Details of the Target

General Information of Target

Target ID LDTP08491
Target Name Protein AHNAK2 (AHNAK2)
Gene Name AHNAK2
Gene ID 113146
Synonyms
C14orf78; KIAA2019; Protein AHNAK2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDCFHMVLPTWPGTPGSVSGRQLQPGEPGAETEDDHSVTEGPADEGIRPRPQGSSPVYE
YTTEAADFGLQEDAPGRQGSAGRRRSWWKRDSGDSRTFFRMSRPEAVQEATEVTLKTEVE
AGASGYSVTGGGDQGIFVKQVLKDSSAAKLFNLREGDQLLSTTVFFENIKYEDALKILQY
SEPYKVQFKIRRQLPAPQDEEWASSDAQHGPQGKEKEDTDVADGCRETPTKTLEGDGDQE
RLISKPRVGRGRQSQRERLSWPKFQSIKSKRGPGPQRSHSSSEAYEPRDAHDVSPTSTDT
EAQLTVERQEQKAGPGSQRRRKFLNLRFRTGSGQGPSSTGQPGRGFQSGVGRAGVLEELG
PWGDSLEETGAATGSRREERAEQDREVMPAQSMPLPTELGDPRLCEGTPQEGGLRAARLH
GKTLEGQAQETAVAQRKPRAQPTPGMSREGEGEGLQSLEIGIARLSLRDTTEGGTQIGPP
EIRVRVHDLKTPKFAFSTEKEPERERRLSTPQRGKRQDASSKAGTGLKGEEVEGAGWMPG
REPTTHAEAQGDEGDGEEGLQRTRITEEQDKGREDTEGQIRMPKFKIPSLGWSPSKHTKT
GREKATEDTEQGREGEATATADRREQRRTEEGLKDKEDSDSMTNTTKIQLIHDEKRLKKE
QILTEKEVATKDSKFKMPKFKMPLFGASAPGKSMEASVDVSAPKVEADVSLLSMQGDLKT
TDLSVQTPSADLEVQDGQVDVKLPEGPLPEGASLKGHLPKVQRPSLKMPKVDLKGPKLDL
KGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKEVTAKDSKFKMPKFKM
PSFGVSAPGKSMEDSVDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAGQVDVK
LPEGPVPEGAGPKVHLPKVEMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDGEVS
LPSMEVDVQAQKAKLDGAWLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIKAL
VDVSAPKVEADLSLPSMQGDLKTTDLSIQPASTDLKVQADQVDVKLPEGHLPEGAGLKGH
LPKVEMPSFKMPKVALKGPQVDVKGPKLDLKSPKAEVTAPDVEVSLPSVEVDVEAPGAKL
DSARLEGELSLADKDVTAKDSRFKMPKFKMPSFGASAPGKSIEASVDVSAPKVEADVSLP
SMQGDLKTTDLSIQPPSADLEVHAGQVDVKLLEGHVPEGAGFKGHLPKVQMPSLKMPKVD
LKGPQVEVRGPKLDLKGHKAEVTAHEVAVSLPSVEVDMQAPGAKLDGAQLDGDLSLADKD
VTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDLSAPKVEADMSLPSMQGDLKTTDLSIQP
PSTDLELQAGQLDVKLPEGPVPEGAGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDL
KDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGGRLEEDMSLADKDLTTKDSKFKMPKFKM
PSFGVSAPGKSIEASVDVSAPKVEADVSLPSMQGDLKATDLSIQPPSADLEVQAGQVDVK
LPEGPVSEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKVEVTAPDVKMS
LSSMEVDVQAPRAKLDGAQLEGDLSLADKAVTAKDSKFKMPKFKMPSFGVSAPGKSIEAS
VDVSEPKVEADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVNVKLPEGPLPEGAGFKGH
LPKVQMPSLKMPKVALKGPQMDVKGPKLDLKGPKAEVMAPDVEVSLPSVEVDVEAPGAKL
DSVRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVDVSAPKVEAEVSLP
SMQGDLKTTDLCIPLPSADLVVQAGQVDMKLPEGQVPEGAGLKGHLPKVDMPSFKMPKVD
LKGPQTDVKGAKLDLKGPKAEVTAPDVEVSLPSMEVDVQAQKAKLDGARLEGDLSLADKD
MTAKDSKFKMPKFKMPSFGVSAPGRSIEASVDVPAPKVEADVSLPSMQGDLKTTDLSIQP
PSADLKVQTGQVDVKLPEGHVPEGAGLKGHLPKVEMPSLKMPKVDLKGPQVDIKGPKLDL
KDPKVEMRVPDVEVSLPSMEVDVQAPRAKLDSAHLQGDLTLANKDLTTKDSKFKMPKFKM
PSFGVSAPGKSIEASVDVSPPKVEADMSLPSMQGDLKTTDLSIQPLSADVKVQAGQVDVK
LLEGPVPEEVGLKGHLPKLQMPSFKVPKVDLKGPEIDIKGPKLDLKDPKVEVTAPDVEVS
LPSVEVDVKAPGAKLDGARLEGDMSLADKDVTAKDSKFKMPKFKMLSFGVSALGKSIEAS
