Details of the Target

General Information of Target

Target ID LDTP01439
Target Name [F-actin]-monooxygenase MICAL2 (MICAL2)
Gene Name MICAL2
Gene ID 9645
Synonyms
KIAA0750; MICAL2PV1; MICAL2PV2; MICALCL; [F-actin]-monooxygenase MICAL2; EC 1.14.13.225; MICAL C-terminal-like protein; Mical-cL; Molecule interacting with CasL protein 2; MICAL-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTW
KAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDS
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGK
LAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFV
MTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFD
TAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVR
PHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMA
SAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPR
KRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQF
PSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVL
WRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPP
SPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIG
AAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGH
FFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEA
TWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTSPKRPKSISEPQHSDAEGDAASPLP
SEWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDTESDYGGSEGSHTEPCEEKPWRPGSP
HLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSFQSPTPSKYQNWRREFWWSLTPVNK
RTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSVSGNAPDGSSPPQMTASEPLSQVSRGHP
SPPTPNFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAE
APLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGARKEEEGGPVLVKEKLGL
KKLVLTQEQKTMLLDWNDSIPESVHLKAGERISQKSAENGRGGRVLKPVRPLLLPRAAGE
PLPTQRGAQEKMGTPAEQAQGERNVPPPKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQ
ESKTLPAQACTRSFSLRKTNSNKDGDQHSPGRNQSSAFSPPDPALRTHSLPNRPSKVFPA
LRSPPCSKIEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRK
DIRDLFGSPKRKVLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSK
NFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKLEKAMKQLVKQEEL
KRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDEAQLLQEWFKLVLEKN
KLMRYESELLIMAQELELEDHQSRLEQKLREKMLKEESQKDEKDLNEEQEVFTELMQVIE
QRDKLVDSLEEQRIREKAEDQHFESFVFSRGCQLSRT
Target Bioclass
Enzyme
Family
Mical family
Subcellular location
Nucleus
Function
Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Uniprot ID
O94851
Ensemble ID
ENST00000256194.8
HGNC ID
HGNC:24693

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.57  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K117(10.00); K68(7.41)  LDD0277  [3]
BTD
 Probe Info  		C150(7.21)  LDD2098  [4]
DBIA
 Probe Info  		C295(1.17); C1029(0.87); C1032(0.87)  LDD0078  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C150(1.29); C703(1.17)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C1059(0.68); C89(1.04); C97(1.04)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1059(1.16); C89(1.00); C97(1.00)  LDD0532  [5]
 LDCM0216  AC100 PaTu 8988t C703(0.81)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C703(0.93)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C703(0.92)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C703(0.98)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C703(0.96)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C703(1.06)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C703(1.03)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C703(0.93)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C703(1.11)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C703(1.55)  LDD1104  [5]
 LDCM0226  AC11 HCT 116 C1059(1.29); C89(0.88); C97(0.88)  LDD0543  [5]
 LDCM0227  AC110 PaTu 8988t C703(1.45)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C703(1.49)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C703(1.05)  LDD1108  [5]
 LDCM0230  AC113 HCT 116 C89(1.01); C97(1.01)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C89(0.94); C97(0.94)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C89(0.94); C97(0.94)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C89(1.45); C97(1.45)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C89(1.33); C97(1.33)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C89(1.15); C97(1.15)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C89(1.12); C97(1.12)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1059(0.95); C89(0.89); C97(0.89)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C89(1.02); C97(1.02)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C89(1.08); C97(1.08)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C89(0.99); C97(0.99)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C89(1.05); C97(1.05)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C89(1.04); C97(1.04)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C89(0.92); C97(0.92)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C89(1.04); C97(1.04)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C89(1.19); C97(1.19)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C703(1.09)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C703(1.07)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C703(1.06)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C703(1.02)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C703(1.17)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C703(1.37)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C703(1.14)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C703(1.19)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C703(1.03)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C703(0.96)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C703(1.01)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C703(1.07)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C1059(1.30); C89(1.06); C97(1.06)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C703(1.36)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C703(0.90)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C703(0.96)  LDD1141  [5]
