Details of the Target

General Information of Target

Target ID LDTP12461
Target Name PDZ and LIM domain protein 7 (PDLIM7)
Gene Name PDLIM7
Gene ID 9260
Synonyms
ENIGMA; PDZ and LIM domain protein 7; LIM mineralization protein; LMP; Protein enigma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSQVTFSDVAIDFSHEEWACLDSAQRDLYKDVMVQNYENLVSVGLSVTKPYVIMLLEDGK
EPWMMEKKLSKAYPFPLSHSVPASVNFGFSALFEHCSEVTEIFELSELCVFWVLHFLSNS
PNSTVEAFSRSKKKKKKKKKRQCFAFLIYFRLGIKMGKQGIINKEGYLYEDSPQPVTMEK
VVKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSV
IKSERINGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSRHWR
IHTGEKPYECRECGKTFSHGSSLTRHQISHSGEKPYKCIECGKAFSHGSSLTNHQSTHTG
EKPYECMNCGKSFSRVSLLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPY
ECRECGKAFCCSSHLTQHQRIHSMKKKYECNKCLKVFSSFSFLVQHQSIHTEEKPFEV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
Uniprot ID
Q9NR12
Ensemble ID
ENST00000355572.6
HGNC ID
HGNC:22958

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.G175D DBIA    Probe Info 
IGR1 SNV: p.P213L DBIA    Probe Info 
KYSE510 SNV: p.S455C DBIA    Probe Info 
MFE319 SNV: p.P118S DBIA    Probe Info 
NCIH1703 SNV: p.M179R DBIA    Probe Info 
OVCAR5 SNV: p.R32L DBIA    Probe Info 
RKO SNV: p.P135S DBIA    Probe Info 
TC71 Substitution: p.S89I DBIA    Probe Info 
U2OS SNV: p.S204P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.27  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
ONAyne
 Probe Info  		K238(1.08)  LDD0274  [3]
STPyne
 Probe Info  		K114(4.25); K22(6.67); K238(9.05); K287(0.39)  LDD0277  [3]
IPM
 Probe Info  		C341(0.00); C400(0.00); C388(0.00); C403(0.00)  LDD0241  [4]
BTD
 Probe Info  		C449(1.31); C341(1.27)  LDD1700  [5]
HHS-475
 Probe Info  		Y104(1.04)  LDD0264  [6]
DBIA
 Probe Info  		C367(0.99); C370(0.99); C388(0.95); C332(0.86)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C449(0.84); C341(0.92); C285(0.95)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C449(1.13); C341(0.92)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C388(5.72)  LDD0371  [14]
 LDCM0214  AC1 HCT 116 C282(0.97); C285(0.97); C329(1.02); C332(0.96)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C282(1.01); C285(1.02); C329(1.13); C332(1.11)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C282(0.72); C285(0.77); C329(1.04); C332(0.95)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C282(0.68); C285(0.72); C329(0.96); C332(0.90)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C282(0.70); C285(0.72); C329(0.89); C332(0.86)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C282(0.63); C285(0.66); C329(0.89); C332(0.99)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C282(0.73); C285(0.72); C329(1.04); C332(0.90)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C282(0.70); C285(0.72); C329(0.90); C332(1.03)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C282(0.67); C285(0.72); C329(0.96); C332(1.11)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C282(0.66); C285(0.64); C329(1.03); C332(0.94)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C282(0.74); C285(0.80); C329(1.10); C332(1.02)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C282(0.68); C285(0.77); C329(1.00); C332(0.89)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C282(1.07); C285(1.08); C329(1.13); C332(1.13)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C282(0.66); C285(0.72); C329(1.14); C332(0.95)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C282(0.69); C285(0.80); C329(1.14); C332(0.98)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C282(0.63); C285(0.63); C329(1.10); C332(0.87)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C282(1.08); C285(1.11); C329(1.25); C332(1.14)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C282(1.11); C285(1.10); C329(1.35); C332(1.31)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C282(1.11); C285(1.11); C329(1.68); C332(1.47)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C282(1.06); C285(1.06); C329(1.56); C332(1.43)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C282(1.06); C285(1.02); C329(1.25); C332(1.21)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C282(1.13); C285(1.11); C329(1.51); C332(1.37)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C282(0.98); C285(0.95); C329(1.21); C332(1.23)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C282(1.11); C285(1.14); C329(1.14); C332(1.14)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C282(1.06); C285(1.09); C329(1.42); C332(1.32)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C282(1.00); C285(0.96); C329(1.24); C332(1.24)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C282(1.07); C285(1.07); C329(1.33); C332(1.28)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C282(1.14); C285(1.00); C329(1.12); C332(1.15)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C282(1.06); C285(1.04); C329(1.35); C332(1.34)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C282(1.00); C285(1.01); C329(1.32); C332(1.26)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C282(1.12); C285(1.12); C329(1.31); C332(1.32)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C282(1.03); C285(1.05); C329(1.33); C332(1.32)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C282(0.77); C285(0.77); C329(1.05); C332(1.02)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C282(0.66); C285(0.66); C329(0.80); C332(0.77)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C282(0.66); C285(0.66); C329(1.19); C332(0.97)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C282(0.63); C285(0.63); C329(0.74); C332(0.79)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C282(0.65); C285(0.65); C329(0.78); C332(0.77)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C282(0.70); C285(0.70); C329(1.04); C332(0.99)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C282(0.64); C285(0.64); C329(1.01); C332(0.94)