Details of the Target

General Information of Target

Target ID LDTP00755
Target Name WD repeat-containing protein 62 (WDR62)
Gene Name WDR62
Gene ID 284403
Synonyms
C19orf14; WD repeat-containing protein 62
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRV
SLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFS
PDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMV
LNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPL
VGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSC
LCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYP
DTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQR
ACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPD
RGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCL
EYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCG
ADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNG
KQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITS
MKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQD
TYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRL
LGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILD
SLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCR
KEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFA
TSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEA
SEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGT
GYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGL
AQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQEL
QAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVS
FPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSG
ALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVD
TGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALL
EHYSELLVQAVRRKARGH
Target Bioclass
Other
Subcellular location
Nucleus
Function
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication.
Uniprot ID
O43379
Ensemble ID
ENST00000270301.12
HGNC ID
HGNC:24502

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y858(9.96)  LDD0257  [3]
STPyne
 Probe Info  		K771(10.00); K855(1.89)  LDD0277  [4]
DA-P3
 Probe Info  		5.78  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C1072(20.00)  LDD0170  [6]
DBIA
 Probe Info  		C1119(11.34)  LDD0209  [7]
ATP probe
 Probe Info  		K102(0.00); K145(0.00)  LDD0199  [8]
N1
 Probe Info  		S715(0.00); S720(0.00)  LDD0245  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C647(0.00); C826(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C1119(0.00); C692(0.00); C647(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		0.00; C1210(0.00); C1300(0.00)  LDD2226  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
HHS-475
 Probe Info  		Y858(0.42)  LDD2238  [15]
HHS-482
 Probe Info  		Y858(0.94)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [16]
STS-2
 Probe Info  		N.A.  LDD0139  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1072(20.00)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C1072(10.05)  LDD0171  [6]
 LDCM0214  AC1 HEK-293T C1119(0.88); C422(1.06)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C1072(1.10); C1119(1.10); C707(0.97); C692(1.10)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C1072(1.11); C1119(0.96); C707(0.97); C1300(1.17)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C1072(1.08); C1119(1.02); C1300(1.40); C422(1.32)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C1072(1.00); C1119(0.92); C1210(0.98); C707(1.01)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C1119(0.87); C692(1.18)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C1119(1.03); C422(1.09)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C1072(1.12); C1119(1.04); C707(1.12); C692(0.96)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C1072(1.01); C1119(1.52); C707(0.88); C1300(0.79)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C1072(1.05); C1119(0.97); C707(1.15); C692(1.00)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C1072(0.94); C1119(0.91); C1300(1.08); C422(1.19)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C1072(1.00); C1119(1.05); C692(0.87)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C1072(1.03); C1119(0.98); C1210(1.07); C707(1.03)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C1119(0.89); C692(0.99)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C1072(1.03); C1119(0.91); C707(1.11); C1300(1.01)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C1119(0.95); C422(1.07)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C1072(1.02); C1119(0.96); C707(1.34); C692(1.04)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C1072(1.04); C1119(1.06); C707(0.97); C1300(0.95)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C1072(0.98); C1119(0.99); C1300(1.17); C422(1.21)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C1072(0.83); C1119(1.07); C692(1.23)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C1072(0.98); C1119(0.93); C707(1.04); C1300(0.96)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C1072(1.07); C1119(0.97); C1210(1.07); C707(1.05)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C1119(0.92); C692(0.88)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C1072(1.07); C1119(0.97); C707(1.19); C1300(1.00)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C1119(0.93); C422(0.84)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C1072(1.09); C1119(1.08); C707(0.93); C692(0.92)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C1072(0.98); C1119(0.91); C707(1.04); C1300(1.00)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C1072(1.08); C1119(1.05); C1300(1.12); C422(1.98)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