Details of the Target

General Information of Target

Target ID LDTP01292
Target Name Protein phosphatase 1B (PPM1B)
Gene Name PPM1B
Gene ID 5495
Synonyms
PP2CB; Protein phosphatase 1B; EC 3.1.3.16; Protein phosphatase 2C isoform beta; PP2C-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD
GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF
SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI
QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIIL
ACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPK
VSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGKR
NVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSYRL
AKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEKI
Target Bioclass
Enzyme
Family
PP2C family
Subcellular location
Cytoplasm, cytosol
Function
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Uniprot ID
O75688
Ensemble ID
ENST00000282412.9
HGNC ID
HGNC:9276
ChEMBL ID
CHEMBL2845

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.E252D .
MDAMB436 SNV: p.S441T .
RKO SNV: p.S250R .
RPMI7951 SNV: p.G353A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y418(6.15)  LDD0257  [2]
Probe 1
 Probe Info  		Y24(13.36); Y205(28.88); Y207(29.56); Y227(9.30)  LDD3495  [3]
BTD
 Probe Info  		C209(1.09)  LDD2117  [4]
DBIA
 Probe Info  		C163(1.05); C172(1.05)  LDD0078  [5]
5E-2FA
 Probe Info  		H315(0.00); H13(0.00); H78(0.00); H74(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C149(0.00); C71(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C149(0.00); C71(0.00); C294(0.00); C172(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C294(0.00); C149(0.00); C71(0.00); C172(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
TFBX
 Probe Info  		C71(0.00); C149(0.00)  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		11.90  LDD0443  [14]
NAIA_5
 Probe Info  		C294(0.00); C149(0.00); C71(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C209(1.09)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C163(0.78); C172(0.49); C149(1.22)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C163(0.83); C172(0.85)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C163(1.00); C172(1.00)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C163(1.01); C172(1.01)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C163(0.92); C172(0.92)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C163(1.11); C172(1.11)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C163(1.10); C172(1.10)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C163(1.20); C172(1.20)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C163(0.85); C172(0.85)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C163(0.90); C172(0.90)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C163(0.72); C172(0.72)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C163(0.91); C172(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C163(0.84); C172(0.86)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C163(0.82); C172(0.82)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C163(0.93); C172(0.93)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C163(0.98); C172(0.98)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C163(1.00); C172(1.00); C149(0.95)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C163(1.37); C172(1.37); C149(0.93)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C163(1.58); C172(1.58); C149(0.86)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C163(1.56); C172(1.56); C149(0.94)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C163(1.38); C172(1.38); C149(0.98)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C163(1.27); C172(1.27); C149(0.95)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C163(1.24); C172(1.24); C149(0.93)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C163(0.62); C172(0.68)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C163(0.86); C172(0.86); C149(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C163(1.31); C172(1.31); C149(0.93)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C163(1.27); C172(1.27); C149(0.94)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C163(1.14); C172(1.14); C149(0.98)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C163(1.17); C172(1.17); C149(0.93)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C163(1.20); C172(1.20); C149(0.99)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C163(1.18); C172(1.18); C149(0.90)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C163(1.37); C172(1.37); C149(0.89)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C163(0.66); C172(0.66); C149(1.70)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C163(0.63); C172(0.63); C149(1.70)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C163(0.67); C172(0.67); C149(1.58)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C163(1.21); C172(1.21); C149(1.72)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C163(0.69); C172(0.69); C149(1.36)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C163(0.69); C172(0.69); C149(1.43)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C163(0.90); C172(0.90); C149(1.22)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C163(0.63); C172(0.63); C149(1.28)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C163(0.70); C172(0.70); C149(1.35)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C163(0.86); C172(0.86); C149(1.06)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C163(1.10); C172(1.10); C149(0.80)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C163(0.79); C172(0.79); C149(0.89)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C163(1.22); C172(1.24)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C163(0.83); C172(0.83); C149(0.74)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C163(0.68); C172(0.68); C149(0.80)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C163(0.77); C172(0.77); C149(1.07)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C163(1.19); C172(1.19); C149(0.89)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C149(0.68); C163(1.45); C172(1.45)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C149(0.81); C163(1.25); C172(1.25)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C149(0.68); C163(1.50); C172(1.50)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C149(0.77); C163(1.34); C172(1.34)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C149(0.59); C163(1.33); C172(1.33)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C149(0.73); C163(1.63); C172(1.63)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C163(0.92); C172(0.94)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C149(0.93); C163(1.16); C172(1.16)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C149(0.98); C163(1.38); C172(1.38)