Details of the Target

General Information of Target

Target ID LDTP10273
Target Name Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB)
Gene Name SGTB
Gene ID 54557
Synonyms
SGT2; Small glutamine-rich tetratricopeptide repeat-containing protein beta; Beta-SGT; Small glutamine-rich protein with tetratricopeptide repeats 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGNDNVTLLFAPLLRDNYTLAPNASSLGPGTDLALAPASSAGPGPGLSLGPGPSFGFSP
GPTPTPEPTTSGLAGGAASHGPSPFPRPWAPHALPFWDTPLNHGLNVFVGAALCITMLGL
GCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAVAVLLCGCCPGG
NLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSWAWINTPIVQLLPLGTVTLT
LCSTLIPIGLGVFIRYKYSRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPELLASIPAAV
YVIAIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQNVQLCTAILKLAFPPQFIGSM
YMFPLLYALFQSAEAGIFVLIYKMYGSEMLHKRDPLDEDEDTDISYKKLKEEEMADTSYG
TVKAENIIMMETAQTSL
Target Bioclass
Other
Family
SGT family
Function Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Uniprot ID
Q96EQ0
Ensemble ID
ENST00000381007.9
HGNC ID
HGNC:23567

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y176(9.47)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C67(2.66)  LDD0169  [2]
DBIA
 Probe Info  		C67(1.46); C123(1.09)  LDD0080  [3]
m-APA
 Probe Info  		N.A.  LDD2234  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		14.70  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C67(2.66)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C67(0.79)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C67(0.73)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C67(1.25)  LDD0824  [3]
 LDCM0230  AC113 PaTu 8988t C67(0.82)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C67(0.93)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C67(0.75)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C67(1.00)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C67(0.80)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C67(1.06)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C67(1.04)  LDD1115  [3]
 LDCM0237  AC12 HEK-293T C67(1.04)  LDD0835  [3]
 LDCM0238  AC120 PaTu 8988t C67(0.98)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C67(1.02)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C67(0.88)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C67(0.97)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C67(0.98)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C67(0.91)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C67(0.90)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C67(0.93)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C67(1.15)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C67(0.97)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C67(0.99)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C67(1.28)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C67(0.80)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C67(1.46)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C67(1.38)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C67(1.48)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C67(1.20)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C67(1.40)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C67(1.24)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C67(1.22)  LDD1137  [3]
 LDCM0259  AC14 HEK-293T C67(0.54)  LDD0857  [3]
 LDCM0260  AC140 PaTu 8988t C67(1.14)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C67(1.03)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C67(1.18)  LDD1141  [3]
 LDCM0263  AC143 HEK-293T C67(1.30)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C67(1.25)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C67(1.24)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C67(1.26)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C67(1.34)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C67(1.51)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C67(1.06)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C67(0.45)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C67(1.21)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C67(1.25)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C67(1.20)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C67(1.14)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C67(1.02)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C67(1.26)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C67(1.46)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C67(1.59)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C67(0.28)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C67(0.37)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C67(0.46)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C67(0.78)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C67(0.34)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C67(0.40)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C67(0.38)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C67(0.37)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C67(0.55)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C67(0.45)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C67(0.26)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C67(0.28)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C67(0.26)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C67(0.34)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C67(1.31)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C67(0.29)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C67(0.57)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C67(0.37)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C67(0.30)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C67(0.29)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C67(1.43)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C67(0.94)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C67(0.87)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C67(0.68)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C67(0.77)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C67(1.35)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C67(0.70)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C67(0.62)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C67(0.61)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C67(1.17)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C67(0.65)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C67(0.78)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C67(1.70)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C67(1.09)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C67(0.90)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C67(0.59)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C67(0.98)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C67(0.69)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C67(0.73)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C67(0.58)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C67(0.81)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C67(0.69)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C67(0.69)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C67(0.77)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C67(0.71)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C67(0.76)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C67(0.58)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C67(1.01)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C67(0.47)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C67(0.51)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C67(0.74)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C67(0.50)