Details of the Target

General Information of Target

Target ID LDTP13733
Target Name Endoribonuclease Dicer (DICER1)
Gene Name DICER1
Gene ID 23405
Synonyms
DICER; HERNA; KIAA0928; Endoribonuclease Dicer; EC 3.1.26.3; Helicase with RNase motif; Helicase MOI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR
VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER
LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR
ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH
EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK
NYNSQTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRS
NSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNR
LGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQ
VDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSK
KLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFP
ALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVT
RNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASK
PSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIP
RGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPP
PSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYS
LDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVE
DSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAA
AIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQ
LSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGN
YVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAG
FPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVD
ATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGS
MEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQ
KKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSS
DHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSN
ALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPK
ANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTV
RPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDV
FSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNL
GEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Helicase family, Dicer subfamily
Subcellular location
Cytoplasm
Function
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
TTD ID
T25386
Uniprot ID
Q9UPY3
DrugMap ID
TTTEOPU
Ensemble ID
ENST00000343455.8
HGNC ID
HGNC:17098
ChEMBL ID
CHEMBL2311232

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.M1407I DBIA    Probe Info 
HCT116 SNV: p.V288I DBIA    Probe Info 
HCT15 SNV: p.E495K; p.S1280N .
HEC1 SNV: p.Y1225H DBIA    Probe Info 
HEC1B SNV: p.Y1225H .
HT115 SNV: p.R1003Q .
HT3 SNV: p.N405H DBIA    Probe Info 
HUH28 SNV: p.E1667K DBIA    Probe Info 
IGROV1 Deletion: p.C1535WfsTer3 DBIA    Probe Info 
JURKAT SNV: p.V1882M .
KMCH1 SNV: p.S1868C DBIA    Probe Info 
KMRC3 SNV: p.S1255I DBIA    Probe Info 
MFE296 SNV: p.R1895Ter DBIA    Probe Info 
MFE319 SNV: p.G13D; p.L785P DBIA    Probe Info 
MOLT4 SNV: p.G483D IA-alkyne    Probe Info 
NCIH1975 SNV: p.I1127F DBIA    Probe Info 
NCIH2172 SNV: p.E1883G DBIA    Probe Info 
NCIH358 SNV: p.E1420Ter DBIA    Probe Info 
PF382 SNV: p.Q1447K DBIA    Probe Info 
SNGM SNV: p.A553T DBIA    Probe Info 
TOV21G SNV: p.K371R DBIA    Probe Info 
UACC257 SNV: p.Y1874H DBIA    Probe Info 
YSCCC SNV: p.L586F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.31  LDD0402  [1]
STPyne
 Probe Info  		K1008(10.00); K1866(4.07); K1901(2.64)  LDD0277  [2]
Probe 1
 Probe Info  		Y1438(32.11); Y1445(6.84)  LDD3495  [3]
BTD
 Probe Info  		C1604(0.84)  LDD1700  [4]
DA-P3
 Probe Info  		4.40  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C1641(4.54)  LDD0168  [6]
HHS-475
 Probe Info  		Y664(1.20)  LDD0264  [7]
DBIA
 Probe Info  		C1621(1.15); C686(1.07); C1197(1.00)  LDD0078  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1053(0.00); C1584(0.00); C1063(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C1063(0.00); C284(0.00); C1621(0.00); C1053(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		C1122(0.00); C1621(0.00); C1648(0.00)  LDD2226  [12]
IPM
 Probe Info  		C1621(0.00); C686(0.00)  LDD0005  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [13]
1c-yne
 Probe Info  		K231(0.00); K975(0.00)  LDD0228  [15]
NAIA_5
 Probe Info  		C1584(0.00); C531(0.00); C686(0.00); C317(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1641(4.54)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1604(2.10); C1235(3.03)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C1122(1.08); C1197(0.97); C1354(1.30); C1406(1.10)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1122(1.13); C1197(0.92); C1354(1.08); C1584(0.77)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1122(0.97); C1197(0.91); C1354(0.89); C1406(0.87)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1122(1.02); C1197(0.86); C1354(0.92); C1406(0.77)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1122(1.01); C1197(0.88); C1354(0.85); C1406(0.82)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1122(1.23); C1197(1.02); C1354(0.92); C1406(0.91)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1122(1.15); C1197(0.94); C1354(0.88); C1406(0.85)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1122(1.13); C1197(0.95); C1354(0.84); C1406(0.91)