Details of the Target

General Information of Target

Target ID LDTP10903
Target Name Ribonucleases P/MRP protein subunit POP1 (POP1)
Gene Name POP1
Gene ID 10940
Synonyms
KIAA0061; Ribonucleases P/MRP protein subunit POP1; hPOP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFLGLFSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMM
ELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHV
NEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLAL
INAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQ
VLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQE
IDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAI
SRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHPETMNTSGHDFEEL
Target Bioclass
Enzyme
Subcellular location
Nucleus, nucleolus
Function
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Uniprot ID
Q99575
Ensemble ID
ENST00000349693.3
HGNC ID
HGNC:30129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.99  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K473(1.63)  LDD0277  [3]
AHL-Pu-1
 Probe Info  		C358(2.16); C706(2.17); C530(2.77); C184(2.50)  LDD0168  [4]
DBIA
 Probe Info  		C777(1.12)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C845(0.00); C408(0.00); C819(0.00); C745(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C745(0.00); C845(0.00); C666(0.00)  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C845(0.00); C408(0.00); C358(0.00); C221(0.00)  LDD0037  [6]
BTD
 Probe Info  		N.A.  LDD0004  [8]
NAIA_4
 Probe Info  		C408(0.00); C705(0.00)  LDD2226  [9]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
PPMS
 Probe Info  		N.A.  LDD0008  [8]
SF
 Probe Info  		N.A.  LDD0028  [10]
TFBX
 Probe Info  		C530(0.00); C481(0.00); C358(0.00); C745(0.00)  LDD0148  [11]
VSF
 Probe Info  		C745(0.00); C358(0.00); C777(0.00)  LDD0007  [8]
Acrolein
 Probe Info  		C777(0.00); H64(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		C777(0.00); C745(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		8.20  LDD0443  [14]
NAIA_5
 Probe Info  		C471(0.00); C530(0.00); C270(0.00); C845(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C343
 Probe Info  		12.21  LDD2005  [15]
FFF probe11
 Probe Info  		8.73  LDD0471  [16]
FFF probe13
 Probe Info  		6.75  LDD0475  [16]
FFF probe14
 Probe Info  		13.06  LDD0477  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C481(0.68); C530(0.54)  LDD2142  [17]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C481(0.90); C530(0.87); C804(0.61)  LDD2112  [17]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C959(0.47)  LDD2095  [17]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C959(0.94); C481(0.87); C530(0.87)  LDD2117  [17]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C959(1.03); C481(1.00); C530(1.22)  LDD2152  [17]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C530(0.83)  LDD2103  [17]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C959(0.51)  LDD2131  [17]
 LDCM0025  4SU-RNA HEK-293T C358(2.16); C706(2.17); C530(2.77); C184(2.50)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C745(3.25); C777(2.14); C358(2.01)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C221(1.71); C358(0.99); C548(0.99); C559(0.99)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C221(1.16); C358(1.00); C471(0.66); C548(0.85)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C358(0.94); C471(1.32); C548(0.60); C559(0.60)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C358(1.01); C471(0.87); C548(0.49); C559(0.49)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C358(1.05); C471(0.97); C548(0.63); C559(0.63)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C358(1.21); C471(0.73); C548(0.30); C559(0.30)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C358(1.13); C471(0.95); C548(0.32); C559(0.32)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C358(1.08); C471(0.90); C548(0.30); C559(0.30)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C358(1.08); C471(0.93); C548(0.34); C559(0.34)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C358(1.14); C471(0.86); C548(0.37); C559(0.37)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C358(0.87); C471(1.16); C548(0.58); C559(0.58)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C358(0.86); C471(1.14); C548(0.57); C559(0.57)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C221(1.11); C358(0.94); C471(0.61); C548(0.68)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C358(0.94); C471(0.98); C548(0.53); C559(0.53)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C358(1.03); C471(0.87); C548(0.51); C559(0.51)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C358(1.08); C471(0.68); C548(0.37); C559(0.37)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C221(1.67); C358(0.78); C548(0.79); C559(0.79)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C221(1.06); C358(0.98); C548(0.61); C559(0.61)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C221(1.12); C358(1.05); C548(0.49); C559(0.49)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C221(0.91); C358(1.10); C548(0.44); C559(0.44)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C221(0.85); C358(1.16); C548(0.73); C559(0.73)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C221(0.97); C358(1.04); C548(0.66); C559(0.66)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C221(0.85); C358(0.99); C548(0.71); C559(0.71)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