 LDCM0263  AC143 HCT 116 C89(0.92); C97(0.92)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C89(0.92); C97(0.92)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C89(0.75); C97(0.75)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C89(0.84); C97(0.84)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C89(0.68); C97(0.68)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C89(0.55); C97(0.55)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C89(0.70); C97(0.70)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C89(0.93); C97(0.93); C1059(1.23)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C89(1.03); C97(1.03)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C89(0.80); C97(0.80)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C89(0.66); C97(0.66)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C89(0.45); C97(0.45)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C89(0.75); C97(0.75)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C89(0.77); C97(0.77)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C89(0.80); C97(0.80)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C89(1.02); C97(1.02)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1059(0.95)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1059(0.92)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C1059(0.92)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1059(0.96); C89(1.04); C97(1.04)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1059(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1059(0.81)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1059(1.00)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1059(0.94)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1059(1.08)  LDD0601  [5]
 LDCM0290  AC3 HCT 116 C1059(0.70); C89(0.95); C97(0.95)  LDD0607  [5]
 LDCM0296  AC35 HCT 116 C1059(1.16)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C1059(1.03)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1059(0.97)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1059(1.02)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1059(0.97)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C1059(0.70); C89(0.89); C97(0.89)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C1059(0.80)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1059(0.98)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1059(1.00)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1059(0.81)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1059(1.03)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1059(0.95)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C89(1.07); C97(1.07)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C89(1.08); C97(1.08)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C89(1.35); C97(1.35)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C89(0.81); C97(0.81)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C1059(0.72); C89(0.97); C97(0.97)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C89(0.85); C97(0.85)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C89(1.55); C97(1.55)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C89(1.14); C97(1.14)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C89(1.01); C97(1.01)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C89(0.87); C97(0.87)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C89(0.99); C97(0.99)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C89(0.75); C97(0.75)  LDD0636  [5]
 LDCM0320  AC57 PaTu 8988t C89(0.60); C97(0.60)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C89(0.57); C97(0.57)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C89(0.52); C97(0.52)  LDD1201  [5]
 LDCM0323  AC6 HCT 116 C89(0.92); C97(0.92); C1059(1.45)  LDD0640  [5]
 LDCM0324  AC60 PaTu 8988t C89(0.52); C97(0.52)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C89(1.07); C97(1.07)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C89(0.87); C97(0.87)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C89(0.51); C97(0.51)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C89(0.81); C97(0.81)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C89(0.72); C97(0.72)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C89(0.83); C97(0.83)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C89(0.69); C97(0.69)  LDD1210  [5]
 LDCM0332  AC68 PaTu 8988t C89(1.17); C97(1.17); C703(0.85)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C89(1.11); C97(1.11); C703(0.89)  LDD1212  [5]
 LDCM0334  AC7 HCT 116 C89(0.96); C97(0.96); C1059(0.98)  LDD0651  [5]
 LDCM0335  AC70 PaTu 8988t C89(1.03); C97(1.03); C703(0.72)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C89(1.56); C97(1.56); C703(0.80)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C89(1.31); C97(1.31); C703(0.81)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C89(1.35); C97(1.35); C703(0.84)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C89(1.19); C97(1.19); C703(0.78)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C89(1.16); C97(1.16); C703(0.82)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C89(1.20); C97(1.20); C703(0.77)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C89(1.41); C97(1.41); C703(0.80)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C89(1.08); C97(1.08); C703(0.74)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C89(1.36); C97(1.36); C703(0.77)  LDD1223  [5]
 LDCM0345  AC8 HCT 116 C89(0.96); C97(0.96); C1059(1.02)  LDD0662  [5]
 LDCM0346  AC80 PaTu 8988t C89(1.30); C97(1.30); C703(0.70)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C89(1.43); C97(1.43); C703(0.70)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C89(1.12); C97(1.12); C703(0.70)  LDD1227  [5]
