Details of the Target

General Information of Target

Target ID LDTP13195
Target Name Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)
Gene Name MALT1
Gene ID 10892
Synonyms
MLT; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; EC 3.4.22.-; MALT lymphoma-associated translocation; Paracaspase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLC
KEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVV
CREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVST
KRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELE
EKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEK
LCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGI
TGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPT
RLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLS
S
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase C14B family
Subcellular location
Cytoplasm, perinuclear region
Function
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
TTD ID
T92678
Uniprot ID
Q9UDY8
DrugMap ID
TTCI81G
Ensemble ID
ENST00000345724.7
HGNC ID
HGNC:6819
ChEMBL ID
CHEMBL3632452

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.I127K IA-alkyne    Probe Info 
MSTO211H SNV: p.M163R DBIA    Probe Info 
OCIAML2 SNV: p.A23D .
P31FUJ SNV: p.I127K DBIA    Probe Info 
SJSA1 SNV: p.T130N .
SKOV3 Deletion: p.K273SfsTer32 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
AHL-Pu-1
 Probe Info  		C317(20.00)  LDD0168  [3]
DBIA
 Probe Info  		C71(0.89); C77(0.89)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C464(0.00); C101(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C464(0.00); C101(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C464(0.00); C101(0.00); C91(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
IPM
 Probe Info  		C439(0.00); C441(0.00); C71(0.00)  LDD0147  [7]
TFBX
 Probe Info  		C230(0.00); C91(0.00)  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C211
 Probe Info  		7.94  LDD1885  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C317(20.00)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C317(20.00)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C190(0.85); C439(1.00); C441(1.00); C71(0.91)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C190(0.94); C439(1.26); C441(1.15); C591(0.90)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C439(0.82); C441(0.82); C71(0.77); C77(0.77)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C439(0.78); C441(0.78); C71(0.71); C77(0.71)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C439(0.76); C441(0.76); C71(0.72); C77(0.72)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C439(0.72); C441(0.72); C71(0.73); C77(0.73)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C439(0.74); C441(0.74); C71(0.76); C77(0.76)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C439(0.75); C441(0.75); C71(0.79); C77(0.79)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C439(0.76); C441(0.76); C71(0.79); C77(0.79)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C439(0.73); C441(0.71); C71(0.84); C77(0.77)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C439(0.82); C441(0.78); C71(0.82); C77(0.84)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C439(0.87); C441(0.84); C71(0.83); C77(0.81)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C190(0.92); C439(0.98); C441(0.84); C591(0.81)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C439(0.85); C441(0.77); C71(0.80); C77(0.81)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C439(0.77); C441(0.77); C71(0.70); C77(0.69)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C439(0.70); C441(0.71); C71(0.80); C77(0.79)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C190(0.81); C439(1.25); C441(1.10); C464(1.06)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C190(0.79); C439(0.98); C441(0.93); C464(0.98)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C190(0.72); C439(1.02); C441(0.96); C464(0.92)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C190(0.70); C439(1.09); C441(1.00); C464(1.08)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C190(0.76); C439(1.02); C441(0.95); C464(0.87)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C190(0.83); C439(0.86); C441(0.86); C464(0.88)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C190(0.75); C439(1.07); C441(1.01); C464(0.98)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C190(1.13); C439(1.14); C441(1.01); C591(0.91)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C190(0.78); C439(1.15); C441(1.12); C464(1.07)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C190(0.77); C439(0.76); C441(0.77); C464(0.99)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C190(0.74); C439(1.07); C441(0.95); C464(0.81)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C190(0.72); C439(0.82); C441(0.82); C464(0.87)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C190(0.66); C439(0.87); C441(0.86); C464(0.93)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C190(0.98); C439(0.90); C441(0.86); C464(0.92)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C190(0.77); C439(0.91); C441(0.83); C464(0.90)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C190(0.82); C439(0.85); C441(0.80); C464(0.86)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C439