Details of the Target

General Information of Target

Target ID LDTP05692
Target Name Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)
Gene Name IRAG2
Gene ID 4033
Synonyms
JAW1; LRMP; Inositol 1,4,5-triphosphate receptor associated 2; Lymphoid-restricted membrane protein; Protein Jaw1) [Cleaved into: Processed inositol 1,4,5-triphosphate receptor associated 2]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESTPFSGVANQIHTLCERPTYGEVKDGALDVKRQHKCPGPTSGPSPGTNLSGCIRMNDD
PSMEENGVERVCPESLLQSREYSSLPLPRHTSSTDGTITSSDPGLEILNMASCDLDRNSL
CKKEEDTRSASPTIEAQGTSPAHDNIAFQDSTSKDKTILNLEAKEEPETIEEHKKEHASG
DSVVSPLPVTTVKSVNLRQSENTSANEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRD
LAEENLKKEITNCLKLLESLTPLCEDDNQAQEIIKKLEKSIKFLSQCAARVASRAEMLGA
INQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQVLLQNERSFNPLEDDDDCQIKKR
SASLNSKPSSLRRVTIASLPRNIGNAGMVAGMENNDRFSRRSSSWRILGSKQSEHRPSLP
RFISTYSWADAEEEKCELKTKDDSEPSGEETVERTRKPSLSEKKNNPSKWDVSSVYDTIA
SWATNLKSSIRKANKALWLSIAFIVLFAALMSFLTGQLFQKSVDAAPTQQEDSWTSLEHI
LWPFTRLRHNGPPPV
Target Bioclass
Transporter and channel
Family
IRAG2 family
Subcellular location
Cytoplasm; Endoplasmic reticulum membrane
Function
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules.
Uniprot ID
Q12912
Ensemble ID
ENST00000354454.7
HGNC ID
HGNC:6690

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C287(1.22)  LDD3312  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C223(1.24); C72(0.89); C264(0.75); C355(0.83)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C223(1.80); C72(1.31); C264(0.91); C355(1.41)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C223(0.40); C72(0.07); C264(0.75)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C223(1.19); C72(1.06); C264(1.04); C355(1.13)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C223(0.86); C72(0.95); C264(0.86); C355(0.65)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C223(1.60); C72(0.60); C264(1.13); C355(0.90)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C223(2.95); C72(0.79); C264(0.96); C355(0.95)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C223(0.78); C72(1.04); C264(0.77); C355(0.59)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C223(0.53); C72(0.63); C264(0.54); C355(0.47)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C223(0.89); C72(0.89); C264(0.93); C355(0.75)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C223(1.09); C72(0.60); C264(1.19); C355(0.69)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C223(1.03); C72(1.13); C264(0.87); C355(1.24)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C223(1.00); C72(0.99); C264(0.86); C355(0.87)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C223(1.14); C72(4.39); C264(0.91); C355(2.50)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C223(0.94); C72(1.13); C264(0.99); C355(0.97)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C223(0.97); C72(1.46); C264(0.88); C355(0.81)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C223(1.68); C72(0.78); C264(1.28); C355(0.70)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C223(0.84); C72(1.06); C264(0.92); C355(0.83)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C223(0.87); C72(1.06); C264(0.75); C355(1.03)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C223(2.85); C72(0.91); C264(0.78); C355(0.45)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C223(1.60); C72(1.06); C264(0.85); C355(1.29)  LDD2188  [4]
 LDCM0022  KB02 Ramos C223(3.06); C72(1.49); C264(0.68); C355(0.85)  LDD2182  [4]
 LDCM0023  KB03 Ramos C223(1.79); C72(0.74); C264(1.02); C355(0.74)  LDD2183  [4]
 LDCM0024  KB05 HMCB C287(1.22)  LDD3312  [1]
 LDCM0170  Structure8 Ramos 4.31  LDD0433  [5]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.