Details of the Target

General Information of Target

Target ID LDTP01090
Target Name Nibrin (NBN)
Gene Name NBN
Gene ID 4683
Synonyms
NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQT
DEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCL
DVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEF
LKAVESKKQPPQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSS
AVVFGGGEARLITEENEEEHNFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQ
GLRPIPEAEIGLAVIFMTTKNYCDPQGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNT
TTYVADTESEQADTWDLSERPKEIKVSKMEQKFRMLSQDAPTVKESCKTSSNNNSMVSNT
LAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNSIRNYFQPSTKKRERDEENQEMSSCKS
ARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSDNNLFTDTDLKSIVKNSASKSH
AAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQEEDVNVRKRPRMDIETN
DTFSDEAVPESSKISQENEIGKKRELKEDSLWSAKEISNNDKLQDDSEMLPKKLLLTEFR
SLVIKNSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELE
EWLRQEMEVQNQHAKEESLADDLFRYNPYLKRRR
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Uniprot ID
O60934
Ensemble ID
ENST00000265433.8
HGNC ID
HGNC:7652
ChEMBL ID
CHEMBL5169101

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y74(20.00)  LDD0257  [2]
STPyne
 Probe Info  		K544(8.13); K715(5.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y679(6.05); Y693(57.87); Y746(14.51)  LDD3495  [4]
BTD
 Probe Info  		C323(0.83)  LDD2100  [5]
DBIA
 Probe Info  		C478(1.00); C487(0.96)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		C407(0.00); C478(0.00); C487(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD0147  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		C407(0.00); C478(0.00); C487(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C323(0.00); C487(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		14.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C323(0.80)  LDD2112  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C323(1.31)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C487(10.54)  LDD0371  [14]
 LDCM0214  AC1 HEK-293T C116(1.06); C119(1.09)  LDD0812  [6]
 LDCM0215  AC10 HCT 116 C116(0.45); C119(0.45)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C163(0.93); C167(0.93)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C163(0.74); C167(0.74)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C163(0.74); C167(0.74)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C163(0.83); C167(0.83)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C163(0.82); C167(0.82)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C163(1.05); C167(1.05)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C163(0.88); C167(0.88)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C163(0.78); C167(0.73)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C163(0.71); C167(0.95)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C163(0.90); C167(0.93)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C116(0.55); C119(0.55)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C163(0.99); C167(1.05)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C163(0.90); C167(0.87)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C163(0.71); C167(0.76)  LDD0546  [6]
 LDCM0230  AC113 HEK-293T C163(1.08); C269(1.09)  LDD0828  [6]
 LDCM0231  AC114 HEK-293T C163(1.12); C269(1.11)  LDD0829  [6]
 LDCM0232  AC115 HEK-293T C163(0.95); C269(0.89)  LDD0830  [6]
 LDCM0233  AC116 HEK-293T C163(1.58); C269(1.24)  LDD0831  [6]
 LDCM0234  AC117 HEK-293T C163(1.54); C269(1.52)  LDD0832  [6]
 LDCM0235  AC118 HEK-293T C163(1.64); C269(1.19)  LDD0833  [6]
 LDCM0236  AC119 HEK-293T C163(1.76); C269(1.49)  LDD0834  [6]
 LDCM0237  AC12 HCT 116 C116(0.56); C119(0.56)  LDD0554  [6]
 LDCM0238  AC120 HEK-293T C163(1.34); C269(1.16)  LDD0836  [6]
 LDCM0239  AC121 HEK-293T C163(1.54); C269(1.21)  LDD0837  [6]
 LDCM0240  AC122 HEK-293T C163(1.89); C269(1.21)  LDD0838  [6]
 LDCM0241  AC123 HEK-293T C163(1.96); C269(1.38)  LDD0839  [6]
 LDCM0242  AC124 HEK-293T C163(1.37); C269(1.38)  LDD0840  [6]
 LDCM0243  AC125 HEK-293T C163(1.89); C269(1.63)  LDD0841  [6]
 LDCM0244  AC126 HEK-293T C163(2.02); C269(2.52)  LDD0842  [6]
 LDCM0245  AC127 HEK-293T C163(2.06); C269(2.57)  LDD0843  [6]
 LDCM0246  AC128 HEK-293T C116(0.62); C119(0.62); C163(0.76); C167(0.76)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C116(0.58); C119(0.58); C163(0.69); C167(0.69)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C116(0.71); C119(0.71); C163(0.63); C167(0.63)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C116(0.51); C119(0.51); C163(0.81); C167(0.81)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C116(0.49); C119(0.49); C163(0.67); C167(0.67)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C116(0.58); C119(0.58); C163(0.76); C167(0.76)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C116(0.74); C119(0.74); C163(0.69); C167(0.69)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C116(0.58); C119(0.58); C163(0.82); C167(0.82)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C116(1.09); C119(1.09); C163(1.13); C167(1.13)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C116(0.55); C119(0.55); C163(0.70); C167(0.70)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C116(0.51); C119(0.51); C163(0.75); C167(0.75)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C116(0.60); C119(0.60); C163(0.61); C167(0.61)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C116(0.42); C119(0.42)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C116(0.63); C119(0.63); C163(0.93); C167(0.93)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C116(0.63); C119(0.63); C163(0.79); C167(0.79)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C116(0.53); C119