Details of the Target

General Information of Target

Target ID LDTP05475
Target Name Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
Gene Name PTPN11
Gene ID 5781
Synonyms
PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily
Subcellular location
Cytoplasm
Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L.
TTD ID
T13057
Uniprot ID
Q06124
DrugMap ID
TT7WUAV
Ensemble ID
ENST00000351677.7
HGNC ID
HGNC:9644
ChEMBL ID
CHEMBL3864

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
Probe 1
 Probe Info  		Y66(20.11); Y396(10.94); Y511(6.18)  LDD3495  [3]
BTD
 Probe Info  		C318(0.58)  LDD2089  [4]
Sulforaphane-probe2
 Probe Info  		1.83  LDD0160  [5]
DA-P3
 Probe Info  		5.16  LDD0181  [6]
AHL-Pu-1
 Probe Info  		C567(3.24)  LDD0168  [7]
HHS-475
 Probe Info  		Y546(0.38); Y584(0.85)  LDD0264  [8]
HHS-465
 Probe Info  		K546(10.00)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0221  [10]
DBIA
 Probe Info  		C567(1.06); C573(1.06); C259(0.97)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C486(0.00); C459(0.00); C333(0.00); C104(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C486(0.00); C259(0.00); C333(0.00); C104(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		C259(0.00); C333(0.00)  LDD2226  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NPM
 Probe Info  		N.A.  LDD0016  [17]
SF
 Probe Info  		Y279(0.00); K199(0.00); K198(0.00)  LDD0028  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
VSF
 Probe Info  		C563(0.00); C318(0.00); C259(0.00); C569(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C318(0.00); C569(0.00)  LDD0018  [20]
W1
 Probe Info  		C490(0.00); C104(0.00)  LDD0236  [21]
AOyne
 Probe Info  		7.00  LDD0443  [22]
NAIA_5
 Probe Info  		C318(0.00); C367(0.00); C486(0.00); C333(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		14.18  LDD0465  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C318(0.55)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C318(0.83)  LDD2112  [4]
 LDCM0025  4SU-RNA HEK-293T C567(3.24)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C573(2.17); C567(2.10)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C104(1.51); C259(1.26); C318(0.35); C333(0.87)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C259(1.11); C318(2.29); C333(1.02); C567(1.21)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C104(0.74); C259(0.98); C333(1.34); C567(1.01)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C104(0.81); C259(1.07); C333(0.85); C567(1.05)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C104(0.94); C259(0.95); C333(1.00); C567(1.09)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C104(0.96); C259(1.22); C333(0.84); C567(1.40)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C104(1.00); C259(0.97); C333(0.90); C567(1.17)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C104(0.96); C259(1.09); C333(0.92); C567(1.25)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C104(0.80); C259(1.17); C333(1.12); C567(1.25)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C104(0.54); C259(1.03); C333(1.03); C567(1.21)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C104(1.85); C259(1.10); C333(0.98); C567(0.91)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C104(1.22); C259(1.00); C333(1.30); C567(1.02)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C259(0.97); C318(2.08); C333(0.91); C567(1.25)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C104(0.72); C259(1.25); C333(0.97); C567(1.09)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C104(1.05); C259(1.16); C333(0.80); C567(1.03)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C104(0.52); C259(1.11); C333(0.69); C567(1.23)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C259(1.00); C333(1.71); C567(1.00); C573(1.00)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C259(1.17); C333(1.20); C567(1.12); C573(1.16)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C259(1.20); C333(1.00); C567(1.28); C573(1.31)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C259(1.21); C333(0.95); C567(1.55); C573(1.61)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C259(1.29); C333(1.29); C567(1.10); C573(1.09)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C259(1.14); C333(1.06); C567(1.05); C573(1.15)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C259(1.24); C333(1.30); C567(1.25); C573(1.23)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C259(0.90); C318(0.37); C333(1.36); C567(1.06)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C259(1.02); C333(1.19); C567(1.19); C573(1.29)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C259(1.41); C333(1.32); C567(1.20); C573(1.15)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C259(1.24); C333(0.83); C567(1.17); C573(1.23)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C259(1.86); C333(1.12); C567(1.09); C573(1.12)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C259(1.45); C333(1.05); C567(1.12); C573(1.13)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C259(1.14); C333(1.19); C567(1.07); C573(1.14)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C259(1.26); C333(1.24); C567(1.36); C573(1.46)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C259(1.49); C333(1.04); C567(1.15); C573(1