ADVSALKVEADVSLPSMQGDLKTTDLSVQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGH
LPKLQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKTDVMAPDVEVSQPSVEVDVEAPGAKL
DGAWLEGDLSVADKDVTTKDSRFKIPKFKMPSFGVSAPGKSIEASVDVSAPKVEADGSLS
SMQGDLKATDLSIQPPSADLEVQAGQVDVKLPEGPVPEGAGLKGHLPKVQMPSFKMPEMD
LKGPQLDVKGPKLDLKGPKAEVTAPDVEMSLSSMEVDVQAPRAKLDGARLEGDLSLADKG
VTAKDSKFKMPKFKMPSFRVSAPGESIEALVDVSELKVEADMSLPSMQGDLKTTDISIQP
PSAQLEVQAGQVDVKLPEGHVPEGAGLKGHLPKLQMPSFKMPEVDLKGPQIDVKGPNVDL
KGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGARLEGDLSLADKGMTAKDSKFKMPKFKM
PSFGVSAPGKSIEASVDVSELKVEADGSFPSMQGDLKTTDIRIQPPSAQLEVQAGQVDVK
LPEGHVPEGAGLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDLKGPKAEVTAPDVEVS
LPSVEVDVEAPRAKLDGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVS
VDVSAPKVEAEVSLPSMQGDLKTTDISIEPPSAQLEVQAGQVDLKLPEGHVPEGAGLKGH
LPKLQMPSFKMPKVDRKGPQIDVKGPKLDLKGPKTDVTAPDVEVSQPGMEVDVEAPGAKL
DGARLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEVLVDVSAPKVEADLSLP
SMQGDLKNTDISIEPPSAQLEVQAGQVDVKLPEGHVLEGAGLKGHLPKLQMPSFKMPKVD
RKGPQIDIKGPKLDLKGPKMDVTAPDVEVSQPSMEVDVEAPGAKLDGARLEGDLSLADKD
VTAKDSKFKMPKFKMPSYRASAPGKSIQASVDVSAPKAEADVSLPSMQGDLKTTDLSIQL
PSVDLEVQAGQVDVKLPEGHVPEGAGLKGHLPKVEMPSFKMPKVDLKSPQVDIKGPKLDL
KVPKAEVTVPDVEVSLPSVEVDVQAPRAKLDGARLEGDLSLAEKDVTAKDSKFKMPKFKM
PSFGVSAPGRSIEASLDVSAPKVEADVSLSSMQGDLKATDLSIQPPSADLEVQAVQVDVE
LLEGPVPEGAGLKGHLPKVEMPSLKTPKVDLKGPQIDVKGPKLDLKGPKAEVRVPDVEVS
LPSVEVDVQAPKAKLDAGRLEGDLSLADKDVTAKDSKFKMPKFKMPSFRVSAPGKSMEAS
VDVSAPKVEADVSLPSMQGDLKTTDLSIQPPSADLKVQAGQMDVKLPEGQVPEGAGLKEH
LPKVEMPSLKMPKVDLKGPQVDIKGPKLDLKVSKAEVTAPDVEVSLPSVEVDVQAPRAKL
DSAQLEGDLSLADKDVTAKDSKFKMPKFKMPSFGVSAPGKSIEASVHVSAPKVEADVSLP
SMQGDLKTTDLSIQPHSADLTVQARQVDMKLLEGHVPEEAGLKGHLPKVQMPSFKMPKVD
LKGPEIDIKGPKLDLKDPKVEVTAPDVEVSLPSVEVDVEAPGAKLDGARLEGDLSLADKD
MTAKDSKFKMPKFKMPSFGVSAPGKSMEASVDVTAPKVEADVSLPSMQGDLKATDLSVQP
PSADLEVQAGQVDVKLPEGPVPEGASLKGHLPKVQMPSFKMPKVDLKGPQIDVKGPKLDL
KGPKAEVTAPDVKMSLSSMEVDVQAPRAKLDGVQLEGDLSLADKDVTAKDSKFKMPKFKM
PSFGVSAPGKSMEASVDVSELKAKADVSLPSMQGDLKTTDLSIQSPSADLEVQAGQVDVK
LPEGPLPKGAGLKGHLPKVQMPCLKMPKVALKGPQVDVKGPKLDLKGPKADVMTPVVEVS
LPSMEVDVEAPGAKLDSVRLEGDLSLADKDMTAKDSKFKMPKFKMPSFGVSAPGKSIEAS
LDVSALKVEADVSLPSMQGDLKTTHLSIQPPSADLEVQAGQEDVKLPEGPVHEGAGLKGH
LPKLQMPSFKVPKVDLKGPQIDVNVPKLDLKGPKVEVTSPNLDVSLPSMEVDIQAPGAKL
DSTRLEGDLSLADKDVTAKDSKFKMPKFKMPSFGMLSPGKSIEVSVDVSAPKMEADMSIP
SMQGDLKTTDLRIQAPSADLEVQAGQVDLKLPEGHMPEVAGLKGHLPKVEMPSFKMPKVD
LKGPQVDVKGPKLDLKGPKAEVMAPDVEVSLPSVETDVQAPGSMLDGARLEGDLSLAHED
VAGKDSKFQGPKLSTSGFEWSSKKVSMSSSEIEGNVTFHEKTSTFPIVESVVHEGDLHDP
SRDGNLGLAVGEVGMDSKFKKLHFKVPKVSFSSTKTPKDSLVPGAKSSIGLSTIPLSSSE
CSSFELQQVSACSEPSMQMPKVGFAGFPSSRLDLTGPHFESSILSPCEDVTLTKYQVTVP
RAALAPELALEIPSGSQADIPLPKTECSTDLQPPEGVPTSQAESHSGPLNSMIPVSLGQV
SFPKFYKPKFVFSVPQMAVPEGDLHAAVGAPVMSPLSPGERVQCPLPSTQLPSPGTCVSQ
GPEELVASLQTSVVAPGEAPSEDADHEGKGSPLKMPKIKLPSFRWSPKKETGPKVDPECS
