Details of the Target

General Information of Target

Target ID LDTP04422
Target Name Transcription activator BRG1 (SMARCA4)
Gene Name SMARCA4
Gene ID 6597
Synonyms
BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; EC 3.6.4.-; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQG
PGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGY
PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL
RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGP
GPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQ
KLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG
LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEV
VVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSIL
QHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK
LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIG
PDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEES
GSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGV
SQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADE
MGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAA
RRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTH
YVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE
TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTD
GSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASG
KFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLK
TFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVR
VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESR
HCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMD
LDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYS
DSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQ
KKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYEL
IRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSV
RQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGS
RAKPVVSDDDSEEEQEEDRSGSGSEED
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2. Binds to RNA in a promiscuous manner. Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities. In brown adipose tissue, involved in the regulation of thermogenic genes expression.
TTD ID
T69200
Uniprot ID
P51532
DrugMap ID
TTVQEZS
Ensemble ID
ENST00000344626.10
HGNC ID
HGNC:11100
ChEMBL ID
CHEMBL3085620

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.D694E DBIA    Probe Info 
A2780 SNV: p.T910M; p.R1356W DBIA    Probe Info 
A498 SNV: p.A923P DBIA    Probe Info 
A549 Deletion: p.Q729CfsTer4 DBIA    Probe Info 
AN3CA SNV: p.P1456L DBIA    Probe Info 
BT549 SNV: p.H1373N DBIA    Probe Info 
C4II SNV: p.R973Q DBIA    Probe Info 
CAL148 SNV: p.N817K DBIA    Probe Info 
CAL51 SNV: p.R885H DBIA    Probe Info 
CCK81 SNV: p.M27I; p.V420A; p.P647L; p.R1445W DBIA    Probe Info 
CCLP1 SNV: p.E590Ter DBIA    Probe Info 
CHL1 Insertion: p.V766delinsGVL DBIA    Probe Info 
DU145 SNV: p.K587N DBIA    Probe Info 
ETK1 SNV: p.P311H DBIA    Probe Info 
GAMG SNV: p.E1499Ter DBIA    Probe Info 
HCC1143 SNV: p.R1323H DBIA    Probe Info 
HCC15 Deletion: p.M272CfsTer31 DBIA    Probe Info 
HCT116 Insertion: p.S122LfsTer7
SNV: p.L1163P		 DBIA    Probe Info 
HCT15 SNV: p.R885C DBIA    Probe Info 
HT SNV: p.C891W DBIA    Probe Info 
HT115 SNV: p.N173H DBIA    Probe Info 
HUH28 SNV: p.P16S DBIA    Probe Info 
ICC12 SNV: p.T629I DBIA    Probe Info 
IGROV1 Deletion: p.E1212del
SNV: p.D1416N		 DBIA    Probe Info 
JURKAT SNV: p.Q201Ter; p.R1192H; p.R1244H Compound 10    Probe Info 
KASUMI1 Deletion: p.G1370AfsTer14 DBIA    Probe Info 
KELLY SNV: p.D1322H DBIA    Probe Info 
KNS42 SNV: p.P285T DBIA    Probe Info 
KYSE150 SNV: p.N944K DBIA    Probe Info 
KYSE30 SNV: p.D1175G DBIA    Probe Info 
KYSE410 SNV: p.V1207I DBIA    Probe Info 
L428 SNV: p.L921F DBIA    Probe Info 
LS513 SNV: p.R973W DBIA    Probe Info 
MELHO SNV: p.E672D DBIA    Probe Info 
MOLT4 SNV: p.P344S; p.R1329H; p.R1336H IA-alkyne    Probe Info 
NALM6 SNV: p.D543N DBIA    Probe Info 
NCIH1155 SNV: p.R466L; p.S1238P DBIA    Probe Info 
NCIH1650 SNV: p.N1164Y DBIA    Probe Info 
NCIH1793 SNV: p.E514Ter DBIA    Probe Info 
NCIH2286 SNV: p.R1135Q DBIA    Probe Info 
NCIH23 Substitution: p.K1566_E1567delinsNTer DBIA    Probe Info 
NCIH446 SNV: p.E623Ter DBIA    Probe Info 
NCIH661 Deletion: p.L1161SfsTer3 .
