Details of the Target

General Information of Target

Target ID LDTP18513
Target Name Cilia- and flagella-associated protein 97 (CFAP97)
Gene Name CFAP97
Gene ID 57587
Synonyms
KIAA1430; Cilia- and flagella-associated protein 97
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGRDFAPPPHLLSERGSLGHRSAAAAARLAPAGPAAQPPAHFQPGKYFPSPLPMASHTA
SSRLMGSSPASSFMGSFLTSSLGSAASTHPSGPSSSPPEQAYRGSHPTTSQIWFSHSHEA
PGYPRFSGSLASTFLPVSHLDHHGNSNVLYGQHRFYGTQKDNFYLRNLPPQPTLLPANHN
FPSVARAAPAHPMGSCSRDRDRGEAGSLQKGPKDFDRFLVGKELGREKAGKAAEGKERPA
AEEDGGKERHKLVLPVPADGHCREGGPAPRGACEGRPKHLTSCLLNTKVLNGEMGRAALA
SCAGGMLGRPGTGVVTSGRCAKEAAGPPEPGPAFSECLERRQMLHHTASYAGPPPPLSTA
AGSFPCLQLHGGPDGLCPLQDKAPRDLKASGPTFVPSVGHLADKGRPFQAAEACAVAGEG
KDRHLEGTMAPDHAAPYGVSYAHLKAEGKGERRPGGFEAALNPRLKGLDYLSSAGPEASF
PGLPKSGLDKSGYFELPTSSQDCARPGHQDPLGGKAPQACCTLDKTVGKEAPAGPPGAQK
VARIRHQQHLMAAEVEQGGIGAEAKRKSLELASLGYSGPHLPPWGVQAGQGTAMAISEER
KAGAYLDPFGSGLQQAALLPQELPAPPDEVSAMKNLLKYSSQALVVGQKAPLVGLGGLKA
SCIQQEAKFLSSKGPGQSERPDCARSREHDTTHGDGEVRQPPVGIAVALARQKDTVSRSE
AAYGTNTARQGRAAPAFKGGGGPRSTHALDLEAEEERTRLCDDRLGLASRELLLQDSKDR
VEFARIHPPSSCPGDLAPHLMMQSGQLGGDPAPHTHPHPPWLPRTRSPSLWMGGHSYGLG
HPALHQNLPPGFPASVAGPVPSVFPLPQDAPTQLVILPSEPTPHSAPHALADVMDQASLW
PPMYGGRGPASHMQHPGQLPVYSRPQLLRQQELYALQQQRAAQFQRKPEDQHLDLEEPAQ
EKAPKSTHKPVALTPTAPGAPSPAAGPTKLPPCCHPPDPKPPASSPTPPPRPSAPCTLNV
CPASSPGPGSRVRSAEEKNGEGQQSTADIITSEPVARAHSVAHAGLEFLASNDPSTSASQ
SFGITDLPPGYLRPMAGLGFSLPSDVHSSNLEDPETMQTTAPGAQPEPTRTFLPGEPPPC
SPRSLEEPGLLSGAREATQDLAATPYPTERGPQGKAADPSPLEGLQELQCAALLEAGGPE
ATGQAHSTQGGAREERSREEGEQGPSSGASSQVLEQRAGSPGALEDEGEQPAPEEDELEE
DELGQQSMEDSEEDCGGAPDNSHPPRALPGLDALVAATINLGDLPSDSPPDPQPPAASGP
PSTVPLPHSSGIHGIALLSELADLAIQRQRSERTVPEEEEDVLAFNLQHLATLATAWSLV
EAAGLDSSTAPAQPPTANPCSGPRLTPRMQILQRKDTWTPKTKPVCPLKAAIDRLDTQEV
GMRVRLAELQRRYKEKQRELARLQRKHDHERDESSRSPARRGPGRPRKRKHSSSLPAPRP
TGPLPRSDGKKVKAVRTSLGLLCAELRGGSGGEPAKKRSKLERSVYAGLQTASVEKAQCK
KSSCQGGLAPSVAHRVAQLKPKVKSKGLPTGLSSFQQKEATPGGRIREKLSRAKSAKVSG
ATRHPQPKGHGSRETPRCPAQPSVAASQEAGSGYDSEDCEGLLGTEAPPREAGLLLHTGA
SVAVLGPSPSSVVKMEANQKAKKKKERQGLLGACRLSSPESEVKIKRRSVKAKVGTTLER
APGQRPPGALGKKKAKGKAKGSLRAEPGATPSRDALFNPSRAFACREEGSQLASERLKRA
TRKGTVLQPVLRRKNGALSITLATRNAKAILGKGRKLSKVKHKAGKQGKGRAVSRLLESF
AVEEDFEFDDNSSFSEEEEDEEEEEEDSGPLSAEQSAALARSCAIHKEDLRDGLPVLIPK
EDSLLYAGSVRTLQPPDIYSIVIEGERGNRQRIYSLEQLLQEAVLDVRPQSSRYLPPGTR
VCAYWSQKSRCLYPGNVVRGASGDEDEDLDSVVVEFDDGDTGHIAVSNVRLLPPDFKIQC
TEPSPALLVSSSCRRTKKVSSEAPPPSEAATPSLSPKAQDGPEALKTPGKKSISKDKAGK
AELLTSGAKSPTGASDHFLGRRGSPLLSWSAVAQTKRKAVAAASKGPGVLQNLFQLNGSS
KKLRAREALFPVHSVATPIFGNGFRADSFSSLASSYAPFVGGTGPGLPRGAHKLLRAKKA
ERVEAEKGGRRRAGGEFLVKLDHEGVTSPKNKTCKALLMGDKDFSPKLGRPLPSPSYVHP
ALVGKDKKGRAPIPPLPMGLALRKYAGQAEFPLPYDSDCHSSFSDEDEDGPGLAAGVPSR
FLARLSVSSSSSGSSTSSSSGSVSTSSLCSSDNEDSSYSSDDEDPALLLQTCLTHPVPTL
LAQPEALRSKGSGPHAHAQRCFLSRATVAGTGAGSGPSSSSKSKLKRKEALSFSKAKELS
RRQRPPSVENRPKISAFLPARQLWKWSGNPTQRRGMKGKARKLFYKAIVRGEETLRVGDC
AVFLSAGRPNLPYIGRIESMWESWGSNMVVKVKWFYHPEETKLGKRQCDGKNALYQSCHE
DENDVQTISHKCQVVAREQYEQMARSRKCQDRQDLYYLAGTYDPTTGRLVTADGVPILC
Target Bioclass
Other
Family
CFAP97 family
Uniprot ID
Q9P2B7
Ensemble ID
ENST00000458385.7
HGNC ID
HGNC:29276