VEDSKLSLVLDKDEVAPQSAIHMDLPPERDGEKGRSTKPGFAMPKLALPKMKASKSGVSL
PQRDVDPSLSSATAGGSFQDTEKASSDGGRGGLGATASATGSEGVNLHRPQVHIPSLGFA
KPDLRSSKAKVEVSQPEADLPLPKHDLSTEGDSRGCGLGDVPVSQPCGEGIAPTPEDPLQ
PSCRKPDAEVLTVESPEEEAMTKYSQESWFKMPKFRMPSLRRSFRDRGGAGKLEVAQTQA
PAATGGEAAAKVKEFLVSGSNVEAAMSLQLPEADAEVTASESKSSTDILRCDLDSTGLKL
HLSTAGMTGDELSTSEVRIHPSKGPLPFQMPGMRLPETQVLPGEIDETPLSKPGHDLASM
EDKTEKWSSQPEGPLKLKASSTDMPSQISVVNVDQLWEDSVLTVKFPKLMVPRFSFPAPS
SEDDVFIPTVREVQCPEANIDTALCKESPGLWGASILKAGAGVPGEQPVDLNLPLEAPPI
SKVRVHIQGAQVESQEVTIHSIVTPEFVDLSVPRTFSTQIVRESEIPTSEIQTPSYGFSL
LKVKIPEPHTQARVYTTMTQHSRTQEGTEEAPIQATPGVDSISGDLQPDTGEPFEMISSS
VNVLGQQTLTFEVPSGHQLADSCSDEEPAEILEFPPDDSQEATTPLADEGRAPKDKPESK
KSGLLWFWLPNIGFSSSVDETGVDSKNDVQRSAPIQTQPEARPEAELPKKQEKAGWFRFP
KLGFSSSPTKKSKSTEDGAELEEQKLQEETITFFDARESFSPEEKEEGELIGPVGTGLDS
RVMVTSAARTELILPEQDRKADDESKGSGLGPNEG
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q8IVF2
Ensemble ID
ENST00000333244.6
HGNC ID
HGNC:20125

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.A4188G DBIA    Probe Info 
A172 Substitution: p.V2471L DBIA    Probe Info 
A2780 Substitution: p.Q1895P DBIA    Probe Info 
A375 Deletion: p.G413DfsTer34
Substitution: p.N2143D		 .
A3KAW SNV: p.F4468L .
ABC1 SNV: p.T788K DBIA    Probe Info 
AGS SNV: p.P1257S .
AN3CA SNV: p.Q4920R DBIA    Probe Info 
CAL62 Substitution: p.N2143D DBIA    Probe Info 
CAMA1 Substitution: p.V2471L DBIA    Probe Info 
CAOV3 SNV: p.D2308Y DBIA    Probe Info 
CCK81 Deletion: p.D983TfsTer9 .
CCLP1 Substitution: p.N2143D DBIA    Probe Info 
CFPAC1 Substitution: p.N2143D DBIA    Probe Info 
CHL1 SNV: p.V1896M DBIA    Probe Info 
COLO679 Substitution: p.N2143D .
COLO792 SNV: p.P3006S DBIA    Probe Info 
CORL88 SNV: p.E2058Ter DBIA    Probe Info 
D283MED SNV: p.L4169H .
DAOY Substitution: p.N2143D DBIA    Probe Info 
DEL Substitution: p.N2143D DBIA    Probe Info 
DOTC24510 Substitution: p.V2471L DBIA    Probe Info 
HCC1143 Substitution: p.N2143D DBIA    Probe Info 
HCC44 Substitution: p.E1146Ter DBIA    Probe Info 
HCT15 SNV: p.K1114M; p.V1122M; p.G2755D; p.P3581L .
HEC1 SNV: p.Y5516C DBIA    Probe Info 
HEL Substitution: p.N2143D .
HG3 Substitution: p.N2143D .
HGC27 SNV: p.E3713Q .
HLF SNV: p.E4269A DBIA    Probe Info 
HS578T Substitution: p.N2143D .
HS936T Substitution: p.G473K DBIA    Probe Info 
HSC3 SNV: p.F833L DBIA    Probe Info 
HT Substitution: p.V2471L .
HT115 SNV: p.K1056Q; p.R5769I .
HT1197 Substitution: p.N2143D DBIA    Probe Info 
HUH7 SNV: p.T598I .
HUPT4 Substitution: p.P1397L .
IGROV1 Deletion: p.D3515TfsTer50 .
IM95 SNV: p.R258M; p.T408A .
IPC298 Substitution: p.N2143D DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.A2439P; p.S3522G DBIA    Probe Info 
JHH1 SNV: p.P5019L DBIA    Probe Info 
JHH4 SNV: p.M1862V DBIA    Probe Info 
JHH6 Substitution: p.S1142G DBIA    Probe Info 
JURKAT SNV: p.V4219M .
