Details of the Target

General Information of Target

Target ID LDTP08536
Target Name Coiled-coil domain-containing protein 117 (CCDC117)
Gene Name CCDC117
Gene ID 150275
Synonyms
Coiled-coil domain-containing protein 117
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALGRPFSGLPLSGGSDFLQPPQPAFPGRAFPPGADGAELAPRPGPRAVPSSPAGSAAR
GRVSVHCKKKHKREEEEDDDCPVRKKRITEAELCAGPNDWILCAHQDVEGHGVNPSVSGL
SIPGILDVICEEMDQTTGEPQCEVARRKLQEIEDRIIDEDEEVEADRNVNHLPSLVLSDT
MKTGLKREFDEVFTKKMIESMSRPSMELVLWKPLPELLSDKPKPSSNTKNYTGESQAKHV
AAGTAFPQRTELFSEPRPTGMSLYNSLETATSTEEEMEL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, spindle
Function Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B.
Uniprot ID
Q8IWD4
Ensemble ID
ENST00000249064.9
HGNC ID
HGNC:26599

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 Insertion: p.K148EfsTer6 .
HCT15 SNV: p.R187M .
HT115 SNV: p.I157S .
HT29 SNV: p.A237G .
MEWO SNV: p.P115L .
ONS76 SNV: p.T183R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C81(9.89)  LDD0169  [2]
DBIA
 Probe Info  		C81(239.02); C81(52.12); C81(31.56)  LDD0209  [3]
HHS-465
 Probe Info  		Y231(10.00)  LDD2237  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		C81(0.00); C67(0.00)  LDD0018  [9]
AOyne
 Probe Info  		14.70  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C81(9.89)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C81(1.10)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C81(1.05)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C81(1.09)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C81(0.96)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C81(0.85)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C81(0.99)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C81(1.13)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C81(1.08)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C81(1.54)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C81(1.05)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C81(0.95)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C81(0.97)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C81(0.87)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C81(0.94)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C81(0.96)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C81(1.10)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C81(1.01)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C81(1.14)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C81(0.94)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C81(0.97)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C81(1.01)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C81(0.92)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C81(0.95)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C81(1.03)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C81(1.16)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C81(0.97)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C81(1.09)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C81(1.01)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C81(0.98)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C81(0.84)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C81(0.98)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C81(1.04)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C81(1.00)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C81(1.10)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C81(1.02)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C81(1.09)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C81(1.08)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C81(1.02)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C81(0.93)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C81(1.03)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C81(1.04)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C81(1.14)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C81(1.03)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C81(0.99)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C81(1.10)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C81(1.00)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C81(0.99)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C81(0.95)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C81(0.98)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C81(1.06)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C81(1.20)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C81(1.07)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C81(1.05)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C81(1.06)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C81(1.07)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C81(1.08)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C81(1.07)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C81(1.07)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C81(1.25)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C81(1.01)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C81(1.16)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C81(1.02)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C81(1.06)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C81(0.99)  LDD1514  [11]
 LDCM0632  CL-Sc Hep-G2 C81(0.65)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C81(0.97)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C81(0.95)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C81(0.94)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C81(1.02)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C81(1.02)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C81(1.03)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C81(0.89)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C81(1.08)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C81(1.00)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C81(0.97)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C81(0.96)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C81(0.93)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C81(0.80)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C81(0.94)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C81(1.01)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C81(0.87)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C81(0.92)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C81(0.98)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C81(1.18)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C81(0.79)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C81(1.06)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C81(1.20)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C81(1.02)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C81(0.91)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C81(0.94)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C81(1.05)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C81(1.09)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C81(1.08)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C81(0.87)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C81(1.42)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C81(1.11)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C81(1.22)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C81(1.05)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C81(1.14)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C81(1.06)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C81(1.06)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C81(0.95)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C81(1.08)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C81(0.92)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C81(1.15)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C81(1.10)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C81(0.91)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C81(0.99)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C81(0.77)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C81(0.86)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C81(0.86)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C81(1.08)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C81(0.99)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C81(1.14)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C81(0.95)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C81(1.01)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C81(1.06)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C81(0.91)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C81(1.20)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C81(0.91)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C81(1.09)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C81(0.81)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C81(0.88)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C81(0.92)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C81(1.05)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C81(1.17)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C81(0.74)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C81(0.93)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C81(1.01)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C81(1.05)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C81(1.19)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C81(0.94)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C81(1.14)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C81(0.83)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C81(0.88)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C81(0.97)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C81(1.15)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C81(1.01)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C81(1.03)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C81(0.94)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C81(1.10)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C81(0.95)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C81(1.13)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C81(1.05)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C81(1.17)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C81(0.86)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C81(0.90)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C81(0.92)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C81(0.98)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C81(1.23)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C81(1.01)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C81(1.14)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C81(0.93)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C81(1.17)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C81(1.02)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C81(1.09)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C81(0.99)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C81(1.11)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C81(1.20)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C81(0.80)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C81(0.92)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C81(0.99)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C81(1.12)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C81(1.05)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C81(1.04)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C81(1.19)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C81(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C81(1.06)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C81(1.03)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C81(0.93)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C81(1.11)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C81(0.87)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C81(0.85)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C81(0.94)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C81(1.63)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C81(1.21)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C81(1.41)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C81(0.88)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C81(1.29)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C81(0.97)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C81(1.28)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C81(1.03)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C81(1.00)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C81(1.05)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C81(0.92)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C81(0.93)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C81(1.31)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C81(0.96)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C81(0.97)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C81(1.25)  LDD1697  [11]
 LDCM0634  CY-0357 Hep-G2 C81(50.00); C81(0.74)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C81(1.48)  LDD1698  [11]
 LDCM0625  F8 Ramos C81(1.80)  LDD2187  [12]
 LDCM0573  Fragment11 Ramos C81(13.15)  LDD2190  [12]
 LDCM0575  Fragment13 Ramos C81(1.26)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C81(1.02)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C81(0.88)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C81(0.90)  LDD2195  [12]
 LDCM0586  Fragment28 Ramos C81(0.76)  LDD2198  [12]
 LDCM0589  Fragment31 Ramos C81(1.51)  LDD2200  [12]
 LDCM0468  Fragment33 HEK-293T C81(1.15)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C81(2.23)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C81(0.95)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C81(1.02)  LDD1631  [11]
 LDCM0614  Fragment56 Ramos C81(2.07)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C81(1.16)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C81(1.37)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C81(0.97)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C81(239.02); C81(52.12); C81(31.56)  LDD0209  [3]
 LDCM0024  KB05 HEK-293T C81(0.99)  LDD1502  [11]
 LDCM0170  Structure8 Ramos 5.07  LDD0433  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stress-induced-phosphoprotein 1 (STIP1) . P31948

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.