(1.34); C441(1.34); C591(0.92); C71(1.06)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C439(1.48); C441(1.48); C591(0.99); C71(1.00)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C439(1.29); C441(1.29); C591(1.19); C71(0.93)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C439(1.12); C441(1.12); C591(0.97); C71(1.04)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C439(1.21); C441(1.21); C591(1.04); C71(1.03)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C439(1.14); C441(1.14); C591(0.98); C71(1.03)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C439(1.10); C441(1.10); C591(1.10); C71(1.08)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C439(1.16); C441(1.16); C591(1.06); C71(1.07)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C439(1.20); C441(1.20); C591(1.14); C71(1.01)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C439(1.27); C441(1.27); C591(0.90); C71(1.02)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C439(1.05); C441(1.05); C591(1.04); C71(1.19)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C439(1.01); C441(1.01); C591(1.18); C71(1.11)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C190(0.84); C439(1.04); C441(0.96); C591(1.01)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C439(1.06); C441(1.06); C591(1.21); C71(1.21)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C439(1.06); C441(1.06); C591(1.29); C71(1.21)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C439(1.06); C441(1.06); C591(1.02); C71(1.04)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C441(0.78); C439(0.89); C190(0.89); C591(0.89)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C441(0.66); C439(0.73); C591(0.78); C190(0.86)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C441(0.77); C591(0.82); C91(0.90); C77(0.92)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C441(0.67); C190(0.68); C439(0.86); C591(0.92)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C441(0.66); C439(0.78); C591(0.84); C77(0.95)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C190(0.63); C441(0.63); C77(0.87); C591(0.87)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C190(0.60); C441(0.67); C77(0.92); C591(0.92)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C77(0.99); C91(1.00); C591(1.01); C71(1.05)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C441(0.76); C439(0.85); C190(0.87); C77(0.89)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C441(0.69); C439(0.76); C77(0.86); C591(0.88)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C441(0.72); C439(0.83); C591(0.83); C190(0.86)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C190(0.53); C441(0.53); C591(0.83); C77(0.89)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C190(0.86); C439(0.79); C441(0.64); C591(0.95)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C190(0.65); C439(0.89); C441(0.70); C591(0.92)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C190(0.76); C439(0.81); C441(0.69); C591(1.02)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C190(0.72); C439(0.83); C441(0.70); C591(0.86)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C71(1.02); C77(1.05); C441(1.26); C439(1.62)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C441(0.85); C439(0.96); C71(1.06); C77(1.10)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C441(1.01); C71(1.03); C77(1.04); C439(1.19)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C190(0.85); C439(0.97); C441(0.97); C77(1.09)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C71(1.03); C77(1.04); C441(1.16); C439(1.42)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C441(0.92); C71(0.97); C77(0.99); C439(1.14)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C71(0.99); C77(1.00); C441(1.10); C439(1.26)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C441(1.00); C439(1.23); C71(1.33); C77(1.35)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C71(1.02); C77(1.03); C441(1.21); C439(1.49)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C441(0.78); C190(0.87); C230(0.92); C91(0.97)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C441(0.65); C190(0.84); C439(0.92); C230(0.93)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C441(0.64); C190(0.91); C439(0.92); C77(1.01)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C441(0.64); C190(0.86); C439(0.93); C230(0.94)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C441(0.59); C439(0.71); C190(0.80); C77(0.94)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C190(0.89); C71(0.96); C77(1.05); C439(1.07)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C441(0.59); C439(0.74); C190(0.86); C230(0.96)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C441(0.56); C439(0.75); C190(0.78); C230(0.93)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C441(0.68); C439(0.75); C190(0.81); C230(0.96)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C441(0.72); C439(0.85); C190(0.86); C230(0.95)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C441(0.68); C190(0.87); C439(0.92); C230(0.93)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C91(0.94); C591(0.99); C71(1.05); C77(1.08)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C230(0.88); C91(0.90); C591(0.97); C190(1.04)