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C149(0.68); C163(1.35); C172(1.35)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C149(0.49); C163(1.21); C172(1.21)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C163(1.56); C172(1.56); C149(0.73)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C163(1.11); C172(1.11); C149(0.89)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C163(1.19); C172(1.19); C149(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C163(1.23); C172(1.23); C149(0.94)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C163(0.83); C172(0.83)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C163(1.57); C172(1.57)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C163(1.12); C172(1.12)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C172(0.72); C163(0.89); C149(0.97)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C163(1.64); C172(1.64)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C163(1.40); C172(1.40)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C163(1.09); C172(1.09)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C163(1.17); C172(1.17)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C163(1.69); C172(1.69)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C163(0.64); C172(0.64); C149(0.99)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C163(0.55); C172(0.55); C149(1.02)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C163(0.67); C172(0.67); C149(1.03)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C163(0.65); C172(0.65); C149(1.07)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C163(0.78); C172(0.78); C149(1.08)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C172(0.60); C163(0.89); C149(1.15)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C163(0.82); C172(0.82); C149(1.09)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C163(0.74); C172(0.74); C149(1.07)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C163(0.87); C172(0.87); C149(0.99)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C163(1.07); C172(1.07); C149(1.19)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C149(0.97); C163(1.47); C172(1.47)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C163(0.44); C172(0.44)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C163(0.53); C172(0.53)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C163(0.61); C172(0.61)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C163(0.78); C172(0.78)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C163(0.58); C172(0.58)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C172(0.67); C163(0.88); C149(1.18)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C163(0.85); C172(0.85)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C163(0.86); C172(0.86)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C163(1.12); C172(1.12)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C163(0.94); C172(0.94)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C163(1.23); C172(1.23)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C163(1.03); C172(1.03)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C163(0.73); C172(0.73)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C163(0.42); C172(0.42)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C163(0.75); C172(0.75)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C163(0.62); C172(0.62)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C172(0.69); C163(1.00); C149(1.09)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C163(0.41); C172(0.41)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C163(0.56); C172(0.56)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C163(0.52); C172(0.52)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C163(0.54); C172(0.54)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C163(0.69); C172(0.69)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C163(0.38); C172(0.38)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C163(0.44); C172(0.44)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C163(0.73); C172(0.73)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C163(1.10); C172(1.10)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C163(0.85); C172(0.85)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C172(1.19); C163(1.22)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C163(0.85); C172(0.85)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C163(0.80); C172(0.80)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C163(0.72); C172(0.72)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C163(0.74); C172(0.74)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C163(0.69); C172(0.69)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C163(0.70); C172(0.70)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C163(0.83); C172(0.83)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C163(0.93); C172(0.93)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C149(0.93); C163(1.70); C172(1.70)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C149(0.75); C163(1.00); C172(1.00)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C172(1.15); C163(1.16)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C149(0.69); C163(1.10); C172(1.10)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C163(1.01); C172(1.01); C149(1.04)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C149(0.91); C163(1.20); C172(1.20)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C149(0.52); C163(1.00); C172(1.00)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C149(0.55); C163(1.16); C172(1.16)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C149(0.49); C163(1.03); C172(1.03)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C149(0.80); C163(1.14); C172(1.14)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C149(0.83); C163(1.24); C172(1.24)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C149(0.97); C163(1.07); C172(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C149(1.07); C163(1.09); C172(1.09)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C172(1.01); C163(1.02)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C149(0.99); C163(1.15); C172(1.15)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C149(1.07); C163(1.38); C172(1.38)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C149(0.54); C163(1.42); C172(1.42)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C149(0.63); C163(1.36); C172(1.36)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C149(0.66); C163(1.08); C172(1.08)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C149(0.78); C163(1.02); C172(1.02)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C149(1.01); C163(1.40); C172(1.40)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C149(0.94); C163(1.14); C172(1.14)