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C282(0.72); C285(0.72); C329(0.84); C332(0.86)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C282(0.71); C285(0.71); C329(0.96); C332(0.94)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C282(0.71); C285(0.71); C329(0.84); C332(0.90)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C282(0.69); C285(0.69); C329(1.15); C332(1.04)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C282(0.61); C285(0.61); C329(0.91); C332(0.83)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C282(0.98); C285(0.99); C329(1.06); C332(1.04)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C282(0.66); C285(0.66); C329(0.90); C332(0.95)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C282(0.61); C285(0.61); C329(0.87); C332(0.87)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C282(0.61); C285(0.61); C329(1.03); C332(0.92)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C364(0.81); C403(0.87); C400(0.87); C282(0.88)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C282(0.92); C400(0.92); C403(0.93); C285(0.96)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C282(0.96); C367(0.96); C329(0.96); C370(0.97)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C282(0.85); C364(0.87); C400(0.91); C285(0.93)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C403(0.93); C285(0.93); C400(0.97); C282(0.98)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C282(0.84); C400(0.84); C403(0.97); C285(0.99)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C282(0.83); C400(0.88); C403(0.97); C285(0.97)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C400(0.83); C403(0.93); C282(1.01); C367(1.02)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C282(0.93); C364(0.96); C285(0.96); C370(0.99)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C282(0.89); C403(0.96); C285(0.99); C400(0.99)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C403(0.75); C400(0.83); C282(0.92); C285(1.00)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C400(0.71); C282(0.75); C403(0.90); C285(0.96)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C282(0.93); C285(1.00); C329(1.02); C332(1.20)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C282(0.86); C285(0.96); C329(0.92); C332(1.18)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C282(0.99); C285(1.09); C329(0.95); C332(1.03)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C282(0.86); C285(0.99); C329(0.94); C332(1.20)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C285(0.87); C282(0.89); C367(1.06); C332(1.09)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C285(0.96); C282(0.99); C400(1.00); C341(1.08)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C400(0.99); C341(1.04); C285(1.07); C403(1.07)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C388(0.79); C282(0.87); C285(0.87); C400(0.93)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C403(0.96); C341(0.98); C285(1.02); C282(1.03)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C400(0.94); C403(0.94); C341(0.95); C332(1.04)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C403(0.90); C400(0.98); C388(0.99); C364(1.02)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C403(0.87); C285(0.91); C400(0.92); C282(0.94)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C282(0.97); C285(0.97); C403(0.99); C329(1.01)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C329(0.96); C388(0.97); C367(0.99); C370(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C400(0.87); C403(0.88); C341(1.00); C388(1.09)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C400(0.96); C341(0.96); C367(0.98); C370(0.98)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C400(0.91); C403(0.92); C367(0.97); C370(0.97)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C400(0.97); C367(0.97); C370(0.97); C403(0.98)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C367(0.75); C370(0.75); C388(0.76); C282(0.90)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C400(1.04); C403(1.07); C367(1.08); C370(1.08)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C400(0.88); C403(0.92); C341(0.95); C367(1.00)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C400(0.91); C403(0.93); C341(0.96); C388(1.09)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C400(0.92); C403(0.95); C341(1.13); C367(1.16)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C400(0.79); C403(0.82); C341(1.11); C367(1.14)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C367(0.85); C370(0.85); C341(1.01); C329(1.02)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C367(0.85); C370(0.85); C329(0.93); C282(1.00)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C367(0.94); C370(0.94); C329(1.02); C332(1.03)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C367(0.85); C370(0.85); C282(0.88); C285(0.98)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C367(0.83); C370(0.83); C388(0.85); C400(0.91)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C367(0.75); C370(0.75); C388(0.79); C329(0.91)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C400(0.90); C367(0.90); C370(0.90); C403(0.91)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C367(0.79); C370(0.79); C285(0.98); C388(0.99)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C285(0.84); C282(0.85); C367(0.92); C370(0.92)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C282(0.87); C400(0.88); C285(0.89); C403(0.90)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C367(0.85); C370(0.85); C400(0.99); C403(1.01)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C403(0.83); C400(0.85); C367(0.95); C370(0.95)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C285(0.83); C282(0.85); C400(0.91); C341(0.93)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C367(0.91); C370(0.91); C341(0.95); C282(0.99)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C367