C221(1.06); C358(0.95); C471(0.88); C548(1.22)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C221(1.49); C358(0.98); C548(0.67); C559(0.67)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C221(0.73); C358(0.82); C548(0.86); C559(0.86)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C221(0.70); C358(0.95); C548(0.87); C559(0.87)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C221(0.76); C358(0.78); C548(1.11); C559(1.11)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C221(0.80); C358(0.96); C548(0.91); C559(0.91)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C221(0.91); C358(0.90); C548(0.72); C559(0.72)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C221(0.92); C358(1.04); C548(0.53); C559(0.53)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C221(0.84); C358(0.94); C548(0.58); C559(0.58)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C221(1.25); C471(0.49); C548(0.48); C559(0.48)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C221(1.01); C471(1.37); C548(1.59); C559(1.59)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C221(0.99); C471(0.67); C548(0.74); C559(0.74)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C221(1.06); C471(1.34); C548(1.34); C559(1.34)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C221(1.15); C471(1.49); C548(1.17); C559(1.17)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C221(1.11); C471(0.94); C548(0.96); C559(0.96)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C221(1.29); C471(0.67); C548(0.67); C559(0.67)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C221(1.27); C471(0.66); C548(0.61); C559(0.61)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C221(1.09); C471(0.91); C548(0.80); C559(0.80)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C221(1.12); C471(1.25); C548(1.07); C559(1.07)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C221(1.31); C471(0.97); C548(0.83); C559(0.83)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C221(1.48); C471(1.12); C548(0.79); C559(0.79)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C221(1.34); C358(0.98); C471(0.86); C548(1.25)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C221(1.30); C471(0.78); C548(0.67); C559(0.67)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C221(1.19); C471(1.02); C548(0.86); C559(0.86)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C221(1.03); C471(1.82); C548(1.62); C559(1.62)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C777(0.72); C548(0.81); C559(0.81); C705(0.93)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C548(0.39); C559(0.39); C221(0.90); C893(0.97)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C548(0.72); C559(0.72); C777(0.90); C893(1.08)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C548(0.51); C559(0.51); C893(1.04); C221(1.14)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C548(0.34); C559(0.34); C893(0.91); C777(1.21)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C548(0.27); C559(0.27); C221(1.08); C893(1.12)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C548(0.31); C559(0.31); C893(1.02); C221(1.12)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C471(0.63); C548(0.89); C559(0.89); C777(1.02)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C548(0.78); C559(0.78); C221(0.85); C893(0.91)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C221(0.83); C548(0.89); C559(0.89); C893(0.99)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C548(0.31); C559(0.31); C893(0.88); C221(1.01)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C548(0.29); C559(0.29); C221(1.09); C893(1.11)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C221(0.83); C548(0.50); C559(0.50); C705(1.91)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C221(1.04); C548(0.50); C559(0.50); C705(1.08)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C221(1.17); C548(0.94); C559(0.94); C705(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C221(1.02); C548(1.04); C559(1.04); C705(1.29)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C347(0.42); C349(0.42); C221(0.75); C745(0.78)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C347(0.44); C349(0.44); C666(0.45); C471(0.50)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C347(0.46); C349(0.46); C548(0.65); C559(0.65)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C548(0.92); C559(0.92); C358(1.10); C893(1.16)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C347(0.63); C349(0.63); C471(0.92); C548(0.95)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C666(0.60); C347(0.62); C349(0.62); C221(0.81)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C347(0.50); C349(0.50); C221(0.84); C893(0.96)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C347(0.65); C349(0.65); C548(0.72); C559(0.72)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C347(0.61); C349(0.61); C666(0.73); C893(0.98)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C471(0.84); C819(0.94); C777(0.98); C893(1.05)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C819(0.44); C471(0.78); C706(0.86); C705(0.88)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C819(0.58); C666(0.61); C471(0.73); C893(0.94)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C666(0.61); C471(0.67); C819(0.69); C893(0.91)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C819(0.40); C666(0.58); C471(0.76); C705(0.91