Details of the Target

General Information of Target

Target ID LDTP07301
Target Name ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4)
Gene Name ARL6IP4
Gene ID 51329
Synonyms
ADP-ribosylation factor-like protein 6-interacting protein 4; ARL-6-interacting protein 4; Aip-4; HSP-975; HSVI-binding protein; SR-15; SRp25; SR-25; Splicing factor SRrp37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHVGSRKRSRSRSRSRGRGSEKRKKKSRKDTSRNCSASTSQGRKASTAPGAEASPSPCI
TERSKQKARRRTRSSSSSSSSSSSSSSSSSSSSSSSSSDGRKKRGKYKDKRRKKKKKRKK
LKKKGKEKAEAQQVEALPGPSLDQWHRSAGEEEDGPVLTDEQKSRIQAMKPMTKEEWDAR
QSIIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDCLAFQMRAGLLP
Target Bioclass
Other
Family
ARL6IP4 family
Subcellular location
Nucleus, nucleolus
Function
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.
Uniprot ID
Q66PJ3
Ensemble ID
ENST00000315580.10
HGNC ID
HGNC:18076

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.38  LDD0402  [1]
C-Sul
 Probe Info  		61.46  LDD0066  [2]
BTD
 Probe Info  		C220(0.77)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C410(2.19); C220(3.53)  LDD0168  [4]
DBIA
 Probe Info  		C349(1.09); C182(0.98)  LDD0078  [5]
ATP probe
 Probe Info  		K211(0.00); K186(0.00); K199(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C59(0.00); C36(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C59(0.00); C36(0.00)  LDD0037  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		C220(0.00); C410(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C220(0.00); C410(0.00)  LDD2213  [10]
IPM
 Probe Info  		C226(0.00); C36(0.00)  LDD0005  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
VSF
 Probe Info  		C226(0.00); C36(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C36(0.00); C226(0.00)  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		9.20  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DFG-out-4
 Probe Info  		4.60  LDD0075  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C220(1.00)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C220(0.92)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C220(0.92)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C410(2.19); C220(3.53)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C220(7.81)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C349(1.07)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C349(0.92)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C349(1.16)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C349(1.10)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C349(0.90)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C349(1.19)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C349(1.06)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C349(1.15)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C349(1.24)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C349(1.27)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C349(1.06)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C349(0.96)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C349(1.11)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C349(1.05)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C349(1.02)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C349(1.04)  LDD0546  [5]
 LDCM0237  AC12 HCT 116 C349(0.95)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C349(1.06)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C349(0.84)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C349(1.13)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C349(1.07)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C349(1.05)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C349(1.35)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C349(1.28)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C349(1.08)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C349(1.10)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C349(1.08)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C349(1.07)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C220(0.95); C410(1.05)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C220(1.08); C410(0.97)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C220(1.02); C410(0.98)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C220(1.06); C243(1.18); C410(1.01)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C220(0.96); C243(1.20); C410(1.00)  LDD1528  [18]
 LDCM0290  AC3 HCT 116 C349(1.26)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C220(1.03); C410(1.00)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C220(1.07); C243(0.89); C410(0.97)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C220(1.10); C410(1.01)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C220(0.99); C410(1.01)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C220(1.02); C410(0.99)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C220(1.32); C410(1.06)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C220(1.04); C243(0.90); C410(0.95)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C220(0.93); C243(0.93); C410(1.03)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C220(1.01); C410(1.00)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C220(1.04); C243(1.43); C410(0.99)  LDD1539  [18]
 LDCM0301  AC4 HCT 116 C349(0.98)  LDD0618  [5]
 LDCM0302  AC40 HEK-293T C220(1.01); C410(1.00)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C220(1.02); C410(1.06)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C220(1.11); C410(0.99)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C220(1.25); C410(1.01)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C220(1.13); C243(1.22); C410(0.95)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C220(1.04); C243(0.95); C410(1.07)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C220(1.05); C410(1.01)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C220(1.00); C243(1.18); C410(1.01)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C220(0.97); C410(1.04)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C220(1.07); C410(1.01)  LDD1550  [18]
 LDCM0312  AC5 HCT 116 C349(0.90)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C220(1.05); C410(0.94)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C220(0.96); C410(0.99)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C220(1.07); C243(0.81); C410(0.97)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C220(0.85); C243(1.19); C410(1.06)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C220(1.00); C410(1.03)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C220(1.03); C243(1.20); C410(0.95)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C220(1.10); C410(0.97)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C220(1.00); C410(1.05)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C220(0.96); C410(0.99)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C220(1.09); C410(0.95)  LDD1561  [18]
 LDCM0323  AC6 HCT 116 C349(1.03)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C220(1.07); C243(0.86); C410(0.98)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C220(1.04); C243(1.18); C410(1.05)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C220(0.96); C410(1.08)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C220(0.94); C243(1.49); C410(0.98)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C220(1.01); C410(1.01)  LDD1567  [18]
 LDCM0334  AC7 HCT 116 C349(1.05)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C349(1.06)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C349(2.09)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C349(1.91)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C349(1.13)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C349(1.44)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C349(1.39)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C349(1.93)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C349(1.95)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C349(0.67)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C349(2.01)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C349(2.49)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C349(1.34)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C349(1.67)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C349(2.37)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C349(2.06)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C349(1.71)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C349(2.02)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C349(1.27)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C349(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C349(1.12)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C349(0.88)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.05  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C349(1.09); C182(0.98)  LDD0078  [5]
 LDCM0632  CL-Sc Hep-G2 C36(1.04); C36(0.91)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C349(1.01)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C349(1.50)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C349(1.19)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C349(1.05)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C349(1.09)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C349(0.95)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C349(0.89)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C349(1.06)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C349(0.98)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C349(1.20)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C349(1.23)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C349(1.14)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C349(1.33)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C349(0.95)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C349(1.23)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C410(1.09)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C220(1.01); C243(0.98); C410(0.99)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C220(0.95); C410(1.02)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C220(1.04); C410(1.01)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C410(0.99)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C220(1.04); C243(1.19); C410(1.02)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C220(1.23); C410(1.03)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C220(1.06); C410(0.96)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C349(1.51)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C410(1.00)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C220(0.94); C243(1.06); C410(0.99)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C220(1.18); C410(1.03)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C220(0.94); C410(0.95)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C410(0.98)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C220(0.99); C243(1.05); C410(0.95)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C220(1.01); C410(1.00)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C220(0.96); C410(1.01)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C410(1.04)  LDD1603  [18]
