Details of the Target

General Information of Target

Target ID LDTP00999
Target Name GDP-mannose 4,6 dehydratase (GMDS)
Gene Name GMDS
Gene ID 2762
Synonyms
GDP-mannose 4,6 dehydratase; EC 4.2.1.47; GDP-D-mannose dehydratase; GMD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA
Target Bioclass
Enzyme
Family
NAD(P)-dependent epimerase/dehydratase family, GDP-mannose 4,6-dehydratase subfamily
Function Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Uniprot ID
O60547
Ensemble ID
ENST00000380815.5
HGNC ID
HGNC:4369
ChEMBL ID
CHEMBL4105807

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.V278D DBIA    Probe Info 
HCC1395 Substitution: p.F218Ter DBIA    Probe Info 
HT115 SNV: p.G129R .
JURKAT SNV: p.R348G .
PF382 SNV: p.V94L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y69(13.15); Y48(7.32); Y84(6.49)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K346(8.33)  LDD0277  [4]
Probe 1
 Probe Info  		Y69(18.03)  LDD3495  [5]
BTD
 Probe Info  		C92(1.37)  LDD2105  [6]
DA-P3
 Probe Info  		4.74  LDD0179  [7]
HHS-482
 Probe Info  		Y84(0.95)  LDD0285  [8]
HHS-475
 Probe Info  		Y197(0.81); Y231(0.94); Y84(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y231(7.99); Y323(10.00); Y324(9.45); Y84(5.40)  LDD2237  [10]
DBIA
 Probe Info  		C336(0.90)  LDD0078  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C237(0.00); C92(0.00); C336(0.00); C142(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C237(0.00); C92(0.00); C336(0.00); C142(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C237(0.00); C92(0.00); C336(0.00); C142(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		C8(0.00); C336(0.00)  LDD0026  [14]
NAIA_4
 Probe Info  		C92(0.00); C336(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
IPM
 Probe Info  		N.A.  LDD0005  [16]
PF-06672131
 Probe Info  		N.A.  LDD0152  [17]
SF
 Probe Info  		Y197(0.00); Y84(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Acrolein
 Probe Info  		C92(0.00); C336(0.00)  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C237(0.00); C92(0.00); C142(0.00); C336(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C336(0.95)  LDD0812  [11]
 LDCM0215  AC10 HEK-293T C237(0.76); C336(1.12)  LDD0813  [11]
 LDCM0216  AC100 HEK-293T C237(0.83); C336(0.87)  LDD0814  [11]
 LDCM0217  AC101 HEK-293T C237(0.77); C336(1.13)  LDD0815  [11]
 LDCM0218  AC102 HEK-293T C237(0.93); C336(0.93)  LDD0816  [11]
 LDCM0219  AC103 HEK-293T C237(0.80); C336(0.98)  LDD0817  [11]
 LDCM0220  AC104 HEK-293T C237(0.75); C336(0.86)  LDD0818  [11]
 LDCM0221  AC105 HEK-293T C237(0.78); C336(1.12)  LDD0819  [11]
 LDCM0222  AC106 HEK-293T C237(0.97); C336(1.75)  LDD0820  [11]
 LDCM0223  AC107 HEK-293T C237(0.85); C336(1.05)  LDD0821  [11]
 LDCM0224  AC108 HEK-293T C237(0.94); C336(1.30)  LDD0822  [11]
 LDCM0225  AC109 HEK-293T C237(0.80); C336(1.17)  LDD0823  [11]
 LDCM0226  AC11 HEK-293T C237(0.95); C336(0.98)  LDD0824  [11]
