Details of the Target
General Information of Target
| Target ID | LDTP06148 | |||||
|---|---|---|---|---|---|---|
| Target Name | Semaphorin-3A (SEMA3A) | |||||
| Gene Name | SEMA3A | |||||
| Gene ID | 10371 | |||||
| Synonyms |
SEMAD; Semaphorin-3A; Semaphorin III; Sema III |
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| 3D Structure | ||||||
| Sequence |
MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTF
LLDEERSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKV LKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASL LIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPED DKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNG IDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRD GPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEM TVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGS ACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPK SQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEHGFIQTL LKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQKVWYRDFMQLINHPNLNTMDE FCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRSV |
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| Target Type |
Clinical trial
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| Target Bioclass |
Immunoglobulin
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| Family |
Semaphorin family
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| Subcellular location |
Secreted
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| Function |
Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
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| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
ONAyne Probe Info |
 |
K108(1.15) | LDD0274 | [1] | |
|
STPyne Probe Info |
 |
K282(0.96) | LDD0277 | [1] | |
|
IPM Probe Info |
 |
C269(5.23) | LDD2229 | [2] | |
|
DBIA Probe Info |
 |
C269(4.12) | LDD3365 | [3] | |
|
BTD Probe Info |
 |
C381(2.08) | LDD2123 | [4] | |
|
Jackson_1 Probe Info |
 |
20.00 | LDD0121 | [5] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0071 | Cisar_cp14 | MDA-MB-231 | 20.00 | LDD0121 | [5] |
| LDCM0022 | KB02 | A-172 | C269(2.66) | LDD2251 | [3] |
| LDCM0023 | KB03 | A-172 | C269(7.51) | LDD2668 | [3] |
| LDCM0024 | KB05 | OVCAR-3 | C269(4.12) | LDD3365 | [3] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C381(2.08) | LDD2123 | [4] |
References