Details of the Target

General Information of Target

Target ID LDTP06279
Target Name Septin-2 (SEPTIN2)
Gene Name SEPTIN2
Gene ID 4735
Synonyms
DIFF6; KIAA0158; NEDD5; SEPT2; Septin-2; Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLT
DLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIIS
YIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPV
IAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVV
GSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFR
SERLKRGGRKVENEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDGDGGALGHH
V
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular location
Cytoplasm
Function
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Uniprot ID
Q15019
Ensemble ID
ENST00000360051.7
HGNC ID
HGNC:7729

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
TE4 SNV: p.G16D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.39  LDD0402  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
TH211
 Probe Info  		Y17(15.15); Y296(14.56); Y121(11.55); Y129(11.25)  LDD0257  [3]
TH216
 Probe Info  		Y121(20.00); Y129(20.00); Y17(9.83); Y105(6.12)  LDD0259  [3]
STPyne
 Probe Info  		K190(4.08); K232(10.00); K249(6.99); K275(3.43)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
DBIA
 Probe Info  		C146(1.35)  LDD3310  [5]
BTD
 Probe Info  		C111(0.65)  LDD2089  [6]
AHL-Pu-1
 Probe Info  		C111(2.12)  LDD0169  [7]
HHS-482
 Probe Info  		Y17(1.34)  LDD0285  [8]
HHS-475
 Probe Info  		Y17(0.98)  LDD0264  [9]
HHS-465
 Probe Info  		Y17(4.64)  LDD2237  [10]
5E-2FA
 Probe Info  		H28(0.00); H131(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K232(0.00); K310(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C111(0.00); C148(0.00); C149(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
NAIA_5
 Probe Info  		N.A.  LDD2224  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		K249(0.00); K232(0.00); K3(0.00)  LDD0010  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		K318(0.00); K174(0.00); K3(0.00); K183(0.00)  LDD0228  [19]
1d-yne
 Probe Info  		K232(0.00); K275(0.00)  LDD0357  [19]
Acrolein
 Probe Info  		C111(0.00); H206(0.00); H131(0.00); C114(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		5.20  LDD0443  [22]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C348
 Probe Info  		11.16  LDD2009  [23]
FFF probe13
 Probe Info  		12.96  LDD0475  [24]
FFF probe2
 Probe Info  		6.85  LDD0463  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
DA-2
 Probe Info  		N.A.  LDD0070  [27]
OEA-DA
 Probe Info  		3.66  LDD0046  [28]
STS-1
 Probe Info  		N.A.  LDD0068  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C111(2.12)  LDD0169  [7]
 LDCM0215  AC10 HEK-293T C111(1.09); C114(1.11)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C111(0.87); C114(0.66); C148(0.96)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C111(0.93); C114(0.80); C149(1.14)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C148(0.91)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C111(0.93); C148(0.89)  LDD1513  [30]
 LDCM0277  AC18 HEK-293T C111(0.99); C114(1.19)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C111(1.00); C114(0.66); C148(0.90)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C111(1.07); C114(1.02)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C111(0.93); C114(0.98); C149(0.62)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C111(0.94)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C148(0.93)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C111(0.98); C148(0.79)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C111(1.01); C149(1.09); C148(0.97); C149(0.97)  LDD1523  [30]
 LDCM0286  AC26 HEK-293T C111(0.95); C114(0.78)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C111(0.92); C114(0.69); C148(0.97)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C111(0.97); C114(1.27); C149(0.80)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C111(0.90)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C111(0.86); C114(0.80); C148(0.95)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C148(1.01)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C111(1.07); C148(0.91)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C111(0.81); C149(1.04); C148(0.84); C149(0.84)  LDD1532  [30]
 LDCM0295  AC34 HEK-293T C111(1.09); C114(1.00)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C111(0.93); C114(0.75); C148(1.07)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C111(0.96); C114(1.17); C149(1.23)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C111(0.91)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C148(0.99)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C111(1.01); C148(0.84)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C111(0.95); C114(1.20); C149(1.32)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C111(0.91); C149(0.99); C148(1.14); C149(1.14)  LDD1541  [30]
 LDCM0304  AC42 HEK-293T C111(1.01); C114(1.27)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C111(0.97); C114(1.14); C148(1.00)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C111(0.91); C114(1.02); C149(0.93)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C111(0.86)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C148(0.98)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C111(0.94); C148(0.94)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C111(0.84); C149(1.08); C148(1.02); C149(1.02)  LDD1549  [30]
 LDCM0312  AC5 HEK-293T C111(0.84)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C111(0.97); C114(1.37)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C111(0.95); C114(0.90); C148(0.92)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C111(0.91); C114(1.45); C149(0.96)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C111(0.92)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C148(0.94)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C111(0.90); C148(0.81)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C111(0.99); C149(1.03); C148(0.76); C149(0.76)  LDD1558  [30]
 LDCM0321  AC58 HEK-293T C111(1.06); C114(0.79)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C111(0.95); C114(0.83); C148(0.94)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C148(1.07)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C111(0.92); C114(1.25); C149(1.04)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C111(0.93)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C148(0.96)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C111(1.02); C148(0.86)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C111(0.93); C149(1.05); C148(1.20); C149(1.20)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C111(0.98); C148(0.94)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C111(0.92); C149(1.11); C148(0.73); C149(0.73)  LDD1569  [30]
