0.50); C544(0.50); C631(0.61)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [28]
 LDCM0020  ARS-1620 HCC44 C631(1.11)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C231(0.64); C638(0.65)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C519(0.00); C406(0.00); C231(0.00); H424(0.00)  LDD0222  [26]
 LDCM0367  CL1 HCT 116 C631(0.75); C110(0.89); C542(1.00); C544(1.00)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C513(0.34); C631(0.53); C542(0.56); C544(0.56)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C631(0.78); C111(0.79); C110(0.88); C513(0.96)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C631(0.72); C542(0.82); C544(0.82); C231(0.82)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C631(0.84); C231(0.96); C542(1.07); C544(1.07)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C631(0.95); C231(0.96); C542(1.28); C544(1.28)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C631(0.85); C231(0.96); C542(1.21); C544(1.21)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C513(0.50); C542(0.73); C544(0.73); C631(0.77)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C513(0.26); C542(0.54); C544(0.54); C631(0.73)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C513(0.44); C542(0.60); C544(0.60); C111(0.80)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C513(0.40); C542(0.65); C544(0.65); C111(0.76)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C513(0.60); C542(0.68); C544(0.68); C111(0.85)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C513(0.33); C542(0.52); C544(0.52); C231(0.54)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C513(0.54); C111(0.61); C231(0.62); C542(0.63)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C513(0.64); C111(0.66); C231(0.71); C542(0.72)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C542(0.75); C544(0.81); C231(0.86); C631(0.91)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C542(0.33); C544(0.47); C231(0.59); C111(0.72)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C542(0.48); C544(0.60); C231(0.74); C631(0.82)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C542(0.47); C544(0.62); C231(0.64); C111(0.74)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C542(0.62); C544(0.64); C111(0.67); C231(0.71)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C231(0.38); C542(0.45); C544(0.45); C111(0.47)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C542(0.81); C544(0.81); C631(0.83); C513(0.84)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C231(0.72); C542(0.75); C544(0.75); C110(0.77)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C513(0.36); C542(0.56); C544(0.56); C111(0.58)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C513(0.69); C631(0.73); C542(0.77); C544(0.77)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C231(0.68); C111(0.76); C631(0.82); C110(0.96)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C631(0.68); C542(0.71); C544(0.71); C111(0.81)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C111(0.67); C231(0.72); C542(0.75); C544(0.75)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C111(0.51); C231(0.60); C542(0.72); C544(0.72)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C542(0.85); C544(0.85); C231(0.89); C631(0.97)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C231(0.70); C111(0.70); C542(0.83); C544(0.83)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C542(0.68); C544(0.68); C111(0.80); C231(0.89)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C231(0.59); C542(0.62); C544(0.62); C111(0.67)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C513(0.41); C631(0.68); C542(0.68); C544(0.68)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C631(0.64); C542(0.82); C544(0.82); C513(0.86)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C513(0.29); C631(0.60); C542(0.69); C544(0.69)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C542(0.68); C544(0.68); C513(0.70); C231(0.78)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C513(0.54); C542(0.80); C544(0.80); C231(0.91)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C513(0.41); C542(0.69); C544(0.69); C231(0.85)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C513(0.37); C231(0.70); C542(0.72); C544(0.72)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C631(0.78); C110(1.04); C231(1.19); C542(1.23)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C513(0.45); C542(0.60); C544(0.60); C231(0.63)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C513(0.31); C231(0.40); C542(0.64); C544(0.64)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C513(0.16); C231(0.19); C631(0.45); C542(0.48)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C231(0.60); C542(0.68); C544(0.68); C111(0.71)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C231(0.34); C513(0.38); C111(0.54); C542(0.58)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C110(0.64); C111(0.60); C231(0.50); C513(0.39)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C110(0.84); C111(0.74); C231(0.74); C513(0.52)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C110(0.82); C111(0.82); C231(0.84); C513(0.59)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C110(0.81); C111(0.68); C231(0.57); C513(0.40)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C110(0.73); C111(0.74); C231(0.54); C513(0.34)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C110(1.09); C111(1.22); C231(1.05); C513(0.90)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C110(0.94); C111(0.92); C231(0.80); C513(0.66)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C110(1.01); C111(1.13); C231(0.82); C513(0.69)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