Details of the Target

General Information of Target

Target ID LDTP07502
Target Name Putative ATP-dependent RNA helicase DHX57 (DHX57)
Gene Name DHX57
Gene ID 90957
Synonyms
Putative ATP-dependent RNA helicase DHX57; EC 3.6.4.13; DEAH box protein 57
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGGGGGGGNRKASSRIWDD
GDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLRDLQE
QDADAGSERGLSGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPEFT
VSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQIS
LDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGLELEYLTSRFRKSKPKESTKNVQEN
SLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRIERSVDDSHLNAIEDASFLYELEIRFS
KDHKYPYQAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESE
IVKLLTNTHHKYSDPPVNFLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESEES
DEDDGPAPVIVENESYVNLKKKISKRYDWQAKSVHAENGKICKQFRMKQASRQFQSILQE
RQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQ
PRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQ
GVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITI
PGRTFPVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLS
LHLQDQDSVKDAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVD
GKHSYPPGAILVFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFV
KPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQ
RKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSV
FSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRC
LDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVR
ASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATG
EEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDG
YVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRG
EFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISTIV
KLVTTQ
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily
Function Probable ATP-binding RNA helicase.
Uniprot ID
Q6P158
Ensemble ID
ENST00000457308.6
HGNC ID
HGNC:20086

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCFSTTG1 SNV: p.E482D .
ETK1 SNV: p.L1073F DBIA    Probe Info 
HGC27 SNV: p.R617T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.I1264T DBIA    Probe Info 
JURKAT SNV: p.D508E .
MCC13 SNV: p.S1301F DBIA    Probe Info 
MDAMB436 SNV: p.D785G DBIA    Probe Info 
MOLT4 SNV: p.T724A IA-alkyne    Probe Info 
NCIH1793 SNV: p.E1105K DBIA    Probe Info 
SSP25 SNV: p.L1073F DBIA    Probe Info 
TF1 SNV: p.S283N DBIA    Probe Info 
U2OS SNV: p.Q1157K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C453(0.66)  LDD2099  [2]
DA-P3
 Probe Info  		4.02  LDD0184  [3]
AHL-Pu-1
 Probe Info  		C65(2.73); C1369(2.41)  LDD0168  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C453(1.06); C65(0.98); C1367(0.89); C1369(0.89)  LDD0078  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		C1369(0.00); C453(0.00)  LDD0005  [10]
NPM
 Probe Info  		N.A.  LDD0016  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
VSF
 Probe Info  		C1369(0.00); C1349(0.00)  LDD0007  [10]
AOyne
 Probe Info  		8.10  LDD0443  [12]
NAIA_5
 Probe Info  		C1080(0.00); C571(0.00); C644(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		6.68  LDD1761  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C453(0.63)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C65(2.73); C1369(2.41)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C65(2.43)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C1367(1.05); C1369(1.03); C1003(1.52); C1349(1.19)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1367(1.13); C1369(1.07); C1146(1.10); C453(0.73)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C1367(0.95); C1369(1.00); C1146(0.61); C1349(1.27)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C1367(1.10); C1369(1.17); C1146(0.69); C1349(1.05)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C1367(1.00); C1369(0.91); C1146(0.58); C1349(1.08)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C1367(1.21); C1369(1.23); C1146(0.60); C1349(0.95)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C1367(1.00); C1369(0.92); C1146(1.37); C1349(1.02)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C1367(1.22); C1369(1.27); C1146(0.66); C1349(0.95)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C1367(1.00); C1369(1.24); C1146(0.54); C1349(1.07)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C1367(0.98); C1369(1.24); C1146(0.53); C1349(0.71)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C1367(0.99); C1369(1.18); C1146(0.60); C1349(0.75)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C1367(0.84); C1369(0.94); C1146(0.60); C1349(0.98)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C1367(1.22); C1369(1.16); C1146(1.49); C453(0.79)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C1367(0.98); C1369(0.92); C1146(0.54); C1349(1.10)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C1367(0.98); C1369(1.06); C1146(0.44); C1349(1.31)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C1367(0.94); C1369(0.98); C1146(0.65); C1349(0.89)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C1367(1.09); C1369(1.09); C1003(1.06); C1146(1.44)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1367(1.17); C1369(1.28); C1003(0.95); C1146(1.21)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1367(1.46); C1369(1.38); C1003(0.83); C1146(0.96)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1367(1.31); C1369(1.34); C1003(1.00); C1146(0.84)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1367(1.20); C1369(1.21); C1003(1.35); C1146(1.04)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1367(1.17); C1369(1.18); C1003(1.21); C1146(1.22)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1367(1.34); C1369(1.75); C1003(1.14); C1146(1.30)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1367(1.02); C1369(0.93); C1146(2.10); C453(0.75)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1367(0.93); C1369(1.14); C1003(1.03); C1146(1.01)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1367(1.15); C1369(1.27); C1003(1.55); C1146(0.85)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1367(1.27); C1369(1.31); C1003(0.98); C1146(1.25)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1367(0.99); C1369(1.10); C1003(1.63); C1146(0.65)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1367(1.17); C1369(1.29); C1003(0.99); C1146(0.91)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1367(1.48); C1369(1.58); C1003(0.80); C1146(0.94)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1367(1.16); C1369(1.20); C1003(0.81); C1146(1.12)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1367(1.29); C1369(1.33); C1003(1.16); C1146(1.24)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C1367(1.27); C1369(1.27); C1003(1.68); C1146(0.98)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C1367(1.08); C1369(1.08); C1003(1.56); C1146(1.42)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C1367(1.39); C1369(1.39); C1003(1.37); C1146(0.81)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C1367(1.13); C1369(1.13); C1003(1.21); C1146(0.69)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C1367(1.24); C1369(1.24); C1003(1.21); C1146(0.54)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C1367(1.29); C1369(1.29); C1003(1.50); C1146(1.13)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C1367(1.47); C1369(1.47); C1003(1.02); C1146(0.60)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C1367(1.44); C1369(1.44); C1003(1.14); C1146(0.45)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C1367(1.19); C1369(1.19); C1003(1.01); C1146(0.36)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C1367(1.14); C1369(1.14); C1003(1.09); C1146(0.62)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C1367(1.55); C1369(1.55); C1003(0.97); C1146(0.46)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C1367(1.50); C1369(1.50); C1003(0.96); C1146(0.45)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C1367(1.00); C1369(0.92); C1146(1.44); C453(0.74)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C1367(1.52); C1369(1.52); C1003(1.02); C1146(0.54)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C1367(1.51); C1369(1.51); C1003(1.04); C1146(0.45)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C1367(1.21); C1369(1.21); C1003(1.19); C1146(0.41)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C1367(1.25); C1369(1.25); C1146(0.96); C1349(1.08)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C1146(0.54); C644(1.03); C1349(1.04); C571(1.10)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C1146(0.63); C1349(0.87); C644(1.00); C65(1.05)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1146(0.73); C1349(0.98); C644(0.99); C571(1.07)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C1146(0.60); C571(0.95); C1349(0.98); C644(0.98)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C1146(0.52); C1349(0.87); C644(0.94); C571(0.99)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C1146(0.57); C644(0.86); C571(1.08); C1349(1.08)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C453(0.73); C644(1.09); C571(1.13); C1367(1.14)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C1146(0.62); C1349(0.97); C644(0.99); C453(1.05)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C65(0.89); C644(0.93); C1349(1.01); C453(1.03)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1146(0.50); C644(0.88); C1349(0.92); C65(0.99)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C1146(0.46); C1349(0.96); C644(0.98); C571(1.29)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1367(1.24); C1369(1.20); C1146(0.47); C1349(0.98)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1367(1.05); C1369(1.02); C1146(0.66); C1349(1.00)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1367(1.04); C1369(1.07); C1146(0.83); C1349(0.89)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1367(1.13); C1369(1.10); C1146(0.61); C1349(0.85)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C453(0.80); C244(0.84); C571(1.00); C644(1.07)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C453(0.93); C1369(0.97); C644(0.97); C571(1.05)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C453(0.73); C1146(0.89); C571(0.96); C244(0.96)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C453(0.72); C571(0.89); C644(0.90); C1349(1.13)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C453(0.73); C1146(0.87); C244(1.01); C571(1.04)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1146(0.87); C453(0.90); C571(0.92); C644(1.00)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C453(0.82); C571(0.98); C244(1.05); C644(1.10)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C453(0.76); C1146(0.87); C571(0.93); C644(0.98)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C453(0.72); C1146(0.88); C244(0.95); C1369(1.02)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1367(0.84); C65(0.88); C1349(0.93); C644(0.98)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C644(0.87); C65(0.92); C571(1.04); C1369(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C644(0.91); C1369(0.97); C1367(0.99); C65(1.00)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C644(0.81); C1369(0.92); C1349(1.09); C1367(1.10)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C644(0.82); C1369(0.99); C571(1.14); C1349(1.16)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C453