(0.53); C163(0.65); C167(0.65)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C116(0.92); C119(0.92)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C116(1.16); C119(1.16)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C116(0.65); C119(0.65)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C116(0.67); C119(0.67)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C116(0.75); C119(0.75)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C116(0.77); C119(0.77)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C116(0.98); C119(0.98)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C116(0.43); C119(0.43)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C116(0.91); C119(0.91)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C116(0.73); C119(0.73)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C116(0.89); C119(0.89)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C116(0.98); C119(0.98)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C116(0.97); C119(0.97)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C116(0.94); C119(0.94)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C116(1.27); C119(1.27)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C116(1.73); C119(1.73)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C116(0.61); C119(0.61); C163(0.61); C167(0.61)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C116(0.64); C119(0.64); C163(0.80); C167(0.80)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C116(0.70); C119(0.70); C163(0.69); C167(0.69)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C116(1.15); C119(1.23)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C116(0.66); C119(0.66); C163(0.94); C167(0.94)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C116(0.96); C119(0.96); C163(0.98); C167(0.98)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C116(0.81); C119(0.81); C163(1.00); C167(1.00)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C116(1.01); C119(1.01); C163(1.04); C167(1.04)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C116(0.90); C119(0.90); C163(0.96); C167(0.96)  LDD0882  [6]
 LDCM0285  AC25 HCT 116 C116(1.01); C119(1.01)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C116(1.00); C119(1.00)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C116(0.89); C119(0.89)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C116(1.58); C119(1.58)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C116(1.09); C119(1.09)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C116(0.93); C119(1.12)  LDD0888  [6]
 LDCM0291  AC30 HCT 116 C116(1.04); C119(1.04)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C116(1.06); C119(1.06)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C116(1.02); C119(1.02)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C116(1.02); C119(1.02)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C116(1.01); C119(1.01)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C116(0.89); C163(0.93); C167(0.93)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C116(1.10); C163(0.99); C167(0.99)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C116(1.20); C163(0.72); C167(0.72)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C116(1.04); C163(1.41); C167(1.41)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C116(1.19); C163(1.42); C167(1.42)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C116(1.03); C119(1.22)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C116(1.10); C163(1.03); C167(1.03)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C116(1.05); C163(1.15); C167(1.15)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C116(1.09); C163(0.80); C167(0.80)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C116(1.16); C163(0.74); C167(0.74)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C116(1.30); C163(0.94); C167(0.94)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C116(1.07); C163(1.05); C167(1.05)  LDD0905  [6]
 LDCM0308  AC46 HCT 116 C116(1.66); C119(1.66)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C116(1.55); C119(1.55)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C116(1.08); C119(1.08)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C116(1.16); C119(1.16)  LDD0628  [6]
 LDCM0312  AC5 HEK-293T C116(1.09); C119(1.03)  LDD0910  [6]
 LDCM0313  AC50 HCT 116 C116(1.02); C119(1.02)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C116(1.02); C119(1.02)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C116(1.07); C119(1.07)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C116(1.14); C119(1.14)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C116(1.05); C119(1.05)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C116(0.91); C119(0.91)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C116(1.15); C119(1.15)  LDD0636  [6]
 LDCM0320  AC57 HEK-293T C116(0.92); C163(0.87); C167(0.87); C269(0.89)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C116(1.04); C163(0.90); C167(0.90); C269(0.85)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C116(0.93); C163(0.85); C167(0.85); C269(0.82)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C116(0.48); C119(0.48)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C116(0.76); C163(0.88); C167(0.88); C269(0.69)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C116(1.32); C163(1.09); C167(1.09); C269(1.08)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C116(1.00); C163(0.99); C167(0.99); C269(0.73)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C116(0.94); C163(0.87); C167(0.87); C269(0.91)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C116(0.84); C163(1.00); C167(1.00); C269(0.93)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C116(1.04); C163(0.98); C167(0.98); C269(0.96)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C116(0.84); C163(0.91); C167(0.91); C269(0.86)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C116(1.13); C163(0.96); C167(0.96); C269(1.02)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C116(0.81); C119(0.81); C163(1.19); C167(1.19)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C116(0.93); C119(0.93); C163(1.20); C167(1.20)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C116(0.41); C119(0.41)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C116(0.69); C119(0.69); C163(1.09); C167(1.09)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C116(0.86); C119(0.86); C163(1.19); C167(1.19)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C116(1.03); C119(1.03); C163(1.16); C167(1.16)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C116(0.88); C119(0.88); C163(1.32); C167(1.32)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C116(0.75); C119(0.75); C163(1.55); C167(1.55)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C116(0.96); C119(0.96); C163(1.13); C167(1.13)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C116(0.85); C119(0.85); C163(1.14); C167(1.14)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C116(0.89); C119(0.89); C163(1.26); C167(1.26)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C116(1.17); C119(1.17); C163(1.20); C167(1.20)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C116(0.77); C119(0.77); C163(1.16); C167(1.16)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C116(0.42); C119(0.42)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C116(0.94); C119(0.94); C163(1.09); C167(1.09)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C163(0.80); C167(0.80); C116(0.93); C119(0.93)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C116(0.87); C119(0.87); C163(1.05); C167(1.05)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C116(0.53); C119(0.53); C163(1.24); C167(1.24)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C116(0.49); C119(0.49); C163(1.13); C167(1.13)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C116(0.49); C119(0.49); C163(0.97); C167(0.97)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C116(0.64); C119(0.64); C163(1.16); C167(1.16)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C116(0.64); C119(0.64); C163(1.03); C167(1.03)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C116(0.65); C119(0.65); C163(1.01); C167(1.01)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C116(0.66); C119(0.66); C163(1.28); C167(1.28)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C116(0.86); C119(0.86); C163(1.02); C167(1.02)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C116(0.60); C119(0.60); C163(1.32); C167(1.32)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C116(0.65); C119(0.65); C163(1.21); C167(1.21)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C116(0.84); C119(0.84); C163(1.14); C167(1.14)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C116(0.81); C119(0.81); C163(1.18); C167(1.18)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C116(0.88); C119(0.88); C163(1.12); C167(1.12)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C116(0.80); C119(0.80); C163(1.09); C167(1.09)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C116(0.68); C119(0.68); C163(1.28); C167(1.28)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C163(0.86); C167(0.86)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C163(0.95); C167(0.95)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C116(0.60); C119(0.60)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C116(0.41); C119(0.41)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C116(0.41); C119(0.41)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C478(1.00); C487(0.96)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C269(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C163(0.88); C167(0.88)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C163(0.88); C167(0.88)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C116(1.38); C119(1.28)  LDD0967  [6]
 LDCM0370  CL101 HCT 116 C116(0.55); C119(0.55)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C116(0.34); C119(0.34)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C116(0.72); C119(0.72)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C116(0.69); C119(0.69)  LDD0690  [6]
 LDCM0374  CL105 HEK-293T C116(1.24); C119(1.24); C163(1.15); C167(1.15)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C116(0.96); C119(0.96); C163(0.70); C167(0.70)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C116(1.13); C119(1.13); C163(0.93); C167(0.93)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C116(0.70); C119(0.70); C163(0.64); C167(0.64)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C116(0.96); C119(0.96); C163(0.91); C167(0.91)  LDD0976  [6]
 LDCM0379  CL11 HCT 116 C163(1.02); C167(1.02)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C116(0.65); C119(0.65); C163(0.69); C167(0.69)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C116(0.92); C119(0.92); C163(0.95); C167(0.95)  LDD0979  [6]
 LDCM0382  CL112 HCT 116 C116(1.15); C119(1.15)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C116(1.03); C119(1.03)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C116(1.03); C119(1.03)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C116(1.16); C119(1.16)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C116(1.05); C119(1.05)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C116(0.86); C163(1.19); C167(1.19)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C116(0.93); C163(0.93); C167(0.93)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C116(1.27); C163(1.08); C167(1.08)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C163(1.10); C167(1.10)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C116(1.22); C163(1.39); C167(1.39)  LDD0989  [6]