)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C548(1.03); C559(1.03); C358(1.12); C893(1.17)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C819(0.39); C666(0.53); C471(0.71); C706(0.91)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C819(0.56); C471(0.72); C221(0.94); C893(0.94)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C819(0.44); C471(0.45); C666(0.50); C706(0.87)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C471(0.50); C666(0.55); C819(0.78); C221(0.82)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C471(0.37); C666(0.47); C819(0.55); C706(0.74)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C358(0.97); C347(1.30); C349(1.30); C777(1.36)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C819(0.80); C358(1.09); C705(1.10); C706(1.10)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C358(0.95); C221(1.17); C777(1.23); C347(1.27)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C705(0.87); C706(0.87); C358(1.10); C221(1.12)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C705(0.69); C706(0.69); C347(1.02); C349(1.02)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C548(0.87); C559(0.87); C358(1.11); C893(1.25)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C705(0.54); C706(0.54); C347(0.61); C349(0.61)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C347(1.06); C349(1.06); C221(1.06); C358(1.13)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C221(0.90); C471(1.02); C705(1.12); C706(1.12)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C819(0.86); C705(0.89); C706(0.89); C347(0.97)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C705(0.83); C706(0.83); C347(0.93); C349(0.93)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C819(0.57); C347(0.59); C349(0.59); C705(0.72)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C666(0.78); C893(0.79); C221(0.83); C819(0.93)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C666(0.74); C893(0.76); C347(0.81); C349(0.81)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C666(0.74); C819(0.77); C548(0.77); C559(0.77)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C347(0.29); C349(0.29); C666(0.31); C471(0.52)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C548(0.75); C559(0.75); C358(1.08); C777(1.18)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C347(0.32); C349(0.32); C242(0.54); C666(0.54)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C893(0.72); C745(0.80); C777(0.85); C221(0.89)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C221(0.58); C666(0.59); C548(0.82); C559(0.82)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C347(0.48); C349(0.48); C221(0.61); C471(0.63)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C347(0.46); C349(0.46); C666(0.57); C221(0.58)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C347(0.34); C349(0.34); C471(0.55); C242(0.55)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C347(0.28); C349(0.28); C471(0.58); C242(0.58)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C548(0.27); C559(0.27); C347(0.55); C349(0.55)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C548(0.27); C559(0.27); C347(0.34); C349(0.34)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C548(0.19); C559(0.19); C347(0.27); C349(0.27)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C471(0.62); C777(0.74); C819(0.78); C548(0.79)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C548(0.37); C559(0.37); C347(0.58); C349(0.58)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C548(0.30); C559(0.30); C471(0.85); C893(0.89)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C548(0.16); C559(0.16); C347(0.21); C349(0.21)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C548(0.26); C559(0.26); C347(0.41); C349(0.41)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C548(0.19); C559(0.19); C347(0.26); C349(0.26)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C548(0.17); C559(0.17); C347(0.45); C349(0.45)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C548(0.21); C559(0.21); C347(0.63); C349(0.63)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C548(0.12); C559(0.12); C347(0.20); C349(0.20)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C347(0.60); C349(0.60); C819(0.96); C777(0.99)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C347(0.75); C349(0.75); C819(0.91); C358(0.95)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C777(0.61); C471(0.83); C819(0.91); C358(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C347(0.45); C349(0.45); C358(0.95); C221(1.01)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C358(0.92); C777(1.02); C347(1.17); C349(1.17)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C347(0.57); C349(0.57); C221(1.00); C358(1.04)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C347(0.32); C349(0.32); C819(0.97); C358(1.11)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C347(0.28); C349(0.28); C358(1.01); C777(1.11)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C347(0.26); C349(0.26); C221(0.90); C819(1.15)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C347(0.40); C349(0.40); C221(0.96); C358(1.00)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C347(0.38); C349(0.38); C819(0.87); C221(0.93)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C358(1.04); C819(1.11); C777(1.11); C221(1.14)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C819(0.94); C347(0.99); C349(0.99); C221(1.09)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C548(0.62); C559(0.62); C777(0.75); C471(0.76)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C347(0.51); C349(0.51); C221(0.94); C358(0.95)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C221(0.87); C358(1.08); C777(1.09); C347(1.28)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C347(0.22); C349(0.22); C819(0.98); C221(1.05)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C347(0.19); C349(0.19); C548(0.23); C559(0.23)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C347(0.24); C349(0.24); C548(0.25); C559(0.25)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C548(0.43); C559(0.43); C347(0.58); C349(0.58)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C548(0.55); C559(0.55); C471(0.64); C347(0.64)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C819(0.76); C548(0.79); C559(0.79); C893(0.87)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C548(0.55); C559(0.55); C347(0.62); C349(0.62)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C548(0.35); C559(0.35); C347(0.37); C349(0.37)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C819(0.79); C745(0.98); C548(1.01); C559(1.01)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C347(0.18); C349(0.18); C548(0.21); C559(0.21)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C347(0.22); C349(0.22); C548(0.23); C559(0.23)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C548(0.56); C559(0.56); C471(0.62); C347(0.69)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C548(0.64); C559(0.64); C471(0.80); C347(0.81)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C548(0.72); C559(0.72); C893(0.78); C819(0.88)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C548(0.50); C559(0.50); C347(0.50); C349(0.50)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C548(0.26); C559(0.26); C347(0.29); C349(0.29)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C548(0.18); C559(0.18); C471(0.53); C819(0.65)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C548(0.57); C559(0.57); C819(0.68); C745(0.89)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C959(0.51)  LDD2138  [17]
 LDCM0248  AKOS034007472 HCT 116 C221(1.03); C358(1.12); C471(0.96); C548(1.58)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C777(0.67); C471(0.77); C548(0.85); C559(0.85)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C471(0.24); C548(0.31); C559(0.31); C819(0.92)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.39  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C777(1.12)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C959(0.51); C481(0.65)  LDD2091  [17]
 LDCM0630  CCW28-3 231MFP C705(1.39)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa C804(0.00); C777(0.00); C845(0.00); C471(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C530(1.61)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C471(0.72); C548(0.74); C559(0.74); C745(0.92)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C548(0.54); C559(0.54); C242(0.66); C745(0.77)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C548(0.82); C559(0.82); C893(1.07); C221(1.10)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C548(0.60); C559(0.60); C471(0.60); C777(0.68)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C777(0.59); C471(0.80); C358(0.97); C819(0.98)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C777(0.76); C471(0.80); C548(0.90); C559(0.90)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C777(0.77); C471(0.79); C745(0.98); C819(1.04)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C347(0.28); C349(0.28); C548(0.51); C559(0.51)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C347(0.19); C349(0.19); C548(0.36); C559(0.36)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C347(0.23); C349(0.23); C548(0.36); C559(0.36)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C347(0.18); C349(0.18); C548(0.29); C559(0.29)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C347(0.36); C349(0.36); C666(0.54); C548(0.57)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C548(0.43); C559(0.43); C242(0.44); C471(0.64)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C347(0.27); C349(0.27); C548(0.46); C559(0.46)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C347(0.36); C349(0.36); C666(0.57); C548(0.64)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C819(0.59); C666(0.72); C893(0.83); C471(0.94)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C819(0.40); C471(0.54); C666(0.62); C221(0.78)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C819(0.36); C666(0.50); C221(0.71); C471(0.79)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C819(0.47); C666(0.57); C221(0.68); C471(0.73)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C819(0.59); C221(0.75); C666(0.76); C471(0.78)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C347(0.39); C349(0.39); C471(0.75); C819(0.76)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C471(0.98); C347(1.02); C349(1.02); C705(1.02)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C347(0.75); C349(0.75); C705(0.79); C706(0.79)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C548(0.36); C559(0.36); C242(0.40); C471(0.78)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C705(0.74); C706(0.74); C347(0.95); C349(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C666(