 LDCM0227  AC110 HEK-293T C237(0.80); C336(0.97)  LDD0825  [11]
 LDCM0228  AC111 HEK-293T C237(0.94); C336(1.22)  LDD0826  [11]
 LDCM0229  AC112 HEK-293T C237(0.85); C336(1.05)  LDD0827  [11]
 LDCM0230  AC113 HEK-293T C237(0.51); C336(0.92)  LDD0828  [11]
 LDCM0231  AC114 HEK-293T C237(0.76); C336(0.94)  LDD0829  [11]
 LDCM0232  AC115 HEK-293T C237(1.12); C336(1.02)  LDD0830  [11]
 LDCM0233  AC116 HEK-293T C237(0.70); C336(0.76)  LDD0831  [11]
 LDCM0234  AC117 HEK-293T C237(0.67); C336(0.79)  LDD0832  [11]
 LDCM0235  AC118 HEK-293T C237(0.57); C336(0.73)  LDD0833  [11]
 LDCM0236  AC119 HEK-293T C237(0.68); C336(0.71)  LDD0834  [11]
 LDCM0237  AC12 HEK-293T C237(1.07); C336(1.00)  LDD0835  [11]
 LDCM0238  AC120 HEK-293T C237(0.74); C336(0.75)  LDD0836  [11]
 LDCM0239  AC121 HEK-293T C237(0.59); C336(0.72)  LDD0837  [11]
 LDCM0240  AC122 HEK-293T C237(0.65); C336(0.72)  LDD0838  [11]
 LDCM0241  AC123 HEK-293T C237(0.61); C336(0.73)  LDD0839  [11]
 LDCM0242  AC124 HEK-293T C237(0.70); C336(0.74)  LDD0840  [11]
 LDCM0243  AC125 HEK-293T C237(0.53); C336(0.73)  LDD0841  [11]
 LDCM0244  AC126 HEK-293T C237(0.65); C336(0.76)  LDD0842  [11]
 LDCM0245  AC127 HEK-293T C237(0.91); C336(0.89)  LDD0843  [11]
 LDCM0246  AC128 HEK-293T C336(1.16)  LDD0844  [11]
 LDCM0247  AC129 HEK-293T C336(0.98)  LDD0845  [11]
 LDCM0249  AC130 HEK-293T C336(1.58)  LDD0847  [11]
 LDCM0250  AC131 HEK-293T C336(0.87)  LDD0848  [11]
 LDCM0251  AC132 HEK-293T C336(0.92)  LDD0849  [11]
 LDCM0252  AC133 HEK-293T C336(0.95)  LDD0850  [11]
 LDCM0253  AC134 HEK-293T C336(0.84)  LDD0851  [11]
 LDCM0254  AC135 HEK-293T C336(0.97)  LDD0852  [11]
 LDCM0255  AC136 HEK-293T C336(1.12)  LDD0853  [11]
 LDCM0256  AC137 HEK-293T C336(0.90)  LDD0854  [11]
 LDCM0257  AC138 HEK-293T C336(1.03)  LDD0855  [11]
 LDCM0258  AC139 HEK-293T C336(1.07)  LDD0856  [11]
 LDCM0259  AC14 HEK-293T C237(0.81); C336(1.23)  LDD0857  [11]
 LDCM0260  AC140 HEK-293T C336(1.07)  LDD0858  [11]
 LDCM0261  AC141 HEK-293T C336(0.88)  LDD0859  [11]
 LDCM0262  AC142 HEK-293T C336(0.95)  LDD0860  [11]
 LDCM0263  AC143 HEK-293T C237(0.77); C336(1.02)  LDD0861  [11]
 LDCM0264  AC144 HEK-293T C237(0.95); C336(1.01)  LDD0862  [11]
 LDCM0265  AC145 HEK-293T C237(0.76); C336(0.96)  LDD0863  [11]
 LDCM0266  AC146 HEK-293T C237(0.77); C336(0.98)  LDD0864  [11]
 LDCM0267  AC147 HEK-293T C237(0.66); C336(1.16)  LDD0865  [11]
 LDCM0268  AC148 HEK-293T C237(0.49); C336(1.05)  LDD0866  [11]
 LDCM0269  AC149 HEK-293T C237(0.79); C336(1.13)  LDD0867  [11]
 LDCM0270  AC15 HEK-293T C237(0.72); C336(1.48)  LDD0868  [11]
 LDCM0271  AC150 HEK-293T C237(0.78); C336(0.94)  LDD0869  [11]
 LDCM0272  AC151 HEK-293T C237(0.83); C336(1.02)  LDD0870  [11]
 LDCM0273  AC152 HEK-293T C237(1.06); C336(1.11)  LDD0871  [11]
 LDCM0274  AC153 HEK-293T C237(0.79); C336(1.05)  LDD0872  [11]
 LDCM0621  AC154 HEK-293T C237(1.02); C336(0.92)  LDD2162  [11]
 LDCM0622  AC155 HEK-293T C237(0.91); C336(0.97)  LDD2163  [11]