 LDCM0392  CL121 HCT 116 C116(1.46); C119(1.46)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C116(0.96); C119(0.96)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C116(1.30); C119(1.30)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C116(0.98); C119(0.98)  LDD0712  [6]
 LDCM0396  CL125 HEK-293T C116(0.96); C163(0.96); C167(0.96); C269(0.86)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C116(0.88); C163(0.82); C167(0.82); C269(0.79)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C116(0.69); C163(0.77); C167(0.77); C269(0.83)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C116(0.74); C163(0.88); C167(0.88); C269(0.86)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C163(1.03); C167(1.03)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C163(0.91); C167(0.91)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C163(0.98); C167(0.98)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C116(1.11); C119(1.56); C163(1.00); C167(0.90)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C116(0.70); C119(0.88); C163(0.72); C167(0.61)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C116(0.90); C119(0.97); C163(1.26); C167(0.75)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C116(0.96); C119(0.98); C163(0.96); C167(0.90)  LDD1004  [6]
 LDCM0407  CL2 HCT 116 C163(0.90); C167(0.90)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C116(0.70); C119(1.03); C163(0.82); C167(0.72)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C116(0.72); C119(0.98); C163(1.13); C167(0.81)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C116(0.69); C119(1.00); C163(1.14); C167(0.73)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C116(0.80); C119(0.94); C163(0.87); C167(0.77)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C116(0.79); C119(0.98); C163(0.87); C167(0.62)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C116(0.76); C119(0.92); C163(0.81); C167(0.67)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C116(0.81); C119(0.87); C163(0.91); C167(0.78)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C116(0.90); C119(1.01); C163(0.97); C167(0.84)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C116(0.68); C119(0.94); C163(0.95); C167(0.78)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C116(0.82); C119(0.90); C163(1.11); C167(0.86)  LDD1015  [6]
 LDCM0418  CL3 HCT 116 C163(0.85); C167(0.85)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C116(0.73); C119(0.86); C163(0.93); C167(0.69)  LDD1017  [6]
 LDCM0420  CL31 HCT 116 C116(0.97); C119(0.97)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C116(0.99); C119(0.99)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C116(1.04); C119(1.04)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C116(1.13); C119(1.13)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C116(1.21); C119(1.21)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C116(1.05); C119(1.05)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C116(1.29); C119(1.29)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C116(1.17); C119(1.17)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C163(0.95); C167(0.95)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C116(0.95); C119(0.95)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C116(0.88); C119(0.88)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C116(0.83); C119(0.83)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C116(1.33); C119(1.33)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C116(1.20); C119(1.20)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C116(1.02); C119(1.02)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C116(1.56); C119(1.56)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C116(1.38); C119(1.38)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C116(1.65); C119(1.65)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C116(1.88); C119(1.88)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C163(1.00); C167(1.00)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C116(1.45); C119(1.45)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C116(1.62); C119(1.62)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C116(1.33); C119(1.33)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C116(1.94); C119(1.94)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C116(1.84); C119(1.84)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C116(2.00); C119(2.00)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C116(1.03); C119(1.03)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C116(1.21); C119(1.21)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C116(1.52); C119(1.52)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C116(1.40); C119(1.40)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C163(1.08); C167(1.08)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C116(1.47); C119(1.47)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C116(0.97); C119(0.97)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C116(0.96); C119(0.96)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C116(0.68); C119(0.68)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C116(0.77); C119(0.77)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C116(0.77); C119(0.77)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C116(0.73); C119(0.73)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C116(0.75); C119(0.75)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C116(0.58); C119(0.58)