KATOIII SNV: p.S2344P DBIA    Probe Info 
KMRC1 SNV: p.L115V DBIA    Probe Info 
KMS27 Substitution: p.P1397L DBIA    Probe Info 
KNS42 SNV: p.D995H DBIA    Probe Info 
KYSE150 SNV: p.K2575N; p.A3033S DBIA    Probe Info 
LS180 SNV: p.G3844W
Substitution: p.G5547E		 DBIA    Probe Info 
LU65 Substitution: p.P1397L DBIA    Probe Info 
MCC13 SNV: p.K1602R;p.G2805S
Substitution: p.S2777F		 DBIA    Probe Info 
MDAMB157 Substitution: p.G1839E .
MDAMB453 SNV: p.E200K; p.D2975N; p.D3140N DBIA    Probe Info 
MDAMB468 Substitution: p.D1318N; p.G1839E DBIA    Probe Info 
MDST8 SNV: p.P4578S DBIA    Probe Info 
MEWO SNV: p.P886S; p.A3170S DBIA    Probe Info 
MFE319 SNV: p.E2743V; p.A3989V DBIA    Probe Info 
MKN45 SNV: p.V966A DBIA    Probe Info 
MOLT4 SNV: p.A81S; p.P394S .
MONOMAC6 Substitution: p.V2471L .
NALM6 SNV: p.Q4526H .
NCIH1048 Deletion: p.K5690NfsTer13 DBIA    Probe Info 
NCIH1155 SNV: p.S4046N
Substitution: p.N2143D		 DBIA    Probe Info 
NCIH146 Substitution: p.N2143D DBIA    Probe Info 
NCIH1793 Deletion: p.D1485_L1486delinsE
SNV: p.G461V;p.V1848M;p.S2448T;p.E3110D;p.E3275D		 DBIA    Probe Info 
NCIH1993 Substitution: p.N2143D .
NCIH2172 Deletion: p.E3383RfsTer38
Substitution: p.G1967S		 DBIA    Probe Info 
NCIH2291 SNV: p.P511S DBIA    Probe Info 
NCIH661 SNV: p.G775C; p.D5326N .
NOMO1 SNV: p.A5551P .
NUGC3 SNV: p.E4692V DBIA    Probe Info 
ONS76 SNV: p.P2685L DBIA    Probe Info 
OPM2 SNV: p.V4424A .
OSRC2 SNV: p.G2064A DBIA    Probe Info 
OV90 SNV: p.K4708N DBIA    Probe Info 
OVCAR5 Substitution: p.N2143D DBIA    Probe Info 
OVCAR8 SNV: p.M3842I .
OVISE Substitution: p.S1142G .
PANC0403 Substitution: p.N2143D DBIA    Probe Info 
PEO1 SNV: p.P4436A DBIA    Probe Info 
RH41 Substitution: p.V2471L DBIA    Probe Info 
RKO SNV: p.G5353C
Substitution: p.D1815A		 DBIA    Probe Info 
RL SNV: p.D4460H;p.F5654V
Substitution: p.N2143D		 .
SCC25 Substitution: p.V2471L DBIA    Probe Info 
SF295 Substitution: p.V2471L DBIA    Probe Info 
SG231 SNV: p.S338Ter DBIA    Probe Info 
SHP77 SNV: p.G2664C DBIA    Probe Info 
SJSA1 Substitution: p.A1190E; p.D1320A DBIA    Probe Info 
SKMEL24 Substitution: p.N2143D DBIA    Probe Info 
SKNAS SNV: p.P2786A .
SNGM SNV: p.H2134Y DBIA    Probe Info 
SUDHL4 Substitution: p.N2143D .
SW1116 Substitution: p.N2143D DBIA    Probe Info 
SW1271 SNV: p.G3544C;p.S4713Y
Substitution: p.V2471L		 DBIA    Probe Info 
T98G Substitution: p.N2143D DBIA    Probe Info 
TCCSUP Substitution: p.V2471L DBIA    Probe Info 
TFK1 Substitution: p.P1686L DBIA    Probe Info 
U2OS Substitution: p.V2471L DBIA    Probe Info 
U937 Substitution: p.V2471L .
UACC62 SNV: p.R247K DBIA    Probe Info 
UMUC3 Substitution: p.V2471L DBIA    Probe Info 
WM115 Substitution: p.N2143D .