C110(1.14); C111(0.94); C231(0.79); C513(0.51)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C110(1.06); C111(0.91); C231(0.72); C513(0.53)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C110(1.09); C111(0.72); C231(0.47); C513(0.32)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C110(1.11); C111(0.60); C231(0.51); C513(0.44)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C110(1.06); C111(0.88); C231(0.62); C513(0.52)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C110(0.92); C111(0.57); C231(0.52); C513(0.38)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C110(0.90); C111(0.76); C231(0.51); C513(0.43)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C110(1.04); C111(1.13); C231(0.91); C513(0.97)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C110(1.10); C111(0.87); C231(0.54); C513(0.57)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C110(1.10); C111(0.93); C231(0.67); C513(0.56)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C110(1.13); C111(0.55); C231(0.37); C513(0.14)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C110(0.94); C111(0.61); C231(0.46); C513(0.36)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C110(1.04); C111(1.05); C231(0.71); C513(0.34)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C110(0.89); C111(0.78); C231(0.54); C513(0.25)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C110(1.02); C111(1.28); C231(1.92); C542(2.17)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C110(1.24); C111(1.25); C231(1.88); C542(2.04)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C110(1.15); C111(1.24); C231(1.97); C542(1.90)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C110(0.95); C111(1.14); C231(1.73); C542(1.70)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C110(1.05); C111(1.19); C231(1.18); C513(0.80)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C110(0.99); C111(1.21); C231(1.76); C542(1.74)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C110(0.92); C111(1.13); C231(1.84); C542(1.71)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C110(0.99); C111(1.06); C231(1.75); C542(1.73)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C110(1.07); C111(1.07); C231(1.95); C542(1.95)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C110(1.04); C111(1.28); C231(1.87); C542(1.76)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C110(1.03); C111(1.35); C231(1.89); C542(2.05)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C110(0.96); C111(0.98); C231(1.15); C542(1.41)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C110(0.99); C111(1.22); C231(1.60); C542(1.66)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C110(1.27); C111(1.38); C231(1.88); C542(2.20)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C110(0.97); C111(1.31); C231(1.41); C542(1.59)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C110(0.92); C111(1.09); C231(1.04); C513(0.40)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C110(1.06); C111(1.14); C231(1.48); C542(1.60)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C110(0.79); C111(0.88); C231(0.94); C542(0.76)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C110(0.58); C111(0.68); C231(0.87); C542(0.82)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C110(0.56); C111(0.61); C231(0.68); C542(0.73)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C110(0.56); C111(0.56); C231(0.53); C542(0.61)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C110(0.84); C111(0.79); C231(0.77); C542(0.89)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C110(0.61); C111(0.56); C231(0.29); C542(0.55)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C110(0.84); C111(0.59); C231(0.48); C542(0.75)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C110(0.88); C111(0.69); C231(0.63); C542(0.59)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C110(0.84); C111(0.90); C231(1.18); C542(0.71)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C110(0.73); C111(0.69); C231(0.85); C513(0.41)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C110(0.74); C111(0.64); C231(0.69); C542(0.55)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C110(0.69); C111(0.64); C231(0.58); C542(0.68)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C110(0.86); C111(0.98); C231(0.89); C542(0.81)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C110(0.69); C111(0.75); C231(0.62); C542(0.71)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C110(0.67); C111(0.62); C231(0.61); C542(0.77)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C110(1.13); C111(1.00); C231(0.86); C513(0.62)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C110(0.85); C111(0.80); C231(0.80); C513(1.20)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C110(0.98); C111(0.75); C231(0.81); C513(0.77)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C110(1.02); C111(0.66); C231(0.56); C513(0.55)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C110(0.78); C111(0.52); C231(0.58); C513(0.37)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C110(1.22); C111(1.05); C231(0.92); C513(0.82)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C110(1.03); C111(0.84); C231(0.75); C513(0.70)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C110(0.87); C111(0.55); C231(0.29); C513(0.32)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C110(0.83); C111(0.51); C231(0.38); C513(0.38)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C110(0.68); C111(0.40); C231(0.20); C513(0.24)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C110(0.90); C111(0.76); C231(0.81); C513(0.63)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