(0.62); C370(0.62); C400(0.86); C403(0.88)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C403(0.82); C400(0.84); C341(0.86); C282(0.87)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C388(0.75); C367(0.78); C370(0.78); C332(0.88)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C400(0.78); C282(0.82); C403(0.84); C341(0.96)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C367(0.80); C370(0.80); C285(0.92); C332(0.98)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C400(0.96); C367(0.98); C370(0.98); C285(1.01)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C400(0.83); C282(0.87); C403(0.88); C285(0.99)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C400(0.80); C403(0.89); C282(0.96); C285(1.06)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C400(0.83); C403(0.90); C282(0.93); C285(1.03)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C400(0.65); C403(0.74); C282(0.79); C285(0.97)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C364(0.72); C282(0.78); C285(0.84); C403(0.86)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C282(0.68); C285(0.77); C364(0.84); C403(0.84)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C364(0.74); C282(0.77); C285(0.84); C403(0.88)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C364(0.86); C388(0.99); C400(0.99); C370(1.06)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C403(0.74); C282(0.74); C364(0.82); C285(0.83)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C282(0.72); C364(0.73); C285(0.80); C400(0.82)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C364(0.76); C403(0.78); C282(0.79); C400(0.84)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C364(0.72); C403(0.79); C282(0.82); C400(0.84)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C282(0.72); C403(0.72); C364(0.73); C400(0.79)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C282(0.69); C285(0.77); C364(0.83); C403(0.90)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C282(0.66); C285(0.74); C403(0.85); C364(0.88)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C403(0.56); C282(0.58); C400(0.62); C285(0.68)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C367(0.91); C282(0.92); C370(0.94); C329(0.94)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C329(0.79); C282(0.80); C332(0.85); C403(0.86)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C367(0.85); C370(0.87); C341(0.88); C400(0.93)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C282(0.66); C329(0.77); C332(0.82); C367(0.83)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C329(0.68); C282(0.72); C332(0.74); C388(0.86)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C329(0.81); C403(0.85); C282(0.86); C332(0.88)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C403(0.68); C282(0.69); C329(0.75); C400(0.75)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C282(0.63); C403(0.68); C400(0.76); C329(0.88)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C282(0.63); C400(0.64); C403(0.65); C329(0.86)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C329(0.70); C282(0.72); C403(0.79); C332(0.84)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C329(0.79); C332(0.83); C282(0.88); C388(0.98)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C329(0.67); C282(0.69); C332(0.72); C400(0.79)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C329(0.71); C282(0.72); C332(0.80); C403(0.84)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C341(0.82); C367(0.89); C403(0.97); C400(0.97)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C282(0.74); C403(0.76); C329(0.76); C400(0.84)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C329(0.71); C332(0.82); C282(0.85); C403(0.89)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C282(0.49); C400(0.56); C403(0.60); C285(0.77)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C364(0.66); C403(0.72); C400(0.77); C282(0.90)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C403(0.66); C400(0.76); C364(0.81); C282(0.88)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C364(0.79); C403(0.82); C329(0.86); C282(0.87)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C388(0.83); C364(0.87); C282(0.90); C285(0.90)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C282(0.86); C285(0.86); C364(0.91); C341(0.93)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C364(0.76); C341(0.89); C400(0.95); C367(0.98)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C364(0.80); C400(0.85); C403(0.91); C282(0.93)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C388(0.75); C364(0.79); C282(0.87); C285(0.87)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C400(0.79); C403(0.84); C364(0.91); C282(1.01)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C400(0.82); C403(0.84); C364(0.85); C367(0.94)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C364(0.83); C400(0.87); C403(0.92); C367(1.01)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C388(0.91); C282(0.93); C285(0.93); C400(0.95)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C400(0.78); C282(0.80); C285(0.80); C364(0.85)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C282(0.80); C285(0.80); C400(0.81); C403(0.83)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C400(0.79); C403(0.85); C364(0.86); C282(1.02)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C403(0.41); C400(0.43); C282(0.52); C285(0.57)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C282(0.69); C403(0.71); C285(0.71); C400(0.73)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C449(0.92); C341(0.60)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C282(0.94); C285(0.95); C329(1.02); C332(1.01)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C367(0.89); C370(0.93); C400(0.94); C388(0.98)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C400(0.85); C367(0.97); C282(0.97); C285(0.98)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C367(0.99); C370(0.99); C388(0.95); C332(0.86)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C449(0.53)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa