Details of the Target

General Information of Target

Target ID LDTP03939
Target Name Lysine-specific demethylase 5C (KDM5C)
Gene Name KDM5C
Gene ID 8242
Synonyms
DXS1272E; JARID1C; SMCX; XE169; Lysine-specific demethylase 5C; EC 1.14.11.67; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; Protein Xe169; [histone H3]-trimethyl-L-lysine(4) demethylase 5C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV
EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP
FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG
AGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSH
SPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPE
IPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTEL
VEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMP
VLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSL
AAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRA
YHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDL
NLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALA
CYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVA
LEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACVSRALGLVSGQEAGP
HRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAEAREALASLPSSPGL
LQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAVMRGLLVAGASV
APSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAENIPVHLPNIQ
ALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHS
WREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDL
RDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGAL
QCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILA
LLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPR
PEEPPNYPAAPASDPLREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGSGKRDLELLSSL
LPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLEL
EKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEE
ETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLTPRLHLPCPQQPPQQQL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
JARID1 histone demethylase family
Subcellular location
Nucleus
Function
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
TTD ID
T85540
Uniprot ID
P41229
DrugMap ID
TT94UCF
Ensemble ID
ENST00000375379.7
HGNC ID
HGNC:11114
ChEMBL ID
CHEMBL2163176

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R1271W .
A3KAW SNV: p.R378P DBIA    Probe Info 
AN3CA SNV: p.L1413P .
EFO21 SNV: p.R136W DBIA    Probe Info 
HSC4 Deletion: p.C654_A663del DBIA    Probe Info 
HT115 SNV: p.L1381S .
IM95 SNV: p.L556R DBIA    Probe Info 
MCC13 SNV: p.S151F DBIA    Probe Info 
NALM6 SNV: p.V1463G .
NCIH1155 SNV: p.R313Q DBIA    Probe Info 
NCIH716 Insertion: p.P998_P999insTPP .
SW620 SNV: p.V1146M .
WM2664 Insertion: p.T1513HfsTer71 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.45  LDD0402  [1]
Alkylaryl probe 2
 Probe Info  		19.00  LDD0389  [2]
BTD
 Probe Info  		C990(1.22)  LDD2136  [3]
DBIA
 Probe Info  		C371(2.17); C376(1.89); C327(1.32)  LDD0080  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C990(0.00); C1280(0.00); C589(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C990(0.00); C589(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C990(0.00); C589(0.00)  LDD0037  [5]
IPM
 Probe Info  		C1280(0.00); C1551(0.00); C305(0.00); C267(0.00)  LDD2156  [6]
TFBX
 Probe Info  		C589(0.00); C818(0.00)  LDD0148  [7]
NAIA_5
 Probe Info  		C865(0.00); C129(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C990(1.00)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C990(1.01)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C818(0.31); C825(0.31)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C818(0.63); C825(0.63)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C818(0.29); C825(0.29)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C818(0.39); C825(0.39)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C818(0.30); C825(0.30)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C818(0.43); C825(0.43)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C818(0.34); C825(0.34)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C818(0.43); C825(0.43)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C818(0.53); C825(0.53)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C818(0.40); C825(0.40)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C990(0.97)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C818(0.36); C825(0.36)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C818(0.39); C825(0.39)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C818(0.27); C825(0.27)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C640(1.27); C649(1.27)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C640(1.52); C649(1.52)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C640(1.10); C649(1.10)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C640(1.31); C649(1.31)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C640(1.24); C649(1.24)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C640(1.36); C649(1.36)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C640(1.23); C649(1.23)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C990(0.99)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C640(1.22); C649(1.22)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C640(1.23); C649(1.23)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C640(1.18); C649(1.18)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C640(1.04); C649(1.04)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C640(1.31); C649(1.31)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C640(1.28); C649(1.28)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C640(1.11); C649(1.11)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C640(1.23); C649(1.23)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C649(0.98)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C649(1.18)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C649(1.29)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C649(1.24)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C649(1.17)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C649(1.17)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C649(1.17)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C649(1.02)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C649(1.15)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C649(1.23)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C649(1.08)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C649(1.21)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C990(1.08)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C649(1.13)