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C591(0.85); C91(0.90); C77(1.06); C230(1.06)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C230(0.84); C591(0.97); C91(0.97); C71(1.01)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C591(0.86); C190(1.02); C230(1.03); C91(1.07)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C190(0.81); C71(0.92); C439(1.00); C441(1.00)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C230(0.99); C591(1.00); C190(1.03); C91(1.07)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C591(0.86); C190(0.92); C91(1.02); C230(1.02)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C230(0.93); C190(0.95); C591(0.98); C91(1.11)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C230(0.85); C190(0.85); C591(0.94); C77(0.97)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C591(0.93); C91(0.96); C190(1.03); C77(1.08)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C591(0.91); C190(0.99); C91(1.02); C77(1.10)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C439(0.85); C91(0.89); C190(0.95); C77(0.96)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C439(0.80); C230(0.87); C91(0.90); C77(0.93)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C439(0.80); C77(0.86); C71(0.94); C91(1.01)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C439(0.85); C230(0.85); C77(0.91); C190(0.97)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C190(0.84); C71(0.95); C439(1.05); C441(1.05)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C439(0.72); C230(0.85); C190(0.91); C91(0.94)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C439(0.72); C230(0.88); C77(0.90); C71(0.95)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C439(0.83); C91(0.96); C77(1.00); C71(1.02)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C230(0.84); C91(0.97); C190(0.98); C441(1.17)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C439(0.78); C230(0.88); C190(0.93); C91(0.95)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C190(0.92); C91(0.97); C230(0.98); C77(1.00)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C439(0.84); C230(0.87); C190(0.98); C91(1.01)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C190(0.84); C439(0.87); C441(0.87); C71(0.91)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C439(0.85); C441(0.85); C91(0.89); C77(0.90)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C190(0.79); C91(0.93); C439(0.95); C441(0.95)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C591(0.80); C91(0.88); C439(0.96); C190(1.03)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C190(0.71); C439(0.81); C441(0.81); C91(0.81)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C439(0.75); C441(0.75); C190(0.77); C91(0.85)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C190(0.65); C71(0.93); C91(0.93); C439(0.93)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C190(0.68); C91(0.83); C71(0.87); C77(0.91)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C190(0.80); C439(0.89); C441(0.89); C91(0.95)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C190(0.72); C439(0.79); C441(0.79); C91(0.98)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C439(0.79); C441(0.79); C190(0.83); C91(0.91)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C190(0.64); C439(0.71); C441(0.71); C464(0.84)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C441(0.84); C439(0.87); C464(0.92); C71(1.03)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C464(0.90); C71(0.90); C441(0.95); C77(1.01)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C591(0.77); C91(0.95); C71(1.09); C77(1.12)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C77(0.82); C71(0.87); C441(0.88); C91(0.89)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C71(0.88); C441(0.97); C464(0.99); C439(1.01)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C77(0.90); C441(0.96); C71(0.96); C464(0.99)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C441(0.85); C439(0.86); C77(0.88); C464(0.89)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C464(0.86); C71(0.90); C77(0.92); C441(0.96)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C441(0.81); C439(0.83); C464(1.00); C71(1.15)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C441(0.94); C439(0.97); C71(0.99); C77(1.02)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C464(0.89); C441(0.96); C439(0.96); C71(1.02)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C441(0.83); C464(0.83); C439(0.85); C71(0.87)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C441(0.89); C439(0.92); C464(1.00); C71(1.02)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C591(0.77); C91(0.97); C77(1.03); C71(1.07)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C439(0.93); C441(0.93); C71(0.96); C464(1.03)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C441(0.84); C439(0.89); C464(0.97); C71(1.07)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C441(0.95); C439(0.99); C71(1.01); C77(1.08)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C190(0.50); C439(0.88); C77(0.97); C91(0.98)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C190(0.47); C439(0.90); C77(0.92); C71(0.97)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C190(0.46); C77(0.92); C230(0.96); C71(0.96)