 LDCM0623  AC156 HEK-293T C237(0.84); C336(1.18)  LDD2164  [11]
 LDCM0624  AC157 HEK-293T C237(0.93); C336(1.19)  LDD2165  [11]
 LDCM0276  AC17 HEK-293T C237(0.79); C336(0.46)  LDD0874  [11]
 LDCM0277  AC18 HEK-293T C237(0.79); C336(0.62)  LDD0875  [11]
 LDCM0278  AC19 HEK-293T C237(1.03); C336(0.82)  LDD0876  [11]
 LDCM0279  AC2 HEK-293T C336(0.99)  LDD0877  [11]
 LDCM0280  AC20 HEK-293T C237(0.87); C336(0.53)  LDD0878  [11]
 LDCM0281  AC21 HEK-293T C237(0.90); C336(0.67)  LDD0879  [11]
 LDCM0282  AC22 HEK-293T C237(0.78); C336(0.55)  LDD0880  [11]
 LDCM0283  AC23 HEK-293T C237(0.61); C336(0.64)  LDD0881  [11]
 LDCM0284  AC24 HEK-293T C237(1.00); C336(0.58)  LDD0882  [11]
 LDCM0285  AC25 HEK-293T C237(1.31); C336(0.88)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C237(1.60); C336(0.90)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C237(1.09); C336(0.79)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C237(0.90); C336(0.65)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C237(1.08); C336(0.74)  LDD0887  [11]
 LDCM0290  AC3 HEK-293T C336(1.21)  LDD0888  [11]
 LDCM0291  AC30 HEK-293T C237(1.33); C336(0.91)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C237(1.56); C336(0.95)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C237(1.42); C336(0.74)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C237(1.28); C336(0.72)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C237(1.68); C336(0.79)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C336(1.18)  LDD0894  [11]
 LDCM0297  AC36 HEK-293T C336(0.92)  LDD0895  [11]
 LDCM0298  AC37 HEK-293T C336(0.96)  LDD0896  [11]
 LDCM0299  AC38 HEK-293T C336(0.84)  LDD0897  [11]
 LDCM0300  AC39 HEK-293T C336(0.90)  LDD0898  [11]
 LDCM0301  AC4 HEK-293T C336(1.01)  LDD0899  [11]
 LDCM0302  AC40 HEK-293T C336(0.91)  LDD0900  [11]
 LDCM0303  AC41 HEK-293T C336(0.95)  LDD0901  [11]
 LDCM0304  AC42 HEK-293T C336(0.85)  LDD0902  [11]
 LDCM0305  AC43 HEK-293T C336(0.87)  LDD0903  [11]
 LDCM0306  AC44 HEK-293T C336(0.89)  LDD0904  [11]
 LDCM0307  AC45 HEK-293T C336(0.98)  LDD0905  [11]
 LDCM0308  AC46 PaTu 8988t C237(1.05)  LDD1187  [11]
 LDCM0309  AC47 PaTu 8988t C237(1.04)  LDD1188  [11]
 LDCM0310  AC48 PaTu 8988t C237(1.18)  LDD1189  [11]
 LDCM0311  AC49 PaTu 8988t C237(1.30)  LDD1190  [11]
 LDCM0312  AC5 HEK-293T C336(1.02)  LDD0910  [11]
 LDCM0313  AC50 PaTu 8988t C237(1.37)  LDD1192  [11]
 LDCM0314  AC51 PaTu 8988t C237(1.30)  LDD1193  [11]
 LDCM0315  AC52 PaTu 8988t C237(1.26)  LDD1194  [11]
 LDCM0316  AC53 PaTu 8988t C237(1.41)  LDD1195  [11]
 LDCM0317  AC54 PaTu 8988t C237(1.60)  LDD1196  [11]
 LDCM0318  AC55 PaTu 8988t C237(1.22)  LDD1197  [11]
 LDCM0319  AC56 PaTu 8988t C237(1.28)  LDD1198  [11]
 LDCM0320  AC57 HEK-293T C237(0.97); C336(1.13)  LDD0918  [11]
 LDCM0321  AC58 HEK-293T C237(0.98); C336(1.15)  LDD0919  [11]
 LDCM0322  AC59 HEK-293T C237(1.13); C336(1.07)  LDD0920  [11]