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1122(1.19); C1197(1.00); C1354(0.93); C1406(0.99)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1122(0.92); C1197(0.86); C1354(0.86); C1406(0.78)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1122(0.86); C1197(0.85); C1354(0.80); C1406(1.00)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1122(0.91); C1197(0.83); C1354(0.82); C1406(0.82)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1122(1.34); C1197(0.93); C1354(1.24); C1584(0.70)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1122(0.90); C1197(0.88); C1354(1.08); C1406(0.86)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1122(0.93); C1197(0.92); C1354(1.09); C1406(0.88)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1122(0.98); C1197(0.94); C1354(0.83); C1406(0.72)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1122(1.03); C1197(0.77); C1235(1.06); C1354(0.94)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1122(1.17); C1197(1.17); C1235(0.94); C1354(0.90)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1122(1.20); C1197(1.27); C1235(1.05); C1354(0.92)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1122(1.25); C1197(1.19); C1235(0.92); C1354(1.20)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1122(1.08); C1197(0.87); C1235(0.87); C1354(1.02)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1122(1.05); C1197(1.11); C1235(0.96); C1354(1.08)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1122(1.22); C1197(1.32); C1235(0.77); C1354(1.04)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1122(1.03); C1197(1.01); C1354(1.16); C1584(0.81)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1122(1.16); C1197(1.43); C1235(1.25); C1354(0.94)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1122(0.95); C1197(1.00); C1235(0.86); C1354(0.98)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1122(1.06); C1197(1.11); C1235(1.10); C1354(1.00)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1122(0.93); C1197(1.04); C1235(1.16); C1354(0.79)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1122(0.99); C1197(0.80); C1235(0.86); C1354(1.08)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1122(1.02); C1197(1.00); C1235(1.25); C1354(0.91)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1122(1.19); C1197(1.27); C1235(0.99); C1354(1.00)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1122(1.16); C1197(1.75); C1235(0.83); C1354(0.93)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1122(0.99); C1197(0.86); C1354(0.98); C1584(0.96)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1122(0.81); C1197(0.63); C1354(0.94); C1584(1.05)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1122(0.90); C1197(0.82); C1354(0.95); C1584(0.92)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1122(0.92); C1197(0.92); C1354(0.95); C1584(1.02)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1122(0.82); C1197(0.79); C1354(1.44); C1584(1.10)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1122(0.85); C1197(0.79); C1354(0.99); C1584(0.89)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1122(1.01); C1197(0.85); C1354(1.02); C1584(0.94)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1122(0.91); C1197(0.83); C1354(1.01); C1584(1.00)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1122(0.96); C1197(0.89); C1354(1.03); C1584(0.86)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1122(0.90); C1197(0.92); C1354(0.98); C1584(0.93)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1122(0.86); C1197(0.90); C1354(1.16); C1584(0.89)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1122(1.01); C1197(0.83); C1354(1.32); C1584(0.91)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1122(1.06); C1197(0.87); C1354(1.09); C1584(0.68)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1122(0.99); C1197(0.83); C1354(1.48); C1584(0.92)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1122(1.01); C1197(0.83); C1354(1.39); C1584(0.89)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1122(0.79); C1197(0.80); C1354(1.27); C1584(1.02)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1122(1.12); C1197(1.00); C1354(0.91); C1406(1.09)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1406(0.82); C1354(0.91); C1641(1.02); C199(1.04)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1641(0.91); C1122(1.10); C686(1.12); C1354(1.15)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1354(0.99); C686(1.02); C1641(1.04); C1406(1.15)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1354(0.88); C1641(1.00); C1406(1.08); C199(1.12)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1354(0.81); C196(0.92); C1641(1.00); C193(1.01)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1641(0.92); C1354(0.96); C196(1.01); C1406(1.08)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1584(0.75); C251(0.79); C257(0.79); C196(0.82)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1641(0.91); C1406(1.02); C1197(1.03); C1354(1.05)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C193(0.87); C1641(1.01); C1354(1.02); C199(1.05)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