 LDCM0248  AKOS034007472 HEK-293T C111(0.84)  LDD1511  [30]
 LDCM0275  AKOS034007705 HEK-293T C111(0.90); C149(1.01); C148(0.77); C149(0.77)  LDD1514  [30]
 LDCM0108  Chloroacetamide HeLa H295(0.00); C111(0.00); H206(0.00); H131(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C111(1.27); C148(0.91)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C148(1.29)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C111(1.11); C149(1.69)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C111(0.86); C148(0.98)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C148(0.95)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C111(0.81); C148(1.15)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C111(0.98); C149(1.01)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C111(0.98); C148(1.08)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C148(0.82)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C111(0.76); C148(1.16)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C111(1.04); C149(1.25)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C111(0.92); C148(0.93)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C111(1.10); C148(0.83)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C148(0.50)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C111(0.86); C148(1.13)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C111(1.14); C149(1.31)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C111(1.27); C148(1.00)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C148(0.99)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C111(0.81); C148(1.06)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C111(1.06); C149(1.74)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C111(0.87); C148(0.98)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C148(0.90)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C111(0.93); C148(0.92)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C111(1.08); C149(0.89); C148(0.64); C149(0.64)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C111(1.05); C149(1.22)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C111(0.74); C148(1.02)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C148(0.70)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C111(0.70); C148(0.90)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C111(0.99); C149(0.81)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C111(1.11); C148(0.94)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C148(0.71)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C111(1.02); C148(0.90)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C111(1.11); C149(1.09)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C111(1.30); C148(0.87)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C148(0.80)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C111(0.80); C148(0.87)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C111(1.11); C149(1.24)  LDD1607  [30]
 LDCM0405  CL18 HEK-293T C111(1.11); C114(1.38)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C111(0.98); C114(0.67); C148(0.94)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C148(0.91)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C111(1.00); C114(0.96); C149(0.57)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C111(0.87)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C148(1.05)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C111(1.15); C148(0.92)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C111(1.04); C149(0.95); C148(0.52); C149(0.52)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C111(0.98); C148(0.96)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C148(1.08)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C111(0.81); C148(1.13)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C111(1.02); C149(1.08)  LDD1620  [30]
 LDCM0418  CL3 HEK-293T C111(0.96); C148(0.81)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C111(1.00); C114(0.55)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C111(0.89); C114(0.70); C148(0.94)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C111(0.91); C114(0.80); C149(0.77)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C111(0.85)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C148(1.18)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C111(1.02); C148(1.02)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C111(0.90); C149(0.90); C148(0.60); C149(0.60)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C111(0.91); C148(0.98)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C111(0.87); C148(1.00)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C111(1.07); C149(0.87)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C111(1.00); C149(1.45)  LDD1634  [30]
 LDCM0432  CL42 HEK-293T C111(1.12); C114(0.55)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C111(0.99); C114(0.57); C148(1.01)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C111(0.99); C114(0.72); C149(0.81)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C111(0.92)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C148(1.25)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C111(1.03); C148(0.98)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C111(1.18); C149(0.94); C148(0.68); C149(0.68)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C111(1.28); C148(1.04)  LDD1643  [30]
 LDCM0441  CL50 HEK-293T C148(1.01)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C111(1.04); C149(1.09)  LDD1646  [30]
 LDCM0445  CL54 HEK-293T C111(0.99); C114(0.88)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C111(0.94); C114(0.51); C148(0.95)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C111(0.97); C114(0.63); C149(0.63)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C111(0.93)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C148(1.14)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C111(0.99); C148(0.87)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C111(1.14); C114(0.70)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C111(0.98); C149(0.94); C148(0.71); C149(0.71)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C111(1.21); C148(1.07)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C148(0.98)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C111(0.95); C148(1.01)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C111(0.94); C149(1.00)  LDD1659  [30]