H246(0.00); C341(0.00); C388(0.00); C285(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C367(0.81); C370(0.81); C282(0.83); C285(0.83)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C403(0.80); C400(0.81); C282(0.86); C285(0.86)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C367(0.79); C370(0.79); C388(0.93); C400(0.97)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C341(0.95); C400(1.00); C403(1.08); C285(1.14)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C400(0.93); C341(0.95); C403(1.00); C332(1.04)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C332(0.95); C329(0.96); C388(0.98); C403(0.99)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C285(0.88); C282(0.88); C341(0.91); C332(0.94)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C341(0.83); C285(0.88); C282(0.90); C403(0.91)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C285(0.87); C282(0.89); C341(0.94); C400(0.94)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C285(0.84); C282(0.87); C341(0.94); C403(1.01)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C285(0.83); C282(0.86); C341(0.90); C388(0.99)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C285(0.87); C282(0.89); C400(0.92); C403(0.95)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C403(0.71); C400(0.78); C282(0.89); C285(0.89)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C285(0.78); C282(0.79); C388(0.84); C400(0.87)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C403(0.78); C285(0.80); C282(0.82); C400(0.82)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C341(0.76); C388(0.96); C400(0.98); C403(0.98)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C400(0.82); C403(0.84); C341(0.86); C329(1.12)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C400(0.76); C403(0.77); C329(0.91); C332(0.96)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C341(1.01); C400(1.04); C403(1.08); C367(1.16)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C388(0.91); C400(0.96); C403(0.99); C367(1.02)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C403(0.74); C400(0.75); C282(0.83); C285(0.95)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C367(0.85); C370(0.85); C285(0.95); C282(0.99)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C367(0.88); C370(0.88); C400(0.93); C282(0.94)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C403(0.87); C367(0.97); C370(0.97); C400(0.98)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C367(0.78); C370(0.78); C282(0.92); C285(0.94)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C285(0.99); C341(1.00); C282(1.13); C400(1.14)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C403(0.78); C282(0.81); C400(0.83); C285(0.91)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C341(0.71); C367(0.80); C370(0.80); C403(0.81)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C400(0.80); C403(0.81); C282(0.91); C285(0.98)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C364(0.78); C282(0.86); C285(0.90); C388(0.95)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C341(0.82); C364(0.83); C282(0.87); C285(0.87)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C364(0.73); C285(0.85); C282(0.85); C400(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C364(0.77); C282(0.83); C341(0.83); C285(0.90)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C403(0.72); C400(0.83); C282(0.86); C285(0.86)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C367(0.80); C370(0.80); C403(0.88); C400(0.89)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C403(0.76); C400(0.84); C282(0.93); C285(0.93)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C341(0.96); C400(0.97); C403(1.00); C367(1.22)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C388(0.89); C341(0.92); C332(0.99); C282(1.00)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C403(0.78); C400(0.79); C341(1.12); C282(1.13)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C403(0.92); C400(0.92); C341(0.95); C388(1.04)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C367(0.90); C370(0.90); C403(0.96); C400(0.97)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C403(1.09); C341(1.11); C400(1.12); C388(1.24)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C403(0.85); C400(0.88); C341(0.89); C367(1.12)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C403(0.82); C400(0.83); C341(0.96); C282(1.31)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C341(0.92); C367(1.11); C370(1.11); C400(1.26)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C403(1.00); C400(1.02); C341(1.17); C388(1.25)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C282(1.48); C285(1.48); C329(1.69); C332(1.61)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C282(1.39); C285(1.39); C329(1.56); C332(1.48)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C282(1.42); C285(1.42); C329(1.35); C332(1.35)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C282(1.26); C285(1.26); C329(2.22); C332(1.84)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C282(1.31); C285(1.31); C329(1.50); C332(1.47)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C282(0.99); C285(0.99); C329(1.17); C332(1.08)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C282(1.38); C285(1.38); C329(1.42); C332(1.32)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C282(0.79); C285(0.80); C329(1.05); C332(1.03)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C282(0.82); C285(0.82); C329(0.93); C332(0.98)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C282(0.72); C285(0.73); C329(0.92); C332(0.93)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C282(0.78); C285(0.78); C329(1.51); C332(1.35)