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C149(0.88); C163(1.31); C172(1.31)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C149(0.84); C163(1.28); C172(1.28)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C163(0.86); C172(0.86); C149(0.94)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C149(0.59); C163(1.01); C172(1.01)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C149(0.75); C163(1.03); C172(1.03)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C149(0.80); C163(0.87); C172(0.87)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C163(0.76); C172(0.76); C149(0.97)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C163(0.99); C172(0.99); C149(1.06)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C149(0.93); C163(0.97); C172(0.97)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C149(0.76); C163(0.87); C172(0.87)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C163(0.79); C172(0.79)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C163(0.90); C172(0.90)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C163(0.73); C172(0.74)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C172(0.82); C163(0.85)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C163(0.85); C172(0.86)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.95  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C163(1.05); C172(1.05)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C163(0.71)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C149(0.74)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C149(0.84)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C172(0.52); C163(0.77); C149(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C172(1.13); C163(1.18)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C172(1.18); C163(1.22)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C172(0.94); C163(0.95)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C172(0.99); C163(1.02)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C163(1.17); C172(1.17)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C163(1.37); C172(1.37)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C163(1.05); C172(1.05)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C163(0.95); C172(0.95)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C163(0.88); C172(0.88)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C149(0.68)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C163(1.13); C172(1.13)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C163(1.51); C172(1.51)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C163(0.88); C172(0.88); C149(0.95)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C149(0.79); C163(1.02); C172(1.02)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C149(0.92); C163(1.37); C172(1.37)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C149(1.02); C163(1.42); C172(1.42)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C149(0.92); C163(1.21); C172(1.21)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C163(0.93); C172(0.93)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C163(0.63); C172(0.63)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C163(0.59); C172(0.59)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C149(0.96)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C163(0.64); C172(0.64)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C163(0.76); C172(0.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C163(0.96); C172(0.96)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C163(0.62); C172(0.62)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C163(0.55); C172(0.55)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C163(0.78); C172(0.78)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C163(1.09); C172(1.09)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C163(0.99); C172(0.99)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C163(0.74); C172(0.74)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C149(0.95)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C149(1.04)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C149(0.82)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C163(1.03); C172(1.03)  LDD0720  [5]
 LDCM0404  CL17 HEK-293T C149(0.79); C163(1.99); C172(1.29)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C149(0.98); C163(1.07); C172(1.04)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C149(0.89); C163(1.22); C172(1.18)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C149(0.83)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C149(0.93); C163(1.19); C172(1.22)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C149(0.86); C163(2.36); C172(2.24)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C149(0.87); C163(1.69); C172(1.62)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C149(0.86); C163(1.11); C172(1.21)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C149(1.00); C163(1.13); C172(1.19)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C149(0.90); C163(1.44); C172(1.26)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C149(0.99); C163(1.14); C172(1.10)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C149(0.98); C163(1.09); C172(1.04)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C149(0.88); C163(1.40); C172(1.19)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C149(0.93); C163(1.18); C172(1.22)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C149(0.84)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C149(0.77); C163(1.22); C172(1.36)  LDD1017  [5]
 LDCM0420  CL31 HCT 116 C172(0.97)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C163(1.26); C172(0.98)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C163(1.66); C172(1.17)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C163(1.26); C172(1.05)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C163(0.72); C172(1.23)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C163(1.41); C172(1.28)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C163(0.86); C172(1.23)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C163(1.07); C172(1.13)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C149(0.98)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C163(1.07); C172(1.12)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C163(1.38); C172(1.17)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C163(1.08); C172(1.19)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C163(0.96); C172(0.81)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C163(0.85); C172(0.80)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C163(0.85); C172(0.79)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C163(0.83); C172(0.81)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C163(1.04); C172(1.01)