OVK18 Deletion: p.P109RfsTer194; p.L1161SfsTer3 DBIA    Probe Info 
RAMOS SNV: p.R1135W IA-alkyne    Probe Info 
RL952 Deletion: p.K887del
SNV: p.E1577G		 DBIA    Probe Info 
SBC5 Deletion: p.A1245LfsTer13 DBIA    Probe Info 
SHSY5Y SNV: p.R973W .
SKHEP1 SNV: p.E1582Ter DBIA    Probe Info 
SKMEL5 Deletion: p.Q1053SfsTer53 DBIA    Probe Info 
SKNSH SNV: p.R973W .
SNGM SNV: p.P1455Q DBIA    Probe Info 
SW1271 SNV: p.N774K DBIA    Probe Info 
SW837 SNV: p.K1375E DBIA    Probe Info 
TOV21G SNV: p.E419Ter DBIA    Probe Info 
VMRCRCW SNV: p.P647L DBIA    Probe Info 
YSCCC SNV: p.E457Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
TH211
 Probe Info  		Y731(5.66)  LDD0257  [2]
TH216
 Probe Info  		Y507(13.28); Y731(12.08)  LDD0259  [2]
Probe 1
 Probe Info  		Y718(47.83); Y1379(9.65)  LDD3495  [3]
BTD
 Probe Info  		C1205(0.83)  LDD2132  [4]
AHL-Pu-1
 Probe Info  		C1359(3.53)  LDD0168  [5]
HHS-475
 Probe Info  		Y834(0.89); Y187(0.92)  LDD0264  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
DBIA
 Probe Info  		C936(2.45); C1359(1.68); C423(3.95)  LDD0080  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C998(0.00); C1205(0.00); C1359(0.00); C423(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C1205(0.00); C1359(0.00)  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C998(0.00); C1205(0.00); C1359(0.00); C423(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
NAIA_5
 Probe Info  		C1359(0.00); C423(0.00)  LDD2224  [13]
TFBX
 Probe Info  		C998(0.00); C1205(0.00)  LDD0027  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
IPM
 Probe Info  		N.A.  LDD0005  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
W1
 Probe Info  		R521(0.00); R526(0.00)  LDD0236  [17]
HHS-465
 Probe Info  		K835(0.00); Y834(0.00)  LDD2240  [18]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		7.19  LDD0475  [19]
FFF probe3
 Probe Info  		7.24  LDD0465  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1205(0.83)  LDD2132  [4]
 LDCM0025  4SU-RNA HEK-293T C1359(3.53)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C936(2.76); C423(2.87); C1359(3.35)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C1205(1.21); C1359(0.84); C423(1.03); C936(1.29)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1205(0.96); C1359(1.13); C423(0.90); C936(1.16)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1205(0.76); C1359(0.68); C423(1.26); C936(0.83)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1205(0.91); C1359(0.90); C423(1.19); C936(0.89)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1205(0.87); C1359(0.93); C423(1.01); C936(0.83)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1205(1.03); C1359(0.83); C423(1.16); C936(1.13)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1205(0.96); C1359(0.66); C423(1.02); C936(1.16)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1205(1.08); C1359(0.72); C423(1.25); C936(0.93)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1205(1.16); C1359(0.73); C423(1.38); C936(0.94)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1205(1.22); C1359(0.64); C423(1.07); C936(0.92)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1205(0.91); C1359(0.72); C423(0.93); C936(1.37)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1205(0.80); C1359(0.56); C423(0.97); C936(1.22)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1205(0.94); C1359(1.22); C423(0.92); C936(1.14)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1205(0.80); C1359(0.77); C423(1.16); C936(1.11)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1205(0.86); C1359(0.76); C423(1.01); C936(1.05)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1205(0.93); C1359(0.73); C423(1.10); C936(0.87)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1205(1.70); C1359(1.10); C423(0.91); C936(1.07)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1205(1.63); C1359(1.05); C423(1.12); C936(1.05)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1205(3.23); C1359(0.97); C423(0.95); C936(1.22)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1205(1.15); C1359(0.97); C423(1.14); C936(1.45)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1205(1.28); C1359(0.81); C423(1.20); C936(1.17)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1205(1.64); C1359(0.99); C423(1.05); C936(0.86)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1205(1.31); C1359(0.97); C423(1.03); C936(1.17)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1205(1.15); C1359(1.17); C423(0.82); C936(0.97)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1205(1.32); C1359(1.00); C423(1.16); C936(1.00)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1205(1.55); C1359(0.82); C423(0.84); C936(0.81)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1205(1.12); C1359(1.06); C423(0.92); C936(1.12)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1205(1.54); C1359(0.83); C423(0.77); C936(1.01)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1205(1.41); C1359(0.91); C423(0.96); C936(1.16)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1205(1.95); C1359(0.95); C423(0.98); C936(0.95)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1205(1.57); C1359(1.16); C423(0.96); C936(1.06)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1205(2.50); C1359(1.05); C423(1.22); C936(1.28)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C423(1.18); C936(1.26); C998(1.19)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C423(0.99