.23)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C259(1.39); C333(0.87); C567(0.98); C573(0.98)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C259(0.93); C333(1.21); C567(0.76); C573(0.76)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C259(0.96); C333(0.82); C567(0.86); C573(0.86)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C259(0.97); C333(1.14); C567(0.79); C573(0.79)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C259(1.04); C333(1.23); C567(0.74); C573(0.74)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C259(1.19); C333(0.89); C567(0.85); C573(0.85)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C259(1.30); C333(0.96); C567(0.86); C573(0.86)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C259(1.22); C333(0.97); C567(0.86); C573(0.86)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C259(1.01); C333(1.00); C567(0.85); C573(0.85)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C259(0.98); C333(0.89); C567(0.80); C573(0.80)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C259(1.26); C333(0.87); C567(0.89); C573(0.89)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C259(1.21); C333(1.13); C567(0.86); C573(0.86)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C259(0.98); C318(3.06); C333(0.84); C567(1.11)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C259(1.11); C333(1.06); C567(0.93); C573(0.93)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C259(1.07); C333(0.88); C567(0.88); C573(0.88)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C259(1.02); C333(0.85); C567(0.78); C573(0.78)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C333(0.55); C104(0.88); C259(0.89); C567(1.07)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C333(0.57); C104(0.79); C259(0.91); C567(1.22)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C333(0.71); C104(0.71); C259(0.94); C573(1.04)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C333(0.40); C104(0.84); C259(1.04); C567(1.28)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C333(0.79); C104(0.80); C259(1.01); C573(1.36)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C333(0.34); C104(0.54); C259(1.27); C567(1.58)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C333(0.41); C104(0.98); C259(1.18); C567(1.44)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C318(0.67); C259(1.05); C333(1.10); C567(1.11)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C104(0.97); C567(1.06); C573(1.09); C259(1.25)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C333(0.63); C259(0.97); C104(0.99); C567(1.09)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C333(0.50); C104(0.81); C259(1.07); C567(1.39)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C333(0.25); C104(0.32); C259(1.46); C567(1.74)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C104(0.91); C259(0.97); C333(0.53); C567(1.19)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C104(0.87); C259(1.09); C333(0.59); C567(1.22)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C104(1.00); C259(0.93); C333(0.71); C567(1.05)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C104(0.51); C259(0.78); C333(0.58); C567(1.03)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C318(0.54); C104(0.90); C567(0.96); C573(0.96)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C333(0.81); C104(0.84); C318(1.24); C567(1.36)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C104(0.66); C318(0.68); C333(0.86); C567(0.99)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C318(0.21); C567(1.00); C573(1.00); C333(1.06)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C104(0.77); C333(0.98); C318(1.02); C567(1.05)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C104(0.59); C333(0.95); C259(1.17); C567(1.18)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C318(0.59); C104(0.64); C333(0.93); C567(1.10)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C104(0.48); C333(0.95); C318(1.03); C567(1.05)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C104(0.79); C567(0.95); C573(0.95); C333(1.20)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C259(1.00); C567(1.12); C573(1.12); C333(1.13)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C333(0.98); C104(1.05); C259(1.12); C567(1.24)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C333(0.97); C259(1.21); C567(1.26); C573(1.26)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C333(0.98); C259(1.17); C104(1.31); C567(1.36)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C104(0.81); C333(0.84); C567(1.33); C573(1.33)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C318(0.15); C567(1.00); C573(1.00); C333(1.16)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C333(0.79); C104(1.03); C567(1.27); C573(1.27)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C333(0.87); C259(1.07); C567(1.13); C573(1.13)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C333(0.79); C104(1.06); C567(1.38); C573(1.38)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C333(0.89); C104(0.96); C259(1.11); C567(1.43)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C333(0.75); C104(1.14); C259(1.14); C567(1.64)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C318(0.26); C259(0.82); C333(0.90); C104(0.93)