Details of the Target

General Information of Target

Target ID LDTP14065
Target Name Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
Gene Name MAP4K5
Gene ID 11183
Synonyms
Mitogen-activated protein kinase kinase kinase kinase 5; EC 2.7.11.1; Kinase homologous to SPS1/STE20; KHS; MAPK/ERK kinase kinase kinase 5; MEK kinase kinase 5; MEKKK 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF
DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD
NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK
DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI
PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH
QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF
GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS
HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE
ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Cytoplasm
Function May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Uniprot ID
Q9Y4K4
Ensemble ID
ENST00000013125.9
HGNC ID
HGNC:6867
ChEMBL ID
CHEMBL4852

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K173(7.14); K36(9.03); K609(5.30)  LDD0277  [1]
Probe 1
 Probe Info  		Y20(19.11)  LDD3495  [2]
m-APA
 Probe Info  		13.30  LDD0403  [3]
BTD
 Probe Info  		C505(1.46)  LDD2098  [4]
DA-P3
 Probe Info  		4.74  LDD0179  [5]
AHL-Pu-1
 Probe Info  		C418(3.97)  LDD0168  [6]
HHS-465
 Probe Info  		Y837(7.72)  LDD2237  [7]
DBIA
 Probe Info  		C437(0.98); C418(0.91)  LDD0078  [8]
AMP probe
 Probe Info  		N.A.  LDD0200  [9]
ATP probe
 Probe Info  		K49(0.00); K142(0.00)  LDD0199  [9]
IA-alkyne
 Probe Info  		C497(0.00); C418(0.00); C505(0.00)  LDD0162  [10]
ATP probe
 Probe Info  		K142(0.00); K49(0.00)  LDD0035  [11]
NAIA_4
 Probe Info  		C418(0.00); C497(0.00)  LDD2226  [12]
NAIA_5
 Probe Info  		N.A.  LDD2225  [12]
KY-26
 Probe Info  		N.A.  LDD0301  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C505(1.33)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C505(1.03)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C418(3.97)  LDD0168  [6]
 LDCM0214  AC1 HEK-293T C418(1.09); C497(1.02); C75(1.04); C437(1.15)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C418(1.01); C497(1.00); C75(1.02); C437(1.11)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C418(0.96); C497(0.93); C75(0.99); C437(1.07)  LDD1509  [17]
 LDCM0230  AC113 HEK-293T C497(1.05)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C497(1.00)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C497(0.93)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C497(1.15)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C497(1.07)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C497(1.11)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C497(1.04)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C418(0.98); C497(0.92); C75(1.02)  LDD1510  [17]
 LDCM0238  AC120 HEK-293T C497(1.21)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C497(0.95)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C497(1.10)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C497(1.18)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C497(1.02)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C497(0.93)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C497(0.90)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C497(1.00)  LDD0843  [8]
 LDCM0246  AC128 HEK-293T C497(1.23)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C497(1.10)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C497(1.48)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C497(1.48)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C497(1.28)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C497(1.60)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C497(1.32)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C497(1.30)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C497(0.84)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C497(1.30)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C497(1.62)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C497(1.56)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C418(0.98); C497(0.98); C75(0.88); C437(0.83)  LDD1512  [17]
 LDCM0260  AC140 HEK-293T C497(1.41)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C497(1.08)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C497(1.35)  LDD0860  [8]
 LDCM0270  AC15 HEK-293T C418(0.99); C497(0.90); C75(1.01); C437(1.12)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C418(1.11); C497(0.93); C75(1.00); C437(1.10)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C418(0.96); C497(1.04); C75(1.00); C437(1.12)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C418(1.63); C497(0.95); C75(0.90); C437(1.82)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C418(0.98); C497(1.04); C75(1.10); C437(0.99)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C418(0.99); C497(0.94); C75(0.95)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C418(0.97); C497(0.98); C75(0.89); C437(0.96)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C418(0.96); C497(0.98); C75(0.92); C437(0.88)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C418(0.98); C497(0.93); C75(1.04); C437(1.10)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C418(0.97); C497(1.00); C75(1.06)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C418(1.04); C497(1.00); C75(0.97); C437(1.05)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C418(0.99); C497(1.01); C75(0.98); C437(1.26)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C418(1.01); C497(1.02); C75(0.92); C437(1.08)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C418(1.02); C497(0.97); C75(0.89)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C418(1.07); C497(0.99); C75(1.00); C437(1.03)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C418(1.05); C497(1.09); C75(0.96); C437(0.87)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C418(0.95); C497(0.98); C75(0.96); C437(1.12)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C418(1.01); C497(0.98); C75(1.11); C437(1.14)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C418(1.00); C497(0.95); C75(0.96)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C418(1.15); C497(1.01); C75(1.03); C437(1.17)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