Details of the Target

General Information of Target

Target ID LDTP14415
Target Name GTP-binding protein 1 (GTPBP1)
Gene Name GTPBP1
Gene ID 9567
Synonyms
GTP-binding protein 1; G-protein 1; GP-1; GP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACIYPTTFYTSLPTKSLNMGISLTTILILSVAVLLSTAAPPSCRECYQSLHYRGEMQQY
FTYHTHIERSCYGNLIEECVESGKSYYKVKNLGVCGSRNGAICPRGKQWLCFTKIGQWGV
NTQVLEDIKREQIIAKAKASKPTTPPENRPRHFHSFIQKL
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, GTPBP1 subfamily
Subcellular location
Cytoplasm
Function Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.
Uniprot ID
O00178
Ensemble ID
ENST00000216044.10
HGNC ID
HGNC:4669

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K453(9.09)  LDD0274  [2]
STPyne
 Probe Info  		K330(4.00); K466(4.76)  LDD0277  [2]
DA-P3
 Probe Info  		6.78  LDD0184  [3]
AHL-Pu-1
 Probe Info  		C360(2.26)  LDD0172  [4]
DBIA
 Probe Info  		C669(0.97)  LDD0078  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C313(0.00); C46(0.00); C360(0.00); C515(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C313(0.00); C531(0.00); C275(0.00); C515(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C313(0.00); C360(0.00); C531(0.00); C515(0.00)  LDD0037  [7]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		C662(0.00); C46(0.00); C313(0.00)  LDD2156  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Ox-W18
 Probe Info  		N.A.  LDD2175  [12]
1c-yne
 Probe Info  		K546(0.00); K173(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		6.50  LDD0443  [16]
NAIA_5
 Probe Info  		C360(0.00); C531(0.00); C515(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		5.08  LDD0465  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C360(2.26)  LDD0172  [4]
 LDCM0214  AC1 HEK-293T C313(1.62); C515(1.62)  LDD0812  [5]
 LDCM0215  AC10 HCT 116 C669(0.77)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C669(0.96)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C669(0.91)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C669(0.79)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C669(1.25)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C669(1.19)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C669(1.00)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C669(1.00)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C669(0.88)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C669(1.32)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C669(1.02)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C669(0.80)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C669(1.02)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C669(0.96)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C669(0.89)  LDD0546  [5]
 LDCM0230  AC113 HEK-293T C360(1.18)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C360(1.36)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C360(1.03)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C360(1.62)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C360(1.61)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C360(1.33)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C360(1.26)  LDD0834  [5]
 LDCM0237  AC12 HCT 116 C669(0.71)  LDD0554  [5]
 LDCM0238  AC120 HEK-293T C360(1.18)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C360(1.04)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C360(1.18)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C360(1.00)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C360(1.46)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C360(1.16)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C360(1.60)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C360(1.68)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C360(1.01)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C360(0.99)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C360(0.89)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C360(0.78)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C360(1.14)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C360(1.22)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C360(1.02)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C360(1.17)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C360(1.16)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C360(1.12)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C360(1.40)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C360(1.54)  LDD0856  [5]
 LDCM0259  AC14 HCT 116 C669(0.98)  LDD0576  [5]
 LDCM0260  AC140 HEK-293T C360(1.24)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C360(1.13)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C360(1.04)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C669(1.09)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C669(1.58)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C669(0.97)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C669(1.40)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C669(1.80)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C669(1.69)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C669(1.58)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C669(0.77)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C669(1.29)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C669(1.26)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C669(1.70)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C669(2.23)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C669(1.76)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C669(1.55)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C669(1.23)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C669(1.81)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C360(1.60)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C360(1.63)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C360(1.15)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C313(1.06); C515(1.06)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C360(1.17)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C360(1.44)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C360(1.42)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C360(1.51)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C360(1.42)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C313(0.86); C275(1.04); C46(1.09); C360(1.01)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C313(1.00); C275(1.04); C46(1.04); C360(1.06)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C313(0.96); C275(0.83); C515(0.99); C46(1.15)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C313(1.03); C275(0.99); C515(1.00); C46(1.08)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C313(0.96); C275(0.96); C515(1.26); C46(1.07)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C313(1.10); C515(1.10)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C313(1.00); C275(0.86); C515(1.11); C46(1.00)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C313(1.00); C275(0.87); C515(0.96); C46(0.97)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C313(0.95); C275(1.04); C515(1.05); C46(0.94)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C313(0.95); C275(1.11); C46(1.14); C360(0.88)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C313(0.92); C275(1.04); C46(1.17); C360(1.01)  LDD1534  [20]
 LDCM0296  AC35 PaTu 8988t C360(0.57)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C360(0.58)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C360(0.53)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C360(0.46)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C360(0.59)  LDD1179  [5]
 LDCM0301  AC4 HEK-293T C313(1.09); C515(1.09)  LDD0899  [5]