WM1552C Substitution: p.V2471L DBIA    Probe Info 
YSCCC Substitution: p.S1142G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.45  LDD0402  [1]
STPyne
 Probe Info  		K1078(8.12); K1111(10.00); K185(0.88); K189(10.00)  LDD0277  [2]
BTD
 Probe Info  		C4223(1.76)  LDD1700  [3]
Jackson_1
 Probe Info  		20.00  LDD0121  [4]
DBIA
 Probe Info  		C225(1.40); C5415(1.08); C5425(1.08); C5136(0.97)  LDD0078  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
WYneN
 Probe Info  		C4787(0.00); C5271(0.00); C4223(0.00); C405(0.00)  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		C405(0.00); C5271(0.00); C4223(0.00); C225(0.00)  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C4223(0.95); C5271(0.90)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C4223(1.11)  LDD2152  [3]
 LDCM0214  AC1 PaTu 8988t C5136(1.57); C4741(1.25); C4752(1.25); C225(0.29)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C5136(1.40); C5147(1.40); C5163(2.00); C5415(0.74)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C5415(0.99); C5425(0.99)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C5415(1.05); C5425(1.05)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C5415(1.01); C5425(1.01)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C5415(1.30); C5425(1.30)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C5415(1.06); C5425(1.06)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C5415(1.41); C5425(1.41)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C5415(1.22); C5425(1.22)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C5415(1.17); C5425(1.17)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C5415(0.97); C5425(0.97)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C5415(0.91); C5425(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C5136(1.51); C5147(1.51); C5163(1.75); C5415(1.09)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C5415(1.06); C5425(1.06)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C5415(1.08); C5425(1.08)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C5415(1.29); C5425(1.29)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C5415(0.86); C5425(0.86)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C5415(1.18); C5425(1.15)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C5415(1.03); C5425(1.00)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C5415(1.40); C5425(1.43)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C5415(1.07); C5425(1.14)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C5415(0.99); C5425(1.09)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C5415(0.95); C5425(0.99)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C5136(1.20); C5147(1.20); C5163(1.46); C5415(0.96)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C5415(0.96); C5425(0.96)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C5415(0.91); C5425(0.94)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C5415(1.01); C5425(1.00)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C5415(0.95); C5425(0.98)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C5415(1.08); C5425(1.10)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C5415(1.17); C5425(1.19)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C5415(1.11); C5425(1.12)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C5415(1.04); C5425(1.04)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C5136(0.72); C5147(0.72); C5163(0.72); C5415(0.73)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C5136(0.89); C5147(0.89); C5163(0.89); C5415(0.69)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C5136(0.92); C5147(0.92); C5163(0.92); C5415(0.87)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C5136(0.90); C5147(0.90); C5163(0.90); C5415(0.68)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C5136(0.84); C5147(0.84); C5163(0.84); C5415(0.77)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C5136(1.16); C5147(1.16); C5163(1.16); C5415(0.84)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C5136(1.01); C5147(1.01); C5163(1.01); C5415(0.77)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C5136(0.90); C5147(0.90); C5163(0.90); C5415(0.87)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C5136(1.08); C5147(1.08); C5163(1.08); C5415(0.92)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C5136(1.10); C5147(1.10); C5163(1.10); C5415(0.74)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C5136(0.90); C5147(0.90); C5163(0.90); C5415(0.82)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C5136(0.89); C5147(0.89); C5163(0.89); C5415(0.90)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C5136(1.40); C5147(1.40); C5163(1.82); C5415(0.80)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C5136(1.34); C5147(1.34); C5163(1.34); C5415(0.91)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C5136(1.30); C5147(1.30); C5163(1.30); C5415(0.92)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C5136(0.95); C5147(0.95); C5163(0.95); C5415(0.82)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C5136(2.20); C5163(2.20); C5415(1.01); C5425(1.01)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C5415(0.82); C5425(0.82); C5136(1.17); C5163(1.17)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C5415(0.85); C5425(0.85); C5136(1.15); C5163(1.15)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C5415(1.01); C5425(1.01); C5136(1.98); C5163(1.98)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C5415(0.91); C5425(0.91); C5136(1.18); C5163(1.18)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C5136(1.09); C5163(1.09); C5415(1.90); C5425(1.90)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C5415(1.55); C5425(1.55); C5136(1.93); C5163(1.93)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C5415(0.70); C5425(0.70); C5136(1.39); C5147(1.39)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C5415(1.04); C5425(1.04); C5136(1.17); C5163(1.17)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C5415(0.91); C5425(0.91); C5136(0.99); C5163(0.99)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C5136(0.82); C5163(0.82); C5415(0.96); C5425(0.96)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C5136(0.97); C5163(0.97); C5415(1.33); C5425(1.33)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C5136(1.13); C5163(1.13); C5415(0.82); C5425(0.82)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C5136(0.94); C5163(0.94); C5415(0.98); C5425(0.98)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C5136(1.17); C5163(1.17); C5415(0.97); C5425(0.97)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C5136(0.90); C5163(0.90); C5415(0.96); C5425(0.96)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C5415(0.64); C5425(0.64)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C5415(0.90); C5425(0.90)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C5415(0.84); C5425(0.84)  LDD0595  [5]
 LDCM0279  AC2 PaTu 8988t C5136(0.99); C4741(0.88); C4752(0.88); C225(0.30)  LDD1158  [5]
 LDCM0280  AC20 HCT 116 C5415(0.77); C5425(0.77)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C5415(0.73); C5425(0.73)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C5415(0.76); C5425(0.76)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C5415(0.79); C5425(0.79)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C5415(0.64); C5425(0.64)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C5415(1.59); C5425(1.59)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C5415(1.75); C5425(1.75)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C5415(1.62); C5425(1.62)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C5415(1.80); C5425(1.80)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C5415(1.99); C5425(1.99)  LDD0606  [5]
