Details of the Target

General Information of Target

Target ID LDTP11601
Target Name (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O)
Gene Name UBE2O
Gene ID 63893
Synonyms
KIAA1734; (E3-independent) E2 ubiquitin-conjugating enzyme; EC 2.3.2.24; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
Target Bioclass
Enzyme
Family
Ubiquitin-conjugating enzyme family
Subcellular location
Cytoplasm
Function
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
Uniprot ID
Q9C0C9
Ensemble ID
ENST00000319380.12
HGNC ID
HGNC:29554
ChEMBL ID
CHEMBL4295940

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.46  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y1251(6.13)  LDD0257  [3]
TH216
 Probe Info  		Y1251(20.00)  LDD0259  [3]
STPyne
 Probe Info  		K132(10.00); K365(7.69); K819(10.00)  LDD0277  [4]
Probe 1
 Probe Info  		Y1094(6.55)  LDD3495  [5]
BTD
 Probe Info  		C341(2.24)  LDD1700  [6]
YY4-yne
 Probe Info  		2.82  LDD0400  [7]
DA-P3
 Probe Info  		5.91  LDD0179  [8]
AHL-Pu-1
 Probe Info  		C585(20.00); C375(9.69); C182(3.56)  LDD0168  [9]
DBIA
 Probe Info  		C375(1.22); C370(1.20); C910(1.17); C913(1.17)  LDD0078  [10]
ATP probe
 Probe Info  		K132(0.00); K514(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1288(0.00); C353(0.00); C230(0.00); C208(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C598(0.00); C370(0.00); C244(0.00); C182(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C353(0.00); C208(0.00); C341(0.00); C182(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C244(0.00); C314(0.00); C598(0.00); 0.00  LDD2226  [14]
TFBX
 Probe Info  		C182(0.00); C1288(0.00); C598(0.00); C314(0.00)  LDD0027  [15]
WYneN
 Probe Info  		C375(0.00); C598(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C598(0.00); C375(0.00); C1288(0.00)  LDD0022  [16]
Compound 10
 Probe Info  		C101(0.00); C182(0.00); C375(0.00); C598(0.00)  LDD2216  [17]
Compound 11
 Probe Info  		C101(0.00); C182(0.00); C375(0.00); C598(0.00)  LDD2213  [17]
ENE
 Probe Info  		C375(0.00); C406(0.00); C1288(0.00); C370(0.00)  LDD0006  [16]
IPM
 Probe Info  		C182(0.00); C341(0.00); C598(0.00); C400(0.00)  LDD0005  [16]
PF-06672131
 Probe Info  		C182(0.00); C370(0.00)  LDD0017  [18]
VSF
 Probe Info  		C1288(0.00); C598(0.00); C910(0.00); C101(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C375(0.00); C341(0.00); C598(0.00)  LDD0018  [19]
1c-yne
 Probe Info  		K825(0.00); K1248(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C182(0.00); C341(0.00); C585(0.00); C101(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C341(0.00); C101(0.00); C182(0.00)  LDD0218  [21]
W1
 Probe Info  		C598(0.00); C1288(0.00); C400(0.00); C406(0.00)  LDD0236  [22]
AOyne
 Probe Info  		9.70  LDD0443  [23]
NAIA_5
 Probe Info  		C1288(0.00); C353(0.00); C230(0.00); C1099(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe3
 Probe Info  		6.22  LDD0464  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C341(1.03)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C341(1.28); C598(1.06)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C341(1.66)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C341(0.62)  LDD2132  [6]
 LDCM0025  4SU-RNA HEK-293T C585(20.00); C375(9.69); C182(3.56)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C406(2.20); C230(3.73); C598(2.71); C400(2.20)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C370(0.97); C101(1.23); C1020(0.41); C1025(0.41)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C370(0.91); C1020(0.67); C1025(0.67); C1040(1.13)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C370(1.12); C101(1.09); C1040(0.79); C1099(0.72)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C370(1.08); C101(1.27); C1040(0.84); C1099(0.73)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C370(1.05); C101(1.11); C1040(0.83); C1099(0.77)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C370(1.41); C101(1.55); C1040(0.92); C1099(0.95)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C370(1.23); C101(1.62); C1040(0.92); C1099(0.71)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C370(1.21); C101(1.38); C1040(0.85); C1099(0.76)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C370(1.33); C101(1.47); C1040(0.90); C1099(0.96)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C370(1.37); C101(1.87); C1040(1.16); C1099(0.91)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C370(1.14); C101(1.11); C1040(0.89); C1099(0.82)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C370(0.94); C101(1.19); C1040(0.87); C1099(0.80)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C370(1.05); C1020(0.79); C1025(0.79); C1040(1.23)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C370(1.05); C101(1.25); C1040(0.91); C1099(0.70)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C370(1.11); C101(1.25); C1040(0.75); C1099(0.84)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C370(1.19); C101(1.24); C1040(0.99); C1099(0.79)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C370(0.99); C101(0.81); C1040(1.07); C1099(1.13)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C370(1.10); C101(0.86); C1040(1.08); C1099(1.23)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C370(1.42); C101(0.82); C1040(1.16); C1099(1.07)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C370(1.29); C101(0.88); C1040(1.26); C1099(1.13)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C370(1.10); C101(1.22); C1