Details of the Target

General Information of Target

Target ID LDTP10109
Target Name Protein ARK2N (ARK2N)
Gene Name ARK2N
Gene ID 147339
Synonyms
ARKL1; C18orf25; Protein ARK2N; ARKadia-like protein 1; Arkadia; RNF111) N-terminal like PKA signaling regulator protein 2N
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQRLEIVEAAIRTLFSVTG
ILAEQFVPDGPHLHLYHENHWIKLMNWQHSTMYLFFAVSGIVDMLTYLVSHVPLGVDRLV
MAVAVFMEGFLFYYHVHNRPPLDQHIHSLLLYALFGGCVSISLEVIFRDHIVLELFRTSL
IILQGTWFWQIGFVLFPPFGTPEWDQKDDANLMFITMCFCWHYLAALSIVAVNYSLVYCL
LTRMKRHGRGEIIGIQKLNSDDTYQTALLSGSDEE
Target Bioclass
Enzyme
Function
AMPK substrate important for exercise capacity and skeletal muscle function. Required for normal contraction-induced signaling.; (Microbial infection) Upon Epstein-Barr virus (EBV) infection, suppresses viral BZLF1 expression and subsequent EBV reactivation by interacting with JUN and inhibiting its transcriptional activitor activity on BZLF1 Z promoter.
Uniprot ID
Q96B23
Ensemble ID
ENST00000615052.5
HGNC ID
HGNC:28172