 LDCM0290  AC3 PaTu 8988t C5136(1.22); C4741(0.82); C4752(0.82); C225(0.35)  LDD1169  [5]
 LDCM0291  AC30 HCT 116 C5415(2.29); C5425(2.29)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C5415(1.40); C5425(1.40)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C5415(2.10); C5425(2.10)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C5415(1.46); C5425(1.46)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C5415(1.33); C5425(1.33)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C5415(1.06); C5425(1.06)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C5415(1.20); C5425(1.20)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C5415(0.76); C5425(0.76)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C5415(1.23); C5425(1.23)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C5415(0.89); C5425(0.89)  LDD0617  [5]
 LDCM0301  AC4 PaTu 8988t C5136(0.95); C4741(0.77); C4752(0.77); C225(0.32)  LDD1180  [5]
 LDCM0302  AC40 HCT 116 C5415(0.89); C5425(0.89)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C5415(1.24); C5425(1.24)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C5415(1.06); C5425(1.06)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C5415(1.64); C5425(1.64)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C5415(0.86); C5425(0.86)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C5415(0.77); C5425(0.77)  LDD0624  [5]
 LDCM0308  AC46 PaTu 8988t C5136(1.26); C4741(0.98); C4752(0.98); C225(1.53)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C5136(1.22); C4741(1.15); C4752(1.15); C225(1.24)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C5136(1.19); C4741(1.49); C4752(1.49); C225(1.11)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C5136(1.85); C4741(1.55); C4752(1.55); C225(2.07)  LDD1190  [5]
 LDCM0312  AC5 PaTu 8988t C5136(1.43); C4741(1.13); C4752(1.13); C225(0.28)  LDD1191  [5]
 LDCM0313  AC50 PaTu 8988t C5136(2.60); C4741(1.49); C4752(1.49); C225(2.83)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C5136(0.57); C4741(1.12); C4752(1.12); C225(0.39)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C5136(1.76); C4741(1.54); C4752(1.54); C225(1.72)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C5136(2.77); C4741(1.77); C4752(1.77); C225(2.04)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C5136(2.35); C4741(2.12); C4752(2.12); C225(2.04)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C5136(1.05); C4741(1.29); C4752(1.29); C225(1.34)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C5136(2.70); C4741(1.39); C4752(1.39); C225(1.63)  LDD1198  [5]
 LDCM0320  AC57 HCT 116 C5415(0.81); C5425(0.81)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C5415(0.93); C5425(0.93)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C5415(0.91); C5425(0.91)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C5415(0.97); C5425(0.97); C5136(1.38); C5147(1.38)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C5415(0.77); C5425(0.77)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C5415(0.94); C5425(0.94)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C5415(0.79); C5425(0.79)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C5415(0.78); C5425(0.78)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C5415(0.84); C5425(0.84)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C5415(1.13); C5425(1.13)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C5415(1.16); C5425(1.16)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C5415(0.87); C5425(0.87)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C5415(1.27); C5425(1.27); C5136(1.33); C5163(1.33)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C5147(0.94); C5136(1.07); C5163(1.07); C5415(1.18)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C5415(0.83); C5425(0.83); C5163(1.25); C5136(1.29)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C5147(1.19); C5415(1.29); C5425(1.29); C5136(1.95)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C5147(0.71); C5415(0.95); C5425(0.95); C5136(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C5147(1.03); C5136(1.17); C5163(1.17); C5415(1.39)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C5415(1.57); C5425(1.57); C5147(1.87); C5136(2.44)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C5415(1.18); C5425(1.18); C5136(1.43); C5163(1.43)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C5136(1.82); C5163(1.82); C5415(1.90); C5425(1.90)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C5147(1.05); C5136(1.06); C5163(1.06); C5415(1.16)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C5415(1.31); C5425(1.31); C5147(1.49); C5136(1.64)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C5147(0.83); C5136(1.07); C5163(1.07); C5415(1.16)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C5147(0.99); C5136(1.05); C5163(1.05); C5415(1.49)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C5415(0.72); C5425(0.72); C5136(1.20); C5147(1.20)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C5415(1.22); C5425(1.22); C5136(1.79); C5163(1.79)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C5136(0.76); C5163(0.76); C5147(0.84); C5415(1.21)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C5147(1.62); C5136(1.67); C5163(1.67); C5415(1.70)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C5415(1.47); C5425(1.47); C5136(1.89); C5147(1.89)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C5415(1.29); C5425(1.29); C5136(1.69); C5147(1.69)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C5415(1.27); C5425(1.27); C5136(1.29); C5147(1.29)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C5415(1.26); C5425(1.26); C5136(1.56); C5147(1.56)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C5415(1.03); C5425(1.03); C5136(1.29); C5147(1.29)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C5415(1.33); C5425(1.33); C5136(1.70); C5147(1.70)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C5415(1.49); C5425(1.49); C5136(2.00); C5147(2.00)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C5415(1.27); C5425(1.27); C5136(1.48); C5147(1.48)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C5415(1.39); C5425(1.39); C5136(1.98); C5147(1.98)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C5415(1.51); C5425(1.51); C5136(2.09); C5147(2.09)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C5415(1.20); C5425(1.20); C5136(1.30); C5147(1.30)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C5415(1.10); C5425(1.10); C5136(1.30); C5147(1.30)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C5136(1.33); C5147(1.33); C5163(1.33); C5415(1.38)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C5415(1.07); C5425(1.07); C5136(1.59); C5147(1.59)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C5415(1.63); C5425(1.63); C5136(2.41); C5147(2.41)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C5415(1.65); C5425(1.65)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C5415(0.94); C5425(0.94)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C4223(0.44)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C5136(1.05); C5147(1.05); C5163(1.20); C5415(0.77)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C5415(1.03); C5425(1.03); C5136(1.99); C5147(1.99)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C5415(0.72); C5425(0.72); C5136(2.00); C5147(2.00)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C225(1.40); C5415(1.08); C5425(1.08); C5136(0.97)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C4223(0.71)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C4787(0.00); C225(0.00); C4979(0.00)  LDD0222  [10]