 LDCM0302  AC40 PaTu 8988t C360(0.49)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C360(0.56)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C360(0.42)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C360(0.55)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C360(0.43)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C360(0.42)  LDD1186  [5]
 LDCM0308  AC46 PaTu 8988t C360(1.11)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C360(1.11)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C360(1.23)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C360(1.13)  LDD1190  [5]
 LDCM0312  AC5 HEK-293T C313(1.06); C515(1.06)  LDD0910  [5]
 LDCM0313  AC50 PaTu 8988t C360(1.02)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C360(0.63)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C360(1.15)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C360(0.96)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C360(0.99)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C360(0.98)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C360(0.92)  LDD1198  [5]
 LDCM0320  AC57 HEK-293T C313(0.94); C275(1.17); C46(0.90); C360(0.97)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C313(0.96); C275(0.99); C46(0.97); C360(1.11)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C313(0.93); C275(0.73); C515(0.94); C46(1.14)  LDD1561  [20]
 LDCM0323  AC6 HCT 116 C669(1.22)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C313(0.95); C275(0.90); C515(1.05); C46(1.05)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C313(1.03); C275(0.94); C515(1.13); C46(1.07)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C313(0.93); C275(0.92); C515(1.21); C46(1.06)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C313(1.03); C275(0.87); C515(1.08); C46(1.04)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C313(0.95); C275(0.97); C515(1.25); C46(0.94)  LDD1567  [20]
 LDCM0332  AC68 HCT 116 C669(0.94)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C669(1.41)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C669(0.81)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C669(1.31)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C669(1.08)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C669(1.81)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C669(1.94)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C669(1.59)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C669(2.09)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C669(1.27)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C669(1.73)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C669(1.49)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C669(1.29)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C669(0.79)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C669(1.58)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C669(1.41)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C669(1.92)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C313(0.93); C360(1.02); C515(0.93)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C313(1.00); C360(0.95); C515(1.00)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C313(1.21); C360(1.00); C515(1.21)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C313(0.95); C360(1.09); C515(0.95)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C313(0.94); C360(1.17); C515(0.94)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C313(1.01); C360(1.18); C515(1.01)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C313(1.29); C360(1.51); C515(1.29)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C313(1.04); C360(1.21); C515(1.04)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C313(1.00); C360(1.15); C515(1.00)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C313(0.89); C360(0.88); C515(0.89)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C313(1.18); C360(1.09); C515(1.18)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C313(0.87); C360(1.46); C515(0.87)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C313(0.90); C360(1.40); C515(0.90)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C313(1.18); C360(1.00); C515(1.18)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C313(1.18); C360(1.82); C515(1.18)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C669(1.63)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C669(0.79)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C669(0.75)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C669(1.56)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C669(0.93)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.97  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C669(0.97)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C313(0.00); C46(0.00)  LDD0222  [14]
 LDCM0367  CL1 HEK-293T C313(1.36); C515(1.36)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C313(1.55); C515(1.55)  LDD0966  [5]
 LDCM0369  CL100 HEK-293T C313(1.03); C515(1.03)  LDD0967  [5]
 LDCM0370  CL101 HCT 116 C669(0.92)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C669(1.41)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C669(0.97)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C669(1.06)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C360(1.40)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C360(1.20)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C360(1.25)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C360(1.48)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C360(1.27)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C313(1.40); C515(1.40)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C360(1.78)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C360(1.34)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C313(0.94); C275(1.12); C515(1.13); C46(1.02)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C313(1.06); C275(1.44); C515(1.07); C46(1.06)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C313(0.88); C275(0.82); C46(0.85)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C313(0.99); C46(1.13)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C313(1.04); C275(1.39); C515(1.04); C46(0.94)  LDD1590  [20]
 LDCM0387  CL117 PaTu 8988t C360(0.49)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C360(0.34)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C360(0.49)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C313(1.25); C515(1.25)  LDD0988  [5]
 LDCM0391  CL120 PaTu 8988t C360(0.49)  LDD1270  [5]
 LDCM0392  CL121 PaTu 8988t C360(0.94)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C360(0.78)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C360(0.78)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C360(0.83)  LDD1274  [5]
 LDCM0396  CL125 HEK-293T C313(1.03); C275(1.03); C515(1.13); C46(1.00)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C313(0.96); C275(0.74); C46(0.82)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C313(1.06); C46(1.06)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C313(0.95); C275(1.00); C515(1.14); C46(0.87)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C313(1.26); C515(1.26)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C313(1.44); C515(1.44)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C313(1.13); C515(1.13)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C313(1.17); C515(1.17)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C313(1.08); C515(1.08)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C313(0.97); C515(0.97)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C313(1.15); C515(1.15)  LDD1004  [5]