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.H221Q .
KMS11 SNV: p.H465Y DBIA    Probe Info 
KP4 SNV: p.A530V .
MFE319 SNV: p.L103M .
SNU1 SNV: p.E128A .
VCAP SNV: p.F353L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		4.11  LDD0433  [1]
DBIA
 Probe Info  		C504(0.63)  LDD0547  [2]
NAIA_4
 Probe Info  		C104(0.00); C504(0.00)  LDD2226  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C504(1.16)  LDD1507  [7]
 LDCM0226  AC11 HEK-293T C504(1.01)  LDD1509  [7]
 LDCM0230  AC113 HCT 116 C504(0.63)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C504(0.52)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C504(0.65)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C504(0.76)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C504(0.50)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C504(0.46)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C504(0.49)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C504(1.13); C27(0.98)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C504(0.36)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C504(0.42)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C504(0.36)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C504(0.28)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C504(0.35)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C504(0.66)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C504(0.47)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C504(0.42)  LDD0562  [2]
 LDCM0263  AC143 HCT 116 C504(1.02)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C504(3.41)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C504(1.24)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C504(1.65)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C504(1.62)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C504(2.05)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C504(1.83)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C504(1.37)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C504(1.07)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C504(1.42)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C504(2.10)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C504(1.48)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C504(2.40)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C504(2.29)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C504(1.51)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C504(1.19)  LDD1515  [7]
 LDCM0278  AC19 HEK-293T C504(1.48)  LDD1517  [7]
 LDCM0280  AC20 HEK-293T C504(1.21); C27(0.94)  LDD1519  [7]
 LDCM0285  AC25 HEK-293T C504(1.18)  LDD1524  [7]
 LDCM0287  AC27 HEK-293T C504(1.05)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C504(1.03); C27(0.99)  LDD1527  [7]
 LDCM0290  AC3 HEK-293T C504(0.91)  LDD1529  [7]
 LDCM0294  AC33 HEK-293T C504(1.00)  LDD1533  [7]
 LDCM0296  AC35 PaTu 8988t C104(1.21)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C104(1.32)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C104(1.23)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C104(1.27)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C104(1.46)  LDD1179  [2]
 LDCM0301  AC4 HEK-293T C504(1.18); C27(0.90)  LDD1540  [7]
 LDCM0302  AC40 PaTu 8988t C104(1.40)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C104(1.14)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C104(1.08)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C104(1.12)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C104(1.12)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C104(1.05)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C104(0.97)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C104(1.04)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C104(1.07)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C104(1.02)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C104(1.10)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C104(0.96)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C104(1.12)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C104(1.23)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C104(1.34)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C104(1.01)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C104(1.21)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C504(1.13)  LDD1559  [7]
 LDCM0322  AC59 HEK-293T C504(1.19)  LDD1561  [7]
 LDCM0324  AC60 HEK-293T C504(1.18); C27(1.10)  LDD1563  [7]
 LDCM0332  AC68 HCT 116 C504(0.69)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C504(1.28)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C504(0.94)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C504(0.65)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C504(1.35)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C504(1.31)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C504(1.14)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C504(1.13)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C504(0.98)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C504(1.51)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C504(1.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C504(0.87)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C504(1.16)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C504(0.94)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C504(0.80)  LDD0665  [2]
 LDCM0349  AC83 PaTu 8988t C104(0.80)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C104(0.77)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C104(0.78)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C104(0.86)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C104(0.89)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C104(0.87)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C104(0.82)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C104(0.91)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C104(0.87)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C104(0.79)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C104(0.80)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C104(0.77)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C104(0.87)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C104(0.74)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C104(0.82)  LDD1243  [2]