 LDCM0071  Cisar_cp14 MDA-MB-231 20.00  LDD0121  [4]
 LDCM0367  CL1 PaTu 8988t C5136(1.27); C4741(1.21); C4752(1.21); C5415(1.13)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C5136(2.55); C4741(1.97); C4752(1.97); C5415(1.32)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C5136(1.04); C4741(0.80); C4752(0.80); C225(0.26)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C5415(0.83); C5425(0.83); C5136(1.68); C5147(1.68)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C5415(0.90); C5425(0.90); C5136(1.36); C5147(1.36)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C5415(0.75); C5425(0.75); C5136(1.20); C5147(1.20)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C5415(0.77); C5425(0.77); C5136(1.31); C5147(1.31)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C5415(0.82); C5425(0.82)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C5415(0.81); C5425(0.81)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C5415(0.82); C5425(0.82)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C5415(0.65); C5425(0.65)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C5415(0.87); C5425(0.87)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C5136(1.57); C4741(1.14); C4752(1.14); C5415(0.86)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C5415(0.68); C5425(0.68)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C5415(0.88); C5425(0.88)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C5415(1.50); C5425(1.50)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C5415(1.71); C5425(1.71)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C5415(1.78); C5425(1.78)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C5415(1.55); C5425(1.55)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C5415(1.59); C5425(1.59)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C5415(1.09); C5425(1.09)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C5415(1.52); C5425(1.52)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C5415(1.49); C5425(1.49)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C5136(1.42); C4741(1.65); C4752(1.65); C5415(1.04)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C5415(1.52); C5425(1.52)  LDD0708  [5]
 LDCM0392  CL121 PaTu 8988t C5136(1.19); C4741(1.13); C4752(1.13); C225(1.03)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C5136(1.44); C4741(1.30); C4752(1.30); C225(1.65)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C5136(1.36); C4741(1.54); C4752(1.54); C225(2.00)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C5136(1.58); C4741(1.19); C4752(1.19); C225(1.58)  LDD1274  [5]
 LDCM0396  CL125 HCT 116 C5415(1.18); C5425(1.18)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C5415(1.02); C5425(1.02)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C5415(0.91); C5425(0.91)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C5415(0.87); C5425(0.87)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C5136(3.30); C4741(3.32); C4752(3.32); C5415(0.98)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C5136(4.02); C4741(4.45); C4752(4.45); C5415(1.09)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C5136(2.20); C4741(1.76); C4752(1.76); C5415(1.25)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C5136(1.76); C225(1.34); C5163(1.76); C5271(1.50)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C5136(1.75); C225(1.39); C5163(1.75); C5271(1.52)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C5136(1.86); C225(1.56); C5163(1.86); C5271(1.61)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C5136(1.83); C225(1.44); C5163(1.83); C5271(1.46)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C5136(2.06); C4741(1.71); C4752(1.71); C5415(1.27)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C5136(2.12); C225(2.79); C5163(2.12); C5271(1.54)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C5136(2.71); C225(3.56); C5163(2.71); C5271(1.97)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C5136(2.22); C225(1.78); C5163(2.22); C5271(1.60)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C5136(2.15); C225(2.38); C5163(2.15); C5271(1.87)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C5136(1.58); C225(1.59); C5163(1.58); C5271(1.54)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C5136(1.20); C225(1.12); C5163(1.20); C5271(1.58)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C5136(2.11); C225(2.57); C5163(2.11); C5271(1.61)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C5136(1.06); C225(1.09); C5163(1.06); C5271(1.45)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C5136(3.01); C225(3.61); C5163(3.01); C5271(1.74)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C5136(2.38); C225(2.79); C5163(2.38); C5271(1.77)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C5136(1.86); C4741(1.92); C4752(1.92); C5415(1.20)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C5136(1.64); C225(1.68); C5163(1.64); C5271(1.70)  LDD1298  [5]
 LDCM0420  CL31 HCT 116 C5415(1.01); C5425(1.01)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C5415(1.04); C5425(1.04)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C5415(1.15); C5425(1.15)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C5415(1.11); C5425(1.11)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C5415(1.05); C5425(1.05)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C5415(1.06); C5425(1.06)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C5415(0.87); C5425(0.87)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C5415(0.92); C5425(0.92)  LDD0745  [5]
 LDCM0429  CL4 PaTu 8988t C5136(1.95); C4741(1.45); C4752(1.45); C5415(0.77)  LDD1308  [5]
 LDCM0430  CL40 HCT 116 C5415(1.07); C5425(1.07)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C5415(0.90); C5425(0.90)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C5415(0.92); C5425(0.92)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C5415(0.95); C5425(0.95)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C5415(0.94); C5425(0.94)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C5415(1.11); C5425(1.11)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C5136(0.68); C5147(1.06); C5163(0.87); C5415(1.57)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C5136(0.58); C5147(1.15); C5163(0.87); C5415(1.32)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C5136(0.74); C5147(0.87); C5163(0.81); C5415(1.16)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C5136(0.88); C5147(1.25); C5163(1.06); C5415(1.34)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C5136(4.17); C4741(2.55); C4752(2.55); C5415(0.98)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C5136(0.73); C5147(1.12); C5163(0.92); C5415(1.21)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C5136(0.95); C5147(1.16); C5163(1.06); C5415(1.30)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C5136(1.06); C5147(1.23); C5163(1.14); C5415(1.51)