(0.72); C644(0.89); C571(0.96); C1349(1.14)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C644(0.84); C1369(1.07); C453(1.10); C65(1.12)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C644(0.86); C65(0.98); C1349(1.05); C453(1.07)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C644(0.76); C453(0.95); C1349(1.21); C571(1.26)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1367(0.91); C644(0.93); C1369(0.97); C1349(0.98)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1369(0.85); C644(0.97); C1349(0.97); C453(1.01)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C65(0.59); C1369(0.85); C1367(0.89); C644(0.91)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C65(0.74); C571(0.90); C644(0.92); C453(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C65(0.71); C571(0.91); C644(0.92); C453(0.94)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C65(0.78); C571(0.88); C644(0.91); C1146(0.92)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C65(0.86); C644(0.87); C571(0.95); C453(1.01)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C453(0.68); C571(0.92); C644(0.94); C1349(1.22)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C644(0.88); C65(0.90); C571(0.99); C1146(1.07)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C65(0.62); C453(0.95); C1369(0.96); C644(0.96)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C65(0.86); C571(0.93); C1146(0.97); C644(0.97)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1146(0.93); C571(0.94); C65(0.96); C644(0.97)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C65(0.94); C571(0.97); C453(0.99); C644(0.99)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C644(0.89); C571(0.98); C1369(1.06); C1367(1.13)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C65(0.83); C1369(0.93); C453(0.93); C644(0.94)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C453(0.84); C65(0.90); C644(0.99); C1369(1.04)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C644(0.92); C1003(0.95); C453(0.96); C1369(1.02)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C453(0.58); C1003(0.89); C644(0.96); C1146(0.98)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C453(0.67); C571(0.94); C644(0.95); C1349(1.09)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C453(0.68); C1146(0.73); C644(0.99); C1003(1.00)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C1146(0.69); C453(0.70); C1003(0.83); C1369(0.85)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C453(0.71); C1003(0.82); C65(0.85); C1367(0.93)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C453(0.64); C571(0.98); C644(0.99); C1369(1.06)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C453(0.66); C1369(0.93); C644(0.98); C1003(0.99)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C453(0.55); C644(0.94); C571(0.99); C65(1.02)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C453(0.64); C644(0.95); C1003(0.96); C571(1.05)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C453(0.93); C644(0.99); C571(1.14); C1003(1.45)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C453(0.87); C644(1.05); C571(1.24); C1003(1.31)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C453(0.84); C644(0.94); C571(1.24); C1003(1.39)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C644(0.96); C453(0.99); C65(1.05); C1146(1.11)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C644(0.73); C453(0.86); C571(1.18); C1003(1.52)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C453(0.74); C644(0.87); C571(1.18); C1003(1.53)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C453(0.78); C644(0.85); C571(1.24); C1003(1.48)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C453(0.79); C644(0.86); C571(1.10); C1003(1.52)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C453(0.76); C644(0.85); C571(1.26); C1367(1.47)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C453(0.61); C644(0.88); C571(1.46); C1003(1.51)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C453(0.61); C644(1.03); C1003(1.07); C571(1.41)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C453(0.64); C644(0.71); C571(1.05); C1003(1.29)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C1146(0.84); C571(0.97); C644(1.02); C1367(1.12)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C571(0.83); C1146(0.85); C644(1.03); C1367(1.11)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C453(0.91); C644(0.98); C65(1.03); C1367(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C571(0.88); C1146(0.90); C644(0.93); C65(1.24)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C571(0.81); C1146(0.93); C644(1.05); C1367(1.11)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C571(0.92); C644(1.03); C1146(1.26); C1367(1.28)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C571(0.88); C1146(0.94); C644(0.96); C1003(1.29)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C1146(0.78); C571(0.82); C644(0.95); C1367(1.50)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C1146(0.71); C571(0.81); C644(1.03); C1003(1.52)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C571(0.82); C1146(0.95); C644(1.01); C1367(1.59)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C571(0.84); C1146(0.89); C644(0.96); C1003(0.98)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C571(0.79); C644(0.97); C65(1.02); C1146(1.06)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C571(0.89); C65(0.94); C1146(1.00); C644(1.08)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C453(0.93); C644(0.98); C1367(0.99); C571(1.07)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C571(0.85); C644(0.98); C1003(1.12); C1146(1.18)