 LDCM0323  AC6 HEK-293T C237(1.15); C336(1.07)  LDD0921  [11]
 LDCM0324  AC60 HEK-293T C237(0.93); C336(0.83)  LDD0922  [11]
 LDCM0325  AC61 HEK-293T C237(0.68); C336(0.86)  LDD0923  [11]
 LDCM0326  AC62 HEK-293T C237(0.83); C336(1.04)  LDD0924  [11]
 LDCM0327  AC63 HEK-293T C237(0.87); C336(1.02)  LDD0925  [11]
 LDCM0328  AC64 HEK-293T C237(0.82); C336(0.91)  LDD0926  [11]
 LDCM0329  AC65 HEK-293T C237(0.70); C336(0.83)  LDD0927  [11]
 LDCM0330  AC66 HEK-293T C237(1.05); C336(0.95)  LDD0928  [11]
 LDCM0331  AC67 HEK-293T C237(1.01); C336(0.83)  LDD0929  [11]
 LDCM0332  AC68 PaTu 8988t C237(1.14)  LDD1211  [11]
 LDCM0333  AC69 PaTu 8988t C237(1.19)  LDD1212  [11]
 LDCM0334  AC7 HEK-293T C237(0.96); C336(0.82)  LDD0932  [11]
 LDCM0335  AC70 PaTu 8988t C237(1.26)  LDD1214  [11]
 LDCM0336  AC71 PaTu 8988t C237(1.19)  LDD1215  [11]
 LDCM0337  AC72 PaTu 8988t C237(1.03)  LDD1216  [11]
 LDCM0338  AC73 PaTu 8988t C237(1.16)  LDD1217  [11]
 LDCM0339  AC74 PaTu 8988t C237(1.16)  LDD1218  [11]
 LDCM0340  AC75 PaTu 8988t C237(1.30)  LDD1219  [11]
 LDCM0341  AC76 PaTu 8988t C237(1.07)  LDD1220  [11]
 LDCM0342  AC77 PaTu 8988t C237(1.26)  LDD1221  [11]
 LDCM0343  AC78 PaTu 8988t C237(1.32)  LDD1222  [11]
 LDCM0344  AC79 PaTu 8988t C237(1.17)  LDD1223  [11]
 LDCM0345  AC8 HEK-293T C237(1.10); C336(1.29)  LDD0943  [11]
 LDCM0346  AC80 PaTu 8988t C237(1.19)  LDD1225  [11]
 LDCM0347  AC81 PaTu 8988t C237(1.25)  LDD1226  [11]
 LDCM0348  AC82 PaTu 8988t C237(1.14)  LDD1227  [11]
 LDCM0349  AC83 HEK-293T C237(1.09)  LDD0947  [11]
 LDCM0350  AC84 HEK-293T C237(1.21)  LDD0948  [11]
 LDCM0351  AC85 HEK-293T C237(1.09)  LDD0949  [11]
 LDCM0352  AC86 HEK-293T C237(1.33)  LDD0950  [11]
 LDCM0353  AC87 HEK-293T C237(1.41)  LDD0951  [11]
 LDCM0354  AC88 HEK-293T C237(0.95)  LDD0952  [11]
 LDCM0355  AC89 HEK-293T C237(0.99)  LDD0953  [11]
 LDCM0357  AC90 HEK-293T C237(1.74)  LDD0955  [11]
 LDCM0358  AC91 HEK-293T C237(1.17)  LDD0956  [11]
 LDCM0359  AC92 HEK-293T C237(1.03)  LDD0957  [11]
 LDCM0360  AC93 HEK-293T C237(1.15)  LDD0958  [11]
 LDCM0361  AC94 HEK-293T C237(0.83)  LDD0959  [11]
 LDCM0362  AC95 HEK-293T C237(0.91)  LDD0960  [11]
 LDCM0363  AC96 HEK-293T C237(0.85)  LDD0961  [11]
 LDCM0364  AC97 HEK-293T C237(1.11)  LDD0962  [11]
 LDCM0365  AC98 HEK-293T C237(0.82); C336(1.18)  LDD0963  [11]
 LDCM0366  AC99 HEK-293T C237(0.85); C336(1.09)  LDD0964  [11]
 LDCM0248  AKOS034007472 HEK-293T C237(0.87); C336(1.56)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C237(0.65); C336(1.20)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C237(0.89); C336(1.22)  LDD0873  [11]
 LDCM0156  Aniline NCI-H1299 12.73  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C336(0.90)  LDD0078  [11]
 LDCM0108  Chloroacetamide HeLa C92(0.00); C237(0.00); C336(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C92(1.10); C336(0.83)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C237(1.16); C336(0.45)  LDD0965  [11]
