Details of the Target

General Information of Target

Target ID LDTP02406
Target Name DNA-directed RNA polymerase II subunit GRINL1A (POLR2M)
Gene Name POLR2M
Gene ID 81488
Synonyms
GRINL1A; DNA-directed RNA polymerase II subunit GRINL1A; DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKA
AIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDN
IKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEASEHHPRHRVSSQ
AEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVLEMRAK
NPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMP
TQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDED
DDWSSDEF
Target Bioclass
Enzyme
Family
GRINL1 family
Subcellular location
Nucleus
Function
[Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Uniprot ID
P0CAP2
Ensemble ID
ENST00000299638.8
HGNC ID
HGNC:14862

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MELHO SNV: p.S261L .
MOLT4 SNV: p.A88T IA-alkyne    Probe Info 
NCIH23 SNV: p.S209Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		4.48  LDD0326  [1]
m-APA
 Probe Info  		12.58  LDD0403  [2]
AHL-Pu-1
 Probe Info  		C265(2.92)  LDD0171  [3]
DBIA
 Probe Info  		C82(8.49)  LDD0209  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C82(0.00); C265(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		13.30  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C265(2.92)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C82(1.22)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C82(1.10)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C82(0.92)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C82(1.04)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C82(0.97)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C82(1.27)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C82(1.04)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C82(1.00)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C82(1.14)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C82(1.14)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C82(0.93)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C82(1.02)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C82(1.05)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C82(1.01)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C82(1.04)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C82(1.14)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C82(0.89)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C82(0.93)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C82(0.94)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C82(1.16)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C82(0.94)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C82(0.88)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C82(0.97)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C82(0.92)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C82(1.20)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C82(0.76)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C82(0.92)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C82(0.85)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C82(0.86)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C82(0.85)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C82(0.85)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C82(0.74)  LDD0562  [11]
 LDCM0259  AC14 HCT 116 C82(0.88)  LDD0576  [11]
 LDCM0263  AC143 HCT 116 C82(1.14)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C82(0.99)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C82(0.99)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C82(1.22)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C82(0.87)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C82(2.00)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C82(1.73)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C82(0.97)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C82(1.11)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C82(1.08)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C82(1.21)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C82(1.45)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C82(1.03)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C82(1.27)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C82(1.19)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C82(1.13)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C82(1.05)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C82(1.07)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C82(1.14)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C82(1.27)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C82(0.96)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C82(0.97)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C82(0.86)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C82(0.91)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C82(1.05)  LDD0601  [11]
 LDCM0285  AC25 HEK-293T C265(0.98); C82(0.86); C115(1.14); C65(1.07)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C265(1.03); C82(0.85); C115(0.93); C65(0.75)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C265(1.16); C82(0.97); C115(1.42); C65(0.97)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C82(0.93); C115(1.06)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C265(1.09); C82(0.97); C115(1.29); C65(1.05)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C82(1.23)  LDD0607  [11]
 LDCM0291  AC30 HEK-293T C265(1.00); C82(1.03); C115(0.95); C65(1.02)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C265(0.98); C82(0.99); C115(0.96); C65(1.09)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C265(1.07); C82(0.93); C115(1.18)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C265(1.08); C82(1.06); C115(1.11); C65(1.00)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C265(1.12); C82(1.05); C115(0.92); C65(0.84)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C265(1.18); C82(1.06); C115(0.96); C65(0.99)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C82(1.01); C115(1.01)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C265(0.91); C82(0.99); C115(0.99); C65(1.09)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C265(1.10); C82(0.98); C115(0.98); C65(0.93)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C265(1.03); C82(0.96); C115(0.93); C65(0.97)  LDD1539  [12]
 LDCM0301  AC4 HCT 116 C82(1.24)  LDD0618  [11]