 LDCM0400  CL13 HCT 116 C349(1.06)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C349(0.93)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C349(0.89)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C349(1.02)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C349(0.77)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C349(0.89)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C349(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C349(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C349(1.06)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C349(1.03)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C349(1.02)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C349(1.44)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C349(0.99)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C349(1.17)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C349(1.42)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C349(0.91)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C349(1.40)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C349(1.01)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C349(1.09)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C349(1.20)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C220(1.14); C410(0.92)  LDD1624  [18]
 LDCM0421  CL32 HCT 116 C349(1.04)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C349(1.11)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C349(1.16)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C349(0.99)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C349(0.87)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C349(1.03)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C349(0.99)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C349(1.06)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C349(0.97)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C349(1.05)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C349(0.84)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C349(0.91)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C349(0.96)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C349(0.86)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C349(1.07)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C349(1.45)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C349(1.77)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C349(1.53)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C349(0.96)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C349(1.38)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C349(1.49)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C349(1.60)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C349(1.14)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C349(1.24)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C349(1.28)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C349(1.46)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C349(1.15)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C349(1.41)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C349(1.32)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C349(1.17)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C349(1.78)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C349(0.74)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C349(0.62)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C349(0.72)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C349(0.71)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C349(0.82)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C349(1.12)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C349(0.89)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C349(0.93)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C349(0.77)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C349(1.09)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C349(0.86)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C349(0.75)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C349(0.90)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C349(0.92)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C349(0.85)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C349(0.94)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C349(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C349(1.18)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C349(0.87)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C349(0.83)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C349(0.91)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C349(0.94)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C349(0.76)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C349(0.81)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C349(1.08)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C349(1.00)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C349(1.28)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C349(0.87)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C349(0.94)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C349(0.91)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C349(1.02)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C349(0.88)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C349(1.17)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C349(0.98)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C349(0.86)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C349(1.10)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C349(1.07)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C349(1.02)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C349(1.07)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C349(0.88)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C349(1.31)  LDD0811  [5]
 LDCM0017  DFG-out-2 A431 4.60  LDD0075  [17]
 LDCM0495  E2913 HEK-293T C220(0.95); C410(1.07)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C410(1.20); C220(1.05)  LDD1702  [3]
 LDCM0625  F8 Ramos C226(1.25); C36(2.12)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C226(1.89); C36(0.98)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C226(0.69); C36(0.95)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C226(1.48); C36(0.65)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C226(1.04); C36(0.92)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C226(1.22); C36(0.80)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C226(1.43); C36(0.59)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C226(1.04); C36(0.96)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C226(1.08); C36(0.88)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C226(0.94); C36(1.12)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C226(0.83); C36(0.85)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C226(1.04); C36(1.02)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C226(1.08); C36(0.89)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C226(2.83); C36(1.26)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C349(0.92)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C226(0.79); C36(0.70)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C226(1.19); C36(0.89)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C349(0.90)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C226(0.90); C36(1.29)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C226(0.98); C36(1.26)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C226(1.57); C36(0.93)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C226(1.54); C36(0.75)  LDD2188  [19]
 LDCM0022  KB02 HCT 116 C349(2.50); C182(1.70)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C349(1.30); C182(1.50)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C349(1.59); C182(1.55)  LDD0082  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C220(1.06)  LDD2092  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C220(0.74)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C220(0.70)  LDD2100  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C220(0.85)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C220(0.89)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C220(0.80)  LDD2111  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C220(0.71)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C220(0.76)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C220(1.08)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C220(0.88)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C220(0.82)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C220(0.88)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C220(0.72)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C220(0.77)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C220(0.85)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C220(0.65)  LDD2141  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C220(0.65)  LDD2148  [3]
 LDCM0170  Structure8 Ramos 8.57  LDD0433  [20]
 LDCM0021  THZ1 HCT 116 C182(1.20)  LDD2173  [5]
 LDCM0112  W16 Hep-G2 C410(0.84)  LDD0239  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) Complex I 30 kDa subunit family O75489
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Caspase-6 (CASP6) Peptidase C14A family P55212
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTP-binding nuclear protein Ran (RAN) Ran family P62826
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Serine/arginine-rich splicing factor 11 (SRSF11) Splicing factor SR family Q05519
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.