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C190(0.62); C230(0.89); C91(0.89); C439(0.96)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C190(0.61); C230(0.92); C77(0.96); C71(0.98)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C190(0.49); C439(0.94); C441(0.97); C91(1.04)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C190(0.50); C91(0.86); C439(0.91); C441(0.98)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C190(0.64); C91(0.89); C464(0.98); C230(0.99)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C190(0.53); C439(0.88); C591(0.91); C230(0.94)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C190(0.47); C230(0.84); C439(0.93); C91(0.96)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C190(0.49); C439(0.92); C464(1.00); C77(1.00)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C190(0.58); C71(0.94); C230(0.96); C77(0.97)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C190(0.42); C464(0.80); C439(0.82); C77(0.87)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C190(0.47); C230(0.89); C71(0.97); C91(0.98)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C190(0.49); C439(0.85); C464(0.98); C230(0.98)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C439(0.58); C441(0.58); C91(0.69); C71(0.75)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C91(0.74); C71(0.75); C77(0.75); C439(0.82)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C190(1.13); C439(1.13); C441(1.00); C591(1.04)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C441(0.95); C91(1.00); C591(1.01); C77(1.07)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C190(0.91); C91(0.94); C439(1.01); C591(1.03)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 12.01  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C71(0.89); C77(0.89)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C190(0.78); C464(0.80); C77(1.24); C71(1.33)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C464(0.78); C190(1.00); C91(1.23); C71(1.33)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C190(0.82); C71(1.06); C439(1.11); C441(1.11)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C190(0.89); C591(0.94); C91(1.00); C439(1.11)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C591(0.85); C91(0.96); C190(1.06); C441(1.33)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C591(0.86); C91(0.97); C190(0.97); C441(1.08)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C591(0.82); C91(0.96); C190(1.03); C441(1.07)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C441(1.00); C439(1.27); C71(1.28); C77(1.35)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C441(0.93); C71(1.11); C77(1.19); C439(1.29)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C441(0.83); C71(0.97); C77(1.03); C439(1.04)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C441(1.00); C71(1.15); C77(1.25); C439(1.33)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C441(0.98); C439(1.09); C71(1.40); C77(1.43)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C190(0.79); C464(0.84); C91(1.20); C441(1.34)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C441(1.26); C439(1.34); C71(1.81); C77(1.84)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C439(1.14); C441(1.15); C71(1.57); C77(1.65)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C441(0.72); C190(0.96); C439(1.01); C230(1.07)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C441(0.62); C439(0.77); C190(0.83); C230(0.91)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C441(0.71); C439(0.78); C190(0.97); C91(0.98)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C441(0.72); C439(0.87); C190(0.88); C230(1.04)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C441(0.64); C190(0.76); C439(0.80); C77(1.02)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C190(0.89); C230(0.98); C591(1.00); C91(1.23)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C230(0.91); C591(0.97); C190(0.98); C91(0.99)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C230(0.85); C591(0.90); C91(1.01); C77(1.03)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C464(0.93); C439(0.94); C441(0.97); C190(1.03)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C230(0.91); C591(0.95); C190(1.02); C91(1.04)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C190(0.81); C230(0.86); C91(0.88); C439(0.92)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C190(0.88); C439(0.90); C230(0.90); C91(0.91)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C230(0.80); C190(0.97); C91(1.09); C439(1.61)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C439(0.81); C230(0.85); C91(0.96); C190(1.10)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C190(0.78); C464(0.97); C91(1.03); C439(1.06)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C190(0.75); C91(0.91); C464(0.97); C439(1.20)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C190(0.76); C91(0.89); C439(0.96); C441(0.96)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C190(0.75); C439(0.85); C441(0.85); C91(0.98)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C464(0.90); C190(0.94); C71(1.03); C77(1.05)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C464(0.66); C190(1.02); C91(1.03); C439(1.30)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C464(