Details of the Target

General Information of Target

Target ID	LDTP17719
Target Name	TBC1 domain family member 19 (TBC1D19)
Gene Name	TBC1D19
Gene ID	55296
Synonyms	TBC1 domain family member 19
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHRPHVKGNSSCYGVLPTE EPVYNWRTVINSAADFYFEGNIHQSLQNITENQLVQPTLLQQKGGKGRKKLRLFEYLHES LYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALRNYGRSG EITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNWNANYNYTYANY HELNHHDC
Target Bioclass	Other
Function	May act as a GTPase-activating protein for Rab family protein(s).
Uniprot ID	Q8N5T2
Ensemble ID	ENST00000264866.9
HGNC ID	HGNC:25624

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
BT549	SNV: p.A338S	.
CCK81	SNV: p.A489V	.
HT115	SNV: p.G99E	.
KMCH1	SNV: p.C377Ter	.
MOLT4	SNV: p.L463F	.
SH4	SNV: p.P125T	.
SW1573	SNV: p.P341R	.
U2OS	SNV: p.L422F	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Jackson_1 Probe Info			20.00	LDD0121	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0071	Cisar_cp14	MDA-MB-231	20.00	LDD0121	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Melanoma-associated antigen 12 (MAGEA12)				.	P43365

References

1	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.