Details of the Target

General Information of Target

Target ID LDTP00580
Target Name Zinc finger protein 185 (ZNF185)
Gene Name ZNF185
Gene ID 7739
Synonyms
Zinc finger protein 185; LIM domain protein ZNF185; P1-A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRS
RATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVR
TANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEA
ASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARS
TPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPD
VEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPE
GLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEA
WQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVA
TKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPS
SCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNV
SSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGI
CSKPMGDLLDQIFIHRDTIHCGKCYEKLF
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function May be involved in the regulation of cellular proliferation and/or differentiation.
Uniprot ID
O15231
Ensemble ID
ENST00000318504.12
HGNC ID
HGNC:12976

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
STPyne
 Probe Info  		K143(5.88); K201(6.19)  LDD0277  [2]
Probe 1
 Probe Info  		Y85(25.88); Y134(86.46); Y141(94.63); Y147(16.47)  LDD3495  [3]
Alkylaryl probe 1
 Probe Info  		20.00  LDD0388  [4]
DBIA
 Probe Info  		C564(2.59); C647(2.52)  LDD3310  [5]
BTD
 Probe Info  		C639(1.07); C615(0.99); C317(0.84)  LDD1700  [6]
Sulforaphane-probe2
 Probe Info  		2.27  LDD0160  [7]
IPM
 Probe Info  		C661(2.29); C629(1.83); C615(1.77); C681(1.48)  LDD1701  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0151  [9]
NAIA_5
 Probe Info  		C466(0.00); C317(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C615(0.76)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C615(0.93)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C681(0.98); C615(0.91); C639(1.08); C532(0.78)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C615(1.05); C639(0.99)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C615(0.89); C532(1.44); C317(0.72)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C615(0.47)  LDD2132  [6]
 LDCM0214  AC1 HEK-293T C615(1.02)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C615(1.13)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C615(0.95)  LDD1509  [10]
 LDCM0270  AC15 HEK-293T C650(0.95)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C615(0.96)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C615(1.13)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C615(1.32)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C615(1.10)  LDD1518  [10]
 LDCM0283  AC23 HEK-293T C650(1.13)  LDD1522  [10]
 LDCM0285  AC25 HEK-293T C615(0.93)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C615(1.09)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C615(1.10)  LDD1526  [10]
 LDCM0290  AC3 HEK-293T C615(1.04)  LDD1529  [10]
 LDCM0292  AC31 HEK-293T C650(0.89)  LDD1531  [10]
 LDCM0294  AC33 HEK-293T C615(0.99)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C615(1.13)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C615(1.13)  LDD1535  [10]
 LDCM0300  AC39 HEK-293T C650(1.08)  LDD1539  [10]
 LDCM0303  AC41 HEK-293T C615(1.05)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C615(1.06)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C615(1.11)  LDD1544  [10]
 LDCM0309  AC47 HEK-293T C650(0.88)  LDD1548  [10]
 LDCM0311  AC49 HEK-293T C615(1.02)  LDD1550  [10]
 LDCM0313  AC50 HEK-293T C615(1.11)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C615(1.08)  LDD1553  [10]
 LDCM0318  AC55 HEK-293T C650(0.91)  LDD1557  [10]
 LDCM0320  AC57 HEK-293T C615(1.05)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C615(1.10)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C615(1.00)  LDD1561  [10]
 LDCM0327  AC63 HEK-293T C650(0.91)  LDD1566  [10]
 LDCM0334  AC7 HEK-293T C650(1.04)  LDD1568  [10]
 LDCM0545  Acetamide MDA-MB-231 C615(0.28)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C615(0.90)  LDD2113  [6]
 LDCM0356  AKOS034007680 HEK-293T C615(1.04)  LDD1570  [10]
 LDCM0498  BS-3668 MDA-MB-231 C532(0.36); C317(0.33); C466(0.46)  LDD2091  [6]
 LDCM0632  CL-Sc Hep-G2 C615(1.43); C317(1.06); C466(1.04); C466(0.82)  LDD2227  [8]
 LDCM0369  CL100 HEK-293T C615(1.01)  LDD1573  [10]
 LDCM0372  CL103 HEK-293T C615(0.94)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C615(1.02)  LDD1577  [10]
 LDCM0376  CL107 HEK-293T C615(1.19)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C615(0.93)  LDD1581  [10]
 LDCM0379  CL11 HEK-293T C650(0.99)  LDD1583  [10]
 LDCM0381  CL111 HEK-293T C615(1.08)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C615(1.07)  LDD1586  [10]
 LDCM0385  CL115 HEK-293T C615(0.98)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C615(0.96)  LDD1590  [10]
 LDCM0389  CL119 HEK-293T C615(1.01)  LDD1593  [10]
 LDCM0391  CL120 HEK-293T C615(1.05)  LDD1595  [10]
 LDCM0394  CL123 HEK-293T C615(1.02)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C615(0.95)  LDD1599  [10]
 LDCM0398  CL127 HEK-293T C615(1.06)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C615(0.99)  LDD1603  [10]
 LDCM0402  CL15 HEK-293T C615(0.98)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C615(1.03)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C615(1.19)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C615(0.96)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C615(1.02)  LDD1610  [10]
 LDCM0411  CL23 HEK-293T C650(1.06)  LDD1615  [10]
 LDCM0415  CL27 HEK-293T C615(1.13)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C615(1.09)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C615(1.06)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C615(0.91)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C615(1.15)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C615(1.18)  LDD1624  [10]
 LDCM0424  CL35 HEK-293T C650(1.06)  LDD1628  [10]
 LDCM0428  CL39 HEK-293T C615(1.04)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C615(0.98)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C615(1.02)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C615(0.93)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C615(1.08)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C615(1.01)  LDD1637  [10]