C418(1.01); C497(0.99); C75(0.94); C437(1.60)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C418(1.00); C497(0.96); C75(0.87); C437(0.98)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C418(0.97); C497(0.95); C75(0.98)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C418(1.01); C497(1.05); C75(0.93); C437(1.09)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C418(0.93); C497(0.98); C75(0.92); C437(0.94)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C418(0.94); C497(0.99); C75(1.00); C437(1.20)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C418(0.98); C497(1.07); C75(0.98)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C418(0.97); C497(0.99); C75(0.96)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C418(1.10); C497(0.98); C75(0.98); C437(1.01)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C418(1.09); C497(0.99); C75(0.98); C437(1.37)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C418(1.10); C497(0.94); C75(0.96); C437(0.95)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C418(1.01); C497(1.01); C75(0.97)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C418(1.03); C497(0.99); C75(0.99); C437(1.25)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C418(0.97); C497(0.96); C75(0.95); C437(0.87)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C418(1.01); C497(1.05); C75(1.17); C437(0.98)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C418(0.99); C497(1.04); C75(1.05)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C418(1.05); C497(1.02); C75(0.94); C437(1.23)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C418(1.00); C497(0.99); C75(0.99); C437(1.05)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C418(0.96); C497(1.03); C75(1.02); C437(1.20)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C418(1.02); C497(1.06); C75(0.98); C437(0.97)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C418(0.98); C497(0.97); C75(0.99)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C418(1.01); C497(1.01); C75(0.96); C437(1.07)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C418(0.97); C497(1.09); C75(1.02); C437(1.04)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C418(1.01); C497(0.97); C75(1.08); C437(1.04)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C418(0.92); C497(0.94); C75(0.97)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C497(1.28)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C497(1.10)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C497(1.05)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C418(1.01); C497(1.01); C75(0.89); C437(0.79)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C497(1.39)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C497(1.46)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C497(1.25)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C497(1.24)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C497(1.47)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C497(1.19)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C497(1.26)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C497(1.17)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C497(1.13)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C497(0.93)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C418(0.96); C497(0.99); C75(0.99); C437(1.01)  LDD1568  [17]
 LDCM0335  AC70 HEK-293T C497(0.83)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C497(1.00)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C497(1.14)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C497(1.35)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C497(1.02)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C497(1.48)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C497(1.19)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C497(0.89)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C497(1.19)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C497(1.22)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C418(0.99); C497(1.04); C75(1.00)  LDD1569  [17]
 LDCM0346  AC80 HEK-293T C497(1.33)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C497(1.38)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C497(0.88)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C497(0.83)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C497(0.99)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C497(0.97)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C497(0.93)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C497(0.97)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C497(1.11)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C497(0.85)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C497(0.96)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C497(0.86)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C497(0.96)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C497(0.73)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C497(0.77)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C497(0.63)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C497(0.82)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C497(0.79)  LDD0962  [8]
 LDCM0248  AKOS034007472 HEK-293T C418(0.95); C497(1.00); C75(0.93); C437(1.24)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C418(1.12); C497(0.95); C75(0.98); C437(1.00)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C418(0.98); C497(0.93); C75(1.01)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 13.30  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C437(0.98); C418(0.91)  LDD0078  [8]