0.80); C190(0.80); C439(1.06); C441(1.23)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C91(0.93); C439(0.94); C441(0.94); C190(0.96)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C190(1.09); C439(1.11); C91(1.16); C441(1.17)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C441(0.76); C439(0.77); C190(0.84); C77(0.85)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C190(0.87); C439(0.87); C441(0.89); C91(1.01)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C190(0.74); C464(0.86); C77(1.09); C71(1.11)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C439(0.79); C441(0.92); C190(0.95); C91(0.99)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C190(0.97); C91(0.97); C439(1.28); C441(1.47)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C439(0.89); C441(0.97); C190(1.13); C91(1.15)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C439(0.88); C441(0.92); C190(0.93); C71(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C190(0.77); C439(0.94); C91(0.95); C441(0.98)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C190(0.77); C439(1.04); C441(0.99); C71(1.56)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C190(0.86); C439(0.92); C441(0.93); C71(1.11)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C190(0.79); C439(0.93); C441(0.97); C71(1.13)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C190(0.82); C439(0.96); C441(1.10); C71(1.32)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C190(0.90); C439(0.84); C441(0.99); C71(1.02)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C190(1.21); C439(0.89); C441(0.97); C464(0.84)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C190(0.78); C439(0.96); C441(0.98); C71(0.93)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C190(0.86); C439(1.03); C441(1.00); C71(1.13)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C190(0.89); C439(0.85); C441(0.81); C71(0.87)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C190(0.96); C439(2.65); C441(2.65); C71(1.16)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C190(0.92); C439(0.94); C441(0.99); C71(1.14)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C190(1.03); C439(0.81); C441(0.83); C71(1.10)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C190(1.27); C439(0.93); C441(0.96); C71(1.13)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C190(1.00); C439(0.85); C441(0.86); C71(1.14)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C190(1.05); C439(1.03); C441(1.04); C71(1.31)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C190(0.93); C439(1.22); C441(1.92); C464(0.98)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C190(0.89); C439(1.22); C441(1.19); C71(1.21)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C190(0.94); C439(0.92); C441(0.91); C71(1.06)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C190(0.92); C439(0.93); C441(0.98); C71(1.41)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C190(0.88); C439(0.87); C441(0.87); C71(0.93)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C190(0.85); C439(0.96); C441(1.00); C71(0.98)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C190(0.88); C439(0.92); C441(0.90); C71(1.10)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C190(1.12); C439(0.91); C441(0.92); C464(0.87)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C190(1.10); C439(1.21); C441(1.28); C464(0.89)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C190(1.00); C439(0.95); C441(0.96); C464(0.98)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C190(1.13); C439(1.05); C441(1.03); C464(1.08)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C190(1.11); C439(1.01); C441(0.97); C464(0.98)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C190(1.24); C439(1.19); C441(1.18); C464(0.86)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C190(0.97); C439(1.04); C441(0.98); C464(0.95)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C190(1.13); C439(1.05); C441(1.01); C464(1.00)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C190(1.94); C439(1.02); C441(1.06); C464(0.94)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C190(1.05); C439(1.32); C441(1.31); C464(0.81)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C190(1.24); C439(0.99); C441(0.98); C464(1.05)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C190(1.31); C439(1.17); C441(1.16); C464(0.89)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C190(1.15); C439(1.03); C441(0.99); C464(0.87)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C190(1.47); C439(0.87); C441(0.85); C464(0.87)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C190(1.24); C439(1.02); C441(1.00); C464(0.94)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C190(0.87); C439(1.08); C441(1.14); C464(0.77)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C190(1.22); C439(0.97); C441(0.96); C464(1.00)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C190(1.00); C439(0.90); C441(0.90); C591(1.04)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C190(1.05); C439(0.70); C441(0.70); C591(1.26)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C190(1.05); C439(0.71); C441(0.71); C591(0.75)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C190(1.03); C439(1.47); C441(1.47); C591(1.00)