 LDCM0368  CL10 HEK-293T C237(0.92); C336(0.40)  LDD0966  [11]
 LDCM0369  CL100 HEK-293T C336(0.92)  LDD0967  [11]
 LDCM0370  CL101 HEK-293T C237(0.84); C336(0.98)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C237(0.72); C336(1.08)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C237(0.75); C336(0.91)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C237(0.88); C336(1.16)  LDD0971  [11]
 LDCM0374  CL105 HEK-293T C237(1.15); C336(0.59)  LDD0972  [11]
 LDCM0375  CL106 HEK-293T C237(0.85); C336(0.83)  LDD0973  [11]
 LDCM0376  CL107 HEK-293T C237(1.09); C336(0.69)  LDD0974  [11]
 LDCM0377  CL108 HEK-293T C237(0.79); C336(0.64)  LDD0975  [11]
 LDCM0378  CL109 HEK-293T C237(0.99); C336(0.68)  LDD0976  [11]
 LDCM0379  CL11 HEK-293T C237(0.87); C336(0.56)  LDD0977  [11]
 LDCM0380  CL110 HEK-293T C237(0.91); C336(0.66)  LDD0978  [11]
 LDCM0381  CL111 HEK-293T C237(1.05); C336(0.55)  LDD0979  [11]
 LDCM0382  CL112 HEK-293T C237(1.48); C336(0.66)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C237(1.31); C336(0.98)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C237(1.08); C336(0.71)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C237(1.13); C336(0.70)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C237(1.25); C336(0.79)  LDD0984  [11]
 LDCM0387  CL117 HEK-293T C336(1.05)  LDD0985  [11]
 LDCM0388  CL118 HEK-293T C336(1.09)  LDD0986  [11]
 LDCM0389  CL119 HEK-293T C336(0.86)  LDD0987  [11]
 LDCM0390  CL12 HEK-293T C237(1.04); C336(0.63)  LDD0988  [11]
 LDCM0391  CL120 HEK-293T C336(0.98)  LDD0989  [11]
 LDCM0392  CL121 PaTu 8988t C237(1.16)  LDD1271  [11]
 LDCM0393  CL122 PaTu 8988t C237(1.15)  LDD1272  [11]
 LDCM0394  CL123 PaTu 8988t C237(1.41)  LDD1273  [11]
 LDCM0395  CL124 PaTu 8988t C237(1.25)  LDD1274  [11]
 LDCM0396  CL125 HEK-293T C237(1.07); C336(1.02)  LDD0994  [11]
 LDCM0397  CL126 HEK-293T C237(0.86); C336(1.09)  LDD0995  [11]
 LDCM0398  CL127 HEK-293T C237(0.84); C336(1.17)  LDD0996  [11]
 LDCM0399  CL128 HEK-293T C237(1.14); C336(1.04)  LDD0997  [11]
 LDCM0400  CL13 HEK-293T C237(1.13); C336(0.70)  LDD0998  [11]
 LDCM0401  CL14 HEK-293T C237(0.99); C336(0.85)  LDD0999  [11]
 LDCM0402  CL15 HEK-293T C237(0.84); C336(0.67)  LDD1000  [11]
 LDCM0403  CL16 HEK-293T C237(1.76); C336(1.15)  LDD1001  [11]
 LDCM0404  CL17 HEK-293T C237(0.86); C336(0.95)  LDD1002  [11]
 LDCM0405  CL18 HEK-293T C237(0.81); C336(0.89)  LDD1003  [11]
 LDCM0406  CL19 HEK-293T C237(0.92); C336(1.02)  LDD1004  [11]
 LDCM0407  CL2 HEK-293T C237(1.28); C336(0.47)  LDD1005  [11]
 LDCM0408  CL20 HEK-293T C237(0.91); C336(0.92)  LDD1006  [11]
 LDCM0409  CL21 HEK-293T C237(0.58); C336(0.80)  LDD1007  [11]
 LDCM0410  CL22 HEK-293T C237(0.69); C336(0.93)  LDD1008  [11]
 LDCM0411  CL23 HEK-293T C237(0.83); C336(1.15)  LDD1009  [11]
 LDCM0412  CL24 HEK-293T C237(0.90); C336(0.98)  LDD1010  [11]
 LDCM0413  CL25 HEK-293T C237(0.94); C336(0.93)  LDD1011  [11]
 LDCM0414  CL26 HEK-293T C237(0.78); C336(0.98)  LDD1012  [11]
