Details of the Target

General Information of Target

Target ID LDTP11760
Target Name Protein unc-93 homolog B1 (UNC93B1)
Gene Name UNC93B1
Gene ID 81622
Synonyms
UNC93; UNC93B; Protein unc-93 homolog B1; Unc-93B1; hUNC93B1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRA
HGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQ
QQQQQQQLNHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEYPPPPVSL
GSSSHTARLPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLP
NPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPPPHALGSRGPPTPAPPGAPGGPACLG
GTPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSES
LRNRAEEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLF
IEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPE
AVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPPGTGALPPAAPSGRGAAAS
LRKRKASPEPPDSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAAGGPPPPP
PPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSP
VSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHE
RLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPWAFMQGEI
ATILAGDVKVKKERDP
Target Bioclass
Transporter and channel
Family
Unc-93 family
Subcellular location
Endoplasmic reticulum membrane
Function
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Uniprot ID
Q9H1C4
Ensemble ID
ENST00000227471.7
HGNC ID
HGNC:13481

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y190(12.93)  LDD0260  [1]
Jackson_14
 Probe Info  		2.00  LDD0123  [2]
DBIA
 Probe Info  		C583(170.45)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
ENE
 Probe Info  		N.A.  LDD0006  [7]
W1
 Probe Info  		C583(0.00); E192(0.00); Y193(0.00); Y196(0.00)  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-DA
 Probe Info  		2.06  LDD0142  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C583(0.91)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C583(1.35)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C583(1.11)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C583(1.20)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C583(1.22)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C583(1.55)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C583(1.24)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C583(1.33)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C583(1.33)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C583(1.23)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C583(1.30)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C583(1.08)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C583(1.28)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C583(1.17)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C583(1.58)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C583(1.26)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C583(1.13)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C583(1.37)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C583(1.37)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C583(1.33)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C583(1.21)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C583(1.17)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C583(1.46)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C583(1.12)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C583(1.44)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C583(1.42)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C583(1.22)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C583(1.14)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C583(1.11)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C583(1.10)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C583(1.60)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C583(1.46)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C583(1.43)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C583(0.84)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C583(1.13)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C583(0.97)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C583(0.73)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C583(0.94)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C583(1.12)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C583(0.94)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C583(1.09)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C583(0.88)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C583(0.93)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C583(0.97)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C583(0.91)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C583(1.14)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C583(0.91)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C583(0.70)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C583(1.29)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C583(1.72)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C583(1.21)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C583(1.48)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C583(1.64)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C583(2.25)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C583(2.20)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C583(1.16)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C583(1.31)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C583(1.38)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C583(1.61)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C583(2.83)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C583(1.64)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C583(1.82)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C583(1.63)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C583(1.32)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C583(0.76)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C583(0.77)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C583(0.72)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C583(0.89)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C583(0.94)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C583(0.81)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C583(0.82)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C583(0.85)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C583(0.81)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C583(1.18)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C583(1.49)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C583(1.61)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C583(1.84)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C583(1.47)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C583(0.89)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C583(1.20)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C583(1.58)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C583(1.61)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C583(1.64)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C583(2.00)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C583(1.15)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C583(1.03)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C583(0.83)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C583(1.04)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C583(1.40)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C583(1.13)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C583(1.10)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C583(1.06)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C583(1.28)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C583(1.19)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C583(0.91)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C583(1.28)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C583(1.03)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C583(0.99)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C583(1.04)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C583(1.48)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C583(1.00)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C583(1.49)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C583(0.89)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C583(1.12)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C583(1.37)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C583(1.24)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C583(1.43)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C583(2.11)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C583(1.31)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C583(1.23)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C583(1.27)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C583(1.17)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C583(1.27)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C583(0.95)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C583(0.94)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C583(1.16)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C583(1.23)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C583(0.65)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C583(0.61)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C583(0.74)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C583(1.83)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C583(1.75)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C583(1.06)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C583(1.96)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C583(1.36)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C583(1.91)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C583(2.28)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C583(1.88)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C583(2.89)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C583(1.60)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C583(1.75)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C583(1.48)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C583(1.71)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C583(1.10)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C583(1.59)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C583(1.64)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C583(2.26)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C583(2.55)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C583(1.88)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C583(1.42)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C583(1.51)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C583(1.30)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C583(1.71)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C583(1.82)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C583(0.89)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C583(2.73)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C583(3.07)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C583(1.72)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C583(1.63)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C583(1.37)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C583(1.92)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C583(2.51)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C583(2.31)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C583(1.03)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C583(1.02)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C583(1.22)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C583(1.69)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C583(0.84)  LDD2171  [10]