1354(0.92); C1406(0.97); C1641(1.07); C199(1.09)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1354(0.94); C199(0.96); C193(1.03); C686(1.06)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1122(1.31); C1197(1.20); C1354(1.10); C1406(1.42)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1122(1.39); C1197(1.39); C1354(1.25); C1406(1.14)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1122(1.00); C1197(1.02); C1354(0.86); C1406(1.15)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1122(1.01); C1197(1.13); C1354(1.26); C1406(1.11)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C251(0.67); C257(0.67); C1406(0.91); C1354(0.94)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C251(0.55); C257(0.55); C196(0.89); C1354(0.94)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C251(0.82); C257(0.82); C1354(0.83); C196(0.88)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C193(0.81); C196(0.81); C199(0.81); C1197(0.85)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C251(0.69); C257(0.69); C686(0.85); C1406(0.96)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C251(0.57); C257(0.57); C1354(0.65); C686(0.81)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C251(0.75); C257(0.75); C1354(0.81); C686(0.91)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C251(0.69); C257(0.69); C686(0.90); C1406(0.99)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C1197(0.78); C251(0.86); C257(0.86); C1354(0.93)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C251(0.63); C257(0.63); C686(0.77); C1584(0.80)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C251(0.61); C257(0.61); C1584(0.62); C193(0.80)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C1584(0.67); C251(0.68); C257(0.68); C193(0.74)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C1584(0.65); C1235(0.69); C193(0.83); C686(0.87)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C1584(0.67); C698(0.82); C699(0.82); C193(0.85)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C193(0.84); C196(0.84); C199(0.84); C1197(0.97)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C1584(0.67); C251(0.79); C257(0.79); C698(0.86)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C1584(0.57); C251(0.67); C257(0.67); C193(0.70)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C1584(0.52); C251(0.57); C257(0.57); C193(0.66)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C251(0.57); C257(0.57); C1584(0.61); C193(0.74)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C251(0.55); C257(0.55); C1584(0.67); C1648(0.72)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C1354(0.64); C196(0.91); C1648(0.92); C686(0.96)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C1354(0.71); C196(0.81); C199(0.84); C251(0.85)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C251(0.66); C257(0.66); C1122(0.77); C1648(0.79)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C251(0.85); C257(0.85); C196(0.89); C1122(0.89)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C1354(0.67); C196(0.87); C686(0.94); C1648(0.95)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C193(0.93); C196(0.93); C199(0.93); C1641(0.97)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C1354(0.65); C251(0.72); C257(0.72); C1648(0.87)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C251(0.61); C257(0.61); C193(0.77); C199(0.82)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C251(0.70); C257(0.70); C1354(0.78); C698(0.94)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C251(0.67); C257(0.67); C1354(0.74); C193(0.75)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C251(0.74); C257(0.74); C1354(0.78); C1648(0.80)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C1354(0.69); C1648(0.74); C193(0.78); C196(0.83)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C1354(0.75); C251(0.78); C257(0.78); C1641(0.89)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C251(0.74); C257(0.74); C1406(0.86); C1354(0.88)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C251(0.61); C257(0.61); C1053(0.79); C698(0.83)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C251(0.66); C257(0.66); C1053(0.67); C196(0.91)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C193(0.75); C196(0.75); C199(0.75); C1197(0.84)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C1053(0.66); C251(0.68); C257(0.68); C193(0.91)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C251(0.63); C257(0.63); C686(0.88); C1641(0.88)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C251(0.67); C257(0.67); C1354(0.80); C698(0.92)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C193(0.84); C199(0.84); C1354(0.87); C251(0.90)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C1354(0.69); C251(0.75); C257(0.75); C1641(0.84)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1053(0.69); C251(0.94); C257(0.94); C193(0.96)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1053(0.60); C251(0.74); C257(0.74); C193(0.84)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C196(0.70); C199(0.70); C193(0.72); C1053(0.72)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