C1072(1.01); C1119(1.11); C692(1.10)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C1072(0.98); C1119(0.96); C1210(1.06); C707(1.02)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C1119(0.88); C692(0.98)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C1072(1.02); C1119(1.09); C1300(1.18); C422(1.33)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C1072(1.05); C1119(0.95); C707(1.13); C1300(1.17)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C1119(0.96); C422(1.34)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C1072(1.15); C1119(1.07); C707(1.00); C692(0.84)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C1072(1.06); C1119(0.99); C707(1.02); C1300(1.01)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C1072(1.04); C1119(1.05); C1300(1.16); C422(1.28)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C1072(0.97); C1119(1.15); C692(1.24)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C1072(1.08); C1119(0.99); C1210(1.06); C707(1.05)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C1119(0.89); C692(0.97)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C1072(0.90); C1119(0.89); C707(1.07); C1300(1.23)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C1119(0.98); C422(1.09)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C1072(0.98); C1119(1.08); C692(1.38)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C1072(1.05); C1119(1.01); C707(0.97); C692(0.97)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C1072(0.94); C1119(1.04); C707(0.97); C1300(0.87)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C1072(0.98); C1119(0.99); C1300(1.04); C422(1.10)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C1072(1.10); C1119(1.13); C692(1.04)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C1072(1.04); C1119(0.92); C1210(0.93); C707(1.10)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C1119(0.95); C692(1.02)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C1072(0.98); C1119(0.92); C707(1.05); C1300(1.09)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C1119(1.03); C422(1.17)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C1072(1.09); C1119(1.04); C707(1.38); C692(0.86)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C1072(0.98); C1119(1.00); C707(1.00); C1300(0.99)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C1072(1.05); C1119(1.09); C1210(0.99); C707(1.05)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C1072(1.00); C1119(1.09); C1300(1.19); C422(1.11)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C1072(1.00); C1119(1.11); C692(1.15)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C1072(1.15); C1119(1.08); C1210(0.91); C707(0.93)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C1119(0.95); C692(1.05)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C1072(0.97); C1119(0.97); C707(1.09); C1300(1.18)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C1119(0.88); C692(0.86)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C1072(0.90); C1119(1.01); C707(1.14); C1300(1.22)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C1072(1.13); C1119(1.02); C692(1.01)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C1119(1.01); C422(1.27)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C1072(0.98); C1119(0.98); C707(1.02); C1300(1.07)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0367  CL1 HEK-293T C1072(0.99); C1119(1.14); C826(1.09); C707(1.05)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C1072(1.13); C1119(1.10); C1210(1.14); C707(1.15)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C1072(1.17); C1119(0.96); C707(0.89); C1300(0.97)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C1072(1.17); C1119(1.11); C826(0.99); C707(1.03)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C1072(1.21); C1119(0.99); C1300(0.81); C422(0.74)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C1072(1.09); C1119(1.04); C1300(0.78); C1169(1.49)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C1072(1.18); C1119(0.91); C707(1.03); C1300(0.89)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C1072(1.19); C1119(1.21); C826(1.04); C707(0.90)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C1072(1.09); C1119(0.82); C1300(1.45); C422(0.85)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C1072(0.92); C1119(1.00); C1300(0.80); C1169(1.44)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C1072(1.00); C1119(0.96); C707(1.02); C1300(0.95)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C1072(1.12); C1119(1.01); C826(1.08); C707(0.92)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C1119(1.06); C692(0.97)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C1072(1.04); C1119(0.92); C1300(1.02); C422(0.76)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C1072(1.02); C1119(0.99); C1300(0.88); C1169(1.25)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C1072(1.00); C1119(0.99); C707(0.96); C1300(1.05)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C1072(1.03); C1119(1.16); C826(0.99); C707(1.01)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C1072(1.05); C1119(0.93); C1300(1.43); C422(1.23)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C1072(1.05); C1119(0.94); C1300(0.76); C1169(1.33)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C1072(1.13); C1119(0.96); C707(0.97); C1300(1.27)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C1072(1.15); C1119(1.10); C826(0.98); C707(1.03)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C1072(1.26); C1119(0.92); C1300(0.85); C422