 LDCM0349  AC83 HCT 116 C1059(1.03); C89(1.03); C97(1.03)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1059(1.00); C89(1.19); C97(1.19)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1059(0.90); C89(1.04); C97(1.04)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C89(1.12); C97(1.12); C1059(1.12)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C89(0.96); C97(0.96); C1059(1.04)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C1059(0.97); C89(1.17); C97(1.17)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1059(1.04); C89(1.06); C97(1.06)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1059(1.06); C89(1.14); C97(1.14)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1059(0.76); C89(1.21); C97(1.21)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1059(0.96); C89(1.04); C97(1.04)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1059(0.94); C89(1.10); C97(1.10)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1059(0.77); C89(1.53); C97(1.53)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1059(1.01); C89(1.16); C97(1.16)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1059(0.89); C89(1.43); C97(1.43)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1059(0.95); C89(1.27); C97(1.27)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C703(1.01)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C703(0.85)  LDD1245  [5]
 LDCM0248  AKOS034007472 HCT 116 C1059(1.22); C89(0.95); C97(0.95)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C89(1.02); C97(1.02); C1059(1.07)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C89(0.79); C97(0.79); C1059(1.57)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 13.49  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C295(1.17); C1029(0.87); C1032(0.87)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C1059(1.06); C89(1.19); C97(1.19)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C89(0.65); C97(0.65); C1059(0.94)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C1059(0.79); C89(0.94); C97(0.94)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C89(1.07); C97(1.07); C1059(1.24)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C1059(0.94); C89(1.03); C97(1.03)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C1059(0.98); C89(1.14); C97(1.14)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C89(1.06); C97(1.06); C1059(1.18)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C1059(0.92)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1059(0.91)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C1059(0.83)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C1059(0.93)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1059(0.93)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C89(0.56); C97(0.56); C1059(0.74)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1059(1.02)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1059(0.88)  LDD0698  [5]
 LDCM0387  CL117 HCT 116 C1059(0.78)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1059(1.00)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1059(0.94)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C89(0.63); C97(0.63); C1059(0.84)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1059(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C89(1.17); C97(1.17)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C89(0.91); C97(0.91)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C89(1.26); C97(1.26)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C89(0.96); C97(0.96)  LDD0712  [5]
 LDCM0396  CL125 PaTu 8988t C89(0.71); C97(0.71)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C89(0.90); C97(0.90)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C89(0.79); C97(0.79)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C89(0.72); C97(0.72)  LDD1278  [5]
 LDCM0400  CL13 HCT 116 C89(0.73); C97(0.73); C1059(0.77)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C1059(0.94); C89(0.96); C97(0.96)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C1059(0.75); C89(0.89); C97(0.89)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C89(0.94); C97(0.94); C1059(1.20)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C89(1.07); C97(1.07); C1059(1.39)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C89(0.97); C97(0.97); C1059(1.09)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C89(0.78); C97(0.78); C1059(0.97)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C89(1.08); C97(1.08); C1059(1.10)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C89(0.70); C97(0.70); C1059(1.19)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C89(0.63); C97(0.63); C1059(1.38)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C89(0.41); C97(0.41); C1059(1.59)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C89(0.86); C97(0.86); C1059(1.12)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C89(0.57); C97(0.57); C1059(1.23)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1059(1.56); C89(0.80); C97(0.80)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1059(1.08); C89(0.81); C97(0.81)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1059(1.32); C89(0.80); C97(0.80)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1059(1.11); C89(0.66); C97(0.66)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1059(1.30); C89(0.65); C97(0.65)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1059(0.97); C89(0.93); C97(0.93)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1059(1.26); C89(0.91); C97(0.91)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1059(1.04); C89(0.75); C97(0.75)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1059(1.13); C89(0.86); C97(0.86)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1059(0.93); C89(1.05); C97(1.05)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1059(1.52); C89(0.56); C97(0.56)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1059(1.05); C89(0.63); C97(0.63)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1059(0.93); C89(0.77); C97(0.77)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1059(1.01); C89(0.66); C97(0.66)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1059(0.77); C89(0.66); C97(0.66)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1059(0.89); C89(1.00); C97(1.00)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1059(0.85); C89(0.65); C97(0.65)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1059(0.85); C89(0.65); C97(0.65)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1059(0.92); C89(0.40); C97(0.40)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1059(0.75); C89(0.52); C97(0.52)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1059(0.80); C89(0.74); C97(0.74)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1059(0.90); C89(0.55); C97(0.55)  LDD0752  [5]