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C163(1.10); C172(1.06)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C163(0.69); C172(0.66)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C149(0.94)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C163(0.86); C172(0.87)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C163(0.70); C172(0.69)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C163(0.86); C172(0.85)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C163(2.06); C172(1.91)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C163(0.91); C172(0.90)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C163(0.80); C172(0.77)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C163(1.02); C172(0.99)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C163(1.23); C172(1.25)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C163(0.78); C172(0.76)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C163(0.85); C172(0.81)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C149(0.80)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C163(0.80); C172(0.79)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C163(0.84); C172(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C163(0.68); C172(0.83)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C163(1.03); C172(1.32)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C163(0.74); C172(0.88)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C163(0.90); C172(1.05)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C163(0.93); C172(1.00)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C163(0.86); C172(1.11)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C163(2.62); C172(3.17)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C163(0.96); C172(1.10)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C149(0.86)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C163(1.03); C172(1.05)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C163(0.95); C172(1.29)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C163(1.12); C172(1.14)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C163(1.15); C172(1.25)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C163(1.12); C172(1.45)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C163(2.05); C172(2.11); C149(1.23)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C163(4.00); C172(4.53); C149(1.22)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C163(1.07); C172(1.12); C149(1.25)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C163(1.38); C172(1.52); C149(1.09)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C149(0.85)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C163(1.02); C172(1.14); C149(1.32)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C163(0.93); C172(1.12); C149(1.24)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C163(1.03); C172(1.00); C149(1.10)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C163(1.52); C172(1.47); C149(0.89)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C163(1.37); C172(1.28); C149(1.01)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C163(1.83); C172(1.69); C149(1.23)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C163(2.19); C172(1.97); C149(1.07)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C163(1.91); C172(1.86); C149(1.35)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C163(2.79); C172(2.46); C149(1.07)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C163(1.75); C172(1.47); C149(1.02)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C149(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C163(1.99); C172(2.04); C149(1.26)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C163(0.98); C172(0.83); C149(1.00)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C163(1.03); C172(1.06); C149(1.02)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C163(0.83); C172(0.74); C149(0.99)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C163(0.95); C172(0.87); C149(1.01)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C163(1.13); C172(1.26); C149(0.99)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C163(1.12); C172(1.11); C149(0.98)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C163(0.98); C172(0.92); C149(0.93)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C163(0.93); C172(0.60); C149(0.97)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C163(0.84); C172(0.51); C149(1.20)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C149(1.03); C172(1.05); C279(0.89); C272(0.85)  LDD1698  [17]
 LDCM0625  F8 Ramos C209(1.19)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C209(0.81)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C209(2.24)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C209(0.67)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C209(1.16)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C209(0.83)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C209(1.33)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C209(0.97)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C209(0.74)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C209(1.15)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C209(0.98)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C209(0.72)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C209(0.65)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C209(0.64)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C163(1.21); C172(1.32)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C209(0.57)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C209(1.04)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C163(0.90); C172(1.04)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C209(0.80)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C209(0.63)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C209(0.82)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C209(0.60)  LDD2188  [18]
 LDCM0022  KB02 HEK-293T C172(0.96); C279(1.07)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C172(1.04); C279(0.99)  LDD1497  [17]
 LDCM0024  KB05 IGR37 C149(6.27)  LDD3314  [19]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C172(1.01)  LDD2124  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C172(0.87)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C172(0.97)  LDD2207  [20]
 LDCM0170  Structure8 Ramos 17.49  LDD0433  [21]
 LDCM0021  THZ1 HCT 116 C163(1.27); C172(1.27)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-arrestin-1 (ARRB1) Arrestin family P49407
Beta-arrestin-2 (ARRB2) Arrestin family P32121
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
Myosin regulatory light chain 2, atrial isoform (MYL7) . Q01449
Ubiquitin-like protein ISG15 (ISG15) . P05161

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.