 LDCM0415  CL27 HEK-293T C237(0.76); C336(0.97)  LDD1013  [11]
 LDCM0416  CL28 HEK-293T C237(0.71); C336(0.96)  LDD1014  [11]
 LDCM0417  CL29 HEK-293T C237(0.85); C336(1.08)  LDD1015  [11]
 LDCM0418  CL3 HEK-293T C237(1.24); C336(0.67)  LDD1016  [11]
 LDCM0419  CL30 HEK-293T C237(0.61); C336(0.82)  LDD1017  [11]
 LDCM0420  CL31 HEK-293T C237(1.43); C336(0.78)  LDD1018  [11]
 LDCM0421  CL32 HEK-293T C237(1.09); C336(0.80)  LDD1019  [11]
 LDCM0422  CL33 HEK-293T C237(0.93); C336(0.64)  LDD1020  [11]
 LDCM0423  CL34 HEK-293T C237(0.82); C336(0.89)  LDD1021  [11]
 LDCM0424  CL35 HEK-293T C237(0.84); C336(0.77)  LDD1022  [11]
 LDCM0425  CL36 HEK-293T C237(0.84); C336(0.87)  LDD1023  [11]
 LDCM0426  CL37 HEK-293T C237(0.77); C336(0.79)  LDD1024  [11]
 LDCM0428  CL39 HEK-293T C237(0.55); C336(0.56)  LDD1026  [11]
 LDCM0429  CL4 HEK-293T C237(1.00); C336(0.56)  LDD1027  [11]
 LDCM0430  CL40 HEK-293T C237(0.70); C336(0.77)  LDD1028  [11]
 LDCM0431  CL41 HEK-293T C237(0.62); C336(0.59)  LDD1029  [11]
 LDCM0432  CL42 HEK-293T C237(0.56); C336(0.62)  LDD1030  [11]
 LDCM0433  CL43 HEK-293T C237(0.47); C336(0.63)  LDD1031  [11]
 LDCM0434  CL44 HEK-293T C237(0.89); C336(0.85)  LDD1032  [11]
 LDCM0435  CL45 HEK-293T C237(0.58); C336(0.67)  LDD1033  [11]
 LDCM0436  CL46 PaTu 8988t C336(1.37); C237(1.08)  LDD1315  [11]
 LDCM0437  CL47 PaTu 8988t C336(1.17); C237(1.10)  LDD1316  [11]
 LDCM0438  CL48 PaTu 8988t C336(1.10); C237(1.14)  LDD1317  [11]
 LDCM0439  CL49 PaTu 8988t C336(1.11); C237(1.09)  LDD1318  [11]
 LDCM0440  CL5 HEK-293T C237(0.98); C336(0.62)  LDD1038  [11]
 LDCM0441  CL50 PaTu 8988t C336(1.37); C237(1.18)  LDD1320  [11]
 LDCM0442  CL51 PaTu 8988t C336(0.91); C237(0.97)  LDD1321  [11]
 LDCM0443  CL52 PaTu 8988t C336(1.02); C237(1.08)  LDD1322  [11]
 LDCM0444  CL53 PaTu 8988t C336(0.84); C237(1.10)  LDD1323  [11]
 LDCM0445  CL54 PaTu 8988t C336(1.39); C237(1.12)  LDD1324  [11]
 LDCM0446  CL55 PaTu 8988t C336(1.50); C237(1.18)  LDD1325  [11]
 LDCM0447  CL56 PaTu 8988t C336(0.32); C237(0.82)  LDD1326  [11]
 LDCM0448  CL57 PaTu 8988t C336(1.16); C237(1.30)  LDD1327  [11]
 LDCM0449  CL58 PaTu 8988t C336(1.40); C237(1.26)  LDD1328  [11]
 LDCM0450  CL59 PaTu 8988t C336(1.08); C237(1.44)  LDD1329  [11]
 LDCM0451  CL6 HEK-293T C237(1.03); C336(0.83)  LDD1049  [11]
 LDCM0452  CL60 PaTu 8988t C336(1.26); C237(1.30)  LDD1331  [11]
 LDCM0453  CL61 HEK-293T C237(1.47)  LDD1051  [11]
 LDCM0454  CL62 HEK-293T C237(1.08)  LDD1052  [11]
 LDCM0455  CL63 HEK-293T C237(1.11)  LDD1053  [11]
 LDCM0456  CL64 HEK-293T C237(1.09)  LDD1054  [11]
 LDCM0457  CL65 HEK-293T C237(1.07)  LDD1055  [11]
 LDCM0458  CL66 HEK-293T C237(1.10)  LDD1056  [11]
 LDCM0459  CL67 HEK-293T C237(0.84)  LDD1057  [11]
 LDCM0460  CL68 HEK-293T C237(0.70)  LDD1058  [11]
 LDCM0461  CL69 HEK-293T C237(1.00)  LDD1059  [11]
 LDCM0462  CL7 HEK-293T C237(0.89); C336(0.47)  LDD1060  [11]
