Details of the Target

General Information of Target

Target ID LDTP01853
Target Name Somatoliberin (GHRH)
Gene Name GHRH
Gene ID 2691
Synonyms
GHRF; Somatoliberin; Growth hormone-releasing factor; GRF; Growth hormone-releasing hormone; GHRH; Somatocrinin; Somatorelin; Sermorelin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDIMSR
QQGESNQERGARARLGRQVDSMWAEQKQMELESILVALLQKHSRNSQG
Target Bioclass
Other
Family
Glucagon family
Subcellular location
Secreted
Function GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Uniprot ID
P01286
Ensemble ID
ENST00000237527.8
HGNC ID
HGNC:4265

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDQP1 SNV: p.T26S .
MFE319 SNV: p.R28G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		20.00  LDD0121  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0071  Cisar_cp14 MDA-MB-231 20.00  LDD0121  [1]

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.