 LDCM0356  AKOS034007680 HEK-293T C504(0.99)  LDD1570  [7]
 LDCM0367  CL1 PaTu 8988t C104(0.87)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C104(1.26)  LDD1247  [2]
 LDCM0371  CL102 HEK-293T C504(0.89); C104(0.99)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C104(1.12)  LDD1576  [7]
 LDCM0375  CL106 HEK-293T C504(0.90); C104(0.96)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C104(0.98)  LDD1580  [7]
 LDCM0379  CL11 PaTu 8988t C104(0.96)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C504(1.19); C104(1.10)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C104(0.93)  LDD1585  [7]
 LDCM0384  CL114 HEK-293T C504(1.03); C104(0.91)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C104(1.00)  LDD1589  [7]
 LDCM0387  CL117 PaTu 8988t C104(1.04)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C104(0.93)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C104(1.20)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C104(1.08)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C104(1.33)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C104(1.01)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C104(1.20)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C104(1.23)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C104(1.13)  LDD1274  [2]
 LDCM0397  CL126 HEK-293T C504(0.96); C104(0.86)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C104(0.90)  LDD1602  [7]
 LDCM0400  CL13 PaTu 8988t C104(1.58)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C104(1.49)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C104(1.15)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C504(0.99)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C504(1.25)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C504(1.54)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C504(1.30)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C104(1.04)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C504(1.41)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C504(1.22)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C504(1.07)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C504(1.03)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C504(1.26)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C504(1.24)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C504(1.11)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C504(1.57)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C504(1.75)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C504(1.68)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C104(1.25)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C504(1.29)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C104(1.16)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C104(1.43)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C104(1.49)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C104(1.74)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C104(1.63)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C104(1.54)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C104(2.02)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C104(1.25)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C104(1.10)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C104(1.16)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C104(1.70)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C104(2.01)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C104(2.22)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C104(1.57)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C104(1.47)  LDD1314  [2]
 LDCM0440  CL5 PaTu 8988t C104(1.47)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C504(0.99); C104(1.24)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C504(0.97)  LDD1647  [7]
 LDCM0446  CL55 HEK-293T C504(1.18)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C504(1.28); C27(1.10)  LDD1650  [7]
 LDCM0451  CL6 PaTu 8988t C104(1.37)  LDD1330  [2]
 LDCM0453  CL61 HCT 116 C504(0.93)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C504(1.08)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C504(1.02)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C504(0.76)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C504(0.85)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C504(0.93)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C504(0.97)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C504(0.84)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C504(0.98)  LDD0778  [2]
 LDCM0462  CL7 PaTu 8988t C104(1.45)  LDD1341  [2]
 LDCM0463  CL70 HCT 116 C504(0.70)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C504(0.77)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C504(1.04)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C504(0.86)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C504(0.82)  LDD0784  [2]
 LDCM0470  CL77 HEK-293T C504(1.01)  LDD1673  [7]
 LDCM0472  CL79 HEK-293T C504(0.94)  LDD1675  [7]
 LDCM0473  CL8 PaTu 8988t C104(1.32)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C504(1.03); C27(1.10)  LDD1677  [7]
 LDCM0480  CL86 HEK-293T C504(0.87); C104(1.02)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C104(1.09)  LDD1684  [7]
 LDCM0483  CL89 HEK-293T C504(1.15)  LDD1686  [7]
 LDCM0484  CL9 PaTu 8988t C104(1.37)  LDD1363  [2]
 LDCM0486  CL91 HEK-293T C504(0.99)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C504(1.02); C27(1.01)  LDD1690  [7]
 LDCM0493  CL98 HEK-293T C504(0.92); C104(0.95)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C104(0.99)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C104(1.02)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C504(0.78)  LDD0785  [2]
 LDCM0427  Fragment51 PaTu 8988t C104(1.60)  LDD1306  [2]
 LDCM0022  KB02 42-MG-BA C27(2.13)  LDD2244  [8]
 LDCM0023  KB03 A101D C104(1.92)  LDD2667  [8]
 LDCM0024  KB05 SKMEL24 C104(2.15)  LDD3323  [8]
 LDCM0170  Structure8 Ramos 4.11  LDD0433  [1]

References

1 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840