 LDCM0463  CL70 HEK-293T C237(1.02)  LDD1061  [11]
 LDCM0464  CL71 HEK-293T C237(0.78)  LDD1062  [11]
 LDCM0465  CL72 HEK-293T C237(1.09)  LDD1063  [11]
 LDCM0466  CL73 HEK-293T C237(0.74)  LDD1064  [11]
 LDCM0467  CL74 HEK-293T C237(0.70)  LDD1065  [11]
 LDCM0469  CL76 HEK-293T C336(0.86)  LDD1067  [11]
 LDCM0470  CL77 HEK-293T C336(0.79)  LDD1068  [11]
 LDCM0471  CL78 HEK-293T C336(0.62)  LDD1069  [11]
 LDCM0472  CL79 HEK-293T C336(0.88)  LDD1070  [11]
 LDCM0473  CL8 HEK-293T C237(1.65); C336(0.88)  LDD1071  [11]
 LDCM0474  CL80 HEK-293T C336(1.00)  LDD1072  [11]
 LDCM0475  CL81 HEK-293T C336(0.74)  LDD1073  [11]
 LDCM0476  CL82 HEK-293T C336(1.04)  LDD1074  [11]
 LDCM0477  CL83 HEK-293T C336(1.08)  LDD1075  [11]
 LDCM0478  CL84 HEK-293T C336(0.67)  LDD1076  [11]
 LDCM0479  CL85 HEK-293T C336(0.88)  LDD1077  [11]
 LDCM0480  CL86 HEK-293T C336(0.75)  LDD1078  [11]
 LDCM0481  CL87 HEK-293T C336(0.64)  LDD1079  [11]
 LDCM0482  CL88 HEK-293T C336(0.82)  LDD1080  [11]
 LDCM0483  CL89 HEK-293T C336(0.87)  LDD1081  [11]
 LDCM0484  CL9 HEK-293T C237(0.98); C336(0.93)  LDD1082  [11]
 LDCM0485  CL90 HEK-293T C336(0.82)  LDD1083  [11]
 LDCM0486  CL91 HEK-293T C336(1.12)  LDD1084  [11]
 LDCM0487  CL92 HEK-293T C336(1.00)  LDD1085  [11]
 LDCM0488  CL93 HEK-293T C336(0.88)  LDD1086  [11]
 LDCM0489  CL94 HEK-293T C336(0.76)  LDD1087  [11]
 LDCM0490  CL95 HEK-293T C336(0.72)  LDD1088  [11]
 LDCM0491  CL96 HEK-293T C336(1.01)  LDD1089  [11]
 LDCM0492  CL97 HEK-293T C336(0.88)  LDD1090  [11]
 LDCM0493  CL98 HEK-293T C336(0.96)  LDD1091  [11]
 LDCM0494  CL99 HEK-293T C336(1.11)  LDD1092  [11]
 LDCM0027  Dopamine HEK-293T 4.74  LDD0179  [7]
 LDCM0495  E2913 HEK-293T C142(1.21); C336(0.97); C237(0.89)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(1.42); C336(1.01)  LDD1702  [6]
 LDCM0625  F8 Ramos C92(1.00); C336(1.13); C142(0.97); C237(0.79)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C92(1.43); C336(1.13); C142(0.49); C237(3.24)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C92(0.10); C336(0.02); C237(0.85)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C92(1.27); C336(1.09); C142(0.43); C237(1.55)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C92(0.99); C336(0.94); C142(1.77); C237(1.14)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C92(1.39); C336(1.06); C142(1.06); C237(0.76)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C92(1.39); C336(1.26); C142(0.58)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C92(1.01); C336(0.89); C142(0.46); C237(1.68)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C92(1.17); C336(0.94); C142(0.51); C237(1.73)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C92(0.90); C336(0.84); C142(0.39); C237(0.77)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C92(0.80); C336(0.78); C142(0.57); C237(0.74)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C92(0.97); C336(1.07); C142(0.48); C237(1.86)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C92(0.85); C336(0.89); C142(0.46); C237(0.81)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C92(1.70); C336(1.47); C142(0.41); C237(1.16)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C237(0.74)  LDD1066  [11]