 LDCM0302  AC40 HEK-293T C265(1.20); C82(1.01); C115(0.85)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C265(0.98); C82(0.94); C115(1.31); C65(1.05)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C265(1.09); C82(0.85); C115(1.14); C65(0.85)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C265(1.12); C82(1.00); C115(1.23); C65(1.01)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C82(1.01); C115(1.05)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C265(0.98); C82(1.00); C115(1.14); C65(0.93)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C265(1.11); C82(0.97); C115(1.13); C65(1.11)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C265(0.89); C82(0.94); C115(0.94); C65(1.16)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C265(1.00); C82(0.99); C115(0.88)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C265(0.96); C82(1.01); C115(1.19); C65(0.82)  LDD1550  [12]
 LDCM0312  AC5 HCT 116 C82(1.33)  LDD0629  [11]
 LDCM0313  AC50 HEK-293T C265(1.11); C82(0.91); C115(0.96); C65(0.80)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C265(1.04); C82(0.97); C115(0.83); C65(1.00)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C82(0.96); C115(1.15)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C265(0.90); C82(0.97); C115(1.14); C65(0.98)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C265(0.99); C82(1.01); C115(1.10); C65(1.06)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C265(0.82); C82(0.88); C115(0.95); C65(1.08)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C265(1.04); C82(0.98); C115(0.80)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C265(0.98); C82(0.89); C115(1.36); C65(0.95)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C265(1.02); C82(1.02); C115(0.96); C65(0.87)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C265(0.93); C82(1.00); C115(0.86); C65(0.98)  LDD1561  [12]
 LDCM0323  AC6 HCT 116 C82(1.19)  LDD0640  [11]
 LDCM0324  AC60 HEK-293T C82(1.02); C115(1.03)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C265(0.90); C82(0.93); C115(1.03); C65(0.93)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C265(0.91); C82(0.94); C115(1.00); C65(1.04)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C265(0.86); C82(0.96); C115(0.97); C65(0.95)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C265(0.91); C82(0.97); C115(0.88)  LDD1567  [12]
 LDCM0334  AC7 HCT 116 C82(1.04)  LDD0651  [11]
 LDCM0345  AC8 HCT 116 C82(1.00)  LDD0662  [11]
 LDCM0365  AC98 HCT 116 C82(1.19)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C82(0.87)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C82(0.93)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C82(0.89)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C82(1.12)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.58  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C265(2.82); C82(0.42)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C82(1.09)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C82(1.32)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C82(1.42)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C82(1.08)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C82(1.18)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C82(0.94)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C82(0.90)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C82(1.03)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C82(0.91)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C82(0.87)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C82(0.88)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C82(0.93)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C82(1.25)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C82(0.95)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C82(0.92)  LDD0698  [11]
 LDCM0382  CL112 HEK-293T C265(1.02); C82(0.90); C115(1.11); C65(0.96)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C265(1.08); C82(0.97); C115(1.13); C65(1.10)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C265(1.03); C82(0.99); C115(0.92); C65(1.09)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C265(0.98); C82(0.90); C115(0.93); C65(1.12)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C265(1.13); C82(0.96); C115(1.23); C65(0.90)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C265(1.01); C82(1.02); C115(1.15); C65(1.15)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C265(0.97); C82(1.09); C115(1.12); C65(1.16)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C265(0.96); C82(0.91); C115(1.19); C65(1.07)  LDD1593  [12]
 LDCM0390  CL12 HCT 116 C82(1.51)  LDD0707  [11]
 LDCM0391  CL120 HEK-293T C265(0.92); C82(0.99); C115(1.10); C65(0.95)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C265(0.99); C82(1.00); C115(0.89); C65(1.09)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C265(0.86); C82(1.01); C115(0.94); C65(1.19)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C265(0.78); C82(0.89); C115(1.04); C65(0.93)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C265(0.80); C82(0.97); C115(0.85); C65(0.99)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C265(0.79); C82(0.98); C115(1.17); C65(1.12)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C265(0.77); C82(1.05); C115(1.02); C65(1.28)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C265(0.82); C82(0.86); C115(1.25); C65(1.27)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C265(0.81); C82(0.90); C115(1.08); C65(0.95)  LDD1603  [12]
 LDCM0400  CL13 HCT 116 C82(0.74)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C82(1.14)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C82(0.99)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C82(0.98)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C82(1.35)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C82(1.11)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C82(1.17)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C82(1.06)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C82(1.34)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C82(1.22)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C82(0.87)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C82(0.86)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C82(0.99)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C82(0.77)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C82(0.91)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C82(1.00)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C82(1.26)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C82(1.07)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C82(1.06)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C82(0.87)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C82(1.09)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C82(0.93)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C82(1.20)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C82(0.97)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C82(1.19)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C82(0.87)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C82(1.11)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C82(1.21)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C82(0.94)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C82(1.00)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C82(0.99)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C82(0.82)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C82(1.06)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C82(1.13)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C82(1.07)  LDD0752  [11]