C1053(0.55); C698(0.62); C699(0.62); C196(0.73)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C1053(0.62); C196(0.67); C199(0.67); C193(0.69)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C251(0.73); C257(0.73); C196(0.78); C199(0.78)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C698(0.48); C699(0.48); C1053(0.58); C196(0.66)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C698(0.48); C699(0.48); C1053(0.58); C196(0.61)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1053(0.53); C698(0.54); C699(0.54); C193(0.69)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C1053(0.55); C698(0.58); C699(0.58); C193(0.64)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C1053(0.53); C193(0.67); C698(0.71); C699(0.71)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C698(0.62); C699(0.62); C1053(0.65); C193(0.65)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C1053(0.61); C698(0.63); C699(0.63); C686(0.71)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C1053(0.34); C698(0.61); C699(0.61); C196(0.71)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C1053(0.70); C1648(0.77); C1641(0.82); C698(0.83)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1053(0.65); C698(0.76); C699(0.76); C196(0.86)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C196(0.83); C199(0.83); C193(0.83); C1584(0.84)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C1053(0.49); C251(0.67); C257(0.67); C196(0.74)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C1648(0.74); C698(0.87); C699(0.87); C196(0.93)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C193(0.78); C251(0.81); C257(0.81); C698(0.82)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1053(0.45); C251(0.61); C257(0.61); C196(0.76)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1053(0.54); C251(0.73); C257(0.73); C698(0.77)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C1053(0.47); C251(0.65); C257(0.65); C193(0.81)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C251(0.76); C257(0.76); C1053(0.76); C698(0.78)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C1053(0.62); C251(0.67); C257(0.67); C698(0.74)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C698(0.68); C699(0.68); C1053(0.77); C251(0.77)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C251(0.86); C257(0.86); C196(0.90); C199(0.90)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C251(0.72); C257(0.72); C1584(0.76); C698(0.84)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C251(0.72); C257(0.72); C193(0.81); C196(0.82)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C1641(0.81); C1648(0.86); C1053(0.93); C698(0.94)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C1053(0.49); C251(0.76); C257(0.76); C196(0.86)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C251(0.37); C257(0.37); C1053(0.44); C698(0.79)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C251(0.40); C257(0.40); C1053(0.52); C698(0.77)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C251(0.40); C257(0.40); C698(0.77); C699(0.77)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C251(0.59); C257(0.59); C1354(0.80); C1053(0.82)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C1641(0.67); C251(0.68); C257(0.68); C1053(0.77)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C251(0.73); C257(0.73); C1641(0.82); C1053(0.85)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C251(0.49); C257(0.49); C1053(0.61); C1641(0.76)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C1641(0.71); C1354(0.96); C686(1.00); C1406(1.03)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C251(0.35); C257(0.35); C1053(0.46); C1641(0.80)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C251(0.42); C257(0.42); C1053(0.64); C698(0.83)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C251(0.60); C257(0.60); C1053(0.76); C698(0.86)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C251(0.57); C257(0.57); C1053(0.81); C698(0.82)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C251(0.40); C257(0.40); C1641(0.59); C1053(0.64)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C251(0.41); C257(0.41); C1053(0.66); C698(0.81)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C251(0.47); C257(0.47); C1053(0.67); C698(0.78)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C251(0.62); C257(0.62); C1354(0.91); C698(0.98)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C1641(0.81); C1406(0.88); C1122(0.95); C1197(0.97)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1122(0.98); C1197(0.87); C1354(1.11); C1584(0.87)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C1584(0.70); C196(0.72); C199(0.72); C193(0.74)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C1584(0.66); C251(0.76); C257(0.76); C196(0.81)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C1621(1.15); C686(1.07); C1197(1.00)  LDD0078  [8]
 LDCM0102  BDHI 8 Jurkat C756(5.39)  LDD0204  [17]
