Details of the Target

General Information of Target

Target ID LDTP14309
Target Name Influenza virus NS1A-binding protein (IVNS1ABP)
Gene Name IVNS1ABP
Gene ID 10625
Synonyms
ARA3; FLARA3; KIAA0850; KLHL39; NS1; NS1BP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl hydrocarbon receptor-associated protein 3; Kelch-like protein 39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRG
GFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTK
KEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPVTDNVEKFAIETELIYKYSPFRT
EEEVMTQFMKIPGDSGTLVIIFNLKLMDNGEPELDIISNPRDIQMAETSPEGTKPERRSF
RAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVAR
IAEEKAREAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQRAL
KEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLV
LEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPS
SELRYKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVEKDYPDTWVCSMNPDPEQDRCEASE
QKQKVPLGTFRKDMKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTR
PSTEEPVRRPQRPRSPPLPAVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAARE
EASTSRLLQPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVV
KKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSA
GEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDR
WVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTA
LSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQN
LCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDEL
DAYIEDLITKGD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
Uniprot ID
Q9Y6Y0
Ensemble ID
ENST00000367498.8
HGNC ID
HGNC:16951

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y376(7.60)  LDD0260  [1]
AHL-Pu-1
 Probe Info  		C274(5.77); C143(4.27)  LDD0171  [2]
HHS-482
 Probe Info  		Y376(0.99)  LDD0285  [3]
HHS-475
 Probe Info  		Y474(0.20); Y376(1.00)  LDD0264  [4]
DBIA
 Probe Info  		C143(1.04); C274(0.89)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C495(0.00); C134(0.00); C482(0.00); C143(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C32(0.00); C381(0.00); C39(0.00); C495(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C32(0.00); C381(0.00); C495(0.00); C482(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
TFBX
 Probe Info  		C32(0.00); C381(0.00); C143(0.00); C121(0.00)  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		C381(0.00); C143(0.00)  LDD0217  [11]
Methacrolein
 Probe Info  		C121(0.00); C134(0.00); C39(0.00)  LDD0218  [11]
AOyne
 Probe Info  		14.70  LDD0443  [12]
NAIA_5
 Probe Info  		C381(0.00); C39(0.00); C495(0.00); C387(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C274(5.77); C143(4.27)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C121(0.92); C134(0.81); C143(1.00); C274(1.27)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C121(1.40); C134(1.28); C143(1.02); C274(1.11)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C121(0.93); C134(0.79); C143(1.02); C274(1.09)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C121(0.97); C134(0.72); C143(0.87); C274(1.23)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C121(0.93); C134(0.74); C143(1.15); C274(1.20)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C121(1.03); C134(0.69); C143(1.01); C274(1.37)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C121(0.94); C134(0.75); C143(1.10); C274(1.07)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C121(0.98); C134(0.78); C143(1.46); C274(1.22)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C121(1.02); C134(0.71); C143(1.41); C274(1.21)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C121(0.96); C134(0.67); C143(1.11); C274(1.08)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C121(0.91); C134(0.66); C143(1.07); C274(1.19)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C121(1.06); C134(0.65); C143(0.96); C274(1.01)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C121(1.24); C134(1.06); C143(1.03); C274(1.15)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C121(1.02); C134(0.71); C143(0.93); C274(1.11)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C121(1.02); C134(0.73); C143(1.08); C274(1.25)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C121(1.03); C134(0.72); C143(1.07); C274(1.31)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C121(0.91); C134(0.94); C143(0.85); C274(1.04)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C121(0.72); C134(0.89); C143(0.99); C274(1.05)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C121(0.66); C134(0.88); C143(1.09); C274(1.12)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C121(0.77); C134(1.02); C143(1.13); C274(1.36)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C121(0.73); C134(1.15); C143(0.87); C274(1.12)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C121(0.89); C134(1.13); C143(1.05); C274(1.02)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C121(0.80); C134(1.09); C143(0.98); C274(1.21)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C121(1.37); C134(1.25); C143(0.97); C274(1.11)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C121(0.73); C134(1.10); C143(0.73); C274(1.17)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C121(0.82); C134(1.19); C143(0.92); C274(1.00)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C121(0.75); C134(1.16); C143(0.96); C274(1.06)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C121(0.92); C134(1.19); C143(0.72); C274(1.01)