Details of the Target

General Information of Target

Target ID LDTP02331
Target Name Dopamine beta-hydroxylase (DBH)
Gene Name DBH
Gene ID 1621
Synonyms
Dopamine beta-hydroxylase; EC 1.14.17.1; Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLE
LSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQK
GQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSL
EAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKG
FSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLA
AWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRF
NAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV
VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGG
FGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFT
SVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQ
GRSPAGPTVVSIGGGKG
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Copper type II ascorbate-dependent monooxygenase family
Subcellular location
Cytoplasmic vesicle, secretory vesicle membrane; Cytoplasmic vesicle, secretory vesicle lumen
Function Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.
TTD ID
T74937
Uniprot ID
P09172
DrugMap ID
TTYIP79
Ensemble ID
ENST00000393056.8
HGNC ID
HGNC:2689
ChEMBL ID
CHEMBL3102

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DAyne
 Probe Info  		3.20  LDD0261  [1]
FBPP2
 Probe Info  		6.76  LDD0318  [2]
DBIA
 Probe Info  		C596(2.41)  LDD3433  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Kelly C390(2.52); C596(1.79)  LDD2417  [3]
 LDCM0023  KB03 Kelly C390(5.43); C596(2.50)  LDD2834  [3]
 LDCM0024  KB05 SK-N-AS C596(2.41)  LDD3433  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aldehyde dehydrogenase 1A1 (ALDH1A1) Aldehyde dehydrogenase family P00352
Copper-transporting ATPase 1 (ATP7A) Cation transport ATPase (P-type) (TC 3.A.3) family Q04656
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
RING finger protein 112 (RNF112) GB1/RHD3 GTPase family Q9ULX5
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Histone H3.2 (H3C15; H3C14; H3C13) Histone H3 family Q71DI3
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Superkiller complex protein 8 (SKIC8) . Q9GZS3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126
Capsaicin Small molecular drug DB06774
Disulfiram Small molecular drug DB00822
Dopamine Small molecular drug DB00988
Methyldopa Small molecular drug DB00968
Propylthiouracil Small molecular drug DB00550
Copper . DB09130
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Etamicastat Small molecular drug D0H5HZ
Nepicastat Oral Small molecular drug D0N5YD

References

1 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840