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C571(0.83); C65(0.92); C644(0.95); C1146(0.98)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1146(0.77); C571(0.84); C644(0.99); C1003(1.36)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C644(0.69); C1146(0.71); C1003(0.97); C571(1.09)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C644(0.69); C1146(0.81); C571(1.05); C1003(1.10)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C644(0.71); C1146(0.92); C571(0.97); C1003(1.10)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C644(0.85); C1146(0.86); C1003(1.01); C571(1.04)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C644(0.81); C1146(0.97); C571(0.97); C453(0.98)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C1146(0.76); C1003(0.83); C644(0.84); C571(1.01)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1146(0.70); C644(0.82); C1003(0.94); C571(1.01)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C1003(0.80); C453(0.82); C1146(0.92); C1349(0.95)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C644(0.74); C1146(0.76); C571(0.98); C1003(1.09)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C644(0.79); C1146(0.80); C571(1.01); C1003(1.04)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1146(0.75); C644(0.82); C1003(0.91); C1349(0.99)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C1146(0.81); C644(0.83); C1349(1.02); C453(1.05)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C1003(0.74); C644(0.77); C1146(0.78); C571(1.01)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C644(0.74); C1146(0.86); C571(0.98); C453(1.19)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C1146(0.75); C644(0.77); C1003(0.84); C571(1.02)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C1146(0.48); C571(0.75); C644(0.76); C1367(1.03)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C1146(0.57); C453(0.80); C644(0.82); C1369(0.86)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C1367(1.03); C1369(1.06); C1146(1.58); C453(0.71)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C453(0.81); C644(0.93); C571(1.09); C65(1.22)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C453(0.78); C1146(0.92); C644(0.92); C65(1.18)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C453(1.06); C65(0.98); C1367(0.89); C1369(0.89)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C453(2.27)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C1003(0.84); C571(0.97); C453(1.04); C1146(1.09)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C1146(0.62); C453(0.79); C644(0.88); C571(0.95)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C453(0.76); C571(0.96); C644(1.05); C1349(1.20)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C453(0.81); C644(1.04); C571(1.06); C1367(1.12)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C453(0.79); C571(0.99); C644(1.04); C1369(1.14)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C453(0.70); C571(0.99); C1369(1.04); C644(1.06)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C453(0.70); C571(1.03); C1367(1.05); C644(1.11)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C244(0.61); C1146(0.68); C453(0.85); C571(0.96)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1146(0.50); C453(0.89); C644(0.95); C244(0.96)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1146(0.87); C453(0.90); C644(0.97); C571(1.04)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1146(0.77); C453(0.91); C644(1.01); C571(1.06)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C453(0.79); C1146(0.85); C644(0.95); C571(0.96)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1146(0.77); C453(0.82); C644(0.85); C571(0.93)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1146(0.77); C244(0.79); C453(0.83); C571(0.91)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C244(0.76); C453(0.83); C644(0.93); C1146(0.96)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C65(0.70); C644(0.84); C1349(0.99); C571(1.06)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C644(0.85); C453(0.96); C65(1.00); C1349(1.11)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C644(0.85); C571(1.11); C453(1.11); C1349(1.28)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C644(0.85); C1349(1.07); C571(1.12); C1369(1.19)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C644(0.84); C1367(0.91); C65(0.94); C1349(1.01)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C1146(0.76); C644(0.84); C571(0.93); C453(1.12)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C65(0.74); C453(0.84); C571(0.89); C644(0.91)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C65(0.87); C571(0.95); C453(0.96); C644(0.98)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C453(0.75); C644(0.82); C571(0.98); C1146(1.00)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C65(0.60); C453(0.94); C644(0.98); C1146(1.05)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C65(0.58); C1369(0.77); C644(0.86); C453(0.90)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C453(0.71); C644(0.89); C571(1.01); C1003(1.01)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C453(0.57); C1146(0.78); C644(0.94); C571(0.98)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C453(0.66); C1146(0.95); C571(0.98); C644(0.99)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C453(0.88); C644(0.92); C571(1.18); C1367(1.33)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C453(0.89); C644(0.94); C571(1.00); C1003(1.18)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C453(0.78); C644(0.95); C571(1.10); C1003(1.30)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C453(0.88); C644(0.96); C571(1.20); C1003