 LDCM0436  CL46 PaTu 8988t C89(0.86); C97(0.86); C703(0.99)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C89(0.97); C97(0.97); C703(1.03)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C89(1.39); C97(1.39); C703(1.15)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C89(1.13); C97(1.13); C703(1.06)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C1059(0.85); C89(0.92); C97(0.92)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C89(0.85); C97(0.85); C703(1.09)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C89(1.24); C97(1.24); C703(1.19)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C89(0.73); C97(0.73); C703(1.19)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C89(0.81); C97(0.81); C703(1.27)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C89(0.81); C97(0.81); C703(1.22)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C89(0.98); C97(0.98); C703(1.19)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C89(0.23); C97(0.23); C703(1.22)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C89(0.32); C97(0.32); C703(1.03)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C89(0.70); C97(0.70); C703(1.06)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C89(0.39); C97(0.39); C703(1.00)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C1059(0.97); C89(1.06); C97(1.06)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C89(0.51); C97(0.51); C703(0.97)  LDD1331  [5]
 LDCM0453  CL61 HCT 116 C1059(1.02)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1059(1.17)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1059(0.89)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1059(1.01)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1059(0.96)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1059(0.88)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1059(0.96)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1059(0.94)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1059(0.92)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1059(0.91); C89(0.70); C97(0.70)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1059(0.79)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1059(0.89)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1059(1.11)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1059(0.91)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1059(0.84)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1059(1.08); C89(1.01); C97(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1059(1.64); C89(1.03); C97(1.03)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1059(1.13); C89(0.98); C97(0.98)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1059(0.92); C89(0.86); C97(0.86)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1059(1.07); C89(0.56); C97(0.56)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1059(0.83); C89(1.03); C97(1.03)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1059(0.88); C89(1.00); C97(1.00)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1059(0.90); C89(0.88); C97(0.88)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1059(0.93); C89(0.87); C97(0.87)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1059(0.87); C89(0.77); C97(0.77)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1059(0.98); C89(1.22); C97(1.22)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1059(0.99); C89(1.08); C97(1.08)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1059(0.95); C89(1.25); C97(1.25)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1059(0.94); C89(0.96); C97(0.96)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1059(0.85); C89(0.68); C97(0.68)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1059(1.01); C89(0.84); C97(0.84)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1059(1.64); C89(1.39); C97(1.39)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1059(1.22); C89(1.01); C97(1.01)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1059(1.35); C89(1.27); C97(1.27)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1059(0.88); C89(1.04); C97(1.04)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1059(0.94); C89(0.98); C97(0.98)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1059(1.17); C89(1.11); C97(1.11)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1059(1.05); C89(1.23); C97(1.23)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1059(1.04); C89(1.18); C97(1.18)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1059(0.81); C89(1.01); C97(1.01)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1059(0.95); C89(0.95); C97(0.95)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C150(3.36); C97(2.00); C703(0.60)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C1059(1.02)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1059(1.23); C89(0.44); C97(0.44)  LDD0744  [5]
 LDCM0022  KB02 HEK-293T C703(1.03)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C703(1.05)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C295(2.21)  LDD3310  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C150(7.21)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C703(0.91)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C150(1.05); C703(0.64); C552(0.83)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C84(1.06)  LDD2114  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C150(1.64)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C150(0.75); C703(0.80); C552(1.47)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C703(0.93); C552(1.19)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C703(1.08)  LDD2127  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C150(0.82); C703(0.96)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C703(0.67)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C703(0.65)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C150(1.05)  LDD2144  [4]
 LDCM0021  THZ1 HCT 116 C703(0.81)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nitric oxide synthase 3 (NOS3) NOS family P29474
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840