 LDCM0436  CL46 HEK-293T C265(1.02); C82(1.26); C115(1.08); C65(0.86)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C265(1.06); C82(1.30); C115(0.93); C65(1.76)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C265(0.91); C82(1.27); C115(0.94)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C265(0.92); C82(0.89); C115(0.90); C65(1.14)  LDD1643  [12]
 LDCM0440  CL5 HCT 116 C82(0.91)  LDD0757  [11]
 LDCM0441  CL50 HEK-293T C265(0.95); C82(1.04); C115(0.91); C65(1.03)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C265(1.01); C82(1.16); C115(1.15); C65(1.07)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C265(1.07); C82(1.02); C115(1.07); C65(1.20)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C265(0.93); C82(0.95); C115(0.84); C65(0.81)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C265(1.02); C82(1.12); C115(1.22); C65(1.20)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C82(1.32); C115(1.25)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C265(1.00); C82(1.40); C115(0.95); C65(1.14)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C265(1.01); C82(1.19); C115(1.28); C65(1.00)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C265(0.84); C82(1.29); C115(0.98); C65(1.21)  LDD1653  [12]
 LDCM0451  CL6 HCT 116 C82(0.98)  LDD0768  [11]
 LDCM0452  CL60 HEK-293T C265(1.12); C82(1.29); C115(0.82)  LDD1655  [12]
 LDCM0453  CL61 HCT 116 C82(1.14)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C82(1.16)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C82(1.40)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C82(1.44)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C82(0.96)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C82(1.69)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C82(1.37)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C82(1.37)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C82(1.07)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C82(1.01)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C82(1.16)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C82(1.35)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C82(1.03)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C82(1.27)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C82(1.26)  LDD0784  [11]
 LDCM0469  CL76 HEK-293T C265(0.87); C82(0.83); C115(1.30); C65(0.96)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C265(0.99); C82(0.99); C115(1.08); C65(1.22)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C265(0.98); C82(0.88); C115(1.06); C65(0.75)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C265(0.90); C82(1.13); C115(1.44); C65(1.09)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C82(1.78)  LDD0790  [11]
 LDCM0474  CL80 HEK-293T C82(1.12); C115(1.04)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C265(0.87); C82(1.12); C115(1.17); C65(1.32)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C265(1.02); C82(1.14); C115(1.10); C65(0.95)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C265(0.89); C82(1.21); C115(1.01); C65(1.10)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C265(0.83); C82(1.10); C115(0.93)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C265(0.83); C82(0.85); C115(1.11); C65(1.00)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C265(0.70); C82(0.97); C115(1.01); C65(1.26)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C265(0.83); C82(0.86); C115(1.20); C65(1.11)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C265(0.82); C82(1.16); C115(0.91); C65(1.24)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C265(0.73); C82(0.85); C115(1.20); C65(1.03)  LDD1686  [12]
 LDCM0484  CL9 HCT 116 C82(0.85)  LDD0801  [11]
 LDCM0485  CL90 HEK-293T C265(0.84); C82(0.84); C115(0.99); C65(0.77)  LDD1688  [12]
 LDCM0486  CL91 HCT 116 C82(1.17)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C82(1.02)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C82(1.12)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C82(1.42)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C82(1.23)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C82(1.10)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C82(1.28)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C82(1.25)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C82(1.18)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C265(1.08); C82(1.19); C115(0.92); C65(1.00)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C82(1.32)  LDD1702  [13]
 LDCM0574  Fragment12 Ramos C82(0.93)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C82(1.26)  LDD2192  [14]
 LDCM0579  Fragment20 Ramos C82(1.22)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C82(1.12)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C82(1.08)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C82(1.17)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C82(0.76)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C82(0.74)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C82(1.04)  LDD2200  [14]
 LDCM0468  Fragment33 HCT 116 C82(1.09)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C82(0.81)  LDD2203  [14]
 LDCM0427  Fragment51 HCT 116 C82(0.97)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C82(0.62)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C82(0.91)  LDD2205  [14]
 LDCM0022  KB02 HEK-293T C265(0.92); C82(0.92); C115(0.97)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C82(8.49)  LDD0209  [4]
 LDCM0024  KB05 NALM-6 C65(0.98); C115(0.98)  LDD3339  [15]
 LDCM0170  Structure8 Ramos 4.38  LDD0433  [16]

References

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Mass spectrometry data entry: PXD010277
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.