Details of the Target

General Information of Target

Target ID LDTP10806
Target Name Myeloid-associated differentiation marker (MYADM)
Gene Name MYADM
Gene ID 91663
Synonyms
Myeloid-associated differentiation marker; Protein SB135
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLR
FTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSM
EHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAE
RRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESI
ACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEVEK
RKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPLSVKNTKRRLE
GAKKAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSR
SRSRSDSPPRQAPRSAPYKGSEIRGSRKSKDCKYPQKPHKSRSRSSSRSRSRSRERADNP
GKYKKKSHYYRDQRRERSRSYERTGRRYERDHPGHSRHRR
Target Bioclass
Transporter and channel
Family
MAL family
Subcellular location
Membrane
Uniprot ID
Q96S97
Ensemble ID
ENST00000391768.2
HGNC ID
HGNC:7544

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
BTD
 Probe Info  		C279(1.73)  LDD1700  [2]
DBIA
 Probe Info  		C288(0.90)  LDD0532  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
IPM
 Probe Info  		C288(0.00); C279(0.00)  LDD2156  [5]
AOyne
 Probe Info  		8.50  LDD0443  [6]
NAIA_5
 Probe Info  		C288(0.00); C279(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C279(0.84)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C279(1.47)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C279(0.73)  LDD2117  [2]
 LDCM0214  AC1 PaTu 8988t C288(0.58)  LDD1093  [3]
 LDCM0215  AC10 HCT 116 C288(0.90)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C288(0.64)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C288(0.72)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C288(0.68)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C288(0.62)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C288(0.75)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C288(0.68)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C288(0.64)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C288(0.67)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C288(0.74)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C288(0.87)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C288(0.93)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C288(0.71)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C288(0.68)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C288(0.63)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C288(0.88)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C288(0.74)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C288(0.78)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C288(0.75)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C288(0.86)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C288(0.82)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C288(0.71)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C288(1.20)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C288(0.95)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C288(0.84)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C288(0.68)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C288(0.84)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C288(0.82)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C288(1.31)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C288(0.79)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C288(0.75)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C288(0.72)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C288(0.94)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C288(0.66)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C288(0.83)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C288(0.90)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C288(0.86)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C288(0.74)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C288(0.75)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C288(0.76)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C288(0.74)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C288(0.79)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C288(0.87)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C288(0.86)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C288(0.82)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C288(0.76)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C288(0.71)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C288(0.90)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C288(0.70)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C288(0.83)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C288(0.72)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C288(0.76)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C288(0.71)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C288(0.69)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C288(0.81)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C288(0.91)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C288(0.86)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C288(0.73)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C288(0.66)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C288(0.68)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C288(0.76)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C288(0.75)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C288(0.70)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C288(1.05)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C288(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C288(0.93)  LDD0595  [3]
 LDCM0279  AC2 PaTu 8988t C288(0.64)  LDD1158  [3]
 LDCM0280  AC20 HCT 116 C288(1.08)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C288(0.93)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C288(1.18)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C288(1.04)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C288(1.05)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C288(1.10)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C288(1.18)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C288(1.31)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C288(1.10)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C288(1.21)  LDD0606  [3]
 LDCM0290  AC3 PaTu 8988t C288(0.71)  LDD1169  [3]
 LDCM0291  AC30 HCT 116 C288(1.10)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C288(1.14)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C288(1.18)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C288(1.11)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C288(1.10)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C288(0.80)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C288(0.57)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C288(0.86)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C288(0.75)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C288(0.81)  LDD1179  [3]
 LDCM0301  AC4 PaTu 8988t C288(0.84)  LDD1180  [3]
 LDCM0302  AC40 PaTu 8988t C288(0.59)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C288(0.93)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C288(1.00)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C288(0.86)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C288(0.82)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C288(0.99)  LDD1186  [3]
 LDCM0308  AC46 HCT 116 C288(0.99)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C288(0.94)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C288(0.71)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C288(1.18)  LDD0628  [3]
 LDCM0312  AC5 PaTu 8988t C288(0.67)  LDD1191  [3]
 LDCM0313  AC50 HCT 116 C288(0.90)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C288(1.03)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C288(0.98)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C288(0.94)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C288(0.96)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C288(0.80)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C288(0.80)  LDD0636  [3]
 LDCM0323  AC6 HCT 116 C288(1.06)  LDD0640  [3]
 LDCM0334  AC7 HCT 116 C288(0.90)  LDD0651  [3]
 LDCM0345  AC8 HCT 116 C288(0.87)  LDD0662  [3]
