Details of the Target

General Information of Target

Target ID LDTP05293
Target Name Ankyrin-2 (ANK2)
Gene Name ANK2
Gene ID 287
Synonyms
ANKB; Ankyrin-2; ANK-2; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTC
NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG
ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA
ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA
AHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL
TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD
VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY
GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV
RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE
GQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL
HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK
QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD
QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL
LQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMT
EVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR
SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALS
SSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPM
VEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVE
IPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRIC
RIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP
MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRL
LCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE
IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKP
IYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGL
VHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS
PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLE
KVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVR
IDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGK
DIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGED
PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK
TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPS
AKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSG
RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK
TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR
EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP
EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETE
KAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLME
GTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHP
TTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETP
TGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ
GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPL
KESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDD
SLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKK
RFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHT
GSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD
SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYD
KLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEK
DTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTD
ETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSE
ESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE
STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK
EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMT
KRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEAD
LLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVK
QISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES
KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQ
LSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRER
AEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEE
ISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWD
ESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ
IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERI
SHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVG
YSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTE
TSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESS
PRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT
RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm, cytoskeleton
Function
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration.
Uniprot ID
Q01484
Ensemble ID
ENST00000357077.9
HGNC ID
HGNC:493

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Jackson_1
 Probe Info  		10.27  LDD0121  [2]
AHL-Pu-1
 Probe Info  		C3859(5.78)  LDD0168  [3]
DBIA
 Probe Info  		C1425(1.23); C60(1.17)  LDD0080  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		C375(0.00); C1425(0.00); C305(0.00); C406(0.00)  LDD0165  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
YN-1
 Probe Info  		N.A.  LDD0447  [8]
AOyne
 Probe Info  		12.70  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C3859(5.78)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C3859(4.40)  LDD0169  [3]
 LDCM0215  AC10 PaTu 8988t C1425(1.45)  LDD1094  [4]
 LDCM0216  AC100 HEK-293T C1425(0.94)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C1425(0.78)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C1425(0.69)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C1425(0.95)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C1425(0.64)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C1425(0.66)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C1425(0.75)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C1425(0.76)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C1425(0.93)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C1425(0.82)  LDD0823  [4]
 LDCM0226  AC11 PaTu 8988t C1425(1.53)  LDD1105  [4]
 LDCM0227  AC110 HEK-293T C1425(0.86)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C1425(0.72)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C1425(0.71)  LDD0827  [4]
 LDCM0237  AC12 PaTu 8988t C1425(0.98)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C1425(1.54)  LDD1138  [4]
 LDCM0263  AC143 HEK-293T C1425(2.27)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C1425(0.65)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C1425(0.59)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C1425(0.53)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C1425(0.54)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C1425(0.57)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C1425(0.74)  LDD0867  [4]
 LDCM0270  AC15 PaTu 8988t C1425(1.69)  LDD1149  [4]
 LDCM0271  AC150 HEK-293T C1425(0.60)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C1425(0.51)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C1425(0.68)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C1425(0.61)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C1425(0.79)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C1425(0.84)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C1425(0.56)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C1425(0.48)  LDD2165  [4]
 LDCM0285  AC25 HEK-293T C1425(1.01)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C1425(0.80)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C1425(1.32)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C1425(0.93)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C1425(0.88)  LDD0887  [4]
 LDCM0291  AC30 HEK-293T C1425(0.92)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C1425(0.66)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C1425(0.96)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C1425(0.97)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C1425(0.74)  LDD0893  [4]
 LDCM0296  AC35 PaTu 8988t C1425(1.09)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C1425(0.54)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C1425(1.21)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C1425(0.81)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C1425(0.75)  LDD1179  [4]
 LDCM0302  AC40 PaTu 8988t C1425(0.71)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C1425(0.69)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C1425(0.71)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C1425(0.73)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C1425(0.64)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C1425(0.52)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C1425(0.86)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C1425(1.73)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C1425(1.02)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C1425(1.08)  LDD1190  [4]