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C318(0.36); C333(0.67); C259(0.95); C567(0.96)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C318(0.50); C333(0.69); C259(0.85); C567(0.94)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C259(0.91); C567(0.94); C573(0.94); C104(0.97)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C318(0.43); C333(0.76); C567(1.04); C573(1.04)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C318(0.22); C567(1.01); C573(1.01); C333(1.19)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C333(0.63); C318(0.98); C104(1.15); C259(1.19)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C333(0.78); C567(1.00); C573(1.00); C104(1.04)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C333(0.98); C259(1.10); C104(1.11); C567(1.14)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C333(0.70); C318(1.05); C567(1.05); C573(1.05)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C333(0.72); C567(1.09); C573(1.09); C259(1.13)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C333(0.65); C104(1.15); C259(1.29); C567(1.36)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C333(0.87); C567(0.97); C573(0.97); C259(0.98)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C567(0.99); C573(0.99); C259(1.08); C333(1.09)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C333(0.73); C567(0.92); C573(0.92); C259(1.32)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C333(0.79); C567(1.25); C573(1.25); C259(1.42)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C318(0.13); C567(0.98); C573(0.98); C333(1.05)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C333(0.83); C567(1.32); C573(1.32); C259(1.35)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C259(0.87); C567(0.88); C573(0.88); C333(1.40)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C259(0.92); C567(1.03); C573(1.03); C333(1.33)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C333(0.86); C567(1.26); C573(1.26); C259(1.40)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C567(1.17); C573(1.17); C259(1.29); C333(1.31)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C333(0.66); C567(1.31); C573(1.31); C259(1.62)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C333(0.59); C567(1.46); C573(1.46); C259(2.13)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C567(0.99); C573(0.99); C104(1.06); C259(1.11)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C104(1.01); C567(1.02); C573(1.02); C333(1.02)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C567(1.03); C573(1.03); C104(1.22); C259(1.22)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C333(0.88); C259(1.10); C567(1.26); C573(1.26)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C333(0.95); C567(0.97); C573(0.97); C104(1.08)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C567(0.88); C573(0.88); C333(0.91); C259(1.16)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C567(1.04); C573(1.04); C104(1.10); C333(1.17)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C567(1.00); C573(1.00); C104(1.05); C259(1.06)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C104(1.07); C333(1.08); C259(1.19); C567(1.31)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C567(0.86); C573(0.86); C259(1.34); C333(1.35)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C567(0.78); C573(0.78); C259(1.27); C333(1.34)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C333(0.74); C104(0.74); C567(0.93); C573(0.93)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C333(0.70); C567(1.04); C573(1.04); C259(1.07)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C333(0.65); C567(1.00); C573(1.00); C259(1.19)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C333(1.00); C567(1.02); C573(1.02); C259(1.28)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C333(0.59); C567(1.07); C573(1.07); C259(1.08)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C259(0.89); C567(0.95); C573(0.95); C333(0.97)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C333(0.76); C259(1.06); C567(1.13); C573(1.13)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C333(0.48); C567(1.28); C573(1.28); C259(1.56)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C333(0.61); C567(1.30); C573(1.30); C259(1.44)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C333(0.38); C567(1.60); C573(1.60); C259(1.72)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C333(0.87); C567(1.17); C573(1.17); C259(1.24)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C333(0.64); C567(1.20); C573(1.20); C259(1.32)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C333(0.75); C259(1.08); C567(1.10); C573(1.10)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C333(1.01); C259(1.09); C567(1.12); C573(1.12)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C333(1.01); C259(1.05); C567(1.14); C573(1.14)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C333(1.00); C567(1.12); C573(1.12); C259(1.16)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C333(0.71); C259(1.00); C567(1.25); C573(1.25)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C333(0.50); C259(1.50); C567(1.72); C573(1.72)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C333(0.79); C104(1.01); C259(1.60); C567(1.60)