 LDCM0437  CL47 HEK-293T C650(0.93)  LDD1641  [10]
 LDCM0440  CL5 HEK-293T C615(1.02)  LDD1644  [10]
 LDCM0443  CL52 HEK-293T C615(1.07)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C615(1.01)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C615(1.06)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C615(1.00)  LDD1649  [10]
 LDCM0450  CL59 HEK-293T C650(1.05)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C615(1.06)  LDD1654  [10]
 LDCM0455  CL63 HEK-293T C615(1.01)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C615(1.01)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C615(1.09)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C615(1.03)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C615(1.04)  LDD1662  [10]
 LDCM0462  CL7 HEK-293T C615(1.03)  LDD1665  [10]
 LDCM0464  CL71 HEK-293T C650(1.00)  LDD1667  [10]
 LDCM0469  CL76 HEK-293T C615(1.06)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C615(0.95)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C615(1.17)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C615(0.99)  LDD1675  [10]
 LDCM0477  CL83 HEK-293T C650(1.03)  LDD1680  [10]
 LDCM0481  CL87 HEK-293T C615(1.07)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C615(1.02)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C615(1.03)  LDD1686  [10]
 LDCM0485  CL90 HEK-293T C615(1.04)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C615(1.02)  LDD1689  [10]
 LDCM0490  CL95 HEK-293T C650(0.95)  LDD1693  [10]
 LDCM0494  CL99 HEK-293T C615(1.08)  LDD1697  [10]
 LDCM0634  CY-0357 Hep-G2 C615(0.19)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C615(0.94)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C317(2.05); C615(1.42); C532(1.22); C661(1.06)  LDD1702  [6]
 LDCM0468  Fragment33 HEK-293T C615(1.04)  LDD1671  [10]
 LDCM0022  KB02 HEK-293T C615(0.92)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C615(0.92)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C564(2.59); C647(2.52)  LDD3310  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C615(0.89); C317(0.91); C466(0.73)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C615(0.52); C317(0.51)  LDD2121  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C615(0.52); C532(0.53); C317(0.47)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C615(1.06); C639(1.31); C317(1.01); C466(1.30)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C615(0.87); C639(0.80); C532(0.84); C317(0.72)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C681(0.93); C615(1.02)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C615(1.01); C639(1.24); C532(1.18); C317(1.04)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C615(0.81); C639(0.39); C317(1.05); C466(2.29)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C615(1.04); C639(0.73); C532(0.79); C317(0.97)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C615(0.72); C639(0.79); C532(0.65); C317(0.46)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C615(1.27); C532(1.53); C317(0.56)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C615(0.76); C317(0.73)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C615(1.24); C639(1.38); C532(2.41); C317(1.14)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C615(0.70); C317(0.84)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C615(0.87); C639(0.99); C532(0.79); C317(0.81)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C615(0.77); C532(0.99)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C681(0.60); C615(0.73); C639(0.77); C317(0.62)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C615(0.88)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C681(0.73); C615(1.02)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C615(0.70); C317(0.75)  LDD2114  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C615(0.95); C639(0.58)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C615(1.01); C639(0.81); C317(1.31)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C615(1.76); C639(2.13)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C615(0.94); C317(1.01); C466(0.92)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C615(0.89); C639(0.83); C317(1.15)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C615(0.73); C639(0.83)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C615(0.96); C639(1.22); C317(1.18)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C681(0.71); C615(0.63); C639(0.89); C532(1.06)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C615(0.88); C317(1.16)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C615(1.15); C639(0.94); C532(0.86); C317(0.91)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C615(0.79); C317(0.86); C466(0.66)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C681(0.91); C615(0.73); C639(0.63); C532(0.58)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C615(0.76); C639(0.77); C317(0.31)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C615(0.96); C639(0.93); C317(1.05)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C615(0.88); C639(0.87)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C639(1.07); C615(0.99); C317(0.84)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C615(0.71); C639(1.08); C532(0.80); C317(0.70)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C615(1.01); C317(0.83)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C615(1.23); C317(1.04)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C681(1.77); C615(2.29); C639(3.45)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C615(0.68); C317(0.61)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C615(3.00); C317(6.98)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C639(0.48)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C615(0.92)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C681(1.09); C615(0.34); C532(0.30); C317(0.38)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C615(1.82)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C615(1.51); C639(1.29); C317(1.80); C466(1.63)  LDD2153  [6]
 LDCM0099  Phenelzine MDA-MB-231 20.00  LDD0388  [4]
 LDCM0003  Sulforaphane MDA-MB-231 2.27  LDD0160  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Proline-rich protein 23B (PRR23B) PRR23 family Q6ZRT6
Chromobox protein homolog 8 (CBX8) . Q9HC52
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402