 LDCM0313  AC50 PaTu 8988t C1425(1.36)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C1425(0.77)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C1425(1.33)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C1425(1.91)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C1425(1.46)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C1425(2.27)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C1425(1.25)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C1425(0.95)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1425(1.16)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1425(1.18)  LDD0920  [4]
 LDCM0323  AC6 PaTu 8988t C1425(1.37)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C1425(1.17)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1425(1.27)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1425(1.23)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1425(1.04)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1425(1.48)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1425(1.12)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1425(1.31)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1425(0.88)  LDD0929  [4]
 LDCM0334  AC7 PaTu 8988t C1425(0.96)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C1425(0.88)  LDD1224  [4]
 LDCM0349  AC83 HEK-293T C1425(0.88)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1425(1.09)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1425(0.94)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1425(0.99)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1425(0.84)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1425(1.04)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1425(1.11)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1425(0.98)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1425(0.90)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1425(0.81)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1425(1.10)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1425(1.02)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1425(0.89)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1425(0.81)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1425(0.87)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C1425(0.86)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C1425(0.82)  LDD0964  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C1425(1.27)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C1425(1.96)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C1425(1.61)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0071  Cisar_cp14 MDA-MB-231 10.27  LDD0121  [2]
 LDCM0370  CL101 PaTu 8988t C1425(1.21)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C1425(1.17)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C1425(1.64)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C1425(1.55)  LDD1252  [4]
 LDCM0382  CL112 HEK-293T C1425(0.74)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C1425(0.82)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C1425(0.90)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C1425(1.02)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C1425(0.80)  LDD0984  [4]
 LDCM0387  CL117 PaTu 8988t C1425(0.67)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C1425(0.73)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C1425(0.64)  LDD1268  [4]
 LDCM0391  CL120 PaTu 8988t C1425(0.67)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C1425(0.92)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C1425(1.00)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C1425(1.21)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C1425(1.20)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C1425(1.19)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1425(1.58)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1425(1.22)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1425(1.28)  LDD0997  [4]
 LDCM0403  CL16 HEK-293T C1425(1.35)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1425(0.61)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1425(1.24)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1425(1.62)  LDD1004  [4]
 LDCM0408  CL20 HEK-293T C1425(1.54)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1425(1.31)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1425(1.55)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1425(1.45)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1425(1.13)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1425(1.01)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1425(1.27)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1425(1.49)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1425(0.82)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1425(1.21)  LDD1015  [4]
 LDCM0419  CL30 HEK-293T C1425(0.89)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C1425(1.41)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1425(1.19)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1425(1.41)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1425(1.31)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1425(1.49)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1425(1.48)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1425(1.58)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1425(2.19)  LDD1026  [4]
 LDCM0430  CL40 HEK-293T C1425(1.60)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1425(1.89)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1425(1.57)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1425(1.79)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1425(1.65)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1425(1.83)  LDD1033  [4]
 LDCM0436  CL46 PaTu 8988t C1425(1.42)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C1425(1.25)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C1425(1.40)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C1425(1.34)  LDD1318  [4]
 LDCM0441  CL50 PaTu 8988t C1425(1.35)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C1425(1.78)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C1425(1.35)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C1425(1.44)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C1425(1.57)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C1425(1.39)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C1425(0.78)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C1425(2.39)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C1425(1.45)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C1425(1.92)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C1425(2.04)  LDD1331  [4]
 LDCM0469  CL76 PaTu 8988t C1425(0.54)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C1425(0.85)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C1425(1.10)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C1425(1.53)  LDD1351  [4]
 LDCM0474  CL80 PaTu 8988t C1425(1.04)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C1425(0.87)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C1425(1.31)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C1425(0.79)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C1425(1.09)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C1425(0.82)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C1425(0.89)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C1425(1.18)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C1425(0.91)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C1425(0.71)  LDD1362  [4]
 LDCM0485  CL90 PaTu 8988t C1425(0.74)  LDD1364  [4]
 LDCM0427  Fragment51 HEK-293T C1425(1.25)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C1425(1.23); C60(1.17)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C1425(1.24); C60(1.26)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C1425(1.40); C60(1.22)  LDD0082  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 3 (EHD3) Dynamin/Fzo/YdjA family Q9NZN3
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) . O00154
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium/calcium exchanger 1 (SLC8A1) Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family P32418
ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) Inward rectifier-type potassium channel family Q14654
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.