Details of the Target

General Information of Target

Target ID LDTP04844
Target Name Actin-related protein 2/3 complex subunit 4 (ARPC4)
Gene Name ARPC4
Gene ID 10093
Synonyms
ARC20; Actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa subunit; p20-ARC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEK
VLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITN
FHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
Target Bioclass
Other
Family
ARPC4 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Uniprot ID
P59998
Ensemble ID
ENST00000397261.8
HGNC ID
HGNC:707

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.Ter169KfsTer87 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.79  LDD0402  [1]
CHEMBL5175495
 Probe Info  		5.78  LDD0196  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K44(9.32)  LDD0277  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
OPA-S-S-alkyne
 Probe Info  		K44(7.73)  LDD3494  [6]
DBIA
 Probe Info  		C40(1.52)  LDD3311  [7]
THZ1-DTB
 Probe Info  		C21(0.98)  LDD0460  [8]
AHL-Pu-1
 Probe Info  		C21(2.43)  LDD0170  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
Acrolein
 Probe Info  		H33(0.00); C21(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		4.70  LDD0443  [16]
MPP-AC
 Probe Info  		N.A.  LDD0428  [17]
NAIA_5
 Probe Info  		C21(0.00); C87(0.00)  LDD2223  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [17]
TPP-AC
 Probe Info  		N.A.  LDD0427  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C21(2.43)  LDD0170  [9]
 LDCM0214  AC1 HEK-293T C21(1.08)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C21(0.98)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C21(0.92)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C21(0.99)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C21(1.16)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C21(0.97)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C21(0.99)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C21(1.00)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C21(0.93)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C21(1.01)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C21(0.92)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C21(0.95)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C21(1.27)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C21(0.91)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C21(0.91)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C21(0.99)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C21(1.00)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C21(1.01)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C21(0.90)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C21(1.06)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C21(0.93)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C21(1.16)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C21(0.78)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C21(0.92)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C21(0.99)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C21(1.01)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C21(0.90)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C21(1.02)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C21(0.97)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C21(1.02)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C21(0.89)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C21(0.98)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C21(1.01)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C21(1.09)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C21(1.06)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C21(0.90)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C21(1.14)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C21(0.98)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C21(1.11)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C21(0.80)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C21(0.97)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C21(1.01)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C21(0.94)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C21(0.94)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C21(1.00)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C21(0.95)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C21(0.94)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C21(1.12)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C21(0.84)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C21(0.90)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C21(1.04)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C21(1.05)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C21(1.00)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C21(1.22)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C21(1.04)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C21(0.97)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C21(1.11)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C21(0.88)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C21(1.04)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C21(0.84)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C21(0.92)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C21(1.03)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C21(0.95)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C21(0.97)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C21(2.13)  LDD2214  [19]
 LDCM0108  Chloroacetamide HeLa C21(0.00); H33(0.00)  LDD0222  [15]
 LDCM0367  CL1 HEK-293T C21(1.09)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C21(1.14)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C21(0.93)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C21(1.06)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C21(1.07)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C21(1.09)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C21(0.88)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C21(1.04)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C21(1.00)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C21(1.12)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C21(0.96)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C21(0.99)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C21(0.89)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C21(0.98)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C21(1.10)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C21(0.85)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C21(1.10)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C21(1.02)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C21(0.90)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C21(0.87)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C21(1.10)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C21(1.08)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C21(1.00)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C21(0.96)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C21(0.76)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C21(1.07)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C21(1.14)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C21(1.20)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C21(0.94)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C21(1.29)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C21(1.21)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C21(0.99)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C21(0.91)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C21(1.12)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C21(1.15)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C21(0.92)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C21(0.82)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C21(0.98)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C21(0.83)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C21(0.93)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C21(1.17)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C21(0.96)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C21(0.89)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C21(1.06)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C21(0.92)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C21(0.87)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C21(0.99)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C21(1.08)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C21(1.03)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C21(0.86)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C21(1.02)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C21(0.98)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C21(0.94)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C21(0.98)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C21(1.01)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C21(0.96)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C21(1.10)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C21(0.73)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C21(0.91)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C21(1.09)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C21(1.14)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C21(1.02)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C21(0.91)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C21(0.95)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C21(1.03)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C21(0.97)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C21(1.05)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C21(1.05)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C21(1.05)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C21(0.84)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C21(0.88)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C21(1.14)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C21(1.14)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C21(1.07)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C21(0.95)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C21(1.02)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C21(0.93)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C21(1.02)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C21(1.11)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C21(0.97)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C21(1.11)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C21(0.94)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C21(1.09)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C21(0.89)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C21(1.06)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C21(1.05)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C21(1.15)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C21(0.84)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C21(1.04)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C21(1.05)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C21(0.95)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C21(1.00)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C21(0.92)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C21(0.95)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C21(1.16)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C21(1.04)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C21(0.96)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C21(1.08)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C21(1.18)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C21(0.93)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C21(1.14)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C21(1.14)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C21(0.97)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C21(1.07)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C21(1.10)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C21(1.04)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C21(1.01)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C21(1.11)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C21(1.06)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C21(1.23)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C21(1.17)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C21(1.07)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C21(1.03)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C21(1.14)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C21(0.92)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C21(1.04)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C21(1.01)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C21(1.01)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C21(0.95)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C21(1.04)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C21(0.81)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C21(0.99)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C21(1.02)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C21(1.07)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C21(0.97)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C21(0.94)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C21(0.80)  LDD1702  [20]
 LDCM0468  Fragment33 HEK-293T C21(1.09)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C21(1.07)  LDD1631  [18]
 LDCM0107  IAA HeLa C21(0.00); H33(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C21(0.85)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C21(0.89)  LDD1497  [18]
 LDCM0024  KB05 G361 C40(1.52)  LDD3311  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0021  THZ1 HeLa S3 C21(0.98)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-lysine methyltransferase METTL21A (METTL21A) METTL21 family Q8WXB1
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 2/3 complex subunit 3 (ARPC3) ARPC3 family O15145
Actin-related protein 2/3 complex subunit 5-like protein (ARPC5L) ARPC5 family Q9BPX5
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Actin nucleation-promoting factor WASL (WASL) . O00401

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-13-thiazolidin-4-one . DB08236
N-[2-(2-methyl-1h-indol-3-yl)Ethyl]Thiophene-2-carboxamide . DB08235

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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17 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
20 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761