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C116(1.12); C119(1.12)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C163(0.84); C167(0.84)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C116(0.94); C119(0.94)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C116(0.73); C119(0.73)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C116(0.72); C119(0.72)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C116(0.74); C119(0.74)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C116(0.71); C119(0.71)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C116(0.98); C119(0.98); C163(0.92)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C116(0.90); C119(0.90); C163(1.18)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C116(1.00); C119(1.00); C163(0.68)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C116(0.96); C119(0.96); C163(1.10)  LDD1070  [6]
 LDCM0473  CL8 HCT 116 C163(1.12); C167(1.12)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C116(0.90); C119(0.90); C163(1.02)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C116(1.07); C119(1.07); C163(1.99)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C116(1.06); C119(1.06); C163(1.20)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C116(1.06); C119(1.06); C163(1.28)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C116(0.75); C119(0.75); C163(1.07)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C116(0.80); C119(0.80); C163(0.74)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C116(0.81); C119(0.81); C163(0.76)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C116(0.90); C119(0.90); C163(1.08)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C116(0.75); C119(0.75); C163(0.94)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C116(1.11); C119(1.11); C163(1.26)  LDD1081  [6]
 LDCM0484  CL9 HCT 116 C163(1.15); C167(1.15)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C116(0.73); C119(0.73); C163(1.61)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C116(0.92); C119(1.17)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C116(0.93); C119(1.06)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C116(1.12); C119(1.21)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C116(1.50); C119(1.35)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C116(1.57); C119(1.19)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C116(1.25); C119(1.27)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C116(1.14); C119(1.33)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C116(1.16); C119(1.23)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C116(1.08); C119(0.97)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C478(1.02); C323(0.91); C31(0.98); C487(1.05)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C31(2.30); C323(1.38)  LDD1702  [5]
 LDCM0625  F8 Ramos C487(1.08); C478(1.40)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C487(0.66); C478(1.65)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C487(0.59)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C487(1.47); C478(1.11)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C487(0.84); C478(0.96)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C487(0.84); C478(0.89)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C487(0.59); C478(0.92)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C487(1.50); C478(0.93)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C487(1.22); C478(1.78)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C487(1.60); C478(1.02)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C487(1.57); C478(0.69)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C487(0.84); C478(1.40)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C487(1.29); C478(1.18)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C487(0.78); C478(1.68)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C116(0.61); C119(0.61)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C487(1.71); C478(1.04)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C487(1.39); C478(1.17)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C116(0.95); C119(0.95)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C487(0.71); C478(1.21)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C487(0.81); C478(1.68)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C487(1.07); C478(1.46)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C487(0.67); C478(1.40)  LDD2188  [16]
 LDCM0022  KB02 HCT 116 C487(1.97); C478(1.27)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C487(1.32); C478(1.41)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C487(1.60); C478(0.91)  LDD0082  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C323(0.83)  LDD2100  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C323(0.75)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C323(0.63)  LDD2114  [5]
 LDCM0131  RA190 MM1.R C487(1.09)  LDD0304  [17]
 LDCM0170  Structure8 Ramos 4.99  LDD0433  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA endonuclease RBBP8 (RBBP8) COM1/SAE2/CtIP family Q99708
Double-strand break repair protein MRE11 (MRE11) MRE11/RAD32 family P49959
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Histone acetyltransferase p300 (EP300) . Q09472
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2AX (H2AX) Histone H2A family P16104
Integrator complex subunit 3 (INTS3) Integrator subunit 3 family Q68E01
Cell cycle checkpoint protein RAD17 (RAD17) Rad17/RAD24 family O75943
Fanconi anemia group D2 protein (FANCD2) . Q9BXW9
Mediator of DNA damage checkpoint protein 1 (MDC1) . Q14676
Treacle protein (TCOF1) . Q13428

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
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