040(1.11); C1099(1.12)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C370(1.03); C101(0.86); C1040(1.09); C1099(1.20)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C370(1.09); C101(0.87); C1040(1.20); C1099(1.13)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C370(0.87); C1020(1.08); C1025(1.08); C1040(1.14)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C370(1.15); C101(0.88); C1040(1.28); C1099(0.92)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C370(1.07); C101(0.75); C1040(1.10); C1099(1.08)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C370(1.24); C101(0.78); C1040(1.06); C1099(1.02)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C370(1.17); C101(0.79); C1040(0.96); C1099(1.09)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C370(1.04); C101(0.89); C1040(1.04); C1099(1.14)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C370(1.18); C101(0.76); C1040(1.08); C1099(1.09)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C370(1.27); C101(0.81); C1040(1.18); C1099(1.11)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C370(1.47); C101(0.75); C1040(1.14); C1099(1.23)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C370(1.19); C1099(1.61); C163(0.75); C173(0.75)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C370(0.99); C1099(1.00); C163(1.05); C173(1.05)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C370(1.25); C1099(1.62); C163(0.84); C173(0.84)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C370(0.92); C1099(1.04); C163(0.94); C173(0.94)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C370(1.09); C1099(1.52); C163(1.04); C173(1.04)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C370(1.08); C1099(1.57); C163(0.81); C173(0.81)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C370(1.22); C1099(1.73); C163(0.92); C173(0.92)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C370(1.13); C1099(1.52); C163(0.92); C173(0.92)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C370(1.24); C1099(1.11); C163(0.90); C173(0.90)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C370(1.21); C1099(1.43); C163(1.03); C173(1.03)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C370(1.46); C1099(1.39); C163(0.90); C173(0.90)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C370(1.25); C1099(1.51); C163(0.84); C173(0.84)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C370(0.74); C1020(0.49); C1025(0.49); C1040(1.20)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C370(1.45); C1099(2.05); C163(0.92); C173(0.92)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C370(1.37); C1099(1.27); C163(0.91); C173(0.91)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C370(1.03); C1099(1.27); C163(1.23); C173(1.23)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C370(1.33); C353(0.70); C163(0.74); C173(0.74)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C163(0.59); C230(0.69); C173(0.70); C353(0.96)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C163(0.74); C173(0.77); C230(0.88); C182(0.96)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C230(0.59); C163(0.65); C353(0.66); C173(0.67)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C163(0.64); C173(0.67); C230(0.78); C341(0.99)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C230(0.48); C173(0.50); C163(0.66); C353(0.74)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C230(0.58); C173(0.65); C163(0.65); C353(0.86)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C353(0.66); C1020(0.70); C1025(0.70); C230(0.79)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C163(0.68); C173(0.71); C230(0.72); C353(0.99)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C173(0.70); C163(0.77); C230(0.80); C1040(0.97)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C230(0.62); C163(0.67); C173(0.67); C353(0.81)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C230(0.42); C353(0.54); C173(0.56); C163(0.67)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C370(1.41); C101(1.11); C1040(1.03); C1099(1.26)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C370(1.62); C101(1.66); C1040(1.00); C1099(1.08)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C370(1.22); C101(1.15); C1040(0.95); C1099(1.12)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C370(1.15); C101(0.96); C1040(0.82); C1099(0.96)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C400(0.97); C353(0.99); C406(1.01); C182(1.02)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C353(0.83); C163(0.86); C173(0.86); C341(0.89)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C598(0.82); C353(0.95); C406(0.97); C341(0.99)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1020(0.51); C1025(0.51); C163(0.81); C173(0.81)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C163(0.69); C173(0.69); C341(0.78); C353(0.99)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C598(0.84); C163(0.88); C173(0.88); C341(0.89)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C230(0.97); C314(0.99); C341(1.03); C182(1.04)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C353(0.88); C163(0.93); C173(0.93); C341(1.04)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C598(0.84); C163(0.86); C173(0.86); C910(0.93)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C101(0.47); C598(0.63); C910(0.78); C913(0.83)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C101(0.66); C598(0.69); C163(0.70); C173(0.70)