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C333(0.74); C104(0.96); C259(1.32); C567(1.57)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C333(0.96); C104(1.01); C567(1.30); C573(1.30)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C333(0.91); C104(1.12); C259(1.31); C567(1.31)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C333(0.82); C259(1.04); C567(1.13); C573(1.13)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C104(1.09); C333(1.11); C259(1.15); C567(1.27)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C333(0.87); C104(1.03); C259(1.37); C567(1.49)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C104(1.03); C259(1.05); C567(1.07); C573(1.07)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C333(0.83); C104(0.94); C567(1.61); C573(1.61)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C333(1.01); C104(1.05); C259(1.51); C567(1.59)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C333(1.00); C259(1.03); C104(1.07); C567(1.31)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C104(1.11); C333(1.13); C567(1.27); C573(1.27)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C333(0.64); C104(1.03); C567(1.15); C573(1.15)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C104(1.04); C333(1.06); C259(1.38); C567(1.41)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C333(0.79); C104(1.00); C259(1.32); C567(1.66)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C104(0.29); C333(0.55); C259(1.41); C567(1.50)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C104(0.63); C333(0.84); C567(0.97); C573(0.97)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C318(0.59)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C259(0.91); C318(0.80); C333(1.02); C567(1.05)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C259(0.95); C333(0.97); C567(1.18); C573(1.18)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C318(0.48); C333(0.79); C259(1.56); C567(1.66)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C567(1.06); C573(1.06); C259(0.97)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C318(0.55)  LDD2091  [4]
 LDCM0630  CCW28-3 231MFP C569(1.29)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C259(1.00); C318(0.81); C318(0.42)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C104(0.89); C259(0.97); C567(0.97); C573(0.97)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C104(0.65); C333(0.81); C259(1.27); C567(1.42)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C318(0.34); C333(0.97); C567(0.98); C573(0.98)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C333(0.90); C259(1.17); C567(1.33); C573(1.33)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C259(0.88); C333(1.11); C567(1.13); C573(1.13)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C259(0.84); C567(1.20); C573(1.20); C333(1.24)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C259(1.03); C567(1.04); C573(1.04); C333(1.04)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C104(0.73); C333(0.88); C318(1.08); C567(1.11)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C104(0.48); C333(0.78); C567(1.21); C573(1.21)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C318(0.83); C333(0.84); C104(0.88); C567(1.16)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C318(0.66); C333(0.81); C567(1.26); C573(1.26)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C318(0.55); C104(0.75); C333(0.84); C567(1.16)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C104(0.70); C333(0.95); C259(1.24); C567(1.36)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C104(0.71); C333(0.89); C318(1.06); C567(1.31)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C333(0.77); C104(0.83); C567(1.23); C573(1.23)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C333(0.96); C259(1.10); C104(1.15); C567(1.28)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C333(0.78); C104(1.15); C567(1.35); C573(1.35)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C333(0.74); C104(0.80); C567(1.33); C573(1.33)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C333(0.86); C259(1.30); C567(1.41); C573(1.41)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C104(0.86); C333(0.89); C567(1.21); C573(1.21)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C333(0.54); C104(0.71); C318(0.94); C567(1.41)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C318(0.32); C333(0.82); C567(0.98); C573(0.98)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C318(0.19); C333(0.71); C567(1.12); C573(1.12)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C104(0.77); C333(1.06); C259(1.22); C567(1.40)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C318(0.31); C333(0.71); C259(1.05); C567(1.05)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C333(0.87); C259(0.96); C567(2.68); C573(2.68)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C333(0.91); C567(1.07); C573(1.07); C259(1.27)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C333(0.84); C567(1.32); C573(1.32); C259(1.46)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C333(0.80); C567(1.36); C573(1.36); C259(1.65)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C567(0.85); C573(0.85); C259(1.11); C104(1.14)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C259(1.06); C104