); C936(0.66); C998(1.36)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C423(1.00); C936(1.05); C998(1.35)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C423(0.94); C936(0.94); C998(1.19)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C423(0.88); C936(0.83); C998(1.25)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C423(1.07); C936(1.01); C998(1.20)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C423(0.90); C936(1.25); C998(1.16)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C423(0.95); C936(1.15); C998(1.19)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C423(0.90); C936(1.15); C998(1.24)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C423(0.84); C936(1.09); C998(1.30)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C423(0.86); C936(0.96); C998(1.27)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C423(0.90); C936(0.97); C998(1.41)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1205(0.88); C1359(0.91); C423(0.88); C936(1.07)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C423(0.99); C936(1.09); C998(1.72)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C423(0.89); C936(1.11); C998(1.32)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C423(0.83); C936(0.89); C998(1.29)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1359(1.01); C998(1.10); C936(1.17); C423(1.32)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1359(0.85); C998(1.35); C423(1.51); C936(1.72)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1359(1.00); C998(1.13); C423(1.27); C936(1.41)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1359(1.23); C998(1.44); C423(1.55); C936(1.63)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1359(0.91); C998(1.32); C936(1.75); C423(1.77)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1359(1.58); C998(1.97); C423(2.06); C936(2.26)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1359(1.23); C998(1.55); C936(1.80); C423(1.84)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C998(0.78); C423(0.85); C1205(1.05); C1359(1.12)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C998(1.10); C1359(1.18); C936(1.29); C423(1.52)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C1359(0.97); C998(1.14); C936(1.27); C423(1.53)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1359(0.97); C998(1.13); C936(1.93); C423(2.00)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1359(1.73); C998(1.92); C936(2.61); C423(2.63)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1359(1.07); C423(1.83); C936(1.50); C998(1.28)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1359(0.89); C423(1.62); C936(1.47); C998(1.11)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1359(0.79); C423(1.19); C936(1.16); C998(0.97)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1359(0.95); C423(1.26); C936(1.08); C998(1.16)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C998(1.06); C423(1.14); C936(1.20)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C423(0.98); C998(0.99); C936(2.39)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C998(1.01); C423(1.09); C936(1.11)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C998(1.04); C936(1.13); C1359(1.17); C423(1.25)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C998(0.89); C936(1.09); C423(1.10)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C998(0.96); C423(1.09); C936(1.21)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C998(1.01); C423(1.07); C936(1.11)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C998(0.82); C423(1.06); C936(1.14)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C998(0.92); C936(1.01); C423(1.01)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C936(0.88); C423(0.90); C998(0.97); C1205(1.01)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C936(0.93); C1205(1.04); C998(1.16); C423(1.26)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C936(0.95); C998(1.01); C1205(1.26); C423(1.36)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C936(0.61); C998(1.09); C1205(1.13); C423(1.15)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C936(0.85); C998(1.07); C1205(1.14); C423(1.16)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C1359(1.05); C423(1.09); C998(1.18); C1205(1.22)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C936(0.92); C998(0.97); C1205(1.13); C423(1.15)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C1205(0.88); C998(0.92); C423(1.07); C936(1.91)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C936(0.80); C1205(1.03); C998(1.05); C423(1.26)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C936(0.85); C998(0.91); C1205(0.97); C423(1.30)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C936(0.79); C998(0.87); C1205(1.00); C423(1.29)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C1205(0.64); C998(0.83); C936(0.99)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C1205(0.81); C936(0.96); C998(0.99)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C1205(0.69); C936(0.96); C998(1.12)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C1205(0.79); C936(0.93); C998(1.04)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C1205(0.81); C936(0.92); C998(0.97)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C1359(0.95); C423(1.02); C998(1.23); C1205(1.36)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C1205(0.78); C998(1.15); C936(1.23)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C936(0.92); C1205(0.96