 LDCM0367  CL1 HCT 116 C583(1.25)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C583(2.17)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C583(1.03)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C583(1.25)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C583(1.40)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C583(0.99)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C583(1.10)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C583(0.92)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C583(0.73)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C583(0.78)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C583(0.78)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C583(0.87)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C583(2.39)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C583(0.72)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C583(0.74)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C583(1.37)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C583(1.75)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C583(1.72)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C583(1.94)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C583(1.42)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C583(2.32)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C583(1.23)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C583(1.23)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C583(1.43)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C583(1.47)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C583(0.67)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C583(0.86)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C583(1.75)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C583(1.44)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C583(0.88)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C583(1.03)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C583(0.84)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C583(1.30)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C583(1.85)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C583(1.50)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C583(1.42)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C583(0.97)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C583(1.14)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C583(1.00)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C583(0.97)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C583(1.05)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C583(1.19)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C583(1.53)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C583(1.90)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C583(1.02)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C583(1.31)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C583(1.11)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C583(0.98)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C583(1.06)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C583(1.18)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C583(0.95)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C583(0.91)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C583(0.92)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C583(1.29)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C583(1.15)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C583(2.21)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C583(1.60)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C583(1.43)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C583(1.15)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C583(1.50)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C583(3.17)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C583(1.05)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C583(1.63)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C583(1.42)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C583(2.14)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C583(1.80)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C583(1.94)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C583(1.87)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C583(1.48)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C583(1.12)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C583(0.96)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C583(0.90)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C583(0.89)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C583(1.03)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C583(1.39)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C583(1.23)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C583(1.90)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C583(1.34)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C583(1.21)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C583(1.32)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C583(1.76)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C583(1.09)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C583(0.96)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C583(1.21)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C583(1.47)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C583(1.21)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C583(1.26)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C583(1.57)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C583(1.80)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C583(1.18)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C583(1.94)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C583(1.59)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C583(1.78)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C583(1.67)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C583(1.08)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C583(1.36)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C583(1.74)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C583(1.36)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C583(1.70)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C583(1.84)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C583(1.34)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C583(1.43)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C583(1.31)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C583(1.22)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C583(7.53)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C583(1.05)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C583(1.22)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C583(1.03)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C583(1.81)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C583(1.26)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C583(1.20)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C583(1.25)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C583(1.49)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C583(1.35)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C583(1.07)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C583(1.04)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C583(2.08)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C583(1.24)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C583(1.15)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C583(0.96)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C583(1.51)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C583(1.73)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C583(1.13)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C583(0.94)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C583(1.34)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C583(1.26)  LDD0811  [10]
 LDCM0625  F8 Ramos C583(1.46)  LDD2187  [11]
 LDCM0082  FK866 A-549 2.06  LDD0142  [9]
 LDCM0572  Fragment10 Ramos C583(12.27)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C583(7.33)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C583(12.08)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C583(0.95)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C583(1.29)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C583(9.64)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C583(0.91)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C583(0.82)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C583(0.83)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C583(0.43)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C583(1.79)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C583(0.80)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C583(1.83)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C583(1.23)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C583(5.77)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C583(2.07)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C583(1.53)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C583(1.19)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C583(3.87)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C583(10.33)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C583(0.79)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C583(170.45)  LDD0209  [3]
 LDCM0024  KB05 Hs 936.T C583(2.77)  LDD3313  [13]
 LDCM0131  RA190 MM1.R C583(1.35)  LDD0304  [14]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [2]
 LDCM0170  Structure8 Ramos 5.25  LDD0433  [15]
 LDCM0021  THZ1 HCT 116 C583(0.84)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bestrophin-2 (BEST2) Anion channel-forming bestrophin family Q8NFU1
Synapse differentiation-inducing gene protein 1 (SYNDIG1) CD225/Dispanin family Q9H7V2
Claudin-7 (CLDN7) Claudin family O95471
Receptor expression-enhancing protein 1 (REEP1) DP1 family Q9H902
Importin subunit beta-1 (KPNB1) Importin beta family Q14974
Transmembrane 4 L6 family member 18 (TM4SF18) L6 tetraspanin family Q96CE8
Exportin-2 (CSE1L) XPO2/CSE1 family P55060
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
GPCR
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 3 (FFAR3) G-protein coupled receptor 1 family O14843
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
G-protein coupled receptor family C group 5 member D (GPRC5D) G-protein coupled receptor 3 family Q9NZD1
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
HERV-H LTR-associating protein 2 (HHLA2) . Q9UM44
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) LDLR family Q5T700
Coiled-coil domain-containing protein 107 (CCDC107) . Q8WV48
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
14 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
15 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.