0.38); C471(0.58); C893(0.75); C221(0.88)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C819(0.73); C347(0.77); C349(0.77); C548(0.80)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C347(0.53); C349(0.53); C471(0.59); C548(0.67)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C347(0.35); C349(0.35); C548(0.53); C559(0.53)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C221(0.67); C548(0.72); C559(0.72); C893(0.84)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C548(0.48); C559(0.48); C471(0.81); C347(0.85)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C548(0.69); C559(0.69); C358(0.90); C893(1.00)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C548(0.20); C559(0.20); C471(0.41); C347(0.42)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C548(0.50); C559(0.50); C242(0.60); C745(0.78)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C548(0.69); C559(0.69); C745(0.77); C777(0.92)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C471(0.49); C548(0.65); C559(0.65); C745(0.77)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C347(0.74); C349(0.74); C548(0.93); C559(0.93)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C548(0.62); C559(0.62); C745(0.73); C777(0.90)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C548(0.65); C559(0.65); C347(0.78); C349(0.78)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C347(0.63); C349(0.63); C548(0.67); C559(0.67)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C471(0.65); C358(0.65); C745(0.87); C705(0.88)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C347(0.39); C349(0.39); C548(0.41); C559(0.41)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C347(0.29); C349(0.29); C548(0.41); C559(0.41)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C347(0.23); C349(0.23); C548(0.36); C559(0.36)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C548(0.49); C559(0.49); C347(0.58); C349(0.58)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C347(0.24); C349(0.24); C548(0.33); C559(0.33)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C347(0.31); C349(0.31); C548(0.36); C559(0.36)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C347(0.68); C349(0.68); C548(0.56); C559(0.56)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C347(0.62); C349(0.62); C548(0.57); C559(0.57)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C347(0.41); C349(0.41); C548(0.47); C559(0.47)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C347(0.44); C349(0.44); C548(0.46); C559(0.46)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C221(1.15); C242(0.83); C358(0.98); C471(0.73)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C347(0.74); C349(0.74); C548(0.83); C559(0.83)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C242(0.77); C347(0.57); C349(0.57); C358(1.09)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C242(0.77); C347(0.76); C349(0.76); C358(1.06)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C242(0.62); C347(0.32); C349(0.32); C358(1.04)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C242(0.43); C347(0.28); C349(0.28); C358(1.23)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C242(0.40); C347(0.23); C349(0.23); C358(1.18)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C242(0.45); C347(0.28); C349(0.28); C358(1.21)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C242(0.39); C347(0.24); C349(0.24); C358(1.33)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C242(0.41); C347(0.23); C349(0.23); C358(1.21)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C221(1.58); C242(1.25); C358(1.13); C471(0.33)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C242(0.43); C347(0.36); C349(0.36); C358(1.28)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C242(0.59); C347(0.34); C349(0.34); C358(1.13)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C242(0.44); C347(0.20); C349(0.20); C358(1.45)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C242(0.39); C347(0.21); C349(0.21); C358(1.18)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C242(0.55); C347(0.31); C349(0.31); C358(1.15)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C242(0.43); C347(0.31); C349(0.31); C358(1.15)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C347(1.41); C349(1.41); C358(0.95); C705(0.57)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C347(1.59); C349(1.59); C358(0.96); C705(0.96)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C347(1.59); C349(1.59); C358(0.82); C705(0.60)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C347(1.05); C349(1.05); C358(1.12); C705(0.74)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C221(1.58); C242(0.96); C358(0.92); C471(0.83)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C347(1.18); C349(1.18); C358(1.10); C705(0.73)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C347(1.32); C349(1.32); C358(0.98); C705(0.47)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C347(1.38); C349(1.38); C358(0.99); C705(0.62)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C347(1.43); C349(1.43); C358(1.12); C705(0.73)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C347(1.23); C349(1.23); C358(0.93); C705(0.56)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C347(1.11); C349(1.11); C358(0.97); C705(0.77)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C347(1.17); C349(1.17); C358(0.99); C705(1.26)