(1.50)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C453(0.67); C1146(0.80); C644(0.86); C571(0.91)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C453(0.73); C571(0.97); C644(1.03); C1146(1.05)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C453(0.65); C1146(0.80); C644(0.80); C571(0.93)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C1146(0.60); C644(0.78); C571(0.87); C1003(0.88)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C1146(0.55); C571(0.77); C1349(0.79); C65(0.80)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C1146(0.56); C571(0.82); C644(0.85); C65(0.91)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C1146(0.51); C644(0.81); C571(0.84); C453(0.90)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C1003(0.87); C453(0.88); C571(0.92); C644(1.08)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C1146(0.65); C644(0.78); C453(0.87); C571(0.94)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C1146(0.47); C571(0.74); C644(0.79); C1349(0.84)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C1146(0.57); C453(0.77); C644(0.88); C1349(0.93)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1146(0.59); C453(0.77); C1003(0.82); C571(0.91)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1146(0.64); C453(0.79); C644(0.85); C1003(0.90)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1367(1.67); C1369(1.67); C1003(0.74); C1146(0.41)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1367(1.04); C1369(1.04); C1003(0.72); C1146(0.56)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1367(1.11); C1369(1.11); C1003(1.08); C1146(0.58)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1367(1.30); C1369(1.30); C1003(0.77); C1146(0.48)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1367(1.23); C1369(1.23); C1003(1.03); C1146(0.58)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1367(1.25); C1369(1.25); C1003(1.12); C1146(1.01)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1367(1.05); C1369(1.05); C1003(0.90); C1146(0.58)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1367(1.06); C1369(1.06); C1003(2.29); C1146(1.43)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C1367(0.93); C1369(0.93); C1003(1.71); C1146(0.83)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C1367(4.03); C1369(4.03); C1003(1.64); C1146(1.04)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C1367(1.54); C1369(1.54); C1003(1.75); C1146(0.76)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C1367(0.97); C1369(0.97); C1003(1.13); C1146(0.93)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C1367(1.45); C1369(1.45); C1003(1.24); C1146(0.62)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C1367(1.45); C1369(1.45); C1003(1.46); C1146(1.01)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C1367(1.52); C1369(1.52); C1003(1.84); C1146(0.86)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C1367(2.43); C1369(2.43); C1003(0.82); C1146(0.95)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C1367(1.76); C1369(1.76); C1003(1.78); C1146(1.17)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C1367(1.34); C1369(1.34); C1003(1.58); C1146(0.86)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C1367(1.37); C1369(1.37); C1003(1.70); C1146(1.34)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C1367(1.05); C1369(1.05); C1003(1.94); C1146(1.12)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C1367(1.54); C1369(1.54); C1003(1.84); C1146(1.09)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C1367(1.53); C1369(1.53); C1003(1.58); C1146(1.08)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C1367(1.24); C1369(1.24); C1003(1.42); C1146(0.60)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C1367(1.04); C1369(1.04); C1003(1.11); C1146(0.53)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C1367(1.04); C1369(1.04); C1003(1.05); C1146(0.60)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C1367(1.05); C1369(1.05); C1003(1.51); C1146(0.81)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C1367(1.11); C1369(1.11); C1003(1.27); C1146(1.05)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C1367(1.15); C1369(1.15); C1003(1.21); C1146(0.63)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C1367(1.15); C1369(1.15); C1003(1.38); C1146(0.56)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C1367(1.36); C1369(1.36); C1003(0.96); C1146(0.85)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C1367(1.18); C1369(1.18); C1003(1.18); C1146(0.54)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C1367(1.08); C1369(1.08); C1003(1.12); C1146(0.58)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C1367(1.09); C1369(1.09); C1003(1.27); C1146(0.56)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C1367(1.14); C1369(1.14); C1003(1.31); C1146(0.57)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C1367(2.32); C1369(2.32); C1003(1.38); C1146(0.94)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C1367(1.31); C1369(1.31); C1003(1.13); C1146(0.57)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C1367(1.02); C1369(1.02); C1003(1.07); C1146(0.60)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C1367(1.52); C1369(1.52); C1003(1.07); C1146(0.77)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C1367(1.05); C1369(1.05); C1003(1.21); C1146(0.62)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C1367(0.84); C1369(0.84); C1146(1.19); C244(1.11)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1367(0.89); C1369(0.89); C1146(0.75); C244(1.37)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1367(1.03); C1369(1.03); C1146(0.92); C244(1.14)