(0.69)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C1072(1.14); C1119(0.96); C1300(0.80); C1169(1.20)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C1072(1.02); C1119(1.02); C707(1.56); C1300(1.30)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C1072(1.07); C1119(0.94); C707(1.07); C1300(0.77)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C1072(1.13); C1119(1.07); C826(0.98); C707(1.06)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C1072(1.05); C1119(0.98); C1300(1.41); C422(0.66)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C1072(0.96); C1119(0.99); C1300(0.89); C1169(1.12)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C1072(1.10); C1119(0.97); C707(1.00); C1300(1.09)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C1072(1.02); C1119(1.16); C826(1.04); C707(1.04)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C1072(1.13); C1119(0.93); C1300(0.97); C422(1.03)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C1072(0.90); C1119(0.95); C1300(0.78); C1169(1.20)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C1072(1.06); C1119(1.01); C707(0.93); C1300(1.05)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C1072(1.36); C1119(1.09); C826(1.11); C707(0.93)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C1072(1.00); C1119(0.90); C1300(1.33); C422(0.98)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C1072(0.94); C1119(1.04); C1300(1.05); C1169(0.96)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C1072(1.12); C1119(0.87); C707(1.05); C1300(1.15)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C1119(0.90); C422(1.17)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C1072(1.16); C1119(0.98); C707(1.14); C692(1.18)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C1072(0.96); C1119(1.04); C707(1.07); C1300(1.14)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C1072(1.06); C1119(0.89); C1300(1.44); C422(0.69)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C1072(1.08); C1119(1.01); C1300(1.61); C422(1.45)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C1072(1.07); C1119(1.09); C692(1.17)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C1072(1.13); C1119(0.95); C1210(1.15); C707(1.09)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C1119(0.96); C692(1.10)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C1072(0.99); C1119(0.94); C707(1.28); C1300(1.19)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C1072(1.17); C1119(1.03); C826(1.11); C707(1.01)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C1072(0.94); C1119(0.94); C1300(0.97); C422(0.76)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C1072(1.08); C1119(1.04); C1300(0.74); C1169(1.18)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C1072(1.00); C1119(0.98); C707(0.91); C1300(1.07)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C1119(0.93); C422(1.06)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C1072(1.11); C1119(0.98); C1300(0.70); C1169(1.01)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C1072(0.98); C1119(0.93); C707(1.11); C692(1.19)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C1072(1.06); C1119(1.08); C707(1.07); C1300(0.98)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C1072(1.16); C1119(0.99); C1300(1.35); C422(1.29)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C1072(0.98); C1119(1.20); C692(1.24)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C1072(1.01); C1119(0.98); C1210(1.08); C707(1.14)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C1119(0.91); C692(1.27)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C1072(1.13); C1119(1.00); C707(1.34); C1300(1.09)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C1072(0.98); C1119(0.96); C826(1.06); C707(1.10)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C1072(1.15); C1119(1.08); C1300(0.89); C1169(1.41)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C1072(1.14); C1119(0.89); C707(1.01); C1300(1.11)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C1072(1.03); C1119(1.02); C707(0.97); C1300(1.16)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C1119(0.94); C422(1.10)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C1072(1.03); C1119(1.08); C707(1.13); C692(0.96)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C1072(1.00); C1119(0.99); C707(1.09); C1300(0.95)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C1072(1.06); C1119(1.02); C1300(1.27); C422(1.74)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C1072(1.17); C1119(1.15); C692(0.90)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C1072(1.06); C1119(1.08); C1210(0.95); C707(1.19)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C1119(0.96); C692(0.95)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C1072(1.04); C1119(1.01); C707(1.37); C1300(1.32)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C1072(1.00); C1119(1.03); C826(0.91); C707(1.15)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C1119(0.91); C422(1.20)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C1072(1.18); C1119(0.84); C1300(0.68); C422(0.78)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C1072(0.96); C1119(1.01); C707(1.07); C1300(0.81)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C1119(1.00); C422(1.06)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C1072(1.00); C1119(1.03); C707(1.19); C692(0.99)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C1072(1.07); C1119(0.99); C707(0.96); C1300(0.97)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C1072(1.03); C1119(1.22); C