); C998(1.09)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C1205(0.80); C998(1.14); C936(1.27)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C1205(0.87); C936(1.05); C998(1.12)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C1205(0.83); C936(1.06); C998(1.14)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C1205(0.71); C936(1.17); C998(1.29)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C1205(0.75); C423(0.91); C998(1.15)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C1205(0.70); C423(0.98); C998(1.13)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C1205(0.91); C423(1.10); C998(1.30)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C1205(1.11); C998(1.20); C423(1.24)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C1359(0.93); C423(1.09); C998(1.33); C1205(1.41)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C423(0.98); C1205(1.01); C998(1.14)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C1205(0.71); C423(0.93); C998(1.01)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C1205(0.89); C998(1.12); C423(1.24)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C1205(0.81); C998(1.03); C423(1.36)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C1205(0.98); C423(1.00); C998(1.04)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1205(1.09); C998(1.40); C423(1.99)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1205(1.28); C423(1.47); C998(1.54)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C1205(1.09); C936(1.10); C423(1.14); C998(1.26)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C1205(0.94); C423(1.26); C936(1.33); C998(1.34)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C1205(0.98); C423(1.23); C936(1.24); C998(1.28)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C1205(0.86); C998(0.91); C423(1.01); C1359(1.01)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C1205(0.92); C936(1.08); C423(1.12); C998(1.24)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C1205(0.96); C423(1.11); C936(1.16); C998(1.25)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1205(1.08); C423(1.24); C936(1.26); C998(1.53)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C1205(0.85); C936(1.12); C423(1.23); C998(1.41)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C1205(1.05); C936(1.12); C423(1.27); C998(1.38)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C1205(0.97); C936(1.16); C423(1.45); C998(1.70)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C1205(0.97); C936(1.15); C423(1.30); C998(1.39)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C1205(1.05); C936(1.26); C423(1.49); C998(1.73)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C1359(0.86); C998(1.01); C423(1.17)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1359(0.53); C998(1.27); C423(1.28)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C998(0.93); C1205(0.96); C1359(1.00); C423(1.02)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C998(1.17); C423(1.28); C1359(1.52)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C1359(0.81); C423(1.09); C998(1.25)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C1359(0.98); C998(1.13); C423(1.18)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1359(1.33); C998(1.50); C423(1.78)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1359(1.01); C998(1.35); C423(1.50)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C998(1.76); C423(1.76); C1359(2.52)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C1359(0.87); C423(1.24); C998(1.27)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C1359(0.86); C423(1.32); C998(1.41)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C1359(0.86); C998(1.10); C423(1.18)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C1359(0.72); C423(1.17); C998(1.19)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C1205(0.85); C998(0.87); C423(1.11); C1359(1.11)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C1359(0.94); C998(1.13); C423(1.22)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C1359(0.60); C423(1.02); C998(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C1359(1.38); C998(1.54); C423(1.61)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C998(1.28); C423(1.51); C936(2.11)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C998(1.02); C423(1.38); C936(1.91)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C998(1.03); C423(1.23); C936(1.40)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C998(1.19); C936(1.24); C423(1.33)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C936(1.03); C998(1.08); C423(1.13)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C998(1.02); C423(1.13); C936(1.20)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C998(1.13); C936(1.33); C423(1.39)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C936(0.88); C998(1.12); C423(1.18)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C998(1.29); C423(1.60); C936(2.13)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C998(1.26); C423(1.45); C936(1.79)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C998(0.87); C936(1.13); C423(1.16)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C998(0.99); C423(1.24); C936(1.24)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C998(1.06); C936(1.07); C423(1.19)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C998(1.00); C423(1.27); C936(1.29)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C998(1.25); C423(1.48); C936(1.57)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C1359(0.90); C998(1.05); C936(1.31); C1205(1.40)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C1205(0.78); C998(0.79); C1359(0.80); C936(0.81)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1205(0.84); C1359(1.10); C423(1.10); C936(0.98)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C1205(0.87); C998(0.88); C423(0.96); C1359(1.13)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C998(0.89); C423(0.97); C1359(1.09); C1205(1.23)  LDD0592  [8]