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C649(1.22)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C649(1.45)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C376(1.15); C371(0.66); C640(1.14); C649(1.03)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C376(1.33); C371(0.57); C640(0.84); C649(0.96)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C376(1.25); C371(0.61); C640(0.68); C649(0.90)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C376(1.24); C371(0.58); C640(0.76); C649(0.83)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C376(1.16); C371(0.65); C640(1.03); C649(1.09)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C376(0.87); C371(0.87); C640(0.96); C649(0.84)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C376(1.02); C371(1.00); C640(1.04); C649(1.01)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C990(1.08)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C376(1.28); C371(0.82); C640(1.19); C649(1.15)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C376(1.23); C371(0.73); C640(0.93); C649(1.04)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C376(1.03); C371(0.78); C640(1.16); C649(1.13)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C376(1.00); C371(0.73); C640(1.08); C649(1.22)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C376(0.93); C371(1.09); C640(1.15); C649(1.15)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C376(1.21); C371(0.79); C640(1.07); C649(1.11)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C376(1.28); C371(0.76); C640(1.03); C649(1.00)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C376(1.73); C371(0.69); C640(1.26); C649(1.22)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C640(1.24); C649(1.24)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C640(1.14); C649(1.14)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C640(1.32); C649(1.32)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C990(0.91)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C640(1.17); C649(1.17)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C640(1.00); C649(1.00)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C640(1.23); C649(1.23)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C640(0.80); C649(0.80)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C640(1.01); C649(1.01)  LDD0601  [4]
 LDCM0285  AC25 PaTu 8988t C1095(1.02); C1105(1.02); C990(1.26); C1103(1.02)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C1095(0.99); C1105(0.99); C990(1.22); C1103(0.99)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C1095(0.92); C1105(0.92); C990(1.29); C1103(0.92)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C1095(1.00); C1105(1.00); C990(1.23); C1103(1.00)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C1095(1.11); C1105(1.11); C990(1.11); C1103(1.11)  LDD1168  [4]
 LDCM0290  AC3 HCT 116 C990(1.06)  LDD0607  [4]
 LDCM0291  AC30 PaTu 8988t C1095(1.32); C1105(1.32); C990(1.18); C1103(1.32)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C1095(0.83); C1105(0.83); C990(1.19); C1103(0.83)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C1095(1.23); C1105(1.23); C990(1.23); C1103(1.23)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C1095(1.18); C1105(1.18); C990(1.27); C1103(1.18)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C1095(1.40); C1105(1.40); C990(1.03); C1103(1.40)  LDD1174  [4]
 LDCM0296  AC35 HCT 116 C818(1.27); C825(1.27)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C818(0.94); C825(0.94)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C818(1.16); C825(1.16)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C818(0.99); C825(0.99)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C818(0.99); C825(0.99)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C990(0.82)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C818(1.19); C825(1.19)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C818(1.10); C825(1.10)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C818(1.00); C825(1.00)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C818(0.74); C825(0.74)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C818(0.98); C825(0.98)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C818(1.06); C825(1.06)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C640(1.03); C649(1.03); C818(0.69); C990(0.69)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C640(1.01); C649(1.01); C818(0.77); C990(0.77)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C640(0.91); C649(0.91); C818(0.78); C990(0.78)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C640(0.98); C649(0.98); C818(1.03); C990(1.03)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C990(1.13)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C640(0.96); C649(0.96); C818(0.81); C990(0.81)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C640(1.03); C649(1.03); C818(0.80); C990(0.80)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C640(0.86); C649(0.86); C818(0.91); C990(0.91)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C640(0.91); C649(0.91); C818(0.82); C990(0.82)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C640(0.89); C649(0.89); C818(0.96); C990(0.96)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C640(0.86); C649(0.86); C818(0.83); C990(0.83)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C640(1.08); C649(1.08); C818(0.87); C990(0.87)  LDD0917  [4]
 LDCM0320  AC57 HCT 116 C818(0.87); C825(0.87)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C818(0.94); C825(0.94)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C818(1.03); C825(1.03)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C990(1.28)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C818(0.95); C825(0.95)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C818(0.92); C825(0.92)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C818(1.12); C825(1.12)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C818(0.88); C825(0.88)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C818(1.00); C825(1.00)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C818(1.23); C825(1.23)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C818(0.96); C825(0.96)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C818(1.04); C825(1.04)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C818(1.32); C825(1.32)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C818(1.37); C825(1.37)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C990(1.12)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C818(2.59); C825(2.59)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