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C5136(0.69); C5147(1.03); C5163(0.86); C5415(1.05)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C5136(0.68); C5147(1.01); C5163(0.85); C5415(1.32)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C5136(0.72); C5147(1.05); C5163(0.89); C5415(1.14)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C5136(1.08); C5147(1.17); C5163(1.12); C5415(1.26)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C5136(0.81); C5147(0.97); C5163(0.89); C5415(1.23)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C5136(0.83); C5147(1.35); C5163(1.09); C5415(1.27)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C5136(0.85); C5147(1.10); C5163(0.97); C5415(1.12)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C5136(3.35); C4741(1.90); C4752(1.90); C5415(1.09)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C5136(0.89); C5147(1.02); C5163(0.96); C5415(1.28)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C5415(1.04); C5425(1.04)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C5415(1.07); C5425(1.07)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C5415(0.91); C5425(0.91)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C5415(0.94); C5425(0.94)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C5415(1.00); C5425(1.00)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C5415(1.02); C5425(1.02)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C5415(0.94); C5425(0.94)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C5415(0.99); C5425(0.99)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C5415(1.13); C5425(1.13)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C5136(2.42); C4741(3.20); C4752(3.20); C5415(1.20)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C5415(1.14); C5425(1.14)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C5415(1.23); C5425(1.23)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C5415(1.39); C5425(1.39)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C5415(1.23); C5425(1.23)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C5415(1.28); C5425(1.28)  LDD0784  [5]
 LDCM0469  CL76 PaTu 8988t C5136(1.04); C4741(1.17); C4752(1.17); C225(1.02)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C5136(0.99); C4741(1.29); C4752(1.29); C225(1.24)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C5136(0.87); C4741(1.51); C4752(1.51); C225(2.51)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C5136(0.77); C4741(1.32); C4752(1.32); C225(3.43)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C5136(2.13); C4741(1.48); C4752(1.48); C5415(1.56)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C5136(1.02); C4741(1.32); C4752(1.32); C225(2.11)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C5136(1.21); C4741(1.59); C4752(1.59); C225(2.89)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C5136(0.96); C4741(1.36); C4752(1.36); C225(2.78)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C5136(1.30); C4741(1.42); C4752(1.42); C225(3.06)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C5136(1.47); C4741(1.25); C4752(1.25); C225(2.48)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C5136(0.81); C4741(1.30); C4752(1.30); C225(2.45)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C5136(1.15); C4741(1.49); C4752(1.49); C225(2.08)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C5136(1.50); C4741(1.69); C4752(1.69); C225(2.21)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C5136(1.49); C4741(1.89); C4752(1.89); C225(1.87)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C5136(1.25); C4741(1.27); C4752(1.27); C225(1.81)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C5136(3.21); C4741(1.70); C4752(1.70); C5415(1.09)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C5136(1.36); C4741(1.71); C4752(1.71); C225(2.16)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C5136(1.03); C4741(0.72); C4752(0.72); C225(0.25)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C5136(1.35); C4741(0.86); C4752(0.86); C225(0.25)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C5136(1.06); C4741(0.75); C4752(0.75); C225(0.27)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C5136(1.57); C4741(1.00); C4752(1.00); C225(0.41)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C5136(2.04); C4741(1.79); C4752(1.79); C225(0.29)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C5136(1.35); C4741(0.90); C4752(0.90); C225(0.18)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C5136(1.24); C4741(0.83); C4752(0.83); C225(0.20)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C5136(1.46); C4741(1.37); C4752(1.37); C225(0.46)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C5136(1.02); C4741(0.85); C4752(0.85); C225(0.26)  LDD1373  [5]
 LDCM0495  E2913 HEK-293T C405(1.01); C4223(1.08)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4223(1.15); C405(1.03)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C5415(1.03); C5425(1.03)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C5415(1.26); C5425(1.26)  LDD0744  [5]
 LDCM0107  IAA HeLa H5125(0.00); H3380(0.00)  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C5271(0.90)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C5271(0.87)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C405(1.30)  LDD3310  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C4223(0.73)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C4223(0.75)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C4223(0.99)  LDD2093  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C4223(1.01)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C4223(0.87)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C4223(0.85)  LDD2111  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C4223(1.26)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C4223(1.89)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C4223(0.91)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C4223(0.83)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C4223(0.79)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C4223(0.74); C5271(0.93)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C4223(0.81); C5271(0.80)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C4223(1.09)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C4223(0.86)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C4223(0.88)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C4223(0.80); C5271(1.18)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C4223(1.00)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C4223(1.76)  LDD1700  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C4223(1.02)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C4223(2.55)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C4223(1.29)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C4223(0.61)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C4223(0.68)  LDD2150  [3]
 LDCM0021  THZ1 HCT 116 C225(1.20); C4741(1.10); C4752(1.10); C5136(1.11)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Protein FAM3C (FAM3C) FAM3 family Q92520
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Asialoglycoprotein receptor 1 (ASGR1) . P07306
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Proline-rich acidic protein 1 (PRAP1) . Q96NZ9
TPA-induced transmembrane protein (TTMP) . Q5BVD1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840