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C163(0.70); C173(0.70); C598(0.76); C101(0.79)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C353(0.70); C598(0.76); C163(0.78); C173(0.78)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C163(0.45); C173(0.45); C353(0.56); C230(0.76)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1020(0.60); C1025(0.60); C163(0.78); C173(0.78)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C163(0.42); C173(0.42); C353(0.57); C230(0.68)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C163(0.68); C173(0.68); C353(0.71); C598(0.72)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C163(0.44); C173(0.44); C353(0.59); C230(0.77)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C101(0.67); C163(0.77); C173(0.77); C598(0.79)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C230(0.81); C341(0.83); C163(0.85); C173(0.85)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C101(0.77); C598(0.83); C341(0.87); C406(0.93)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C101(0.50); C182(0.89); C353(0.91); C406(0.97)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C101(0.75); C375(0.88); C314(0.89); C182(0.93)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C101(0.64); C182(0.90); C163(0.92); C173(0.92)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C910(0.80); C353(0.82); C101(0.82); C598(0.82)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C1020(0.50); C1025(0.50); C163(0.60); C173(0.60)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C163(0.79); C173(0.79); C353(0.83); C101(0.90)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C314(0.99); C353(0.99); C101(1.01); C1099(1.01)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C101(0.77); C353(0.79); C163(0.85); C173(0.85)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C353(0.81); C101(0.83); C163(0.86); C173(0.86)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C353(0.79); C101(1.00); C341(1.00); C182(1.01)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C353(0.73); C163(0.91); C173(0.91); C101(0.99)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C230(0.67); C375(0.89); C1040(0.90); C585(0.91)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C910(0.77); C913(0.80); C230(0.82); C598(0.91)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C230(0.56); C913(0.60); C910(0.61); C1040(0.92)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C163(0.67); C173(0.67); C585(0.75); C230(0.81)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C1020(0.45); C1025(0.45); C163(0.61); C173(0.61)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C230(0.59); C163(0.75); C173(0.75); C585(0.76)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C230(0.70); C913(0.75); C910(0.75); C1040(0.79)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C230(0.64); C598(0.85); C910(0.89); C1040(0.89)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C585(0.71); C230(0.79); C182(1.00); C163(1.04)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C598(0.79); C585(0.82); C230(0.84); C163(0.88)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C598(0.73); C585(0.76); C163(0.97); C173(0.97)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C230(0.50); C585(0.70); C598(0.77); C163(0.86)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C163(0.75); C173(0.75); C598(0.90); C370(1.02)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C163(0.62); C173(0.62); C230(1.00); C182(1.01)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C163(0.75); C173(0.75); C230(0.89); C182(1.08)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C230(0.66); C1020(0.69); C1025(0.69); C173(0.74)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C163(0.72); C173(0.72); C182(0.90); C353(0.92)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C163(0.74); C173(0.74); C598(0.84); C370(0.99)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C163(0.73); C173(0.73); C353(0.84); C230(0.92)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C230(0.92); C353(0.95); C182(0.97); C163(0.99)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C230(0.67); C370(0.93); C163(0.97); C173(0.97)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C163(0.74); C173(0.74); C406(0.86); C230(0.90)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C406(0.75); C163(0.75); C173(0.75); C400(0.82)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C163(0.62); C173(0.62); C230(0.72); C406(0.94)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C341(0.87); C163(0.87); C173(0.87); C182(0.94)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C163(0.75); C173(0.75); C341(0.81); C598(0.93)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C353(0.78); C230(0.81); C370(0.88); C598(0.90)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C163(0.55); C173(0.55); C230(0.82); C101(0.85)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C910(0.85); C341(0.87); C182(0.88); C913(0.91)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C163(0.75); C173(0.75); C182(0.88); C230(0.92)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C370(1.78); C163(0.56); C173(0.56); C230(0.80)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C163(0.72); C173(0.72); C230(0.75); C341(0.89)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C163(0.60); C173(0.60); C230(0.86); C598(0.97)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C163(0.81); C173(0.81); C101(