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C67(0.53)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C67(0.44)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C67(0.72)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C67(0.49)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C67(0.92)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C67(0.77)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C67(0.59)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C67(0.71)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C67(0.74)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C67(0.69)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C67(0.67)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C67(0.56)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C67(0.71)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C67(0.94)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C67(0.77)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C67(0.73)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C67(0.87)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C67(0.39)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C67(0.79)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C67(0.71)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C67(0.63)  LDD0946  [3]
 LDCM0248  AKOS034007472 HEK-293T C67(0.68)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C67(0.40)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C67(0.44)  LDD0873  [3]
 LDCM0367  CL1 PaTu 8988t C67(1.23)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C67(1.01)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C67(0.77)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C67(0.37)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C67(0.40)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C67(0.39)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C67(0.40)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C67(0.59)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C67(0.63)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C67(0.55)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C67(0.40)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C67(0.58)  LDD0976  [3]
 LDCM0379  CL11 PaTu 8988t C67(0.77)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C67(0.50)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C67(0.65)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C67(0.42)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C67(0.39)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C67(0.25)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C67(0.20)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C67(0.21)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C67(1.32)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C67(0.97)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C67(0.70)  LDD0987  [3]
 LDCM0390  CL12 PaTu 8988t C67(1.47)  LDD1269  [3]
 LDCM0391  CL120 HEK-293T C67(0.69)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C67(0.65)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C67(0.67)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C67(0.88)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C67(0.77)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C67(0.67)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C67(0.66)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C67(0.83)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C67(0.83)  LDD0997  [3]
 LDCM0400  CL13 PaTu 8988t C67(1.63)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C67(1.98)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C67(1.10)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C67(1.01); C123(1.20)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C67(1.13)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C67(0.92); C123(1.04)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C67(1.10)  LDD1610  [8]
 LDCM0407  CL2 PaTu 8988t C67(1.22)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C67(1.17); C123(0.91)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C67(1.23)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C67(1.21); C123(0.95)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C67(1.30); C123(1.26)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C67(1.27)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C67(1.09); C123(1.04)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C67(1.14); C38(1.18); C123(1.37)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C67(1.04); C123(0.88)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C67(1.07); C123(1.12)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C67(0.90)  LDD1621  [8]
 LDCM0418  CL3 PaTu 8988t C67(1.00)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C67(0.92); C123(1.00)  LDD1623  [8]
 LDCM0420  CL31 PaTu 8988t C67(0.98)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C67(0.81)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C67(0.85)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C67(1.01)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C67(1.39)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C67(0.66)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C67(1.09)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C67(0.98)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C67(1.19)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C67(1.02)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C67(1.15)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C67(0.92)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C67(1.00)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C67(1.27)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C67(1.05)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C67(0.55)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C67(0.64)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C67(0.59)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C67(0.68)  LDD1037  [3]
 LDCM0440  CL5 PaTu 8988t C67(1.72)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C67(0.61)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C67(0.59)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C67(1.36)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C67(0.92)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C67(0.76)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C67(0.57)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C67(0.88)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C67(0.58)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C67(0.60)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C67(0.56)  LDD1048  [3]
 LDCM0451  CL6 PaTu 8988t C67(1.31)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C67(0.69)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C67(0.61)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C67(0.52)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C67(0.33)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C67(0.50)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C67(0.44)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C67(0.45)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C67(0.63)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C67(0.62)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C67(0.66)  LDD1059  [3]
 LDCM0462  CL7 PaTu 8988t C67(2.19)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C67(0.56)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C67(0.52)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C67(0.78)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C67(0.55)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C67(0.44)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C67(0.66)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C67(0.55)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C67(0.49)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C67(0.51)  LDD1070  [3]