1300(1.30); C422(1.14)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C1072(0.98); C1119(1.37); C692(0.78)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C1072(1.11); C1119(1.20); C1210(1.01); C707(1.12)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C1119(0.91); C692(0.93)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C1072(1.07); C1119(1.03); C707(1.10); C692(0.98)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C1072(1.03); C1119(1.00); C707(1.18); C1300(0.98)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C1072(1.09); C1119(1.03); C826(0.93); C707(0.98)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C1072(1.21); C1119(0.88); C1300(1.17); C422(0.81)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C1072(0.84); C1119(0.92); C1300(0.90); C1169(1.17)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C1072(1.17); C1119(0.91); C707(1.04); C1300(0.89)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C1119(0.87); C422(1.20)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C1072(1.14); C1119(1.16); C707(1.09); C692(0.87)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C1072(1.18); C1119(1.05); C707(0.97); C1300(0.95)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C1072(1.09); C1119(1.12); C1300(1.27); C422(1.10)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C1072(1.04); C1119(1.08); C692(1.08)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C1072(1.03); C1119(0.96); C707(1.21); C1300(0.84)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C1072(1.07); C1119(0.99); C1210(1.23); C707(1.15)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C1119(0.91); C692(1.11)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C1072(1.02); C1119(1.09); C707(1.39); C1300(1.12)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C1072(1.00); C1119(0.99); C826(1.01); C707(1.12)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C1072(1.01); C1119(0.89); C1300(0.80); C422(1.12)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C1072(1.01); C1119(0.97); C707(1.14); C1300(1.07)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C1119(0.87); C422(1.38)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C1072(1.09); C1119(1.05); C707(1.06); C692(1.05)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C1072(0.98); C1119(0.98); C707(1.04); C1300(0.92)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C1072(1.05); C1119(1.05); C1300(1.32); C422(1.43)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C1072(1.08); C1119(1.01); C1300(1.14); C422(1.39)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C1072(1.01); C1119(1.16); C692(1.02)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C1072(1.03); C1119(0.95); C1210(1.00); C707(1.04)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C1119(0.91); C692(0.79)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C1072(1.06); C1119(0.96); C707(1.18); C1300(0.84)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C1072(1.18); C1119(1.03); C826(1.09); C707(1.05)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C1072(1.07); C1119(0.86); C1300(0.98); C422(0.90)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C1072(0.93); C1119(1.00); C1300(1.03); C1169(0.95)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C1072(1.08); C1119(0.92); C707(1.01); C1300(1.26)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C1119(0.88); C422(0.97)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C1072(0.98); C1119(1.16); C692(1.07)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C1072(1.08); C1119(1.07); C707(1.04); C692(1.13)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C1072(1.01); C1119(0.97); C707(1.02); C1300(1.07)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C1072(0.98); C1119(1.01); C1300(1.15); C422(1.27)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C1072(0.93); C1119(1.19); C692(1.18)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C1072(1.08); C1119(1.06); C1210(0.98); C707(1.08)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C1119(0.94); C692(0.69)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C1072(1.02); C1119(0.96); C707(1.58); C1300(0.89)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C1072(1.25); C1119(1.02); C826(1.08); C707(0.99)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C1072(1.13); C1119(0.97); C1300(0.92); C422(0.78)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C1072(1.08); C1119(1.14); C1300(0.60); C1169(1.27)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C1072(0.90); C1119(0.96); C1300(0.85); C1169(1.24)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1119(3.15)  LDD1702  [18]
 LDCM0468  Fragment33 HEK-293T C1072(1.07); C1119(0.95); C1300(0.92); C1169(1.00)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C1072(1.03); C1119(0.91); C1300(0.99); C422(0.82)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C1072(0.93); C1119(0.89); C707(0.91); C599(0.97)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C1119(11.34)  LDD0209  [7]
 LDCM0024  KB05 MKN-1 C707(1.92); C647(2.18)  LDD3331  [19]
 LDCM0030  Luteolin HEK-293T 7.04  LDD0182  [5]
 LDCM0032  Oleacein HEK-293T 5.29  LDD0184  [5]
 LDCM0029  Quercetin HEK-293T 5.78  LDD0181  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) CMGC Ser/Thr protein kinase family Q92630
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Melanoma-associated antigen B4 (MAGEB4) . O15481
Protein moonraker (KIAA0753) . Q2KHM9
TBC1 domain family member 23 (TBC1D23) . Q9NUY8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840