 LDCM0458  CL66 HEK-293T C111(0.98); C114(0.77)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C111(0.96); C114(0.64); C148(0.95)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C111(0.94); C114(0.73); C149(0.68)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C111(0.85)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C111(0.99); C114(0.55); C148(0.94)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C148(1.14)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C111(1.02); C148(0.88)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C111(0.95); C149(0.96); C148(0.62); C149(0.62)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C111(1.38); C148(1.18)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C148(0.98)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C111(1.07); C149(1.34)  LDD1672  [30]
 LDCM0471  CL78 HEK-293T C111(1.12); C114(0.96)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C111(0.95); C114(0.62); C148(0.98)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C111(0.87); C114(0.85); C149(1.82)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C111(0.97); C114(0.87); C149(0.70)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C111(0.84)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C148(1.09)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C111(0.98); C148(0.88)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C111(0.89); C149(0.86); C148(0.53); C149(0.53)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C111(1.00); C148(1.05)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C148(0.67)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C111(0.94); C148(0.74)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C111(1.08); C149(0.99)  LDD1685  [30]
 LDCM0484  CL9 HEK-293T C111(0.93)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C111(1.22); C114(0.80)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C111(0.90); C114(0.56); C148(0.91)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C111(0.97); C114(0.89); C149(0.94)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C111(0.86)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C148(1.08)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C111(0.91); C148(0.79)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C111(0.84); C149(0.81); C148(0.69); C149(0.69)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C111(1.16); C148(1.01)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C148(0.69)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C111(0.97); C148(0.91)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C111(0.80); C148(0.89)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C111(0.73)  LDD1702  [6]
 LDCM0625  F8 Ramos C111(1.28); 1.39  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C111(0.60); 0.69  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C111(0.01); 0.07  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C111(0.74); 0.60  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C111(1.52); 1.50  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C111(0.80); 0.71  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C111(0.63); 0.48  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C111(1.04); 0.83  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C111(0.83); 0.95  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C111(1.06); 1.10  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C111(0.87); 1.24  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C111(0.91); 0.97  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C111(0.83); 1.12  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C111(0.57); 0.88  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C111(0.83); C148(0.87)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C111(0.85); 0.67  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C111(0.79); 1.11  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C148(0.92)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C111(1.13); 1.27  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C111(1.04); 1.20  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C111(0.63); 0.63  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C111(0.70); 0.67  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y17(0.98)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y17(0.95)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y17(0.88)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y17(1.07)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y17(1.03)  LDD0268  [9]
 LDCM0107  IAA HeLa C111(0.00); H270(0.00); H206(0.00); H131(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y17(1.34)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y105(0.38); Y17(0.54)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y105(1.38); Y17(2.48)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y105(0.75); Y17(1.29)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y105(0.49); Y17(2.15)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y17(1.50)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y17(0.63)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y105(1.15); Y17(1.05)  LDD0292  [8]
 LDCM0022  KB02 HEK-293T C111(1.05)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C111(1.07)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C146(1.35)  LDD3310  [5]
 LDCM0109  NEM HeLa H206(0.00); H270(0.00); C111(0.00); H140(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C111(0.65)  LDD2089  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C111(1.07)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C111(1.07)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C111(0.67)  LDD2109  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C111(1.00)  LDD2125  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C111(1.26)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C111(0.91)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C111(1.28)  LDD2137  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C111(0.96)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C111(0.80)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C111(0.68); C111(0.63); C111(0.61)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C111(0.92); C111(0.43)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C111(1.13)  LDD0304  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Septin-12 (SEPTIN12) Septin GTPase family Q8IYM1
Septin-5 (SEPTIN5) Septin GTPase family Q99719
Septin-6 (SEPTIN6) Septin GTPase family Q14141
V-type proton ATPase subunit d 2 (ATP6V0D2) V-ATPase V0D/AC39 subunit family Q8N8Y2
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) WAL family Q9UIF8
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
TBC1 domain family member 21 (TBC1D21) . Q8IYX1
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.