0.88); C182(0.91)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C163(0.69); C173(0.69); C341(0.89); C230(0.93)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C163(0.86); C173(0.86); C182(0.88); C1040(0.91)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C163(0.82); C173(0.82); C910(0.91); C182(0.92)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C230(0.71); C353(0.76); C173(0.83); C163(0.86)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C598(0.83); C230(0.97); C182(0.99); C341(1.02)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C341(0.82); C1040(0.82); C182(0.89); C101(0.90)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C163(0.74); C173(0.74); C230(0.84); C101(0.88)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C163(0.68); C173(0.68); C230(0.72); C585(0.82)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C163(0.63); C173(0.63); C585(0.64); C230(0.71)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C585(0.55); C230(0.78); C163(0.79); C173(0.79)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C585(0.72); C163(0.78); C173(0.78); C230(0.88)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C585(0.86); C163(0.89); C173(0.89); C230(0.91)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C163(0.80); C173(0.80); C230(0.98); C101(1.00)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C163(0.70); C173(0.70); C230(0.78); C585(0.84)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C101(0.76); C598(0.86); C585(0.94); C230(0.96)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C585(0.73); C163(0.73); C173(0.73); C230(0.84)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C163(0.62); C173(0.62); C585(0.77); C230(0.80)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C163(0.74); C173(0.74); C230(0.81); C585(0.86)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C585(0.83); C101(0.84); C182(0.92); C163(0.95)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C163(0.78); C173(0.78); C585(0.80); C230(0.86)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C585(0.70); C163(0.88); C173(0.88); C230(0.95)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C163(0.61); C173(0.61); C230(0.71); C585(0.73)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C163(0.31); C173(0.31); C230(0.47); C353(0.71)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C1099(0.68); C230(0.74); C353(0.79); C1040(0.82)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C341(0.59)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C370(0.87); C1020(1.03); C1025(1.03); C1040(1.02)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C353(0.71); C1020(0.74); C1025(0.74); C182(0.90)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C353(0.53); C230(0.59); C1020(0.60); C1025(0.60)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 14.16  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C375(1.22); C370(1.20); C910(1.17); C913(1.17)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C341(0.81)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C1288(20.00); C375(2.68); C1040(1.74); C1099(1.45)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C1040(0.85); C598(0.89); C182(0.94); C353(0.96)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C163(0.62); C173(0.62); C230(0.67); C353(0.78)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C1020(0.48); C1025(0.48); C163(0.62); C173(0.62)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C1020(0.48); C1025(0.48); C353(0.60); C230(0.69)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C1020(0.68); C1025(0.68); C341(0.74); C353(0.85)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C1020(0.62); C1025(0.62); C353(0.78); C370(0.81)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C1020(0.77); C1025(0.77); C230(0.78); C182(0.88)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C598(0.78); C353(0.82); C341(0.99); C400(1.06)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C353(0.73); C230(0.83); C163(0.99); C173(0.99)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C353(0.78); C230(0.89); C341(0.90); C163(0.95)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C353(0.73); C230(0.85); C370(1.04); C341(1.10)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C230(0.82); C353(0.83); C182(1.08); C598(1.11)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C163(0.55); C173(0.55); C230(0.66); C353(0.83)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C353(0.58); C230(0.77); C341(1.00); C598(1.06)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C353(0.76); C230(0.85); C163(1.06); C173(1.06)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C101(0.59); C163(0.64); C173(0.64); C353(0.77)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C163(0.43); C173(0.43); C353(0.68); C101(0.76)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C163(0.37); C173(0.37); C353(0.57); C230(0.71)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C163(0.47); C173(0.47); C353(0.71); C230(0.82)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C163(0.75); C173(0.75); C230(0.76); C910(0.80)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C353(0.67); C163(0.74); C173(0.74); C230(0.79)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C353(0.82); C163(0.91); C173(0.91); C182(0.94)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C353(0.89); C163(0.92); C173(0.92); C598(0.95)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