 LDCM0632  CL-Sc Hep-G2 C418(20.00); C497(0.41)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C418(0.89); C497(1.09); C75(0.90)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C418(1.02); C497(0.74); C75(0.88); C437(1.05)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C418(0.97); C497(1.15); C75(1.08); C437(0.99)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C418(0.99); C497(1.06); C75(0.95)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C418(1.00); C497(1.23); C75(0.82); C437(0.90)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C418(1.03); C497(1.02); C75(0.96); C437(0.70)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C418(0.92); C497(1.02); C75(1.08); C437(1.08)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C418(0.92); C497(1.09); C75(0.94)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C418(0.97); C497(1.08); C75(0.86); C437(0.94)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C418(0.92); C497(1.02); C75(1.02); C437(0.93)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C418(0.97); C497(0.99); C75(1.02); C437(1.41)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C418(0.90); C497(1.02); C75(0.97)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C418(1.01); C497(0.78); C75(1.15); C437(1.42)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C418(0.96); C497(1.23); C75(0.92); C437(1.11)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C418(1.01); C497(1.22); C75(0.93); C437(0.82)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C418(0.99); C497(1.05); C75(0.97); C437(0.97)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C418(0.98); C497(1.06); C75(0.93)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C418(0.97); C497(1.28); C75(0.92); C437(1.12)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C418(1.02); C497(1.08); C75(0.94); C437(0.69)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C418(1.03); C497(1.07); C75(1.00); C437(0.89)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C418(0.95); C497(1.02); C75(0.91)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C418(1.06); C497(0.97); C75(0.94); C437(1.03)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C418(0.94); C497(0.98); C75(1.08); C437(0.63)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C418(0.99); C497(0.80); C75(1.02)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C418(1.07); C497(0.99); C75(1.21); C437(1.07)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C418(0.97); C497(1.12); C75(0.90)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C418(0.98); C497(1.05); C75(0.92); C437(1.11)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C418(0.90); C497(1.15); C75(0.88); C437(0.82)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C418(1.02); C497(1.16); C75(1.01); C437(0.97)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C497(1.19)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C497(1.14)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C497(1.23)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C497(1.06)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C418(1.06); C497(0.99); C75(0.87)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C418(0.89); C497(0.99); C75(1.07); C437(1.30)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C418(1.12); C497(1.16); C75(0.94); C437(0.95)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C418(0.92); C497(1.00); C75(0.97); C437(0.99)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C418(1.12); C497(0.76); C75(0.98); C437(0.99)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C418(0.93); C497(0.81); C75(1.00); C437(1.12)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C418(1.08); C497(0.76); C75(0.92); C437(1.10)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C418(0.94); C497(0.94); C75(0.96); C437(1.50)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C418(0.95); C497(0.75); C75(1.07)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C418(1.07); C497(0.80); C75(0.88); C437(1.16)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C418(0.98); C497(0.77); C75(0.89); C437(1.03)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C418(0.99); C497(0.78); C75(1.08); C437(1.26)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C418(0.94); C497(0.79); C75(1.13)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C418(0.84); C497(1.19); C75(0.94)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C418(0.96); C497(1.02); C75(0.93); C437(1.17)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C418(0.94); C497(1.00); C75(1.08); C437(0.98)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C418(0.89); C497(0.89); C75(1.01); C437(0.99)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C418(1.05); C497(0.86); C75(0.96); C437(1.04)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C418(0.93); C497(1.03); C75(1.09); C437(0.75)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C418(0.92); C497(0.90); C75(1.14); C437(1.11)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C418(1.03); C497(0.83); C75(0.93); C437(1.04)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C418(0.95); C497(0.71); C75(1.06)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C418(0.97); C497(1.38); C75(0.78); C437(1.06)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C418(0.95); C497(0.75); C75(0.94); C437(0.87)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C418(0.97); C497(0.74); C75(1.02); C437(1.15)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C418(0.95); C497(0.78); C75(1.09)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C418(0.82); C497(1.14); C75(1.02)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C418(1.06); C497(0.95); C75(0.90); C437(0.84)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C418(0.87); C497(1.05); C75(1.09); C437(0.86)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C418(1.00); C497(0.94); C75(1.10); C437(0.90)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C418(1.01); C497(0.92); C75(0.94); C437(1.16)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C418(0.97); C497(0.87); C75(1.07); C437(1.23)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C418(0.97); C497(0.80); C75(0.91); C437(0.90)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C418(1.05); C497(0.79); C75(1.03)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C418(1.07); C497(0.82); C75(0.88); C437(1.07)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C418(1.04); C497(0.79); C75(0.88); C437(1.09)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C418(1.01); C497(0.71); C75(1.16); C437(1.03)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C418(1.11); C497(0.82); C75(1.01)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C418(0.82); C497(1.05); C75(0.98)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C418(0.99); C497(0.85); C75(1.05); C437(1.40)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