 LDCM0102  BDHI 8 Jurkat C1359(5.25)  LDD0204  [20]
 LDCM0108  Chloroacetamide HeLa H508(0.00); H705(0.00)  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C1359(20.00)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C1205(0.80); C936(0.86); C423(0.87); C998(0.94)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C423(0.86); C998(0.91); C1205(1.02); C936(1.33)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C998(1.01); C423(1.02); C1359(1.03); C1205(1.10)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C998(0.79); C1359(0.81); C1205(0.84); C423(0.91)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C998(0.74); C1205(0.80); C1359(0.80); C936(0.93)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C998(0.87); C1359(0.92); C1205(0.94); C936(0.95)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C998(0.73); C1205(0.80); C1359(0.87); C423(0.90)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C998(1.01); C423(1.03); C936(1.35)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C423(1.09); C998(1.12); C936(1.92)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C423(1.20); C998(1.22); C936(1.79)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C998(1.15); C423(1.32); C936(1.89)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C998(0.99); C423(1.20); C936(1.28)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C423(0.74); C998(0.89); C1205(0.98); C936(1.31)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C998(1.07); C423(1.11); C936(1.70)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C423(1.04); C998(1.09); C936(1.40)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C936(0.49); C1205(0.87); C998(0.88); C423(1.00)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C998(0.88); C1205(0.91); C936(0.93); C423(1.13)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C936(0.79); C998(0.82); C1205(0.85); C423(1.22)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C936(0.72); C1205(0.84); C998(0.92); C423(1.06)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C936(0.67); C998(0.83); C1205(1.02); C423(1.22)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C1205(0.72); C998(1.34); C936(1.51)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C998(1.01); C936(1.10); C1205(1.16)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C1205(0.84); C998(1.04); C936(1.11)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C423(0.76); C998(0.95); C1205(1.18); C936(1.41)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1205(0.85); C936(0.87); C998(1.06)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C1205(0.76); C998(1.01); C423(1.27)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C1205(0.98); C998(1.03); C423(1.04)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1205(0.92); C423(0.96); C998(1.04)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C1205(0.97); C423(1.07); C998(1.30)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C1205(0.71); C936(1.05); C423(1.12); C998(1.14)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C1205(0.99); C936(1.09); C998(1.11); C423(1.22)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C1205(0.82); C998(1.09); C936(1.10); C423(1.22)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C1205(0.98); C936(1.19); C998(1.29); C423(1.36)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C998(1.05); C1205(1.08); C423(1.21); C936(1.29)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C1205(0.84); C423(0.91); C998(0.97); C936(1.07)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C998(0.89); C1205(0.95); C423(1.17); C936(1.23)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C998(0.82); C423(1.08); C1359(1.12); C1205(1.17)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C998(0.85); C936(1.16); C423(1.16); C1205(1.23)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C423(0.95); C998(1.01); C936(1.11); C1205(1.19)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C423(0.97); C998(0.98); C936(1.24); C1205(1.34)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C423(0.93); C936(0.94); C1205(0.96); C998(0.97)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C998(1.07); C423(1.21); C936(1.31); C1205(1.73)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C998(1.11); C423(1.27); C1205(1.36); C936(1.50)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C423(1.28); C998(1.39); C936(1.72); C1205(1.97)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C998(0.86); C423(0.91); C1205(1.06); C936(1.08)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C1205(1.52); C423(0.89); C936(1.56); C998(1.16)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1205(1.85); C423(0.94); C936(1.08); C998(1.09)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1205(1.05); C423(1.04); C936(1.10); C998(0.93)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1205(1.31); C423(0.87); C936(0.97); C998(1.04)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