C163(0.60); C173(0.60); C353(0.82); C230(0.85)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C910(0.85); C353(0.87); C913(0.89); C163(0.91)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C230(0.60); C585(0.90); C598(0.91); C1040(1.02)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C585(0.75); C230(0.77); C598(0.83); C163(0.88)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C230(0.64); C585(0.69); C163(0.94); C173(0.94)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C230(0.65); C585(0.76); C598(0.77); C163(0.83)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C230(0.74); C163(0.88); C173(0.88); C406(0.88)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C163(0.87); C173(0.87); C406(0.90); C341(0.90)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C163(0.87); C173(0.87); C406(0.97); C182(1.00)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C163(0.78); C173(0.78); C598(0.96); C370(0.98)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C163(0.58); C173(0.58); C230(0.80); C182(0.97)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C163(0.85); C173(0.85); C598(0.93); C910(0.93)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C163(0.70); C173(0.70); C230(0.71); C598(0.83)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C230(0.81); C1099(0.86); C163(0.87); C173(0.87)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C101(0.80); C163(0.87); C173(0.87); C598(0.88)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C101(0.66); C163(0.68); C173(0.68); C230(0.78)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C163(0.80); C173(0.80); C230(0.86); C101(0.92)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C598(0.81); C230(0.83); C910(0.94); C913(0.95)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C163(0.70); C173(0.70); C230(0.91); C341(1.04)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C163(0.50); C173(0.50); C230(0.91); C182(1.12)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C163(0.56); C173(0.56); C230(0.86); C598(1.30)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C101(0.74); C163(0.79); C173(0.79); C230(0.82)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C370(1.32); C101(0.97); C1040(1.30); C1099(1.27)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C370(2.08); C101(1.05); C1040(1.32); C1099(1.06)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C370(1.25); C101(0.87); C1040(1.08); C1099(1.04)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C370(1.18); C101(0.76); C1040(1.08); C1099(1.12)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C370(1.35); C101(0.96); C1040(1.17); C1099(0.97)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C370(1.17); C101(1.25); C1040(1.28); C1099(1.24)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C370(1.03); C1040(0.99); C1099(1.12); C163(0.93)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C370(0.96); C101(1.12); C1040(1.08); C1099(0.90)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C370(1.57); C1020(0.86); C1025(0.86); C1040(1.00)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C370(1.31); C1020(0.69); C1025(0.69); C1040(0.97)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C370(3.02); C1020(1.03); C1025(1.03); C1040(0.83)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C370(2.61); C1020(0.84); C1025(0.84); C1040(1.26)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C370(1.69); C1020(0.79); C1025(0.79); C1040(1.19)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C370(1.79); C1020(0.76); C1025(0.76); C1040(1.21)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C370(3.34); C1020(1.13); C1025(1.13); C1040(1.25)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C370(1.87); C1020(0.85); C1025(0.85); C1040(1.28)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C370(1.60); C1040(0.94); C1099(0.97); C163(0.99)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C370(1.91); C1020(0.65); C1025(0.65); C1040(1.12)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C370(2.20); C1020(0.94); C1025(0.94); C1040(1.06)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C370(5.81); C1020(0.96); C1025(0.96); C1040(1.48)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C370(1.94); C1020(0.95); C1025(0.95); C1040(1.24)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C370(1.84); C1020(0.76); C1025(0.76); C1040(1.09)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C370(2.27); C1020(0.67); C1025(0.67); C1040(1.27)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C370(1.02); C101(0.91); C1099(0.95); C163(1.40)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C370(1.01); C101(1.62); C1099(0.90); C163(1.25)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C370(0.96); C101(0.89); C1099(0.92); C163(1.30)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C370(1.01); C101(0.81); C1099(0.99); C163(1.25)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C370(0.83); C1040(1.01); C1099(1.12); C163(0.91)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C370(1.23); C101(0.82); C1099(0.93); C163(1.22)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C370(1.09); C101(1.03); C1099(1.07); C163(1.18)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C370(1.15); C101(0.80); C1099(1.18); C163(1.32)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C370(2.27); C101(1.23); C1099(1.00); C163(1.18)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C370(1.65); C101(0.88); C1099(0.84); C163(1.38)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C370(1.05); C101(0.90); C1099(0.89); C163(1.42)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C370(1.11); C101(1.14); C1099(1.08); C163(1.13)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C370(1.12); C101(1.14); C1099(0.92); C163(1.23)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C370(0.91); C101(0.82); C1099(0.88); C163(1.29)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C370(0.96); C101(1.00); C1099(0.91); C163(1.24)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C370(1.30); C1040(0.96); C1099(1.05); C163(0.69)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C370(1.07); C101(0.97); C1099(0.93); C163(1.16)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C370(1.46); C1040(1.08); C1099(1.20); C163(0.83)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C370(1.23); C1040(1.15); C1099(1.13); C163(0.78)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C370(1.60); C1040(1.17); C1099(1.32); C163(0.69)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C370(1.70); C1040(1.23); C1099(1.34); C163(0.72)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C370(1.22); C1040(1.16); C1099(1.10); C163(0.92)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C370(1.77); C1040(1.51); C1099(1.24); C163(0.74)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C370(1.30); C1040(1.32); C1099(1.19); C163(0.71)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C370(1.45); C1040(1.12); C1099(1.13); C163(0.62)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C370(1.45); C1040(0.86); C1099(1.07); C163(0.75)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C370(1.19); C1040(1.17); C1099(1.24); C163(0.70)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C370(1.36); C1040(1.07); C1099(1.15); C163(0.67)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C370(2.33); C1040(1.11); C1099(1.11); C163(0.70)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C370(1.41); C1040(1.05); C1099(1.08); C163(0.69)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C370(2.37); C1040(1.13); C1099(1.06); C163(0.65)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C370(2.12); C1040(1.13); C1099(1.16); C163(0.66)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C370(1.11); C101(1.02); C1020(0.41); C1025(0.41)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C370(2.12); C101(1.18); C1020(1.05); C1025(1.05)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C370(1.28); C101(0.86); C1020(0.54); C1025(0.54)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C370(1.43); C101(1.23); C1020(0.59); C1025(0.59)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C370(4.67); C1040(1.19); C1099(1.13); C163(0.46)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C370(1.11); C101(0.93); C1020(0.42); C1025(0.42)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C370(1.30); C101(0.83); C1020(0.53); C1025(0.53)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C370(1.85); C101(1.54); C1020(0.49); C1025(0.49)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C370(2.55); C101(1.95); C1020(0.48); C1025(0.48)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C370(2.97); C101(1.86); C1020(0.46); C1025(0.46)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C370(1.35); C101(1.10); C1020(0.48); C1025(0.48)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C370(1.21); C101(1.05); C1020(0.62); C1025(0.62)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C370(1.48); C101(1.54); C1020(0.39); C1025(0.39)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C370(1.65); C101(1.59); C1020(0.43); C1025(0.43)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C370(2.97); C101(1.63); C1020(0.49); C1025(0.49)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C370(1.22); C1040(1.10); C1099(1.29); C163(0.78)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C370(2.04); C101(0.93); C1020(0.75); C1025(0.75)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C370(1.07); C101(1.01); C1020(0.49); C1025(0.49)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C370(1.39); C101(1.50); C1020(0.52); C1025(0.52)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C370(1.04); C101(1.26); C1020(0.71); C1025(0.71)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C370(1.05); C101(1.27); C1020(0.47); C1025(0.47)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C370(9.35); C101(1.53); C1020(0.49); C1025(0.49)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C370(1.98); C101(1.56); C1020(0.45); C1025(0.45)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C370(1.86); C101(1.31); C1020(0.48); C1025(0.48)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C370(1.13); C101(1.29); C1020(0.47); C1025(0.47)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C370(1.05); C101(1.86); C1020(0.44); C1025(0.44)  LDD0811  [10]
 LDCM0191  Compound 21 HEK-293T 3.11  LDD0508  [24]
 LDCM0190  Compound 34 HEK-293T 3.11  LDD0510  [24]
 LDCM0634  CY-0357 Hep-G2 C1288(1.52); C101(0.51); C598(0.42); C1099(0.41)  LDD2228  [14]
 LDCM0027  Dopamine HEK-293T 5.91  LDD0179  [8]
 LDCM0495  E2913 HEK-293T C101(1.09); C375(0.84); C341(0.98); C598(0.95)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C375(1.66); C341(1.48); C598(1.18); C1099(1.15)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.88  LDD0183  [8]
