General Information of Target

Target ID LDTP16652
Target Name Retrotransposon-like protein 1 (RTL1)
Gene Name RTL1
Gene ID 388015
Synonyms
MAR1; MART1; PEG11; Retrotransposon-like protein 1; Mammalian retrotransposon derived protein 1; Paternally expressed gene 11 protein; Retrotransposon-derived protein PEG11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEALQKQQAARLAQGVGPLAPACPLLPPQPPLPDHRTLQAPEGALGNVGAEEEEDAEEDE
EKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYELDADPKRKEFL
DDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPT
TITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTATPLFGLAGP
PPRGAQDPALGPGPAPPATQSSPGPAQGSTSGLPAHACAQLSPSPIKKEESGIPNPCLAL
PVGLALGPTREKLAPEEPPEKRAVLMGPMDPPRPCMPPSFLPRGKVPLREERLDGPLNLA
GSGISSINMALEINGVVYTGVLFARRQPVPASQGPTNPAPPPSTGPPSSILP
Target Bioclass
Other
Subcellular location
Membrane
Function Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
Uniprot ID
A6NKG5
Ensemble ID
ENST00000649591.1
HGNC ID
HGNC:14665

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DAyne
 Probe Info 
2.66  LDD0261  [1]
DBIA
 Probe Info 
C1246(2.55)  LDD3340  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AN3-CA C935(2.86)  LDD2264  [2]
 LDCM0023  KB03 AN3-CA C935(2.92)  LDD2681  [2]
 LDCM0024  KB05 NB1 C1246(2.55)  LDD3340  [2]

References

1 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840