(1.07); C567(1.34); C573(1.34)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C567(0.82); C573(0.82); C104(1.10); C259(1.10)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C567(1.09); C573(1.09); C259(1.21); C104(1.23)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C333(0.89); C104(1.03); C259(1.04); C567(1.13)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C259(0.90); C333(0.94); C104(1.05); C567(1.08)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C104(0.83); C333(1.01); C259(1.11); C567(1.22)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C333(0.74); C259(1.13); C567(1.21); C573(1.21)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C333(0.75); C318(0.91); C104(0.99); C567(1.02)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C333(0.47); C104(0.86); C567(1.12); C573(1.12)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C333(0.62); C104(1.09); C567(1.19); C573(1.19)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C104(0.74); C567(0.96); C573(0.96); C259(1.07)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C333(0.69); C104(0.99); C318(1.09); C259(1.39)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C333(0.56); C104(0.82); C318(1.15); C259(1.45)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C333(0.40); C104(0.58); C318(1.69); C567(1.73)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C318(0.59); C333(0.70); C104(1.14); C259(1.16)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C104(1.18); C259(1.55); C318(0.53); C333(0.59)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C104(0.98); C259(1.44); C318(0.65); C333(0.58)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C104(1.08); C259(1.29); C318(1.31); C333(0.63)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C104(1.43); C259(1.42); C318(0.35); C333(0.80)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C104(0.92); C259(1.32); C318(0.34); C333(0.55)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C104(1.06); C259(1.41); C318(0.17); C333(0.61)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C104(1.61); C259(0.82); C333(1.19); C567(0.99)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C104(1.07); C259(1.05); C318(0.31); C333(0.71)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C104(1.24); C259(1.09); C333(0.93); C567(1.14)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C104(0.94); C259(1.41); C333(0.60); C567(1.12)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C104(1.10); C259(1.36); C333(0.59); C567(1.32)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C104(0.82); C259(1.33); C333(0.61); C567(1.42)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C104(1.04); C259(1.48); C333(0.70); C567(1.54)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C104(1.11); C259(1.36); C333(0.80); C567(1.27)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C104(0.90); C259(1.58); C333(0.77); C567(1.47)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C104(0.86); C259(1.47); C333(0.87); C567(1.61)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C104(1.58); C259(1.11); C333(1.38); C567(1.18)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C104(0.77); C259(1.47); C333(0.81); C567(1.43)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C104(1.33); C259(1.29); C333(0.84); C567(1.41)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C104(0.46); C259(1.87); C333(0.74); C567(1.73)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C104(0.76); C259(1.49); C333(0.76); C567(1.56)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C104(0.76); C259(1.50); C333(0.75); C567(1.37)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C104(0.85); C259(1.62); C333(0.65); C567(1.52)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C104(1.07); C259(0.80); C318(0.69); C333(1.38)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C104(1.25); C259(0.83); C318(0.80); C333(1.25)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C104(0.73); C259(0.85); C318(1.42); C333(1.29)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C104(0.90); C259(0.99); C318(0.29); C333(1.23)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C104(0.73); C259(0.95); C333(1.18); C567(1.01)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C104(1.06); C259(0.89); C318(1.20); C333(1.28)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C104(0.59); C259(0.88); C318(0.58); C333(1.35)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C104(0.82); C259(0.88); C318(1.04); C333(1.26)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C104(1.06); C259(0.97); C318(3.45); C333(1.22)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C104(0.91); C259(0.80); C318(1.06); C333(1.25)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C104(0.85); C259(0.88); C318(0.63); C333(1.57)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C104(0.87); C259(0.78); C318(0.63); C333(1.27)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C104(0.78); C259(0.90); C318(0.94); C333(1.33)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C104(0.81); C259(0.88); C318(0.46); C333(1.27)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C104(0.84); C259(0.87); C318(0.43); C333(1.32)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C104(0.76); C259(1.25); C333(0.81); C567(1.16)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C104(0.84); C259(0.94); C318(0.63); C333(1.08)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C104(0.88); C259(1.14); C318(0.16); C333(1.14)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C104(1.33); C259(1.26); C318(0.33); C333(0.80)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C104(1.03); C259(1.22); C318(0.51); C333(0.74)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C104(1.03); C259(1.35); C318(0.82); C333(0.71)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C104(1.11); C259(1.25); C318(0.30); C333(0.94)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C104(1.31); C259(1.67); C318(0.34); C333(0.68)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C104(1.09); C259(1.32); C318(0.17); C333(0.84)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C104(0.95); C259(1.68); C318(0.05); C333(0.50)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C104(0.90); C259(1.87); C318(0.38); C333(0.44)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C104(0.80); C259(1.12); C333(1.05); C567(1.20)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C104(1.18); C259(1.33); C318(0.08); C333(0.63)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C104(0.89); C259(1.30); C318(0.31); C333(0.74)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C104(1.07); C259(1.23); C318(0.27); C333(0.75)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C104(1.16); C259(1.42); C318(0.29); C333(0.72)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C104(1.17); C259(1.26); C318(0.20); C333(0.77)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C104(0.74); C259(1.18); C318(1.82); C333(0.71)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C104(0.69); C259(0.95); C318(2.27); C333(0.87)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C104(1.06); C259(1.08); C318(1.53); C333(0.92)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C104(1.01); C259(1.56); C318(1.29); C333(0.85)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C104(0.77); C259(1.25); C333(1.36); C567(1.62)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C104(0.67); C259(1.14); C318(0.95); C333(0.72)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C104(0.89); C259(1.16); C318(0.81); C333(1.07)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C104(1.15); C259(1.61); C318(0.37); C333(0.79)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C104(0.88); C259(1.60); C318(1.38); C333(0.83)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C104(0.60); C259(2.09); C318(2.38); C333(0.58)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C104(1.06); C259(1.21); C318(1.98); C333(0.88)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C104(0.83); C259(0.94); C318(1.28); C333(1.09)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C104(1.24); C259(1.23); C318(0.54); C333(0.99)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C104(1.14); C259(1.47); C318(0.63); C333(0.99)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C104(0.71); C259(2.19); C318(1.43); C333(0.57)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C104(0.71); C259(1.19); C333(0.96); C567(1.14)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C104(0.86); C259(1.22); C318(0.85); C333(0.81)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C104(1.28); C259(1.25); C318(0.36); C333(0.93)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C104(0.94); C259(2.14); C318(0.99); C333(1.00)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C104(1.09); C259(1.13); C318(0.35); C333(1.03)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C104(1.25); C259(1.26); C318(0.51); C333(0.90)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C104(1.09); C259(1.37); C318(0.43); C333(1.10)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C104(1.32); C259(1.19); C318(0.42); C333(0.99)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C104(1.34); C259(1.29); C318(0.34); C333(0.91)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C104(1.64); C259(1.40); C318(0.63); C333(0.93)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C104(1.32); C259(1.34); C318(0.43); C333(0.96)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C104(1.94); C318(0.89)  LDD2228  [16]
 LDCM0495  E2913 HEK-293T C104(0.89); C333(1.13); C259(1.13); C486(0.99)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C318(1.22); C259(1.11)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.51  LDD0183  [6]