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C121(0.99); C134(1.00); C143(0.97); C274(1.01)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C121(0.81); C134(1.06); C143(1.00); C274(1.03)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C121(0.79); C134(1.06); C143(1.08); C274(1.11)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C121(0.79); C134(1.19); C143(0.99); C274(1.11)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C134(0.75); C143(0.90); C274(1.10); C39(1.05)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C134(1.28); C143(0.95); C274(1.07); C39(1.12)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C134(0.76); C143(0.90); C274(1.22); C39(1.26)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C134(1.38); C143(0.91); C274(1.10); C39(1.04)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C134(1.09); C143(0.93); C274(1.33); C39(1.30)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C134(0.86); C143(1.11); C274(1.28); C39(1.37)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C134(0.83); C143(1.02); C274(1.35); C39(1.09)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C134(0.74); C143(0.90); C274(1.17); C39(1.08)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C134(0.94); C143(0.94); C274(1.32); C39(1.25)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C134(0.88); C143(0.88); C274(1.45); C39(1.07)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C134(0.79); C143(0.82); C274(1.54); C39(1.02)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C134(0.94); C143(0.98); C274(1.56); C39(1.10)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C121(1.16); C134(1.11); C143(0.87); C274(0.98)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C134(1.00); C143(1.11); C274(1.60); C39(1.14)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C134(0.99); C143(1.07); C274(1.71); C39(1.14)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C134(1.07); C143(0.95); C274(1.31); C39(1.20)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C39(0.79); C121(0.85); C495(0.86); C134(0.94)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C495(0.42); C459(0.61); C121(0.63); C454(0.75)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C495(0.47); C121(0.70); C459(0.81); C454(0.84)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C495(0.47); C121(0.63); C459(0.69); C134(0.69)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C459(0.46); C495(0.57); C121(0.66); C454(0.72)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C459(0.33); C495(0.34); C134(0.61); C121(0.62)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C459(0.45); C495(0.48); C121(0.66); C134(0.69)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C459(0.51); C454(0.76); C134(0.89); C143(0.98)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C495(0.72); C134(0.84); C121(0.86); C459(1.01)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C459(0.70); C134(0.73); C495(0.80); C121(0.81)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C459(0.36); C495(0.43); C121(0.67); C134(0.67)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C495(0.34); C459(0.34); C121(0.63); C134(0.70)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C121(0.73); C134(0.69); C143(1.38); C274(1.22)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C121(0.64); C134(0.62); C143(1.29); C274(1.24)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C121(0.89); C134(0.80); C143(1.03); C274(1.05)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C121(0.79); C134(0.89); C143(1.03); C274(0.94)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C495(0.77); C274(0.94); C39(0.98); C454(1.03)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C495(0.45); C564(0.81); C575(0.81); C39(0.94)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C495(0.77); C134(0.92); C121(1.00); C143(1.04)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C575(0.67); C39(0.88); C134(0.93); C121(0.99)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C495(0.83); C143(0.95); C121(0.99); C134(1.00)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C495(0.66); C121(0.96); C274(0.97); C454(0.99)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C495(0.91); C143(0.95); C121(0.95); C39(0.97)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C495(0.75); C39(0.92); C121(0.93); C143(0.94)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C564(0.88); C575(0.88); C495(0.96); C143(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C564(0.77); C495(0.77); C459(0.78); C575(0.82)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C495(0.62); C459(0.63); C564(0.69); C454(0.80)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C495(0.53); C459(0.55); C564(0.66); C121(0.75)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C459(0.55); C495(0.55); C564(0.72); C454(0.75)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C564(0.56); C495(0.58); C459(0.62); C32(0.64)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C575(0.59); C459(0.93); C454(0.94); C39(0.98)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C495(0.49); C459(0.49); C32(0.62); C121(0.72)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C495(0.55); C459(0.61); C564(0.70); C32(0.80)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C495(0.38); C459(0.45); C121(0.57); C32(0.62)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C495(0.42); C459(0.44); C564(0.58); C32(0.74)