 LDCM0349  AC83 HCT 116 C288(0.59)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C288(0.51)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C288(0.59)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C288(0.77)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C288(0.56)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C288(0.70)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C288(0.66)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C288(0.90)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C288(0.56)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C288(0.55)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C288(0.60)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C288(0.68)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C288(0.59)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C288(0.47)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C288(0.62)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C288(0.46)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C288(0.73)  LDD0683  [3]
 LDCM0545  Acetamide MDA-MB-231 C279(0.69)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C288(1.40)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C288(1.01)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C288(1.07)  LDD0592  [3]
 LDCM0498  BS-3668 MDA-MB-231 C279(0.79)  LDD2091  [2]
 LDCM0367  CL1 PaTu 8988t C288(0.94)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C288(0.62)  LDD1247  [3]
 LDCM0369  CL100 PaTu 8988t C288(0.62)  LDD1248  [3]
 LDCM0370  CL101 HCT 116 C288(0.95)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C288(0.99)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C288(0.93)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C288(0.78)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C288(1.01)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C288(0.75)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C288(1.09)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C288(1.41)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C288(0.90)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C288(0.81)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C288(0.78)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C288(0.94)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C288(1.27)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C288(1.02)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C288(1.16)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C288(1.23)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C288(1.09)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C288(1.21)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C288(1.09)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C288(0.88)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C288(0.84)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C288(0.75)  LDD1270  [3]
 LDCM0392  CL121 HCT 116 C288(0.71)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C288(0.80)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C288(0.93)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C288(1.04)  LDD0712  [3]
 LDCM0400  CL13 PaTu 8988t C288(0.80)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C288(0.68)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C288(0.71)  LDD1281  [3]
 LDCM0407  CL2 PaTu 8988t C288(0.71)  LDD1286  [3]
 LDCM0418  CL3 PaTu 8988t C288(0.69)  LDD1297  [3]
 LDCM0420  CL31 PaTu 8988t C288(0.82)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C288(0.63)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C288(0.73)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C288(0.59)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C288(0.75)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C288(0.26)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C288(0.79)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C288(0.55)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C288(0.70)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C288(0.63)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C288(0.63)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C288(0.79)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C288(0.57)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C288(0.43)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C288(0.60)  LDD1314  [3]
 LDCM0436  CL46 HCT 116 C288(1.14)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C288(1.26)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C288(1.24)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C288(1.25)  LDD0756  [3]
 LDCM0440  CL5 PaTu 8988t C288(0.68)  LDD1319  [3]
 LDCM0441  CL50 HCT 116 C288(1.13)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C288(1.00)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C288(1.06)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C288(1.13)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C288(1.05)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C288(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C288(1.14)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C288(1.16)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C288(1.00)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C288(1.13)  LDD0767  [3]
 LDCM0451  CL6 PaTu 8988t C288(0.90)  LDD1330  [3]
 LDCM0452  CL60 HCT 116 C288(1.15)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C288(1.06)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C288(1.17)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C288(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C288(1.04)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C288(1.18)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C288(1.10)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C288(1.06)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C288(1.12)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C288(1.03)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C288(0.76)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C288(1.03)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C288(1.09)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C288(0.97)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C288(1.51)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C288(1.21)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C288(1.33)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C288(1.36)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C288(1.19)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C288(1.36)  LDD0789  [3]
 LDCM0473  CL8 PaTu 8988t C288(0.62)  LDD1352  [3]
 LDCM0474  CL80 HCT 116 C288(1.13)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C288(1.12)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C288(0.98)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C288(0.98)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C288(0.97)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C288(1.30)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C288(1.18)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C288(1.10)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C288(1.13)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C288(1.07)  LDD0800  [3]
 LDCM0484  CL9 PaTu 8988t C288(0.75)  LDD1363  [3]
 LDCM0485  CL90 HCT 116 C288(1.24)  LDD0802  [3]
 LDCM0486  CL91 PaTu 8988t C288(0.75)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C288(0.66)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C288(0.62)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C288(0.83)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C288(0.52)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C288(0.69)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C288(0.65)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C288(0.54)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C288(0.76)  LDD1373  [3]
 LDCM0468  Fragment33 HCT 116 C288(1.24)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C288(0.54)  LDD1306  [3]
 LDCM0022  KB02 A2780 C288(1.74)  LDD2254  [8]
 LDCM0023  KB03 A2780 C288(2.42)  LDD2671  [8]
 LDCM0024  KB05 MKN-1 C288(1.65)  LDD3331  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C279(0.67)  LDD2089  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C279(1.13)  LDD2097  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C279(0.86)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C279(0.75)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C279(0.76)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C279(2.49)  LDD2119  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C279(0.63)  LDD2127  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C279(0.92)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C279(0.45)  LDD2134  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C279(1.73)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C279(0.67)  LDD2140  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C279(0.62)  LDD2148  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C279(0.49)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Fertilization-influencing membrane protein (FIMP) . Q96LL3
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840