 LDCM0632  CL-Sc Hep-G2 C1621(0.65); C1584(0.42)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C1053(0.79); C1197(0.81); C686(0.90); C1122(0.93)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C251(0.76); C257(0.76); C1053(0.90); C193(1.08)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C193(0.79); C196(0.79); C199(0.79); C1197(0.89)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C196(0.68); C199(0.68); C193(0.72); C1584(0.72)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C193(0.71); C196(0.73); C199(0.73); C1197(0.90)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C1197(0.85); C1584(0.86); C193(0.91); C698(0.93)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1584(0.86); C698(0.87); C699(0.87); C1197(0.96)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C251(0.55); C257(0.55); C1354(0.80); C1406(0.99)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C251(0.36); C257(0.36); C1354(0.85); C1406(0.91)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C251(0.52); C257(0.52); C1406(0.88); C1354(0.95)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C251(0.50); C257(0.50); C1406(0.84); C1354(0.95)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C251(0.66); C257(0.66); C686(0.81); C1354(0.85)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C251(0.72); C257(0.72); C1641(0.94); C1053(1.04)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C251(0.53); C257(0.53); C698(0.93); C699(0.93)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C251(0.66); C257(0.66); C196(0.82); C1354(0.94)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C686(0.78); C1584(0.81); C1406(0.83); C1235(0.94)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C1584(0.58); C251(0.62); C257(0.62); C193(0.74)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C251(0.61); C257(0.61); C1584(0.66); C1406(0.77)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C251(0.66); C257(0.66); C1584(0.68); C698(0.88)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C193(0.64); C1584(0.66); C1406(0.76); C251(0.80)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C1354(0.71); C686(0.99); C698(1.03); C699(1.03)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1354(0.61); C193(0.70); C199(0.80); C196(0.86)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C1354(0.81); C698(0.89); C699(0.89); C196(0.89)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C251(0.80); C257(0.80); C1053(1.07); C193(1.09)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1354(0.69); C1648(0.84); C193(0.90); C251(0.92)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C1053(0.69); C251(0.73); C257(0.73); C686(0.79)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C1053(0.80); C251(0.86); C257(0.86); C698(0.88)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1354(0.73); C698(0.85); C699(0.85); C251(0.86)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C251(0.71); C257(0.71); C1053(0.80); C1354(0.86)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C193(0.75); C196(0.87); C199(0.87); C698(0.89)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C698(0.69); C699(0.69); C196(0.70); C199(0.70)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C193(0.63); C698(0.65); C699(0.65); C196(0.69)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C698(0.65); C699(0.65); C1053(0.72); C193(0.76)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C1197(0.79); C251(0.82); C257(0.82); C1641(0.95)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C251(0.85); C257(0.85); C686(0.94); C193(0.98)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C251(0.87); C257(0.87); C193(1.06); C196(1.06)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C698(0.74); C699(0.74); C1406(0.88); C193(0.88)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C698(0.68); C699(0.68); C196(0.82); C199(0.82)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C698(0.47); C699(0.47); C251(0.74); C257(0.74)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C698(0.67); C699(0.67); C1354(0.85); C1053(0.92)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C686(0.86); C193(0.89); C196(0.89); C199(0.89)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C698(0.69); C699(0.69); C1053(0.73); C251(0.75)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C698(0.54); C699(0.54); C1053(0.68); C251(0.72)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C1053(0.73); C251(0.83); C257(0.83); C193(0.89)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C698(0.71); C699(0.71); C251(0.82); C257(0.82)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C698(0.72); C699(0.72); C251(0.79); C257(0.79)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1053(0.78); C1122(1.49); C1197(1.01); C1354(1.01)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1053(0.81); C1122(1.05); C1197(1.01); C1354(1.42)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1053(0.84); C1122(1.14); C1197(1.05); C1354(0.85)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1053(0.79); C1122(1.21); C1197(1.15); C1354(0.87)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1053(0.69); C1122(1.32); C1197(1.11); C1354(1.05)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1053(1.02); C1122(0.95); C1197(0.78); C1354(0.96)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