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C495(0.34); C459(0.40); C564(0.57); C32(0.60)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C143(0.67); C32(0.93); C274(0.95); C39(0.97)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C143(0.80); C32(0.93); C274(0.94); C39(0.97)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C274(0.81); C143(0.83); C39(0.91); C121(1.00)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C274(0.85); C32(0.88); C143(0.94); C39(1.08)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C143(0.87); C32(0.88); C454(0.90); C459(0.94)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C575(0.61); C459(0.65); C454(0.76); C134(0.84)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C459(0.78); C454(0.85); C143(0.91); C32(0.99)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C32(0.88); C39(0.91); C274(1.01); C143(1.02)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C459(0.91); C39(0.91); C454(0.93); C143(0.97)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C32(0.98); C39(1.04); C121(1.04); C454(1.06)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C459(0.90); C454(0.91); C143(1.02); C39(1.05)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C459(0.78); C454(0.83); C39(0.96); C495(0.98)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C564(0.62); C575(0.62); C32(0.70); C39(0.84)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C564(0.62); C575(0.62); C32(0.84); C39(0.93)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C32(0.75); C39(0.81); C564(0.86); C575(0.86)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C564(0.40); C575(0.40); C32(0.66); C39(0.77)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C575(0.59); C459(0.71); C454(0.81); C134(0.91)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C564(0.52); C575(0.52); C32(0.69); C39(0.81)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C32(0.70); C39(0.87); C274(0.89); C143(1.10)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C564(0.47); C575(0.47); C32(0.70); C39(0.89)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C564(0.53); C575(0.53); C39(0.93); C121(0.93)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C564(0.49); C575(0.49); C32(0.76); C39(0.87)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C564(0.42); C575(0.42); C121(0.91); C134(0.98)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C564(0.34); C575(0.34); C32(0.88); C39(0.90)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C459(0.60); C32(0.62); C454(0.74); C121(0.90)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C32(0.56); C459(0.67); C454(0.83); C134(0.86)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C459(0.47); C32(0.63); C454(0.67); C121(0.87)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C459(0.48); C454(0.79); C32(0.84); C134(0.95)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C32(0.50); C459(0.77); C134(0.90); C121(0.91)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C32(0.54); C121(0.86); C134(0.86); C39(0.99)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C459(0.51); C32(0.62); C454(0.70); C121(0.90)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C32(0.45); C459(0.71); C134(0.79); C454(0.87)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C459(0.53); C32(0.56); C454(0.72); C121(0.93)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C459(0.68); C32(0.75); C454(0.86); C121(0.90)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C32(0.53); C459(0.77); C454(0.94); C134(0.94)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C459(0.39); C32(0.49); C454(0.67); C121(0.83)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C564(0.74); C575(0.74); C495(0.77); C121(0.84)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C495(0.64); C459(0.75); C454(0.77); C564(0.78)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C459(0.68); C454(0.80); C32(0.97); C143(1.03)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C564(0.55); C575(0.55); C495(0.56); C459(0.61)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C143(0.81); C564(0.86); C575(0.86); C32(0.95)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C495(0.61); C459(0.80); C454(0.82); C564(0.87)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C495(0.38); C564(0.47); C575(0.47); C459(0.52)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C495(0.47); C564(0.55); C575(0.55); C459(0.59)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C495(0.37); C564(0.46); C575(0.46); C459(0.49)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C495(0.54); C564(0.64); C575(0.64); C459(0.74)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C564(0.57); C575(0.57); C495(0.58); C459(0.76)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C32(0.82); C121(0.84); C564(0.92); C575(0.92)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C564(0.78); C575(0.78); C32(0.86); C459(0.89)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C459(0.49); C454(0.70); C32(0.96); C143(0.98)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C495(0.70); C459(0.73); C454(0.73); C564(0.74)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C564(0.81); C575(0.81); C495(0.86); C32(0.90)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C495(0.36); C564(0.39); C575(0.39); C459(0.41)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C495(0.39); C459(0.43); C134(0.50); C454(0.59)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C495(0.44); C459(0.47); C134(0.50); C454(0.69)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C134(0.64); C459(0.67); C495(0.78); C454(0.83)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C495(0.63); C459(0.70); C454(0.84); C39(0.91)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C134(0.63); C121(0.84); C274(0.92); C495(1.