 LDCM0596  Fragment38 Ramos C92(0.73); C336(0.71); C142(0.32); C237(2.37)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C92(1.09); C336(0.98); C142(1.25); C237(0.54)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C237(0.89); C336(0.83)  LDD1025  [11]
 LDCM0610  Fragment52 Ramos C92(1.05); C336(0.92); C142(0.81); C237(1.71)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C92(0.97); C336(0.99); C142(0.65); C237(1.68)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C92(0.95); C336(1.11); C142(1.17); C237(0.60)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C92(1.72); C336(1.50); C142(0.97); C237(2.90)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y197(0.81); Y231(0.94); Y84(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y84(0.82); Y231(0.85); Y197(1.09)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y231(0.84); Y197(0.87); Y84(0.92)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y197(0.50); Y231(0.80); Y84(1.14)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y197(0.80); Y231(0.93); Y84(1.19)  LDD0268  [9]
 LDCM0107  IAA HeLa C92(0.00); C336(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y84(0.95)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y84(0.83)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y84(1.07)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y84(2.63)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y84(1.76)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y84(0.69)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y84(0.58)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y84(1.03)  LDD0292  [8]
 LDCM0022  KB02 HCT 116 C237(1.15)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C237(1.56)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C237(1.69)  LDD0082  [11]
 LDCM0109  NEM HeLa C92(0.00); H51(0.00)  LDD0223  [20]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C92(1.37)  LDD2105  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C142(1.27)  LDD2127  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C336(0.85)  LDD2206  [25]
 LDCM0032  Oleacein HEK-293T 11.40  LDD0184  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C336(0.79)  LDD2207  [25]
 LDCM0029  Quercetin HEK-293T 8.91  LDD0181  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GDP-mannose 4,6 dehydratase (GMDS) NAD(P)-dependent epimerase/dehydratase family O60547
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-gated potassium channel subunit beta-3 (KCNAB3) Shaker potassium channel beta subunit family O43448

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Guanosine-5'-diphosphate-rhamnose . DB02547

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.