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C347(1.13); C349(1.13); C358(1.04); C705(0.72)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C347(1.63); C349(1.63); C358(1.00); C705(0.81)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C347(1.20); C349(1.20); C358(1.08); C705(0.71)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C221(1.30); C242(0.71); C358(1.18); C471(0.76)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C347(1.02); C349(1.02); C358(1.15); C705(0.79)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C347(1.24); C349(1.24); C548(0.92); C559(0.92)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C347(0.85); C349(0.85); C548(0.92); C559(0.92)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C347(0.89); C349(0.89); C548(0.84); C559(0.84)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C347(1.12); C349(1.12); C548(0.47); C559(0.47)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C347(0.92); C349(0.92); C548(0.94); C559(0.94)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C347(1.15); C349(1.15); C548(0.29); C559(0.29)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C347(1.05); C349(1.05); C548(0.52); C559(0.52)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C347(2.42); C349(2.42); C548(0.56); C559(0.56)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C347(0.73); C349(0.73); C548(0.66); C559(0.66)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C221(1.65); C242(0.47); C358(1.02); C471(0.91)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C347(0.95); C349(0.95); C548(0.72); C559(0.72)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C347(0.96); C349(0.96); C548(0.58); C559(0.58)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C347(1.32); C349(1.32); C548(0.87); C559(0.87)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C347(1.84); C349(1.84); C548(0.56); C559(0.56)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C347(0.97); C349(0.97); C548(0.61); C559(0.61)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C242(0.86); C347(0.73); C349(0.73); C358(1.14)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C242(1.21); C347(0.60); C349(0.60); C358(1.05)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C242(0.81); C347(0.72); C349(0.72); C358(1.19)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C242(0.51); C347(0.39); C349(0.39); C358(1.24)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C221(1.62); C242(0.43); C358(1.26); C471(1.00)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C242(0.93); C347(0.69); C349(0.69); C358(0.95)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C242(0.69); C347(0.57); C349(0.57); C358(1.20)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C242(0.40); C347(0.25); C349(0.25); C358(1.12)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C242(0.49); C347(0.28); C349(0.28); C358(1.25)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C242(0.45); C347(0.25); C349(0.25); C358(1.46)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C242(0.68); C347(0.52); C349(0.52); C358(1.14)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C242(0.97); C347(0.81); C349(0.81); C358(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C242(0.80); C347(0.59); C349(0.59); C358(1.24)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C242(0.43); C347(0.35); C349(0.35); C358(1.25)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C242(0.40); C347(0.25); C349(0.25); C358(1.41)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C221(1.02); C242(0.56); C358(1.06); C471(0.65)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C242(1.11); C347(0.48); C349(0.48); C358(1.10)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C221(1.18); C358(1.10); C548(0.88); C559(0.88)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C221(0.75); C358(1.03); C548(0.72); C559(0.72)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C221(0.89); C358(0.91); C548(0.84); C559(0.84)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C221(0.85); C358(1.00); C548(0.73); C559(0.73)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C221(0.91); C358(0.97); C548(0.79); C559(0.79)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C221(1.10); C358(1.15); C548(0.82); C559(0.82)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C221(0.91); C358(1.17); C548(0.69); C559(0.69)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C221(1.36); C358(1.23); C548(0.76); C559(0.76)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C221(1.10); C358(1.19); C548(0.69); C559(0.69)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C777(0.81); C358(0.81)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C481(0.99); C745(0.96); C777(1.01); C893(0.94)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C804(2.28); C845(1.80); C349(1.58); C471(1.12)  LDD1702  [17]
 LDCM0572  Fragment10 Ramos C959(0.57)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C959(3.75)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C959(0.87)  LDD2191  [20]
 LDCM0579  Fragment20 Ramos C959(0.67)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C959(1.26)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C959(1.45)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C959(1.44)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C959(0.17)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C959(1.60)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C959(0.93)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C959(0.79)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C347(1.71); C349(1.71); C548(0.65); C559(0.65)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C959(1.39)  LDD2203  [20]