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.A154G DBIA    Probe Info 
COLO678 SNV: p.A154G .
KMS27 SNV: p.G126E .
MOLT4 SNV: p.E38K .
RD SNV: p.A299T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.98  LDD0403  [1]
AHL-Pu-1
 Probe Info  		C57(3.76)  LDD0169  [2]
DBIA
 Probe Info  		C57(1.31)  LDD0532  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C57(3.76)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C57(0.98)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C57(1.31)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C57(1.20)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C57(1.15)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C57(0.83)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C57(1.00)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C57(0.93)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C57(0.84)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C57(1.66)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C57(1.08)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C57(0.89)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C57(1.21)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C57(1.53)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C57(1.14)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C57(0.92)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C57(0.93)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C57(1.02)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C57(0.87)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C57(1.16)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C57(1.00)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C57(1.02)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C57(1.00)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C57(0.86)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C57(1.24)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C57(0.75)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C57(0.93)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C57(0.94)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C57(0.95)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C57(1.16)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C57(1.33)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C57(1.00)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C57(0.69)  LDD1124  [3]
 LDCM0259  AC14 HCT 116 C57(1.08)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C57(1.26)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C57(1.02)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C57(1.05)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C57(1.23)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C57(1.42)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C57(1.36)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C57(1.31)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C57(1.55)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C57(0.99)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C57(1.01)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C57(0.94)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C57(2.01)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C57(1.36)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C57(1.25)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C57(1.38)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C57(1.02)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C57(1.18)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C57(1.06)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C57(1.21)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C57(0.97)  LDD1518  [8]
 LDCM0280  AC20 HCT 116 C57(0.98)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C57(1.42)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C57(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C57(0.91)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C57(1.06)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C57(0.86)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C57(1.12)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C57(1.17)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C57(1.27)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C57(0.90)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C57(1.10)  LDD1529  [8]
 LDCM0291  AC30 HCT 116 C57(1.01)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C57(1.08)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C57(1.50)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C57(1.07)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C57(1.31)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C57(1.23)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C57(1.64)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C57(1.20)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C57(1.69)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C57(1.71)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C57(1.12)  LDD1540  [8]
 LDCM0302  AC40 PaTu 8988t C57(2.08)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C57(1.35)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C57(1.84)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C57(1.64)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C57(2.33)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C57(1.59)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C57(0.83)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C57(0.88)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C57(1.58)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C57(1.11)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C57(0.87)  LDD1551  [8]
 LDCM0313  AC50 PaTu 8988t C57(1.07)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C57(0.92)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C57(1.03)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C57(1.76)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C57(1.59)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C57(1.47)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C57(1.58)  LDD1198  [3]
 LDCM0320  AC57 PaTu 8988t C57(1.41)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C57(1.18)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C57(1.50)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C57(1.30)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C57(1.90)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C57(1.35)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C57(1.41)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C57(1.24)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C57(1.10)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C57(1.23)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C57(1.39)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C57(1.07)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C57(0.78)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C57(1.02)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C57(1.02)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C57(1.22)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C57(0.89)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C57(0.80)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C57(0.98)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C57(0.88)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C57(1.05)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C57(1.16)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C57(1.07)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C57(0.91)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C57(1.28)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C57(0.97)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C57(1.06)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C57(0.95)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C57(1.18)  LDD1227  [3]
 LDCM0365  AC98 PaTu 8988t C57(1.15)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C57(0.88)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C57(1.39)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C57(1.08)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C57(2.17)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C57(1.39)  LDD2214  [9]
 LDCM0367  CL1 PaTu 8988t C57(1.02)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C57(1.22)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C57(0.97)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C57(1.28)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C57(1.29)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C57(1.07)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C57(1.13)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C57(1.28)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C57(1.40)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C57(1.39)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C57(1.53)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C57(1.09)  LDD0695  [3]
 LDCM0379  CL11 PaTu 8988t C57(1.16)  LDD1258  [3]
 LDCM0380  CL110 HCT 116 C57(1.72)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C57(1.34)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C57(0.93)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C57(0.99)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C57(0.97)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C57(1.15)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C57(1.01)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C57(1.47)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C57(2.04)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C57(1.54)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C57(1.34)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C57(1.24)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C57(0.98)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C57(2.37)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C57(1.54)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C57(1.10)  LDD1274  [3]
 LDCM0396  CL125 PaTu 8988t C57(1.45)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C57(1.21)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C57(1.14)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C57(1.68)  LDD1278  [3]
 LDCM0400  CL13 PaTu 8988t C57(0.94)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C57(1.06)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C57(2.08)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C57(0.91)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C57(0.90)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C57(1.12)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C57(1.22)  LDD1610  [8]
 LDCM0407  CL2 PaTu 8988t C57(0.93)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C57(0.91)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C57(0.62)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C57(0.88)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C57(0.95)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C57(0.86)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C57(0.98)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C57(1.14)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C57(1.01)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C57(0.67)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C57(0.85)  LDD1621  [8]
 LDCM0418  CL3 PaTu 8988t C57(1.43)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C57(1.09)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C57(1.12)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C57(1.09)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C57(0.89)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C57(0.89)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C57(1.08)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C57(0.96)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C57(1.08)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C57(0.93)  LDD1632  [8]
 LDCM0429  CL4 PaTu 8988t C57(2.66)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C57(0.85)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C57(0.89)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C57(1.14)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C57(1.03)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C57(1.03)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C57(1.01)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C57(1.19)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C57(1.04)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C57(0.88)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C57(0.94)  LDD1643  [8]
 LDCM0440  CL5 PaTu 8988t C57(1.33)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C57(0.83)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C57(0.86)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C57(0.40)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C57(0.96)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C57(1.13)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C57(1.00)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C57(1.15)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C57(1.11)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C57(0.87)  LDD1653  [8]
 LDCM0451  CL6 PaTu 8988t C57(0.94)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C57(0.82)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C57(1.00)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C57(0.93)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C57(1.03)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C57(0.84)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C57(1.01)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C57(0.99)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C57(1.04)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C57(0.97)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C57(1.12)  LDD1664  [8]
 LDCM0462  CL7 PaTu 8988t C57(1.46)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C57(0.98)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C57(0.97)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C57(1.01)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C57(0.89)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C57(0.90)  LDD1670  [8]
 LDCM0469  CL76 PaTu 8988t C57(1.04)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C57(1.13)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C57(1.21)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C57(1.35)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C57(1.53)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C57(0.99)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C57(1.21)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C57(1.23)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C57(1.30)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C57(0.95)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C57(1.09)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C57(1.10)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C57(1.34)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C57(1.14)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C57(1.05)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C57(1.27)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C57(1.44)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C57(1.14)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C57(0.89)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C57(0.81)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C57(0.94)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C57(0.89)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C57(0.84)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C57(0.90)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C57(0.89)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C57(0.97)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C57(1.02)  LDD1698  [8]
 LDCM0625  F8 Ramos C57(0.98)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C57(2.23)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C57(0.35)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C57(0.77)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C57(1.23)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C57(0.33)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C57(0.33)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C57(0.39)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C57(0.66)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C57(1.01)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C57(0.93)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C57(0.42)  LDD2200  [10]
 LDCM0468  Fragment33 HEK-293T C57(1.05)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C57(0.22)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C57(1.33)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C57(0.93)  LDD1631  [8]
 LDCM0614  Fragment56 Ramos C57(0.43)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C57(3.00)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C57(0.47)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C57(1.03)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C57(1.03)  LDD1497  [8]
 LDCM0024  KB05 MEWO C57(0.85)  LDD3319  [11]
 LDCM0131  RA190 MM1.R C57(1.28)  LDD0304  [12]
 LDCM0170  Structure8 Ramos 4.62  LDD0433  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
Microspherule protein 1 (MCRS1) . Q96EZ8
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
13 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.