Details of the Target

General Information of Target

Target ID LDTP12448
Target Name Gephyrin (GPHN)
Gene Name GPHN
Gene ID 10243
Synonyms
GPH; KIAA1385; Gephyrin [Includes: Molybdopterin adenylyltransferase; MPT adenylyltransferase; EC 2.7.7.75; Domain G; Molybdopterin molybdenumtransferase; MPT Mo-transferase; EC 2.10.1.1; Domain E)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEV
RGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELL
IGYLDSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSED
ILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSFQCSVCN
SSFSSASSFEQHQETCRGDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKKKLICSVC
NKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRL
DQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQ
RHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHK
KTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHT
REKPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRP
LAECQFCHKKFTRNDYLKVHMDNIHGVADS
Target Bioclass
Other
Family
MoaB/Mog family; MoeA family
Subcellular location
Postsynaptic cell membrane
Function
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors.; Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Uniprot ID
Q9NQX3
Ensemble ID
ENST00000315266.9
HGNC ID
HGNC:15465

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y360(19.40)  LDD3495  [2]
DBIA
 Probe Info  		C26(2.65)  LDD3312  [3]
BTD
 Probe Info  		C469(1.63); C133(1.14); C284(1.09)  LDD1700  [4]
DA-P3
 Probe Info  		4.65  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C212(4.24)  LDD0169  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C284(0.00); C469(0.00); C26(0.00); C133(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C284(0.00); C469(0.00); C154(0.00); C635(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C133(0.00); C284(0.00); C469(0.00); C676(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
NAIA_4
 Probe Info  		C284(0.00); C293(0.00); C419(0.00)  LDD2226  [9]
WYneN
 Probe Info  		C284(0.00); C419(0.00)  LDD0021  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
VSF
 Probe Info  		C419(0.00); C284(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C26(0.00); C293(0.00); C419(0.00)  LDD0018  [12]
1d-yne
 Probe Info  		N.A.  LDD0357  [13]
Acrolein
 Probe Info  		C212(0.00); C26(0.00); C284(0.00); C469(0.00)  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		10.70  LDD0443  [16]
NAIA_5
 Probe Info  		C293(0.00); C133(0.00); C154(0.00); C284(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C133(0.64)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C133(0.51); C469(0.70)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C133(0.89); C469(1.07)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C469(1.12)  LDD2103  [4]
 LDCM0025  4SU-RNA DM93 C212(2.97)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C212(4.24)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C212(0.88); C284(1.02); C26(1.17); C419(1.06)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C212(0.93); C284(0.89); C26(1.16); C419(1.04)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C212(1.03); C284(1.03); C26(1.35); C419(1.00)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C212(0.89); C284(0.93); C26(1.09); C419(0.90)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C212(0.95); C284(1.05); C26(1.13); C419(0.99)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C212(1.18); C284(0.87); C26(1.13); C419(1.06)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C212(1.00); C284(1.08); C26(1.15); C419(0.99)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C212(1.04); C284(0.99); C26(1.12); C419(1.27)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C212(0.99); C284(1.87); C26(1.08); C419(0.93)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C212(0.93); C284(0.90); C26(1.21); C419(1.14)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C212(0.95); C284(1.02); C26(1.18); C419(0.99)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C212(0.95); C284(0.94); C26(1.10); C419(0.88)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C212(0.92); C284(1.03); C26(1.22); C419(1.15)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C212(1.05); C284(0.94); C26(1.09); C419(1.08)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C212(0.96); C284(0.94); C26(1.01); C469(0.91)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C212(0.92); C284(1.02); C26(1.07); C419(1.21)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C212(0.95); C284(0.94); C26(1.13); C419(1.08)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C212(0.92); C284(1.00); C26(1.21); C419(0.89)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C212(0.91); C284(1.05); C26(1.14); C419(1.08)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C212(0.85); C284(1.04); C26(1.15); C419(0.99)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C212(0.88); C284(0.91); C26(1.34); C419(0.93)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C212(0.97); C284(1.05); C26(1.12); C419(1.05)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C212(1.03); C284(0.93); C26(1.14); C419(1.05)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C212(1.00); C284(1.00); C26(1.01); C469(1.00)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C212(0.92); C284(1.02); C26(1.14); C419(1.13)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C212(0.90); C284(0.89); C26(1.10); C419(1.17)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C212(0.88); C284(0.87); C26(1.23); C419(1.14)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C212(0.82); C284(0.90); C26(1.08); C419(0.96)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C212(1.02); C284(0.87); C26(1.10); C419(1.06)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C212(0.96); C284(1.06); C26(1.16); C419(1.03)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C212(1.19); C284(0.83); C26(1.05); C419(1.05)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C212(0.87); C284(0.92); C26(1.09); C419(0.88)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C212(0.96); C284(0.98); C26(0.96); C469(1.01)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C212(0.94); C284(0.99); C26(1.20); C419(0.99)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C212(0.90); C284(0.91); C26(1.10); C419(1.14)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C212(1.04); C284(0.91); C26(1.34); C419(0.96)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C212(0.92); C284(0.92); C26(1.15); C