C818(1.36); C825(1.36)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C818(0.96); C825(0.96)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C818(1.66); C825(1.66)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C818(2.15); C825(2.15)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C818(1.75); C825(1.75)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C818(1.48); C825(1.48)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C818(1.59); C825(1.59)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C818(1.19); C825(1.19)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C818(0.95); C825(0.95)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C990(0.88)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C818(1.40); C825(1.40)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C818(0.76); C825(0.76)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C818(1.85); C825(1.85)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C640(0.93); C649(0.93)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C640(0.94); C649(0.94)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C640(0.99); C649(0.99)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C640(0.80); C649(0.80)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C640(1.00); C649(1.00)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C640(0.81); C649(0.81)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C640(0.86); C649(0.86)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C640(0.83); C649(0.83)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C640(0.80); C649(0.80)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C640(0.86); C649(0.86)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C640(0.80); C649(0.80)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C640(0.71); C649(0.71)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C640(0.85); C649(0.85)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C640(0.75); C649(0.75)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C640(0.75); C649(0.75)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C818(0.39); C825(0.39)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C818(0.39); C825(0.39)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C990(1.09)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C990(1.07)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C990(1.40)  LDD0592  [4]
 LDCM0102  BDHI 8 Jurkat C640(21.22); C649(21.22)  LDD0204  [9]
 LDCM0632  CL-Sc Hep-G2 C1551(0.57)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C990(1.02)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C990(0.95)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C990(0.77)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C990(1.00)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C990(0.91)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C990(1.06)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C990(1.01)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C640(0.76); C649(0.76)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C640(1.08); C649(1.08)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C640(1.20); C649(1.20)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C640(0.92); C649(0.92)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C640(1.00); C649(1.00)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C990(0.83)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C640(1.15); C649(1.15)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C640(1.00); C649(1.00)  LDD0698  [4]
 LDCM0382  CL112 PaTu 8988t C1095(0.88); C1105(0.88); C990(1.03); C1103(0.88)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C1095(1.00); C1105(1.00); C990(1.18); C1103(1.00)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C1095(0.92); C1105(0.92); C990(1.02); C1103(0.92)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C1095(0.96); C1105(0.96); C990(1.10); C1103(0.96)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C1095(1.02); C1105(1.02); C990(1.35); C1103(1.02)  LDD1265  [4]
 LDCM0387  CL117 HCT 116 C818(1.20); C825(1.20)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C818(0.79); C825(0.79)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C818(0.97); C825(0.97)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C990(1.17)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C818(0.85); C825(0.85)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C640(1.01); C649(1.01); C818(0.93); C990(0.93)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C640(0.90); C649(0.90); C818(0.92); C990(0.92)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C640(0.95); C649(0.95); C818(0.70); C990(0.70)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C640(0.99); C649(0.99); C818(0.80); C990(0.80)  LDD0993  [4]
 LDCM0396  CL125 HCT 116 C818(0.89); C825(0.89)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C818(0.70); C825(0.70)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C818(1.07); C825(1.07)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C818(0.98); C825(0.98)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C990(1.10)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C990(1.01)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C990(1.02)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C990(0.79)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C990(0.90)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C990(0.80)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C990(0.87)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C990(1.03)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C990(0.84)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C990(1.08)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C990(1.37)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C990(0.86)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C990(0.95)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C990(0.97)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C990(0.82)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C990(0.87)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C990(1.00)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C990(0.93)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C990(0.85)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C990(0.81)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C990(0.82)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C990(1.15)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C990(1.26)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C990(1.22)