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C190(0.96); C439(0.79); C441(0.79); C591(0.86)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C190(0.92); C439(0.96); C441(0.96); C591(1.01)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C190(0.93); C439(0.78); C441(0.78); C591(0.44)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C190(0.85); C439(1.00); C441(1.00); C591(0.30)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C190(0.87); C439(0.61); C441(0.61); C591(0.74)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C190(1.22); C439(0.86); C441(0.83); C464(0.82)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C190(0.89); C439(0.64); C441(0.64); C591(0.67)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C190(0.96); C439(0.77); C441(0.77); C591(0.57)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C190(0.99); C439(1.67); C441(1.67); C591(0.52)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C190(1.50); C439(1.41); C441(1.41); C591(0.42)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C190(1.18); C439(0.86); C441(0.86); C591(0.38)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C190(0.87); C439(0.82); C441(0.92); C464(1.74)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C190(0.90); C439(1.35); C441(1.53); C464(1.43)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C190(1.05); C439(0.89); C441(0.93); C464(1.61)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C190(0.75); C439(0.82); C441(0.97); C464(1.04)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C190(0.82); C439(2.04); C441(2.65); C464(0.86)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C190(0.86); C439(0.76); C441(0.84); C464(1.05)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C190(0.85); C439(0.90); C441(0.97); C464(0.99)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C190(0.94); C439(0.81); C441(0.85); C464(1.10)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C190(0.86); C439(0.82); C441(0.87); C464(1.31)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C190(0.99); C439(0.88); C441(0.90); C464(0.97)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C190(0.94); C439(0.91); C441(0.90); C464(1.05)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C190(1.03); C439(1.03); C441(0.98); C464(1.10)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C190(1.32); C439(1.11); C441(1.09); C464(1.49)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C190(1.05); C439(0.83); C441(0.84); C464(1.17)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C190(1.04); C439(0.74); C441(0.75); C464(0.91)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C190(0.73); C439(1.02); C441(1.10); C464(0.94)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C190(1.01); C439(2.19); C441(2.54); C464(0.88)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C190(0.88); C439(1.15); C441(1.15); C71(1.20)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C190(0.98); C439(1.24); C441(1.24); C71(1.46)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C190(0.96); C439(1.12); C441(1.12); C71(1.09)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C190(0.81); C439(1.30); C441(1.30); C71(1.38)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C190(0.81); C439(1.29); C441(1.29); C71(1.53)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C190(0.95); C439(1.05); C441(1.05); C71(1.29)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C190(0.92); C439(1.04); C441(1.04); C71(1.36)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C190(0.84); C439(1.07); C441(1.07); C71(1.21)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C190(0.97); C439(1.20); C441(1.20); C71(1.12)  LDD0811  [4]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C71(4.41)  LDD0526  [14]
 LDCM0495  E2913 HEK-293T C441(1.22)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C190(0.90); C439(0.89); C441(0.89); C591(1.02)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C190(1.17); C439(1.79); C441(1.86); C71(1.96)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C71(3.64); C77(3.64)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C71(2.51); C77(2.51)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C71(4.21); C77(4.21)  LDD0082  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C71(0.55)  LDD2206  [16]
 LDCM0131  RA190 MM1.R C71(1.43)  LDD0304  [17]
 LDCM0021  THZ1 HCT 116 C71(1.19); C77(1.19); C464(1.22)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Peptidase C14B family Q9UDY8
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
Casein kinase I isoform alpha (CSNK1A1) CK1 Ser/Thr protein kinase family P48729
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein fem-1 homolog A (FEM1A) Fem-1 family Q9BSK4
Protein fem-1 homolog C (FEM1C) Fem-1 family Q96JP0
Progranulin (GRN) Granulin family P28799
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
B-cell lymphoma/leukemia 10 (BCL10) . O95999
Caspase recruitment domain-containing protein 11 (CARD11) . Q9BXL7
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Sequestosome-1 (SQSTM1) . Q13501
Sharpin (SHARPIN) . Q9H0F6
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jnj-67856633 . D3GIQ9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
17 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.