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C282(0.86); C285(0.87); C329(1.48); C332(1.34)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C282(0.79); C285(0.79); C329(1.00); C332(1.04)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C282(0.78); C285(0.79); C329(1.31); C332(1.20)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C282(0.83); C285(0.84); C329(1.32); C332(1.28)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C282(1.09); C285(1.09); C329(1.11); C332(1.11)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C282(0.80); C285(0.82); C329(1.28); C332(1.21)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C282(0.88); C285(0.88); C329(1.17); C332(1.16)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C282(0.75); C285(0.77); C329(1.29); C332(1.26)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C282(0.83); C285(0.85); C329(1.48); C332(1.42)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C282(0.69); C285(0.71); C329(1.17); C332(1.12)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C282(0.71); C285(0.72); C329(1.25); C332(1.23)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C282(1.10); C285(1.10); C329(1.02); C332(0.89)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C282(1.04); C285(1.04); C329(0.99); C332(0.93)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C282(1.01); C285(1.01); C329(0.98); C332(0.91)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C282(1.03); C285(1.03); C329(0.87); C332(0.88)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C282(1.04); C285(1.04); C329(1.05); C332(1.12)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C282(0.95); C285(0.95); C329(0.89); C332(0.88)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C282(1.00); C285(1.00); C329(0.92); C332(0.88)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C282(1.04); C285(1.04); C329(0.97); C332(0.94)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C282(1.01); C285(1.01); C329(0.90); C332(0.89)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C282(1.12); C285(1.12); C329(1.13); C332(0.95)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C282(1.06); C285(1.06); C329(1.02); C332(0.96)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C282(1.04); C285(1.04); C329(1.15); C332(1.08)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C282(1.08); C285(1.08); C329(1.01); C332(0.88)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C282(1.10); C285(1.10); C329(1.08); C332(0.98)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C282(1.03); C285(1.03); C329(1.03); C332(0.98)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C282(0.91); C285(0.91); C329(1.02); C332(1.02)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C282(0.92); C285(0.92); C329(1.03); C332(1.00)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C282(1.14); C285(1.14); C329(1.23); C332(1.11)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C282(1.11); C285(1.11); C329(1.34); C332(1.10)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C282(1.04); C285(1.04); C329(1.29); C332(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C282(1.12); C285(1.12); C329(1.30); C332(1.14)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C282(0.94); C285(0.94); C329(1.21); C332(1.13)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C282(1.00); C285(1.00); C329(1.58); C332(1.29)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C282(1.11); C285(1.11); C329(1.45); C332(1.32)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C282(1.01); C285(1.01); C329(1.21); C332(1.18)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C282(1.02); C285(1.02); C329(1.07); C332(1.06)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C282(1.01); C285(1.01); C329(1.21); C332(1.25)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C282(1.00); C285(1.00); C329(1.23); C332(1.06)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C282(1.06); C285(1.06); C329(1.25); C332(1.19)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C282(1.01); C285(1.01); C329(1.20); C332(1.14)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C282(0.95); C285(0.95); C329(1.18); C332(1.09)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C282(1.00); C285(1.00); C329(1.26); C332(1.09)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C282(0.81); C285(0.81); C329(0.89); C332(0.82)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C282(0.74); C285(0.74); C329(0.78); C332(0.77)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C282(0.83); C285(0.83); C329(1.01); C332(1.02)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C282(0.76); C285(0.76); C329(1.07); C332(1.06)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C282(0.91); C285(0.91); C329(1.06); C332(1.06)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C282(0.79); C285(0.79); C329(0.92); C332(0.90)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C282(0.81); C285(0.81); C329(0.89); C332(0.94)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C282(0.68); C285(0.68); C329(1.02); C332(1.03)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C282(0.65); C285(0.65); C329(1.03); C332(0.98)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C282(0.64); C285(0.64); C329(1.14); C332(1.05)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C282(0.75); C285(0.75); C329(1.00); C332(0.94)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C282(0.80); C285(0.80); C329(0.88); C332(0.86)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C282(0.68); C285(0.68); C329(0.81); C332(0.88)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C282(0.64); C285(0.64); C329(0.87); C332(0.94)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C282(0.60); C285(0.60); C329(1.12); C332(1.08)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C282(0.94); C285(0.94); C329(1.06); C332(1.08)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