419(0.88)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C212(0.98); C284(0.90); C26(1.11); C419(1.04)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C212(0.95); C284(1.05); C26(1.11); C419(0.90)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C212(1.19); C284(0.85); C26(1.30); C419(1.15)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C212(1.00); C284(0.92); C26(1.00); C469(1.01)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C212(1.02); C284(0.97); C26(1.24); C419(0.96)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C212(0.93); C284(0.92); C26(1.22); C419(1.07)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C212(0.94); C284(0.89); C26(1.16); C419(0.95)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C212(1.01); C284(0.95); C26(1.30); C419(0.87)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C212(0.96); C284(0.95); C26(1.15); C419(0.85)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C212(1.07); C284(0.94); C26(1.17); C419(0.95)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C212(0.98); C284(1.05); C26(1.42); C419(0.85)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C212(1.25); C284(0.85); C26(1.21); C419(1.08)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C212(1.00); C284(0.96); C26(0.93); C469(1.00)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C212(0.91); C284(0.98); C26(1.08); C419(1.13)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C212(0.90); C284(0.90); C26(1.17); C419(1.03)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C212(0.88); C284(0.90); C26(1.30); C419(1.08)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C212(0.90); C284(1.08); C26(1.10); C419(1.15)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C212(0.86); C284(0.98); C26(1.10); C419(1.08)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C212(0.86); C284(0.92); C26(1.08); C419(1.04)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C212(0.89); C284(1.03); C26(1.19); C419(1.09)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C212(1.07); C284(0.91); C26(1.08); C419(1.19)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C212(0.91); C284(0.93); C26(1.01); C469(0.92)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C212(1.06); C284(0.86); C26(1.15); C419(1.02)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C212(0.97); C284(1.01); C26(0.97); C469(0.98)  LDD1569  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C133(0.79); C469(0.76); C284(0.77)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C212(1.02); C284(0.90); C26(1.17); C419(0.96)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C212(0.95); C284(0.98); C26(1.18); C419(1.20)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C212(1.00); C284(0.96); C26(0.93); C469(0.98)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C133(0.15)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C419(0.00); C284(0.00); C26(0.00)  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C293(5.01); C419(1.37); C284(0.57)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C212(0.89); C284(0.93); C26(1.03); C419(1.31)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C212(0.79); C284(1.10); C26(0.90); C419(0.97)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C212(0.93); C284(0.91); C26(1.16); C419(1.02)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C212(0.92); C284(0.95); C26(1.07); C419(1.07)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C212(0.81); C284(0.91); C26(1.10); C419(1.17)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C212(1.01); C284(0.97); C26(1.39); C419(0.91)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C212(1.02); C284(0.83); C26(1.18); C419(1.00)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C212(1.06); C284(1.01); C26(1.02); C419(1.14)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C212(1.41); C284(0.97); C26(1.15); C419(1.19)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C212(1.09); C284(0.96); C26(1.31); C419(1.07)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C212(1.01); C284(0.91); C26(1.21); C419(1.02)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C212(0.94); C284(0.98); C26(1.11); C419(1.04)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C212(1.12); C284(0.84); C26(1.02); C419(0.88)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C212(0.73); C284(0.95); C26(1.13); C419(1.10)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C212(0.96); C284(0.99); C26(1.41); C419(1.01)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C212(1.00); C284(0.97); C26(1.15); C419(1.07)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C212(1.04); C284(0.91); C26(1.14); C419(1.01)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C212(0.80); C284(0.88); C26(1.14); C419(1.16)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C212(0.94); C284(1.00); C26(1.47); C419(1.01)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C212(1.02); C284(0.86); C26(1.23); C419(1.02)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C212(1.17); C284(0.95); C26(1.07); C419(1.12)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C212(0.85); C284(0.98); C26(1.17); C419(0.98)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C212(0.89); C284(0.94); C26(1.45); C419(1.06)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C212(1.03); C284(0.92); C26(0.91); C469(0.90)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C212(0.98); C284(0.87); C26(1.25); C419(1.17)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C212(1.01); C284(0.95); C26(1.12); C419(1.09)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C212(0.99); C284(1.01); C26(1.28); C419(1.01)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C212(0.91); C284(0.89); C26(1.43); C419(0.82)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C212(1.02); C284(0.85); C26(1.30); C419(1.02)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C212(0.75); C284(0.95); C26(1.04); C419(0.98)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C212(0.72); C284(0.95); C26(1.17); C419(1.07)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C212(0.86); C284(0.98); C26(1.45); C419(1.09)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C212(0.89); C284(0.94); C26(1.14); C419(1.14)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C212(0.96); C284(1.04); C26(0.89); C419(1.14)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C212(1.05); C284(0.92); C26(1.15); C419(0.82)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C212