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C990(0.88)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C990(1.02)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C990(0.99)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C990(1.12)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C990(0.86)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C990(1.00)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C990(0.98)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C990(0.91)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C990(1.28)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C990(1.11)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C990(1.10)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C640(0.88); C649(0.88)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C640(0.93); C649(0.93)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C640(0.81); C649(0.81)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C640(1.14); C649(1.14)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C990(1.07)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C640(0.86); C649(0.86)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C640(0.86); C649(0.86)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C640(0.87); C649(0.87)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C640(0.87); C649(0.87)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C640(0.86); C649(0.86)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C640(1.12); C649(1.12)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C640(0.81); C649(0.81)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C640(1.00); C649(1.00)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C640(1.02); C649(1.02)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C640(0.84); C649(0.84)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C990(1.39)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C640(0.81); C649(0.81)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C376(1.15); C1103(0.90); C1105(0.90); C640(0.70)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C376(0.90); C1103(0.60); C1105(0.60); C640(0.66)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C376(1.10); C1103(0.75); C1105(0.75); C640(1.11)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C376(0.99); C1103(1.07); C1105(1.07); C640(0.60)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C376(0.83); C1103(0.83); C1105(0.83); C640(0.89)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C376(0.86); C1103(0.81); C1105(0.81); C640(1.21)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C376(0.81); C1103(0.78); C1105(0.78); C640(0.66)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C376(0.66); C1103(0.74); C1105(0.74); C640(0.52)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C376(0.72); C1103(1.03); C1105(1.03); C640(1.03)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C990(1.39)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C376(0.75); C1103(0.84); C1105(0.84); C640(0.48)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C376(0.70); C1103(0.87); C1105(0.87); C640(0.77)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C376(0.74); C1103(0.77); C1105(0.77); C640(0.83)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C376(0.73); C1103(1.00); C1105(1.00); C640(0.71)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C376(1.27); C1103(1.13); C1105(1.13); C640(0.64)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C376(1.08); C1103(0.72); C1105(0.72); C649(0.83)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C376(1.00); C1103(0.97); C1105(0.97); C649(0.81)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C376(0.68); C1103(0.59); C1105(0.59); C649(0.79)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C376(1.08); C1103(0.76); C1105(0.76); C649(0.96)  LDD1070  [4]
 LDCM0473  CL8 HCT 116 C990(1.11)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C376(0.78); C1103(0.90); C1105(0.90); C649(0.83)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C376(1.09); C1103(0.83); C1105(0.83); C649(0.97)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C376(1.16); C1103(1.09); C1105(1.09); C649(1.24)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C376(1.32); C1103(1.04); C1105(1.04); C649(1.06)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C376(1.01); C1103(0.83); C1105(0.83); C649(0.72)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C376(0.90); C1103(0.66); C1105(0.66); C649(0.81)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C376(0.71); C1103(0.77); C1105(0.77); C649(0.76)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C376(1.04); C1103(0.77); C1105(0.77); C649(0.78)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C376(1.19); C1103(0.85); C1105(0.85); C649(0.93)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C376(0.86); C1103(0.80); C1105(0.80); C649(0.97)  LDD1081  [4]
 LDCM0484  CL9 HCT 116 C990(1.19)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C376(1.39); C1103(1.42); C1105(1.42); C649(0.96)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C990(0.63)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C990(0.75)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C990(1.12)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C990(0.79)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C990(0.93)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C990(1.01)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C990(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C990(1.16)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C990(0.97)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C990(1.07); C1551(1.20); C129(0.97); C589(0.98)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C376(1.00); C1103(0.95); C1105(0.95); C640(0.65)  LDD1066  [4]
 LDCM0427  Fragment51 HCT 116 C990(0.85)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C371(2.17); C376(1.89); C327(1.32)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C371(1.97); C376(1.52); C327(1.45)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C371(2.25); C376(1.79); C327(1.43)  LDD0082  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C990(1.22)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C990(0.97)  LDD2137  [3]
 LDCM0099  Phenelzine HEK-293T 3.00  LDD0390  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RE1-silencing transcription factor (REST) . Q13127

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iox2 Small molecular drug D0WA3E
Pbit Small molecular drug D0IQ7Y

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402