C282(0.58); C285(0.58); C329(0.70); C332(0.70)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C282(1.00); C285(1.00); C329(0.89); C332(0.96)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C282(0.99); C285(0.99); C329(0.83); C332(0.88)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C282(1.03); C285(1.03); C329(0.92); C332(0.90)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C282(0.97); C285(0.97); C329(1.03); C332(1.01)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C282(0.80); C285(0.80); C329(0.89); C332(0.89)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C282(1.02); C285(1.02); C329(1.14); C332(1.10)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C282(0.86); C285(0.86); C329(1.09); C332(1.07)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C282(0.91); C285(0.91); C329(0.98); C332(0.97)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C282(0.96); C285(0.96); C329(1.10); C332(1.10)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C388(1.07); C400(1.08); C311(0.90)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C449(1.46); C341(0.90)  LDD1702  [5]
 LDCM0625  F8 Ramos C388(1.12)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C388(0.70)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C388(0.59)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C388(0.71)  LDD2191  [16]
 LDCM0579  Fragment20 Ramos C388(0.59)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C388(1.14)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C388(0.94)  LDD2196  [16]
 LDCM0588  Fragment30 Ramos C388(1.04)  LDD2199  [16]
 LDCM0590  Fragment32 Ramos C388(0.72)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C282(1.08); C285(1.08); C329(1.48); C332(1.28)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C388(0.67)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C388(0.56)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C282(0.77); C285(0.79); C329(1.74); C332(1.61)  LDD0744  [7]
 LDCM0614  Fragment56 Ramos C388(2.65)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C388(0.66)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C388(0.56)  LDD2188  [16]
 LDCM0116  HHS-0101 DM93 Y104(1.04)  LDD0264  [6]
 LDCM0118  HHS-0301 DM93 Y104(0.94)  LDD0266  [6]
 LDCM0120  HHS-0701 DM93 Y104(2.70)  LDD0268  [6]
 LDCM0107  IAA HeLa C282(0.00); H286(0.00); H246(0.00)  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C400(2.48); C403(2.48); C367(1.34); C370(1.34)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C400(2.58); C403(2.58); C367(1.23); C370(1.23)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C400(2.41); C403(2.41); C367(1.47); C370(1.47)  LDD0082  [7]
 LDCM0109  NEM HeLa H246(0.00); H452(0.00); H456(0.00); C329(0.00)  LDD0223  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C449(0.91); C341(1.09)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C449(0.45)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C449(0.98)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C449(0.89)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C449(1.05); C341(0.76)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C449(0.83); C341(0.79)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C449(0.68); C341(0.65); C285(0.76)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C449(0.89); C341(1.02)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C449(0.65); C341(0.67)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C449(0.75)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C449(0.78)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C449(3.34); C341(1.49)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C449(1.05)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C449(0.70)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C449(0.75)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C449(0.84)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C449(1.02); C341(0.84); C285(1.09)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C449(0.80); C341(0.54)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C341(0.81)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C449(0.86); C341(0.66)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C449(1.04); C341(0.66)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C449(0.92); C341(0.92); C285(1.73)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C449(1.10); C341(0.87)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C449(1.31); C341(1.27)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C449(0.59); C341(0.71)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C449(3.46); C341(2.82)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C449(0.69)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C449(1.00); C341(0.64)  LDD2148  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C449(0.84)  LDD2149  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C449(0.71)  LDD2151  [5]
 LDCM0021  THZ1 HCT 116 C308(1.32); C311(1.32); C367(1.06); C370(1.06)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10) Nudix hydrolase family Q8NFP7
GTP-binding protein GEM (GEM) RGK family P55040
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) HEY family Q9UBP5
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Ubiquilin-4 (UBQLN4) . Q9NRR5
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PHD finger protein 1 (PHF1) Polycomblike family O43189
Transcription factor 19 (TCF19) . Q9Y242
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Golgi-associated RAB2 interactor protein 6 (GARIN6) GARIN family Q8NEG0
Gamma-parvin (PARVG) Parvin family Q9HBI0
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Delta and Notch-like epidermal growth factor-related receptor (DNER) . Q8NFT8
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Heat shock factor 2-binding protein (HSF2BP) . O75031
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578