(0.85); C284(1.04); C26(1.21); C419(0.83)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C212(1.08); C284(0.90); C26(1.22); C419(1.09)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C212(0.91); C284(1.00); C26(1.00); C419(0.98)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C212(1.03); C284(0.93); C26(1.10); C419(0.99)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C212(1.12); C284(0.91); C26(1.15); C419(1.11)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C212(1.02); C284(0.93); C26(1.17); C419(1.02)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C212(1.20); C284(0.85); C26(1.07); C419(1.02)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C212(1.11); C284(0.89); C26(1.07); C419(0.96)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C212(1.10); C284(1.14); C26(1.15); C419(1.34)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C212(1.15); C284(0.82); C26(1.09); C419(0.88)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C212(1.20); C284(0.85); C26(1.00); C469(0.99)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C212(0.81); C284(0.92); C26(1.04); C419(1.02)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C212(1.13); C284(0.95); C26(1.16); C419(0.96)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C212(0.97); C284(0.90); C26(1.33); C419(0.94)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C212(1.07); C284(0.90); C26(1.18); C419(1.08)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C212(0.98); C284(0.97); C26(1.01); C419(0.99)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C212(0.92); C284(1.00); C26(1.48); C419(1.03)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C212(1.03); C284(0.96); C26(1.10); C419(1.00)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C212(1.01); C284(0.98); C26(1.23); C419(1.03)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C212(1.19); C284(0.93); C26(1.06); C419(1.01)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C212(1.00); C284(0.86); C26(1.00); C419(0.96)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C212(1.13); C284(1.08); C26(1.13); C419(0.99)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C212(1.11); C284(0.95); C26(1.14); C419(0.91)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C212(1.23); C284(0.89); C26(1.02); C469(0.92)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C212(0.84); C284(0.90); C26(1.06); C419(0.99)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C212(0.97); C284(0.94); C26(1.29); C419(0.93)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C212(0.84); C284(0.87); C26(1.23); C419(1.10)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C212(1.04); C284(0.86); C26(1.15); C419(1.01)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C212(0.92); C284(0.99); C26(1.13); C419(1.16)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C212(1.08); C284(0.87); C26(1.13); C419(1.09)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C212(1.24); C284(0.95); C26(1.26); C419(0.86)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C212(0.98); C284(1.00); C26(1.04); C419(0.87)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C212(1.22); C284(0.98); C26(1.05); C419(0.92)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C212(1.12); C284(1.09); C26(1.05); C419(1.15)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C212(1.12); C284(0.90); C26(1.08); C419(0.99)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C212(1.26); C284(0.96); C26(0.94); C469(0.98)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C212(0.89); C284(0.86); C26(1.08); C419(1.18)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C212(0.86); C284(1.06); C26(1.19); C419(1.27)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C212(0.83); C284(0.89); C26(1.08); C419(1.12)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C212(1.00); C284(0.85); C26(1.22); C419(1.00)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C212(0.85); C284(0.98); C26(1.18); C419(1.16)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C212(0.92); C284(0.80); C26(1.01); C419(1.01)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C212(1.09); C284(0.86); C26(1.24); C419(1.09)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C212(1.00); C284(0.88); C26(1.01); C419(0.99)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C212(1.29); C284(1.08); C26(0.99); C419(0.98)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C212(1.04); C284(1.10); C26(1.09); C419(1.01)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C212(1.37); C284(0.83); C26(1.15); C419(0.95)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C212(0.82); C284(0.87); C26(1.09); C419(1.01)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C212(1.13); C284(0.93); C26(0.94); C469(0.95)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C212(0.87); C284(0.91); C26(1.05); C419(1.21)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C212(1.00); C284(0.92); C26(1.50); C419(0.99)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C212(0.87); C284(0.96); C26(1.29); C419(0.87)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C212(0.92); C284(0.79); C26(1.14); C419(1.05)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C212(0.95); C284(0.97); C26(1.12); C419(1.05)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C212(0.93); C284(0.83); C26(1.08); C419(1.02)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C212(1.06); C284(0.94); C26(1.29); C419(1.05)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C212(1.15); C284(0.88); C26(1.01); C419(0.90)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C212(1.34); C284(0.85); C26(1.10); C419(1.06)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C212(1.07); C284(0.84); C26(1.20); C419(0.96)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C212(1.06); C284(1.04); C26(1.09); C419(1.08)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C212(1.33); C284(0.81); C26(1.15); C419(0.87)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C212(1.22); C284(0.94); C26(1.00); C469(0.97)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C212(0.79); C284(0.87); C26(1.00); C419(0.93)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C212(0.79); C284(0.96); C26(1.14); C419(0.95)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C212(1.05); C284(0.89); C26(1.13); C419(0.98)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C212(0.89); C284(0.90); C26(1.08); C419(1.19)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C212(0.99); C