 LDCM0427  Fragment51 HCT 116 C242(0.32); C347(0.20); C349(0.20); C358(1.28)  LDD0744  [5]
 LDCM0614  Fragment56 Ramos C959(0.66)  LDD2205  [20]
 LDCM0107  IAA HeLa C804(0.00); C347(0.00); H64(0.00); C471(0.00)  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C358(1.93); C777(1.72)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C358(1.37); C777(1.47)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C358(1.74); C777(1.61)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C530(0.94); C745(0.99)  LDD2102  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C959(0.49)  LDD2121  [17]
 LDCM0109  NEM HeLa H64(0.00); H464(0.00)  LDD0223  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C959(0.58)  LDD2089  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C481(0.74); C530(0.86)  LDD2092  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C959(1.01); C530(0.54)  LDD2093  [17]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C481(1.00); C530(1.05); C745(1.27)  LDD2094  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C481(0.65)  LDD2096  [17]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C959(0.73)  LDD2097  [17]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C481(0.92); C530(0.95)  LDD2098  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C959(1.07); C481(0.87); C530(0.72); C358(0.60)  LDD2099  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C530(0.73); C745(0.61)  LDD2100  [17]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C481(0.79); C530(0.95); C745(0.88); C804(0.41)  LDD2104  [17]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C530(1.12); C845(0.63)  LDD2105  [17]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C481(0.68); C530(0.66)  LDD2106  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C959(0.97); C530(1.02)  LDD2107  [17]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C481(0.76); C530(0.64)  LDD2108  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C959(0.68); C481(0.85); C530(0.67)  LDD2109  [17]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C530(1.62)  LDD2110  [17]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C959(1.07); C481(1.01); C530(0.68); C347(1.13)  LDD2111  [17]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C481(0.66); C530(0.75); C804(0.30)  LDD2114  [17]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C959(0.61)  LDD2115  [17]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C481(0.90)  LDD2116  [17]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C959(0.45); C481(0.94)  LDD2118  [17]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C959(1.51); C530(2.07)  LDD2119  [17]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C959(0.45)  LDD2120  [17]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C959(0.21); C481(1.13); C530(0.91); C745(2.20)  LDD2122  [17]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C959(0.97); C481(0.93); C530(0.61)  LDD2123  [17]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C481(1.13); C530(1.01)  LDD2124  [17]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C959(0.68); C530(0.59); C845(1.44); C358(1.09)  LDD2125  [17]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C959(1.06); C481(1.06); C530(0.93); C347(0.49)  LDD2127  [17]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C745(1.03)  LDD2128  [17]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C959(1.14); C481(0.90); C530(0.77)  LDD2129  [17]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C959(0.44)  LDD2134  [17]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C959(1.25); C481(0.93); C530(0.53)  LDD2135  [17]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C959(1.08); C481(1.15); C530(1.02)  LDD2136  [17]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C959(0.92); C481(0.91)  LDD2137  [17]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C959(1.57); C530(0.84)  LDD1700  [17]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C959(0.76); C481(0.99); C530(0.56)  LDD2140  [17]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C481(0.76); C745(0.90)  LDD2141  [17]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C959(0.51); C745(1.06)  LDD2143  [17]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C959(1.71); C481(1.71); C530(2.30)  LDD2144  [17]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C481(2.94)  LDD2145  [17]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C959(0.98); C481(0.75); C530(1.17)  LDD2146  [17]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C959(0.50)  LDD2148  [17]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C959(0.39)  LDD2150  [17]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C481(1.17)  LDD2151  [17]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C530(1.23); C745(1.93)  LDD2153  [17]
 LDCM0131  RA190 MM1.R C705(1.18)  LDD0304  [21]
 LDCM0170  Structure8 Ramos 4.22  LDD0433  [22]
 LDCM0021  THZ1 HCT 116 C358(1.07)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p29 (POP4) Eukaryotic/archaeal RNase P protein component 1 family O95707
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
22 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.