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C134(0.55); C495(0.61); C459(0.67); C454(0.86)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C495(0.50); C459(0.64); C134(0.75); C454(0.81)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C274(0.88); C32(0.98); C121(1.03); C39(1.11)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C495(0.39); C459(0.40); C454(0.58); C134(0.58)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C495(0.37); C459(0.37); C454(0.60); C134(0.67)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C495(0.61); C134(0.61); C459(0.64); C454(0.75)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C495(0.73); C459(0.84); C134(0.87); C454(0.89)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C134(0.69); C121(0.86); C495(0.88); C39(0.91)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C134(0.40); C495(0.55); C459(0.70); C454(0.79)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C459(0.41); C495(0.43); C121(0.67); C454(0.68)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C134(0.72); C39(0.99); C121(1.11); C454(1.23)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C134(0.88); C143(0.93); C121(1.11); C274(1.17)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C121(1.43); C134(1.07); C143(0.92); C274(1.01)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C459(0.66); C454(0.78); C143(1.01); C274(1.11)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C459(0.32); C454(0.71); C32(0.89); C134(1.00)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C143(1.04); C274(0.89)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C274(0.00); C134(0.00); C381(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C274(20.00); C381(0.39)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C32(0.82); C143(0.91); C121(1.01); C274(1.10)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C121(0.84); C495(1.00); C143(1.10); C32(1.12)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C459(0.68); C575(0.70); C454(0.78); C121(0.96)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C459(0.43); C454(0.66); C143(0.89); C32(1.07)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C459(0.76); C454(0.79); C143(0.93); C274(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C459(0.65); C454(0.73); C143(0.97); C274(0.98)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C459(0.68); C454(0.82); C143(0.90); C274(1.08)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C495(0.53); C564(0.88); C575(0.88); C121(0.88)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C495(0.53); C134(0.75); C564(0.84); C575(0.84)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C495(0.44); C564(0.70); C575(0.70); C134(0.86)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C495(0.39); C564(0.59); C575(0.59); C134(0.87)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C495(0.60); C121(0.78); C564(0.83); C575(0.83)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C459(0.80); C121(0.86); C454(0.96); C32(0.98)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C495(0.50); C134(0.77); C121(0.96); C143(1.00)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C495(0.62); C121(0.93); C564(0.96); C575(0.96)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C495(0.73); C143(0.79); C459(0.79); C121(0.80)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C495(0.38); C459(0.44); C32(0.61); C121(0.63)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C495(0.51); C32(0.54); C459(0.67); C121(0.80)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C459(0.52); C495(0.65); C564(0.66); C32(0.67)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C32(0.64); C564(0.65); C495(0.67); C459(0.69)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C459(0.59); C495(0.75); C454(0.79); C39(0.95)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C39(0.93); C32(0.93); C454(0.93); C459(0.94)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C459(0.89); C454(0.90); C32(0.91); C39(0.93)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C459(0.86); C121(0.90); C454(1.02); C495(1.07)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C274(0.92); C32(0.95); C39(0.95); C143(0.98)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C39(0.87); C32(0.88); C143(1.00); C134(1.13)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C564(0.70); C575(0.70); C32(0.77); C121(0.80)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C564(0.61); C575(0.61); C32(0.68); C121(0.80)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C564(0.46); C575(0.46); C32(0.78); C39(0.87)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C32(0.71); C121(0.99); C459(1.00); C134(1.01)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C32(0.83); C459(0.88); C121(0.90); C134(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C32(0.54); C121(0.82); C459(0.93); C454(1.05)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C459(0.49); C32(0.54); C454(0.74); C121(0.87)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C121(0.77); C32(1.02