C110(1.50); C111(0.98); C231(1.05); C513(0.95)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C110(0.99); C111(0.98); C231(0.81); C513(0.67)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C110(0.86); C111(0.75); C231(0.38); C513(0.41)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C110(0.78); C111(0.53); C231(0.19); C513(0.16)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C110(0.75); C111(0.76); C231(0.84); C513(0.71)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C110(1.28); C111(1.04); C231(1.01); C513(1.09)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C110(0.93); C111(0.86); C231(0.96); C513(1.25)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C110(0.95); C111(0.97); C231(1.13); C513(0.99)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C110(0.95); C111(1.14); C231(1.27); C513(1.54)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C110(0.80); C111(0.84); C231(1.13); C513(1.15)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C110(0.79); C111(0.93); C231(1.09); C513(1.36)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C110(0.89); C111(1.17); C231(1.03); C513(1.45)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C110(0.86); C111(0.90); C231(0.94); C513(1.26)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C110(0.82); C111(0.62); C231(0.91); C513(0.89)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C110(0.83); C111(0.72); C231(0.94); C513(1.07)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C631(0.99); C571(1.12); C231(1.06); C406(1.04)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C231(2.13); C122(1.01); C638(0.99); C110(0.92)  LDD1702  [6]
 LDCM0468  Fragment33 HCT 116 C110(1.13); C111(0.80); C231(0.58); C542(0.75)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C110(0.97); C111(0.62); C231(0.40); C513(0.21)  LDD0744  [11]
 LDCM0116  HHS-0101 DM93 Y701(0.65); Y265(0.79); Y628(0.90); Y380(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y265(0.69); Y96(0.71); Y628(0.71); Y380(0.81)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y380(0.71); Y701(0.74); Y265(0.76); Y96(0.82)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y701(0.66); Y380(0.78); Y628(0.81); Y265(0.81)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y265(0.67); Y628(0.76); Y380(0.78); Y96(0.84)  LDD0268  [9]
 LDCM0107  IAA HeLa H704(0.00); H442(0.00); C571(0.00); C110(0.00)  LDD0221  [26]
 LDCM0124  JWB142 DM93 Y380(0.37)  LDD0286  [8]
 LDCM0126  JWB150 DM93 Y380(5.00); Y96(10.10)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y380(2.18)  LDD0289  [8]
 LDCM0129  JWB202 DM93 Y380(0.33); Y96(0.64)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y380(2.02); Y96(0.57)  LDD0292  [8]
 LDCM0022  KB02 HCT 116 C110(1.05)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C110(0.96)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C110(1.02)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C122(0.68)  LDD2121  [6]
 LDCM0109  NEM HeLa H704(0.00); H442(0.00); H424(0.00); H388(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C231(1.00)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C122(1.05)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C571(0.99)  LDD2093  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C542(1.30)  LDD2097  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C571(1.32); C638(1.03); C122(1.09); C513(1.84)  LDD2099  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C122(0.69)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C122(1.31)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C571(1.79); C638(0.82); C513(1.43)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C571(0.66); C638(0.54); C122(0.81)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C571(1.67); C542(1.13)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C638(1.90); C122(2.07); C542(1.04)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C638(0.61)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C571(1.33); C542(0.97); C513(1.32)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C571(1.00); C638(0.76); C122(0.97); C542(0.93)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C571(1.40); C638(0.94); C122(1.39); C542(1.44)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C571(1.86)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C638(0.53)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C638(1.34); C122(1.04)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C571(1.25); C638(0.97)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C638(0.76); C122(0.97); C542(1.20); C513(1.16)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C638(2.34)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C638(0.78)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C571(0.45)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C571(1.72); C638(0.49)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C122(1.59); C544(0.88)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C571(0.38)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C122(1.22); C542(1.76)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C542(0.83)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C231(0.35); C638(0.54)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C110(0.37)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C110(0.87)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C110(1.31)  LDD0304  [35]
 LDCM0021  THZ1 HCT 116 C110(0.95)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM98A (FAM98A) FAM98 family Q8NCA5
RNA transcription, translation and transport factor protein (RTRAF) RTRAF family Q9Y224

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.