1205(1.00); C423(1.31); C936(1.36); C998(0.99)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1205(1.31); C423(1.07); C936(1.36); C998(1.10)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1205(1.01); C423(1.12); C936(0.97); C998(0.90)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1205(1.42); C423(0.99); C936(1.13); C998(0.83)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1205(1.07); C423(0.91); C936(1.35); C998(1.02)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1205(1.03); C1359(1.07); C423(1.03); C936(1.67)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1205(1.04); C1359(1.13); C423(1.03); C936(1.47)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1205(1.32); C1359(1.21); C423(0.90); C936(1.99)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1205(1.29); C1359(1.12); C423(1.06); C936(2.03)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1205(1.24); C1359(0.99); C423(0.89); C936(2.09)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1205(1.38); C1359(1.25); C423(1.03); C936(2.35)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1205(1.27); C1359(1.31); C423(0.89); C936(1.49)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1205(0.87); C423(0.98); C936(0.92); C998(0.84)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1205(1.18); C1359(1.00); C423(0.73); C936(1.81)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1205(1.23); C1359(1.19); C423(0.85); C936(1.86)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1205(1.67); C1359(1.00); C423(0.87); C936(2.90)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1205(1.39); C1359(1.15); C423(0.89); C936(2.32)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1205(1.22); C1359(1.19); C423(1.02); C936(2.02)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1205(1.25); C1359(1.32); C423(1.01); C936(1.79)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1205(0.92); C423(1.09); C936(0.64); C998(1.19)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1205(1.06); C423(1.06); C936(0.73); C998(1.09)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1205(0.67); C423(0.97); C936(0.92); C998(1.15)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1205(0.88); C423(1.04); C936(0.95); C998(1.14)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1205(1.01); C423(1.02); C936(0.98); C998(0.97)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1205(0.69); C423(0.96); C936(0.72); C998(1.14)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1205(0.90); C423(1.14); C936(0.77); C998(1.25)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1205(0.99); C423(1.32); C936(0.74); C998(1.14)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1205(1.04); C423(0.97); C936(0.77); C998(0.84)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1205(1.04); C423(0.77); C936(0.69); C998(1.07)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1205(0.86); C423(0.91); C936(0.90); C998(1.24)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1205(0.93); C423(0.83); C936(0.95); C998(1.06)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1205(1.20); C423(1.04); C936(0.71); C998(1.01)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1205(1.08); C423(1.05); C936(0.84); C998(1.07)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1205(1.07); C423(0.93); C936(1.00); C998(1.03)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1205(1.01); C423(1.09); C936(1.09); C998(0.98)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1205(0.84); C423(1.01); C936(0.87); C998(1.03)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1205(1.07); C423(1.07); C936(1.14); C998(1.04)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1205(1.11); C423(0.99); C936(1.15); C998(1.02)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1205(0.96); C423(1.25); C936(1.24); C998(1.05)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1205(1.09); C423(1.30); C936(1.20); C998(1.12)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1205(1.10); C423(1.25); C936(1.18); C998(1.14)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1205(1.29); C423(1.33); C936(1.55); C998(1.20)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1205(0.99); C423(1.30); C936(1.53); C998(1.08)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1205(0.92); C423(1.11); C936(1.15); C998(1.07)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1205(1.05); C423(1.38); C936(0.93); C998(1.06)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1205(1.10); C423(1.12); C936(1.25); C998(1.09)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1205(1.10); C423(1.17); C936(1.25); C998(1.12)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1205(0.94); C423(1.61); C936(1.22); C998(1.00)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1205(0.94); C423(1.18); C936(1.12); C998(1.02)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1205(1.02); C423(1.15); C936(1.32); C998(1.05)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1205(0.90); C423(1.26); C936(1.32); C998(1.09)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C423(0.92); C936(1.16); C998(1.15)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C423(1.09); C936(1.41); C998(0.98)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C423(1.15); C936(1.21); C998(1.15)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C423(1.05); C936(1.67); C998(1.21)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1205(1.02); C423