 LDCM0625  F8 Ramos C1288(1.39); C1099(0.65); C375(1.91); C598(1.87)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C1288(0.85); C598(0.81); C314(1.19)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C1288(0.13); C1099(0.78); C375(7.85); C598(0.66)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C1288(0.84); C1099(1.50); C375(1.16); C598(0.57)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C1288(1.15); C1099(1.57); C375(1.18); C598(0.92)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C1288(0.81); C1099(0.75); C375(1.64); C598(0.51)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C1288(0.66); C1099(1.96); C375(1.75); C598(0.72)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C1288(0.94); C1099(2.11); C375(1.11); C598(0.73)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C1288(0.56); C375(1.14); C598(0.89); C314(1.35)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C1288(0.96); C1099(1.34); C375(1.08); C598(1.26)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C1288(0.75); C1099(0.43); C375(0.75); C598(0.72)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C1288(1.26); C1099(1.40); C375(1.20); C598(1.05)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C1288(0.96); C1099(1.54); C375(1.04); C598(1.13)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C1288(0.84); C1099(0.58); C375(2.12); C598(0.85)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C370(1.46); C1040(1.17); C1099(1.07); C163(0.88)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C1288(0.84); C1099(1.62); C375(0.85); C598(0.61)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C1288(0.75); C1099(1.58); C375(1.25); C598(0.73)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C370(3.70); C1020(0.97); C1025(0.97); C1040(1.43)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C1288(1.20); C375(1.35); C598(0.94); C314(1.07)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C1288(1.34); C1099(1.37); C375(1.52); C314(1.15)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C1288(0.67); C1099(0.70); C375(1.31); C598(0.59)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C1288(0.79); C1099(1.14); C375(1.44); C598(1.48)  LDD2188  [26]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C406(2.21); C370(9.89); C910(2.50); C913(2.50)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C406(1.46); C370(6.19); C910(1.11); C913(1.11)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C406(3.49); C370(3.32); C910(2.60); C913(2.60)  LDD0082  [10]
 LDCM0030  Luteolin HEK-293T 8.51  LDD0182  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C341(0.85)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0225  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C341(1.00)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C341(1.24); C598(1.00)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C341(1.47)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C598(0.37)  LDD2096  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C341(1.39); C598(0.92); C1288(0.98)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C341(1.08); C598(1.09); C1288(1.50)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C341(1.13)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C341(1.27); C598(0.97)  LDD2111  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C598(0.50)  LDD2118  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C341(0.39)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C598(0.66)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C341(0.95); C598(0.85)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C598(0.47)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C341(1.23); C598(0.98); C375(0.62)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C598(0.48)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C341(1.18); C598(1.06); C375(1.30)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C341(0.43)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C341(1.38)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C341(1.52)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C341(1.73); C598(0.89); C375(1.76); C1288(1.40)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C341(0.99); C598(0.93); C375(0.98)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C341(2.24)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C341(1.13); C598(0.86)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C341(0.50)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C341(3.42)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C341(1.27)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C341(0.41)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C341(0.60)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C341(0.56)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C598(0.11)  LDD2206  [27]
 LDCM0032  Oleacein HEK-293T 5.97  LDD0184  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C1099(1.87)  LDD2207  [27]
 LDCM0029  Quercetin HEK-293T 5.10  LDD0181  [8]
 LDCM0131  RA190 MM1.R C314(1.37)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C375(1.18); C910(1.14); C913(1.14); C370(1.01)  LDD2173  [10]
 LDCM0112  W16 Hep-G2 C370(0.69)  LDD0239  [22]
 LDCM0154  YY4 T cell 2.82  LDD0400  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) WD repeat G protein beta family P62879
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1
Scm-like with four MBT domains protein 2 (SFMBT2) . Q5VUG0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.