284(0.87); C26(1.11); C419(1.09)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C212(1.25); C284(0.97); C26(1.27); C419(1.00)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C212(0.76); C284(0.80); C26(0.85); C419(0.71)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C212(1.15); C284(0.92); C26(1.05); C419(1.15)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C212(1.24); C284(0.89); C26(1.13); C419(0.99)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C212(1.01); C284(1.11); C26(1.07); C419(1.08)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C212(1.15); C284(0.82); C26(1.12); C419(0.86)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C212(1.01); C284(0.91); C26(0.88); C469(1.01)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C212(0.71); C284(0.87); C26(1.12); C419(1.16)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C212(0.86); C284(0.89); C26(1.13); C419(1.07)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C212(0.86); C284(0.94); C26(1.43); C419(0.97)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C212(0.82); C284(0.87); C26(1.22); C419(1.09)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C212(0.89); C284(0.93); C26(1.20); C419(1.15)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C212(1.20); C284(0.92); C26(1.09); C419(1.01)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C212(0.68); C284(0.80); C26(1.05); C419(0.77)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C212(0.96); C284(0.90); C26(1.25); C419(0.88)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C212(0.87); C284(0.94); C26(1.02); C419(0.87)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C212(1.07); C284(0.86); C26(1.11); C419(0.92)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C212(1.02); C284(0.99); C26(1.05); C419(0.95)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C212(1.02); C284(0.82); C26(0.98); C419(0.89)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C212(0.80); C284(0.88); C26(0.95); C469(1.04)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C212(0.87); C284(0.91); C26(0.98); C419(1.03)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C212(0.77); C284(0.97); C26(1.22); C419(1.06)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C212(0.90); C284(1.03); C26(1.36); C419(0.88)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C212(0.93); C284(1.42); C26(1.34); C419(1.15)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C419(1.48)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C212(1.02); C284(0.94); C26(1.24); C419(0.87)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C212(1.29); C284(0.96); C26(1.17); C419(1.04)  LDD1631  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 HEK-293T C212(1.02); C469(1.01); C284(1.00); C26(1.03)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C212(1.06); C469(0.94); C284(1.00); C26(0.98)  LDD1497  [17]
 LDCM0024  KB05 HMCB C26(2.65)  LDD3312  [3]
 LDCM0030  Luteolin HEK-293T 10.13  LDD0182  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C469(0.89)  LDD2102  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C469(0.59); C284(0.42)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C133(0.93); C469(1.04)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C133(0.98)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C133(0.55); C469(0.70)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C469(0.92)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C469(1.63); C284(0.70)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C133(1.18); C469(0.95); C284(1.19)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C133(0.30)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C133(0.53)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C133(1.25); C469(0.85); C284(0.63)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C133(0.40); C469(0.60); C284(0.59)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C469(0.77)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C469(0.98)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C133(0.59); C284(0.74)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C133(0.34)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C133(1.81)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C133(0.52); C469(0.88); C284(0.58)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C133(2.51)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C133(0.85); C469(0.92); C284(0.58)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C133(0.17)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C133(0.65); C284(0.62)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C469(0.81)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C133(0.80)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C133(0.67); C469(0.78); C284(0.80)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C469(0.51); C284(0.77)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C133(0.87); C284(0.75)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C469(0.94); C284(0.77)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C133(0.73); C469(0.95); C284(0.62)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C469(1.63); C133(1.14); C284(1.09)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C133(0.57); C469(0.69); C284(0.43)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C469(0.31)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C469(0.78)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C133(2.79); C469(3.16); C284(1.14)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C133(0.24); C469(0.24)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C133(0.64); C469(0.89); C284(0.76)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C469(1.76)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C469(1.08); C284(0.64)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C469(0.43)  LDD2150  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C469(1.47)  LDD2153  [4]
 LDCM0032  Oleacein HEK-293T 6.42  LDD0184  [5]
 LDCM0029  Quercetin HEK-293T 4.65  LDD0181  [5]
 LDCM0131  RA190 MM1.R C419(1.23)  LDD0304  [18]
 LDCM0112  W16 Hep-G2 C284(0.86)  LDD0239  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
MIT domain-containing protein 1 (MITD1) . Q8WV92

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Propanoic Acid Small molecular drug DB03766
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Formic Acid Small molecular drug DB01942
Imidazole . DB03366

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.