(1.11); C936(1.88); C998(0.80)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C423(1.08); C936(1.41); C998(1.06)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C423(1.09); C936(1.28); C998(1.12)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C423(1.18); C936(2.06); C998(1.42)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C423(1.09); C936(1.69); C998(1.23)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C423(1.00); C936(2.01); C998(1.68)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C423(0.90); C936(1.20); C998(1.18)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C423(1.14); C936(1.12); C998(1.10)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C423(1.18); C936(1.42); C998(1.12)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C423(1.18); C936(1.60); C998(1.32)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C423(1.29); C936(2.35); C998(1.60)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1205(1.07); C423(1.00); C936(1.20); C998(0.95)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C423(1.28); C936(0.97); C998(0.96)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1205(1.14); C1359(0.75); C423(1.07); C936(1.17)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1205(1.02); C1359(0.72); C423(1.18); C936(1.27)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1205(1.20); C1359(0.88); C423(1.20); C936(1.34)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1205(1.11); C1359(0.95); C423(1.11); C936(1.46)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1205(1.04); C1359(0.75); C423(1.13); C936(1.38)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1205(1.07); C1359(0.91); C423(1.27); C936(1.14)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1205(1.09); C1359(0.99); C423(1.23); C936(1.23)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1205(1.12); C1359(0.93); C423(1.13); C936(1.50)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1205(1.20); C1359(0.92); C423(1.07); C936(1.12)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C998(0.35)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C998(0.95); C423(0.93); C1359(0.91); C1205(0.97)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C423(0.75)  LDD1702  [4]
 LDCM0625  F8 Ramos C1205(1.04); C998(2.19)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C1205(0.81); C998(0.22)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C1205(2.70); C998(2.96)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C1205(0.82); C998(0.42)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C1205(0.96); C998(1.53)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C1205(0.99); C998(1.30)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C1205(0.75)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C1205(1.04); C998(1.35)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C1205(0.71); C998(0.23)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C1205(0.94); C998(0.84)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C1205(0.72)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C1205(1.20); C998(0.90)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C1205(0.95); C998(0.91)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C1205(1.07); C998(0.26)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C1205(0.85); C423(1.35); C936(1.23); C998(0.99)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C1205(0.93); C998(0.85)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C1205(0.92); C998(1.10)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C1205(1.40); C1359(1.11); C423(0.93); C936(2.18)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C1205(1.14)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C1205(1.22); C998(1.10)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C1205(1.01); C998(1.04)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C1205(0.95)  LDD2188  [22]
 LDCM0116  HHS-0101 DM93 Y834(0.89); Y187(0.92)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y187(0.52); Y834(0.72)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y834(0.65); Y187(0.73)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y187(0.68); Y834(0.71)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y834(0.75); Y187(1.21)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HCT 116 C936(2.45); C1359(1.68); C423(3.95)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C936(2.50); C1359(1.71); C423(1.78)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C936(3.96); C1359(1.89); C423(1.59)  LDD0082  [8]
 LDCM0109  NEM HeLa H705(0.00); H736(0.00); H508(0.00)  LDD0223  [7]
 LDCM0131  RA190 MM1.R C936(3.03)  LDD0304  [23]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomerase reverse transcriptase (TERT) Reverse transcriptase family O14746
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF complex subunit SMARCC1 (SMARCC1) SMARCC family Q92922
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
AT-rich interactive domain-containing protein 1A (ARID1A) . O14497
AT-rich interactive domain-containing protein 1B (ARID1B) . Q8NFD5
AT-rich interactive domain-containing protein 2 (ARID2) . Q68CP9
Protein polybromo-1 (PBRM1) . Q86U86
RE1-silencing transcription factor (REST) . Q13127
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2AX (H2AX) Histone H2A family P16104
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pfi-3 Small molecular drug D09GNM

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.