 LDCM0625  F8 Ramos C318(0.98); 1.52  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C318(1.68)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C318(19.00)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C318(0.36); 0.82  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C318(0.45)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos 1.50  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C318(0.52); 0.75  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C318(0.44); 0.52  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C318(0.60)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C318(0.52)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C318(1.21)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C318(0.49); 0.91  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C318(0.28)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C318(0.84)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C104(1.20); C259(1.24); C318(0.15); C333(0.74)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C318(0.32); 0.62  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C318(0.71); 0.08  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C104(0.65); C259(2.02); C333(0.74); C567(1.99)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C318(0.73)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C318(0.80)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C318(0.99); 1.77  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C318(0.52)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y546(0.38); Y584(0.85)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y546(0.50); Y584(0.72)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y546(0.37); Y584(0.76)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y546(0.53); Y584(0.72)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y546(0.69); Y584(0.80)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HCT 116 C333(1.95); C567(2.41); C573(2.41); C259(1.78)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C333(2.06); C567(1.14); C573(1.14); C259(1.69)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C333(1.97); C567(1.69); C573(1.69); C259(1.25)  LDD0082  [11]
 LDCM0030  Luteolin HEK-293T 8.15  LDD0182  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C318(0.51)  LDD2121  [4]
 LDCM0109  NEM HeLa H287(0.00); H196(0.00)  LDD0223  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C318(0.58)  LDD2089  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C318(0.92)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C318(0.97)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C318(0.76)  LDD2106  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C318(0.90)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C318(0.89)  LDD2109  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C318(0.61)  LDD2114  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C318(0.85)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C318(0.68)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C318(0.57)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C318(0.79)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C318(0.85)  LDD2128  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C318(0.83)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C318(0.69)  LDD2137  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C318(0.82)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C318(0.79)  LDD2143  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C318(2.28)  LDD2147  [4]
 LDCM0032  Oleacein HEK-293T 5.02  LDD0184  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C259(0.77)  LDD2207  [28]
 LDCM0029  Quercetin HEK-293T 5.16  LDD0181  [6]
 LDCM0131  RA190 MM1.R C259(1.07)  LDD0304  [29]
 LDCM0003  Sulforaphane MDA-MB-231 1.83  LDD0160  [5]
 LDCM0021  THZ1 HCT 116 C567(1.25); C573(1.25)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase tousled-like 1 (TLK1) Ser/Thr protein kinase family Q9UKI8
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Ephrin type-A receptor 2 (EPHA2) Tyr protein kinase family P29317
Epithelial discoidin domain-containing receptor 1 (DDR1) Tyr protein kinase family Q08345
Insulin receptor (INSR) Tyr protein kinase family P06213
Insulin-like growth factor 1 receptor (IGF1R) Tyr protein kinase family P08069
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
E3 ubiquitin-protein ligase TRIM32 (TRIM32) TRIM/RBCC family Q13049
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gastrin/cholecystokinin type B receptor (CCKBR) G-protein coupled receptor 1 family P32239
Immunoglobulin
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Myeloid cell surface antigen CD33 (CD33) SIGLEC (sialic acid binding Ig-like lectin) family P20138
Myelin protein zero-like protein 1 (MPZL1) Myelin P0 protein family O95297
Natural killer cell receptor 2B4 (CD244) . Q9BZW8
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Programmed cell death protein 1 (PDCD1) . Q15116
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Parafibromin (CDC73) CDC73 family Q6P1J9
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
GRB2-associated-binding protein 2 (GAB2) GAB family Q9UQC2
Geminin (GMNN) Geminin family O75496
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Paxillin (PXN) Paxillin family P49023
Fibroblast growth factor receptor substrate 2 (FRS2) . Q8WU20
Insulin receptor substrate 1 (IRS1) . P35568

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jab-3312 Small molecular drug D1LEU5
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bbp-398 Small molecular drug DN7M4T
Jab-3068 Small molecular drug DM16HS
Rly-1971 Small molecular drug DYQZ38
Sar442720 Small molecular drug DS9R3G
Tno155 . D08IID
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dodecane-trimethylamine Small molecular drug D0P7KP
Dodecyltrimethylammonium Small molecular drug DB02779
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nsc-87877 Small molecular drug D00MFW

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.