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1367(1.07); C1369(1.07); C1146(0.77); C244(1.28)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1367(0.84); C1369(0.84); C1146(0.43); C244(1.33)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1367(1.20); C1369(1.20); C1146(0.63); C244(1.47)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1367(0.86); C1369(0.86); C1146(0.82); C244(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1367(1.14); C1369(1.14); C1146(0.57); C244(1.02)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1367(1.43); C1369(1.43); C1146(0.70); C244(1.24)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1367(1.42); C1369(1.42); C1003(1.16); C1146(1.00)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1367(0.73); C1369(0.73); C1146(0.67); C244(1.04)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1367(0.91); C1369(0.91); C1146(0.51); C244(1.15)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1367(0.98); C1369(0.98); C1146(0.61); C244(1.31)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1367(1.04); C1369(1.04); C1146(0.57); C244(1.03)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1367(0.80); C1369(0.80); C1146(0.81); C244(1.13)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1367(1.21); C1369(1.21); C1003(1.13); C453(0.99)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1367(1.25); C1369(1.25); C1003(0.81); C453(0.98)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1367(1.25); C1369(1.25); C1003(0.15); C453(1.06)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1367(1.36); C1369(1.36); C1003(1.01); C453(1.06)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1367(9.13); C1369(9.13); C1003(1.13); C1146(0.87)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1367(1.03); C1369(1.03); C1003(1.07); C453(0.89)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1367(1.18); C1369(1.18); C1003(1.42); C453(1.08)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1367(1.48); C1369(1.48); C1003(1.68); C453(0.92)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1367(1.62); C1369(1.62); C1003(0.97); C453(0.89)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1367(2.12); C1369(2.12); C1003(1.08); C453(0.96)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1367(1.23); C1369(1.23); C1003(1.12); C453(0.84)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1367(1.08); C1369(1.08); C1003(1.17); C453(0.81)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1367(1.59); C1369(1.59); C1003(1.25); C453(0.81)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1367(1.40); C1369(1.40); C1003(2.36); C453(0.85)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1367(1.56); C1369(1.56); C1003(1.16); C453(0.95)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1367(1.66); C1369(1.66); C1003(1.26); C1146(0.93)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1367(5.76); C1369(5.76); C1003(1.44); C453(0.92)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1367(1.83); C1369(1.55); C1003(1.07); C1349(0.75)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1367(2.06); C1369(1.75); C1003(1.05); C1349(0.92)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1367(1.51); C1369(1.36); C1003(1.35); C1349(1.10)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1367(2.58); C1369(2.10); C1003(1.24); C1349(1.35)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1367(2.02); C1369(1.75); C1003(1.16); C1349(0.88)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1367(1.95); C1369(1.64); C1003(1.11); C1349(0.96)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1367(1.53); C1369(1.40); C1003(0.97); C1349(0.86)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1367(2.21); C1369(1.87); C1003(1.18); C1349(0.93)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1367(2.08); C1369(1.74); C1003(1.39); C1349(1.09)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C571(1.00); C1349(1.12); C65(1.19); C453(0.87)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C453(1.00)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C1367(1.34); C1369(1.34); C1146(0.75); C244(1.25)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C1367(2.03); C1369(2.03); C1003(1.37); C1146(0.57)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C142(2.57); C143(2.57); C305(1.63); C1367(7.47)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C142(1.70); C143(1.70); C305(1.63); C1367(2.47)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C142(2.39); C143(2.39); C305(2.07); C1367(1.68)  LDD0082  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C453(0.30)  LDD2121  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C453(0.66)  LDD2099  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1349(0.96)  LDD2106  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1003(0.47); C598(0.42)  LDD2109  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C453(0.64)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C453(0.68)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C453(0.80)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1003(1.08)  LDD2129  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C453(0.90)  LDD2136  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C453(0.15)  LDD2150  [2]
 LDCM0032  Oleacein HEK-293T 4.02  LDD0184  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 473 (ZNF473) Krueppel C2H2-type zinc-finger protein family Q8WTR7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
R-spondin-4 (RSPO4) R-spondin family Q2I0M5
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Chromobox protein homolog 2 (CBX2) . Q14781

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402