 LDCM0473  CL8 PaTu 8988t C67(1.12)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C67(0.63)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C67(0.56)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C67(0.80)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C67(0.72)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C67(0.47)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C67(0.59)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C67(0.54)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C67(0.63)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C67(0.66)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C67(0.59)  LDD1081  [3]
 LDCM0484  CL9 PaTu 8988t C67(1.43)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C67(0.56)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C67(0.86)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C67(0.97)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C67(0.94)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C67(0.50)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C67(0.50)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C67(0.69)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C67(0.91)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C67(0.96)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C67(1.05)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C67(1.14); C123(0.94)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C67(0.47)  LDD1066  [3]
 LDCM0427  Fragment51 PaTu 8988t C67(1.28)  LDD1306  [3]
 LDCM0022  KB02 HCT 116 C67(1.46); C123(1.09)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C67(1.35); C123(1.04)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C67(1.95); C123(1.08)  LDD0082  [3]
 LDCM0170  Structure8 Ramos 4.31  LDD0433  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family G member 4 (ABCG4) ABCG family Q9H172
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Ethanolamine kinase 1 (ETNK1) Choline/ethanolamine kinase family Q9HBU6
Extracellular superoxide dismutase [Cu-Zn] (SOD3) Cu-Zn superoxide dismutase family P08294
Peptidyl-prolyl cis-trans isomerase C (PPIC) Cyclophilin-type PPIase family P45877
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
tRNA-specific adenosine deaminase 2 (ADAT2) Cytidine and deoxycytidylate deaminase family Q7Z6V5
NADH-cytochrome b5 reductase 1 (CYB5R1) Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHQ9
Glutathione peroxidase 7 (GPX7) Glutathione peroxidase family Q96SL4
Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP) ITPRIP family Q8IWB1
Nucleoside diphosphate kinase 3 (NME3) NDK family Q13232
ATP-dependent (S)-NAD(P)H-hydrate dehydratase (NAXD) NnrD/CARKD family Q8IW45
Inactive ribonuclease-like protein 10 (RNASE10) Pancreatic ribonuclease family Q5GAN6
Gamma-glutamyl hydrolase (GGH) Peptidase C26 family Q92820
Protein disulfide-isomerase A6 (PDIA6) Protein disulfide isomerase family Q15084
E3 ubiquitin-protein ligase RNF144A (RNF144A) RBR family P50876
Thioredoxin domain-containing protein 12 (TXNDC12) . O95881
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Defensin-6 (DEFA6) Alpha-defensin family Q01524
Calreticulin (CALR) Calreticulin family P27797
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Protein eva-1 homolog A (EVA1A) EVA1 family Q9H8M9
Glycophorin-A (GYPA) Glycophorin A family P02724
Vascular endothelial growth factor C (VEGFC) PDGF/VEGF growth factor family P49767
Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5) Potassium channel KCNE family Q9UJ90
Syndecan-4 (SDC4) Syndecan proteoglycan family P31431
Uroplakin-3a (UPK3A) Uroplakin-3 family O75631
Adiponectin (ADIPOQ) . Q15848
Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) . Q9BVT8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein beta chain (CD79B) . P40259
Cytokine and receptor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 3-like 1 (CCL3L1; CCL3L3) Intercrine beta (chemokine CC) family P16619
Osteopontin (SPP1) Osteopontin family P10451
Interleukin-6 receptor subunit beta (IL6ST) Type I cytokine receptor family P40189
Oncostatin-M-specific receptor subunit beta (OSMR) Type I cytokine receptor family Q99650
Interleukin-6 receptor subunit alpha (IL6R) Type I cytokine receptor family P08887
Other
Click To Hide/Show 58 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Porimin (TMEM123) CD164 family Q8N131
CD99 antigen-like protein 2 (CD99L2) CD99 family Q8TCZ2
Acetylcholinesterase collagenic tail peptide (COLQ) COLQ family Q9Y215
Reticulocalbin-1 (RCN1) CREC family Q15293
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Dermokine (DMKN) Dermokine family Q6E0U4
Dexamethasone-induced protein (DEXI) DEXI family O95424
Collagen alpha-2(I) chain (COL1A2) Fibrillar collagen family P08123
Fibrillin-1 (FBN1) Fibrillin family P35555
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
P antigen family member 3 (PAGE3) GAGE family Q5JUK9
Gastric inhibitory polypeptide (GIP) Glucagon family P09681
Lutropin subunit beta (LHB) Glycoprotein hormones subunit beta family P01229
Heat shock 70 kDa protein 13 (HSPA13) Heat shock protein 70 family P48723
Fibroblast growth factor 21 (FGF21) Heparin-binding growth factors family Q9NSA1
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Pancreatic adenocarcinoma up-regulated factor (ZG16B) Jacalin lectin family Q96DA0
Zymogen granule membrane protein 16 (ZG16) Jacalin lectin family O60844
Macrosialin (CD68) LAMP family P34810
Myeloid-derived growth factor (MYDGF) MYDGF family Q969H8
Alpha-sarcoglycan (SGCA) Sarcoglycan alpha/epsilon family Q16586
Selenoprotein M (SELENOM) Selenoprotein M/F family Q8WWX9
Serglycin (SRGN) Serglycin family P10124
Pigment epithelium-derived factor (SERPINF1) Serpin family P36955
Plasminogen activator inhibitor 1 (SERPINE1) Serpin family P05121
Serpin I2 (SERPINI2) Serpin family O75830
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Nucleotide exchange factor SIL1 (SIL1) SIL1 family Q9H173
Chorionic somatomammotropin hormone 1 (CSH1) Somatotropin/prolactin family P0DML2
Chorionic somatomammotropin hormone 2 (CSH2) Somatotropin/prolactin family P0DML3
Synaptotagmin-11 (SYT11) Synaptotagmin family Q9BT88
Synaptotagmin-4 (SYT4) Synaptotagmin family Q9H2B2
Cartilage oligomeric matrix protein (COMP) Thrombospondin family P49747
Antileukoproteinase (SLPI) . P03973
Basic salivary proline-rich protein 3 (PRB3) . Q04118
Brorin (VWC2) . Q2TAL6
Cadherin-15 (CDH15) . P55291
Collagen alpha-1(X) chain (COL10A1) . Q03692
Complement C1q subcomponent subunit A (C1QA) . P02745
Complement C1q tumor necrosis factor-related protein 5 (C1QTNF5) . Q9BXJ0
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6) . Q9BXI9
Complement C1q-like protein 4 (C1QL4) . Q86Z23
Endoplasmic reticulum resident protein 29 (ERP29) . P30040
Extracellular matrix protein 1 (ECM1) . Q16610
Probetacellulin (BTC) . P35070
Proline-rich acidic protein 1 (PRAP1) . Q96NZ9
Proline-rich protein 4 (PRR4) . Q16378
Psoriasis susceptibility 1 candidate gene 2 protein (PSORS1C2) . Q9UIG4
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3
Serine protease inhibitor Kazal-type 4 (SPINK4) . O60575
Stromal cell-derived factor 2-like protein 1 (SDF2L1) . Q9HCN8
T-cell surface glycoprotein CD3 delta chain (CD3D) . P04234
Transmembrane protein 108 (TMEM108) . Q6UXF1
Trefoil factor 1 (TFF1) . P04155
Ubiquitin-like protein 4A (UBL4A) . P11441
Uncharacterized protein C5orf46 (C5orf46) . Q6UWT4
WAP four-disulfide core domain protein 12 (WFDC12) . Q8WWY7

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.