 LDCM0407  CL2 HEK-293T C313(0.98); C515(0.98)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C313(0.91); C515(0.91)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C313(1.03); C515(1.03)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C313(1.07); C515(1.07)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C313(0.80); C515(0.80)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C313(1.07); C515(1.07)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C313(1.10); C515(1.10)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C313(1.02); C515(1.02)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C313(1.08); C515(1.08)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C313(1.09); C515(1.09)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C313(0.98); C515(0.98)  LDD1015  [5]
 LDCM0418  CL3 HEK-293T C313(1.05); C515(1.05)  LDD1016  [5]
 LDCM0419  CL30 HEK-293T C313(1.12); C515(1.12)  LDD1017  [5]
 LDCM0420  CL31 HEK-293T C313(0.75); C515(0.75)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C313(0.96); C515(0.96)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C313(0.70); C515(0.70)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C313(0.81); C515(0.81)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C313(0.83); C515(0.83)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C313(1.11); C515(1.11)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C313(0.91); C515(0.91)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C313(1.05); C515(1.05)  LDD1026  [5]
 LDCM0429  CL4 HEK-293T C313(1.26); C515(1.26)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C313(1.18); C515(1.18)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C313(1.04); C515(1.04)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C313(1.12); C515(1.12)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C313(1.09); C515(1.09)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C313(1.03); C515(1.03)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C313(0.83); C515(0.83)  LDD1033  [5]
 LDCM0436  CL46 PaTu 8988t C360(0.88)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C360(0.85)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C360(0.79)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C360(0.93)  LDD1318  [5]
 LDCM0440  CL5 HEK-293T C313(1.20); C515(1.20)  LDD1038  [5]
 LDCM0441  CL50 PaTu 8988t C360(0.86)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C360(0.77)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C360(0.85)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C360(0.63)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C360(0.75)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C360(0.71)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C360(0.66)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C360(0.80)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C360(0.74)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C360(0.85)  LDD1329  [5]
 LDCM0451  CL6 HEK-293T C313(1.30); C515(1.30)  LDD1049  [5]
 LDCM0452  CL60 PaTu 8988t C360(0.75)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C313(0.97)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C313(1.20)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C313(1.09)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C313(1.21)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C313(1.25)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C313(1.19)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C313(1.20)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C313(0.96)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C313(0.97)  LDD1340  [5]
 LDCM0462  CL7 HEK-293T C313(1.34); C515(1.34)  LDD1060  [5]
 LDCM0463  CL70 PaTu 8988t C313(0.92)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C313(0.98)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C313(1.00)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C313(0.96)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C313(0.79)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C313(0.97); C360(0.88)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C313(0.93); C360(0.92)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C313(1.13); C360(1.00)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C313(1.03); C360(1.12)  LDD1351  [5]
 LDCM0473  CL8 HEK-293T C313(1.11)  LDD1071  [5]
 LDCM0474  CL80 PaTu 8988t C313(0.89); C360(0.88)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C313(0.92); C360(1.02)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C313(0.96); C360(1.02)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C313(0.84); C360(0.82)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C313(1.01); C360(1.03)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C313(1.03); C360(1.21)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C313(1.13); C360(0.85)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C313(0.97); C360(0.93)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C313(0.96); C360(0.99)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C313(0.97); C360(0.92)  LDD1362  [5]
 LDCM0484  CL9 HEK-293T C313(1.09)  LDD1082  [5]
 LDCM0485  CL90 PaTu 8988t C313(1.04); C360(0.98)  LDD1364  [5]
 LDCM0486  CL91 HEK-293T C313(0.96); C515(0.96)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C313(1.15); C515(1.15)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C313(1.04); C515(1.04)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C313(1.00); C515(1.00)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C313(1.09); C515(1.09)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C313(1.02); C515(1.02)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C313(1.03); C515(1.03)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C313(1.02); C515(1.02)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C313(1.06); C515(1.06)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C313(1.06); C46(1.45)  LDD1698  [20]
 LDCM0625  F8 Ramos C46(1.22)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C46(0.95)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C46(0.53)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C46(1.16)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C46(1.00)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C46(1.19)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C46(0.80)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C46(1.18)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C46(1.13)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C46(1.21)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C46(0.96)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C46(1.03)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C46(0.94)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C46(1.00)  LDD2201  [21]
 LDCM0468  Fragment33 PaTu 8988t C313(0.87)  LDD1347  [5]
 LDCM0596  Fragment38 Ramos C46(0.81)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C46(0.82)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C313(0.93); C515(0.93)  LDD1025  [5]
 LDCM0610  Fragment52 Ramos C46(1.31)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C46(0.92)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C46(0.88)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C46(0.73)  LDD2188  [21]
 LDCM0022  KB02 HCT 116 C669(1.83); C662(2.79)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C669(1.07); C662(1.33)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C669(1.63); C662(1.55)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0032  Oleacein HEK-293T 6.78  LDD0184  [3]
 LDCM0021  THZ1 HCT 116 C662(1.18); C669(1.18)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UPF0415 protein C7orf25 (C7orf25) UPF0415 family Q9BPX7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578