1053(0.89); C1122(1.20); C1197(1.10); C1354(0.89)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1053(1.01); C1122(1.15); C1197(0.94); C1235(0.94)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1122(1.37); C1197(0.95); C1235(1.06); C1354(1.42)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1122(1.38); C1197(1.15); C1235(1.09); C1354(1.04)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1122(1.42); C1197(1.12); C1235(1.09); C1354(1.55)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1122(1.48); C1197(1.10); C1235(1.10); C1354(1.45)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1122(1.34); C1197(1.08); C1235(1.22); C1354(1.71)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1122(1.50); C1197(0.96); C1235(1.48); C1354(1.69)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1122(1.31); C1197(1.00); C1235(1.04); C1354(1.86)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1053(1.10); C1122(1.18); C1197(0.68); C1354(0.95)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1122(1.48); C1197(1.01); C1235(1.29); C1354(1.18)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1122(1.25); C1197(1.04); C1235(1.64); C1354(1.30)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1122(1.91); C1197(0.97); C1235(1.66); C1354(1.67)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1122(1.59); C1197(1.02); C1235(1.12); C1354(1.46)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1122(1.36); C1197(0.98); C1235(1.16); C1354(1.16)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1122(1.54); C1197(0.96); C1235(0.77); C1354(1.42)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1122(0.78); C1197(0.86); C1354(1.03); C1406(1.00)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1122(0.79); C1197(0.96); C1354(1.03); C1406(1.04)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1122(0.74); C1197(1.04); C1354(1.07); C1406(1.01)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1122(0.98); C1197(0.86); C1354(1.11); C1406(1.00)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1053(1.19); C1122(1.04); C1197(1.62); C1354(1.10)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1122(0.80); C1197(1.14); C1354(1.12); C1406(0.93)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1122(0.85); C1197(0.92); C1354(0.98); C1406(1.04)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1122(0.90); C1197(0.84); C1354(1.13); C1406(1.06)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1122(0.90); C1197(1.13); C1354(0.86); C1406(0.96)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1122(0.76); C1197(0.96); C1354(1.07); C1406(0.94)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1122(0.83); C1197(0.84); C1354(0.97); C1406(0.89)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1122(0.85); C1197(0.87); C1354(0.95); C1406(1.07)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1122(0.89); C1197(0.84); C1354(1.05); C1406(0.86)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1122(0.82); C1197(0.87); C1354(0.96); C1406(0.86)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1122(0.96); C1197(0.95); C1354(1.06); C1406(0.96)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1053(1.07); C1122(1.18); C1197(1.26); C1354(1.11)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1122(0.84); C1197(0.70); C1354(1.13); C1406(0.99)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1122(0.88); C1197(1.09); C1354(0.84); C1406(0.96)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1122(0.93); C1197(1.13); C1354(0.86); C1406(0.83)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1122(0.99); C1197(1.00); C1354(0.91); C1406(0.89)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1122(1.10); C1197(1.00); C1354(0.96); C1406(1.06)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1122(0.88); C1197(1.03); C1354(1.00); C1406(0.88)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1122(0.89); C1197(1.04); C1354(1.12); C1406(1.03)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1122(0.94); C1197(1.07); C1354(0.93); C1406(0.83)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1122(0.87); C1197(0.95); C1354(0.78); C1406(1.01)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1122(1.09); C1197(1.05); C1354(0.82); C1406(1.07)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1053(1.26); C1122(1.28); C1197(1.20); C1354(1.75)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1122(0.97); C1197(0.94); C1354(0.96); C1406(0.98)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1122(0.90); C1197(1.03); C1354(0.85); C1406(0.97)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1122(1.07); C1197(1.00); C1354(0.97); C1406(1.29)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1122(0.97); C1197(1.03); C1354(0.95); C1406(1.13)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1122(1.04); C1197(1.00); C1354(1.04); C1406(1.11)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1053(0.92); C1122(1.27); C1354(0.97); C1406(0.97)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1053(1.12); C1122(1.01); C1354(1.00); C1406(1.10)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1053(1.13); C1122(1.23); C1354(1.10); C1406(0.99)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1053(0.77); C1122(1.49); C1354(1.26); C1406(0.92)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1053(1.10); C1122(1.72); C1197(1.35); C1354(0.97)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1053(0.91); C1122(1.34); C1354(1.15); C1406(0.96)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1053(0.87); C1122(1.30); C1354(1.11); C1406(1.01)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1053(0.67); C1122(2.18); C1354(1.10); C1406(0.97)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1053(0.63); C1122(1.75); C1354(1.00); C1406(0.97)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1053(0.66); C1122(2.42); C1354(1.12); C1406(0.92)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1053(0.82); C1122(1.22); C1354(0.92); C1406(0.96)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1053(1.03); C1122(1.07); C1354(1.10); C1406(0.89)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1053(1.39); C1122(1.28); C1354(1.06); C1406(0.90)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1053(0.92); C1122(1.61); C1354(1.00); C1406(0.90)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1053(0.61); C1122(2.47); C1354(1.46); C1406(0.89)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1053(0.95); C1122(1.18); C1197(0.71); C1354(1.44)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1053(1.27); C1122(0.98); C1354(1.01); C1406(1.03)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1122(1.16); C1197(1.00); C1354(1.11); C1406(1.29)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1122(1.11); C1197(1.02); C1354(1.17); C1406(1.44)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1122(0.95); C1197(0.89); C1354(1.07); C1406(1.06)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1122(1.27); C1197(0.91); C1354(0.86); C1406(1.19)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1122(1.18); C1197(1.27); C1354(1.06); C1406(1.20)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1122(1.21); C1197(0.98); C1354(1.12); C1406(1.17)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1122(1.21); C1197(1.04); C1354(1.09); C1406(1.13)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1122(1.16); C1197(1.08); C1354(1.46); C1406(1.19)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1122(1.05); C1197(0.91); C1354(1.21); C1406(1.17)  LDD0811  [8]
 LDCM0634  CY-0357 Hep-G2 C1553(50.00); C1535(2.99); C1648(0.68); C1122(0.50)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C1354(0.97); C1648(0.93); C214(1.05); C1406(1.13)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1621(1.07); C1354(0.44)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C1122(0.95); C1197(0.97); C1354(1.14); C1406(1.06)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C1122(2.08); C1197(1.06); C1235(3.13); C1354(1.78)  LDD0744  [8]
 LDCM0116  HHS-0101 DM93 Y664(1.20)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y664(1.25)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y664(0.73)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y664(1.11)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y664(1.95)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C1197(2.23); C1122(2.09); C686(1.65); C196(1.01)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C1197(1.30); C1122(1.47); C686(1.43); C196(1.36)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C1197(2.17); C1122(1.67); C686(1.31); C196(1.29)  LDD0082  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C686(1.03)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1354(1.02)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1604(0.97)  LDD2127  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1354(1.28)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1604(0.57)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1604(0.84)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1604(0.39); C1354(0.96)  LDD2140  [4]
 LDCM0032  Oleacein HEK-293T 5.26  LDD0184  [5]
 LDCM0029  Quercetin HEK-293T 4.40  LDD0181  [5]
 LDCM0021  THZ1 HCT 116 C196(1.53); C199(1.53); C1122(1.06); C686(0.78)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
Piwi-like protein 1 (PIWIL1) Argonaute family Q96J94
ATP-dependent RNA helicase DHX58 (DHX58) Helicase family Q96C10
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) Ser/Thr protein kinase family P19525
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) Tumor necrosis factor family O43508
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-1 (AGO1) Argonaute family Q9UL18
Far upstream element-binding protein 2 (KHSRP) KHSRP family Q92945
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) PRKRA family O75569
RISC-loading complex subunit TARBP2 (TARBP2) TARBP2 family Q15633

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 138612 Antisense drug D0O2ZR
Isis 138613 Antisense drug D0OV0E
Isis 138616 Antisense drug D0DH8B
Isis 138647 Antisense drug D0D7NA
Isis 138648 Antisense drug D0O4MI
Isis 138649 Antisense drug D07NRU
Isis 138678 Antisense drug D0LF3W

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402