); C454(1.11); C495(1.12)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C32(0.74); C121(0.86); C274(1.08); C454(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C121(0.70); C32(0.84); C143(1.03); C454(1.08)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C459(0.62); C121(0.68); C495(0.82); C134(0.96)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C134(0.76); C121(0.77); C459(0.92); C454(0.96)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C134(0.64); C121(0.65); C39(0.98); C274(1.12)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C459(0.65); C121(0.71); C134(0.76); C495(0.85)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C32(0.75); C143(0.99); C274(1.00); C121(1.07)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C495(0.51); C459(0.58); C134(0.72); C121(0.79)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C459(0.47); C495(0.52); C134(0.64); C121(0.69)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C459(0.33); C495(0.38); C134(0.69); C121(0.76)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C459(0.51); C495(0.61); C121(0.73); C134(0.76)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C459(0.45); C495(0.50); C121(0.68); C134(0.74)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C121(0.67); C134(0.78); C143(1.42); C274(1.37)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C121(0.81); C134(0.84); C143(1.31); C274(1.07)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C121(0.74); C134(0.78); C143(1.43); C274(1.06)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C121(0.72); C134(0.68); C143(1.42); C274(1.23)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C121(0.75); C134(0.75); C143(1.68); C274(1.18)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C121(1.05); C143(1.08); C274(0.98); C32(0.71)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C121(0.75); C134(0.93); C143(1.30); C274(1.00)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C121(0.76); C134(0.70); C143(0.83); C274(1.08)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C121(0.82); C134(0.63); C143(0.79); C274(1.26)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C121(0.59); C134(0.64); C143(1.29); C274(1.30)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C121(0.81); C134(0.57); C143(1.07); C274(1.33)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C121(0.72); C134(0.60); C143(1.02); C274(1.31)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C121(0.67); C134(0.66); C143(1.12); C274(1.21)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C121(0.67); C134(0.68); C143(1.22); C274(1.23)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C121(0.70); C134(0.71); C143(1.20); C274(1.40)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C121(0.87); C143(1.07); C274(0.96); C32(0.97)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C121(0.62); C134(0.72); C143(1.14); C274(1.41)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C121(0.76); C134(0.67); C143(1.04); C274(1.18)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C121(0.74); C134(0.60); C143(1.09); C274(1.78)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C121(0.71); C134(0.66); C143(1.20); C274(1.32)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C121(0.72); C134(0.61); C143(1.05); C274(1.33)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C121(0.73); C134(0.72); C143(1.17); C274(1.57)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C121(0.85); C134(1.01); C143(0.99); C274(0.84)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C121(0.85); C134(1.44); C143(1.03); C274(0.83)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C121(0.90); C134(1.36); C143(1.08); C274(0.71)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C121(0.81); C134(1.09); C143(0.89); C274(0.87)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C121(0.85); C143(1.16); C274(1.01); C32(0.90)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C121(0.87); C134(1.50); C143(0.95); C274(0.93)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C121(0.93); C134(1.51); C143(1.17); C274(0.80)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C121(0.88); C134(1.09); C143(1.05); C274(0.92)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C121(0.88); C134(1.06); C143(0.87); C274(0.94)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C121(1.03); C134(1.05); C143(0.91); C274(0.87)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C121(0.82); C134(1.05); C143(0.89); C274(0.84)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C121(0.87); C134(1.05); C143(0.84); C274(0.84)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C121(0.76); C134(1.17); C143(0.90); C274(0.90)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C121(1.14); C134(1.09); C143(0.85); C274(0.83)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C121(0.87); C134(1.49); C143(0.98); C274(0.87)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C121(0.71); C143(1.07); C274(1.21); C32(0.75)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C121(0.85); C134(1.14); C143(1.02); C274(0.91)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C121(0.90); C134(0.87); C143(0.96); C274(1.09)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C121(0.80); C134(0.84); C143(1.27); C274(1.16)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C121(0.70); C134(0.73); C143(1.37); C274(1.38)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