C418(0.97); C497(1.09); C75(0.91); C437(1.17)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C418(1.03); C497(0.96); C75(1.13); C437(0.90)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C418(1.05); C497(0.86); C75(0.88); C437(1.06)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C418(0.97); C497(0.79); C75(0.79); C437(1.12)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C418(1.13); C497(0.74); C75(0.92); C437(1.21)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C418(1.10); C497(0.74); C75(1.06)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C418(1.13); C497(0.69); C75(0.82); C437(1.44)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C418(0.95); C497(0.75); C75(0.94); C437(1.31)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C418(1.02); C497(0.77); C75(0.98); C437(1.14)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C418(0.93); C497(0.85); C75(1.03); C437(1.33)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C418(1.04); C497(0.79); C75(1.04)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C418(0.86); C497(1.03); C75(1.05)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C418(1.00); C497(1.05); C75(0.99); C437(1.26)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C418(1.01); C497(0.95); C75(0.92); C437(0.78)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C418(0.98); C497(1.34); C75(1.00); C437(1.06)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C418(1.12); C497(0.87); C75(1.08); C437(1.01)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C418(0.99); C497(0.88); C75(0.83); C437(1.12)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C418(1.04); C497(0.85); C75(1.03); C437(1.05)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C418(0.95); C497(0.77); C75(1.03)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C418(1.01); C497(0.64); C75(0.93); C437(1.12)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C418(1.04); C497(0.83); C75(0.95); C437(1.21)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C418(0.97); C497(0.81); C75(0.90); C437(1.04)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C418(0.99); C497(0.76); C75(1.01); C437(1.32)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C418(1.04); C497(0.77); C75(1.08)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C418(0.86); C497(1.25); C75(1.05)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C418(0.87); C497(1.00); C75(0.97); C437(0.89)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C418(0.98); C497(1.00); C75(1.05); C437(0.91)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C418(1.04); C497(0.89); C75(0.91); C437(1.38)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C418(0.91); C497(0.85); C75(1.04); C437(1.41)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C418(0.99); C497(0.90); C75(0.94); C437(1.05)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C418(0.94); C497(0.72); C75(0.72)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C418(0.93); C497(0.80); C75(0.91)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C418(0.95); C497(0.83); C75(0.95); C437(1.18)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C418(1.01); C497(0.87); C75(0.93); C437(0.88)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C418(1.01); C497(0.78); C75(1.00); C437(0.99)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C418(0.96); C497(0.88); C75(1.07)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C418(0.85); C497(1.04); C75(1.08)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C418(0.90); C497(0.98); C75(0.92); C437(1.12)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C418(0.97); C497(1.17); C75(1.06); C437(0.84)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C418(0.89); C497(1.07); C75(1.09); C437(1.12)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C418(0.96); C497(0.97); C75(0.99); C437(1.07)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C418(0.99); C497(0.87); C75(0.98); C437(1.10)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C418(1.02); C497(0.89); C75(0.69); C437(1.22)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C418(0.96); C497(0.84); C75(1.01); C437(0.90)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C418(0.99); C497(0.80); C75(1.06)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C418(0.90); C497(0.79); C75(0.86); C437(1.24)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C418(1.01); C497(0.80); C75(0.69); C437(1.02)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C418(1.00); C497(0.78); C75(0.89); C437(1.07)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C418(0.89); C497(0.97); C75(0.96)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C418(0.89); C497(1.21); C75(1.02)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C418(0.99); C497(1.06); C75(0.87); C437(1.25)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C418(1.05); C497(1.02); C75(0.99); C437(0.69)  LDD1697  [17]
 LDCM0027  Dopamine HEK-293T 4.74  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C418(1.08); C497(0.95); C75(0.96); C437(0.68)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C497(3.02); C511(1.44); C505(1.32)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C418(0.98); C497(0.99); C75(0.93); C437(1.04)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C418(1.01); C497(0.95); C75(0.90); C437(1.29)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C418(0.93); C437(1.36); C511(1.06); C497(0.97)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C418(0.95); C437(1.11); C511(1.09); C497(1.02)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C418(1.57)  LDD3310  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C505(0.99)  LDD2102  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C505(1.46)  LDD2098  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C505(1.44)  LDD2105  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C505(1.15)  LDD2129  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C505(0.92)  LDD2136  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C505(1.77)  LDD2153  [4]
 LDCM0032  Oleacein HEK-293T 4.18  LDD0184  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adapter molecule crk (CRK) CRK family P46108
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840