C121(0.76); C134(0.71); C143(1.20); C274(1.17)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C121(0.87); C134(1.02); C143(1.22); C274(1.21)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C121(0.72); C134(0.73); C143(1.20); C274(1.43)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C121(0.72); C134(0.73); C143(1.17); C274(1.16)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C121(0.67); C134(0.82); C143(1.11); C274(1.18)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C121(0.68); C134(0.79); C143(1.17); C274(1.09)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C121(0.93); C143(1.26); C274(1.21); C32(1.02)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C121(0.74); C134(0.74); C143(0.99); C274(1.38)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C121(0.80); C134(0.72); C143(1.05); C274(1.31)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C121(0.82); C134(0.87); C143(1.05); C274(1.13)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C121(0.73); C134(0.86); C143(1.23); C274(1.39)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C121(0.77); C134(0.75); C143(1.18); C274(1.19)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C121(0.86); C134(0.92); C143(1.06); C274(1.03)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C121(1.16); C134(0.90); C143(1.43); C274(0.96)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C121(0.91); C134(1.18); C143(1.00); C274(1.03)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C121(0.88); C134(0.89); C143(1.23); C274(1.19)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C121(0.78); C143(1.33); C274(1.58); C32(0.55)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C121(0.83); C134(1.21); C143(0.90); C274(1.02)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C121(0.98); C134(0.94); C143(0.98); C274(1.06)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C121(0.78); C134(1.16); C143(1.25); C274(1.28)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C121(0.84); C134(1.08); C143(1.14); C274(1.41)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C121(1.03); C134(0.93); C143(1.44); C274(1.61)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C121(0.87); C134(0.99); C143(1.02); C274(1.15)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C121(0.95); C134(0.81); C143(1.00); C274(1.07)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C121(0.91); C134(0.91); C143(1.03); C274(1.20)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C121(0.90); C134(1.07); C143(1.04); C274(1.28)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C121(0.84); C134(1.36); C143(1.30); C274(1.70)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C121(0.85); C143(1.01); C274(1.17); C32(0.98)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C121(1.34); C134(1.08); C143(0.84); C274(1.14)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C121(0.87); C134(0.85); C143(1.08); C274(1.11)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C121(0.92); C134(0.77); C143(1.03); C274(1.13)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C121(0.99); C134(0.85); C143(1.02); C274(0.97)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C121(0.87); C134(0.73); C143(0.92); C274(1.27)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C121(0.80); C134(0.67); C143(1.00); C274(1.44)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C121(0.84); C134(0.91); C143(1.10); C274(1.13)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C121(0.92); C134(0.97); C143(1.07); C274(1.34)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C121(0.93); C134(0.90); C143(1.04); C274(1.33)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C121(1.00); C134(0.78); C143(1.12); C274(1.26)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C143(1.08)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C39(1.08); C32(1.07); C143(0.92); C274(0.97)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C121(0.71); C134(0.84); C143(1.07); C274(1.11)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C121(0.75); C134(0.63); C143(1.15); C274(1.56)  LDD0744  [5]
 LDCM0116  HHS-0101 DM93 Y474(0.20); Y376(1.00)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y376(0.83)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y474(0.56); Y376(0.86)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y474(0.52); Y376(0.96)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y376(1.03)  LDD0268  [4]
 LDCM0123  JWB131 DM93 Y376(0.99)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y376(0.56)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y376(1.37)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y376(1.90)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y376(1.87)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y376(1.01)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y376(0.42)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y376(0.98)  LDD0292  [3]
 LDCM0022  KB02 HCT 116 C274(1.60); C143(1.58); C39(1.04)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C274(1.07); C143(1.32); C39(1.11)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C274(1.64); C143(1.50); C39(0.95)  LDD0082  [5]
 LDCM0170  Structure8 Ramos 5.97  LDD0433  [16]
 LDCM0021  THZ1 HCT 116 C274(0.92); C143(0.89)  LDD2173  [5]

References

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2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.