Details of the Target

General Information of Target

Target ID LDTP01073
Target Name DnaJ homolog subfamily A member 2 (DNAJA2)
Gene Name DNAJA2
Gene ID 10294
Synonyms
CPR3; HIRIP4; DnaJ homolog subfamily A member 2; Cell cycle progression restoration gene 3 protein; Dnj3; Dj3; HIRA-interacting protein 4; Renal carcinoma antigen NY-REN-14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANVADTKLYDILGVPPGASENELKKAYRKLAKEYHPDKNPNAGDKFKEISFAYEVLSNP
EKRELYDRYGEQGLREGSGGGGGMDDIFSHIFGGGLFGFMGNQSRSRNGRRRGEDMMHPL
KVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRGVRIMIRQLAPGMVQ
QMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRITFTGEADQA
PGVEPGDIVLLLQEKEHEVFQRDGNDLHMTYKIGLVEALCGFQFTFKHLDGRQIVVKYPP
GKVIEPGCVRVVRGEGMPQYRNPFEKGDLYIKFDVQFPENNWINPDKLSELEDLLPSRPE
VPNIIGETEEVELQEFDSTRGSGGGQRREAYNDSSDEESSSHHGPGVQCAHQ
Target Bioclass
Other
Subcellular location
Membrane
Function Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
Uniprot ID
O60884
Ensemble ID
ENST00000317089.10
HGNC ID
HGNC:14884
ChEMBL ID
CHEMBL4295671

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y35(13.27)  LDD0257  [1]
TH216
 Probe Info  		Y69(14.31)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K131(6.74); K158(1.73); K226(8.97); K25(0.65)  LDD0277  [3]
Probe 1
 Probe Info  		Y69(22.72); Y320(20.73)  LDD3495  [4]
BTD
 Probe Info  		C143(1.70); C146(1.61); C308(1.48)  LDD1700  [5]
HPAP
 Probe Info  		3.19  LDD0062  [6]
HHS-482
 Probe Info  		Y69(1.38)  LDD0285  [7]
HHS-475
 Probe Info  		Y69(0.91); Y35(0.99); Y54(2.48)  LDD0264  [8]
HHS-465
 Probe Info  		Y35(10.00); Y69(2.77)  LDD2237  [9]
Acrolein
 Probe Info  		N.A.  LDD0221  [10]
DBIA
 Probe Info  		C308(0.88)  LDD0078  [11]
5E-2FA
 Probe Info  		H268(0.00); H36(0.00); H118(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K25(0.00); K26(0.00); K33(0.00); K39(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H268(0.00); H118(0.00); H36(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C280(0.00); C308(0.00); C143(0.00); C146(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C280(0.00); C308(0.00); C143(0.00); C146(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		K158(0.00); K152(0.00)  LDD0035  [16]
IPM
 Probe Info  		N.A.  LDD0147  [17]
PF-06672131
 Probe Info  		N.A.  LDD0152  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
1c-yne
 Probe Info  		K8(0.00); K255(0.00); K48(0.00)  LDD0228  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		C143(0.00); C146(0.00); C308(0.00)  LDD0236  [21]
NAIA_5
 Probe Info  		C280(0.00); C146(0.00); C308(0.00)  LDD2223  [22]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		8.94  LDD0471  [23]
FFF probe13
 Probe Info  		12.88  LDD0475  [23]
FFF probe2
 Probe Info  		13.54  LDD0463  [23]
FFF probe3
 Probe Info  		13.25  LDD0464  [23]
STS-1
 Probe Info  		N.A.  LDD0136  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C308(0.33)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C308(0.59)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C308(0.50)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C308(0.92)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C308(0.91); C146(0.78); C143(0.88)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C308(1.15); C143(1.32)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C308(0.34)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C308(0.69)  LDD2131  [5]
 LDCM0214  AC1 HCT 116 C143(1.05); C146(1.05); C186(0.90); C189(0.90)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C143(1.05); C146(1.01); C186(1.43); C189(1.43)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C143(1.24); C146(1.24); C308(0.99)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C143(0.85); C146(0.86); C308(0.92)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C143(0.64); C146(0.64); C308(1.03)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C143(0.67); C146(0.67); C308(0.89)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C143(0.67); C146(0.68); C308(0.89)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C143(0.96); C146(0.95); C308(0.92)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C143(0.66); C146(0.66); C308(0.92)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C143(0.91); C146(0.57); C308(0.96)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C143(0.77); C146(0.89); C308(0.93)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C143(0.72); C146(0.88); C308(0.91)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C143(1.04); C146(1.04); C186(1.67); C189(1.67)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C143(0.64); C146(0.76); C308(0.92)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C143(0.62); C146(0.74); C308(0.76)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C143(0.64); C146(0.66); C308(0.75)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C143(1.19); C146(1.19); C186(0.57); C189(0.57)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C143(1.28); C146(1.28); C186(1.15); C189(0.94)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C143(1.11); C146(1.11); C186(0.93); C189(0.77)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C143(1.24); C146(1.24); C186(0.94); C189(1.09)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C143(1.05); C146(1.05); C186(0.80); C189(0.61)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C143(1.17); C146(1.17); C186(0.81); C189(1.24)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C143(1.25); C146(1.25); C186(0.96); C189(0.82)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C143(1.14); C146(1.10); C186(1.30); C189(1.30)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C143(1.39); C146(1.39); C186(0.91); C189(1.10)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C143(1.22); C146(1.22); C186(0.91); C189(0.74)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C143(1.49); C146(1.49); C186(1.00); C189(0.85)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C143(1.39); C146(1.39); C186(0.92); C189(0.61)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C143(1.50); C146(1.50); C186(0.72); C189(0.50)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C143(1.42); C146(1.42); C186(1.01); C189(0.74)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C143(1.27); C146(1.27); C186(1.09); C189(1.02)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C143(1.31); C146(1.31); C186(0.82); C189(0.82)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C143(0.87); C146(0.87); C308(1.60)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C143(0.86); C146(0.86); C308(1.38)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C143(0.89); C146(0.89); C308(1.34)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C143(0.99); C146(0.99); C308(1.37)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C143(0.79); C146(0.79); C308(1.15)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C143(0.94); C146(0.94); C308(1.24)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C143(0.74); C146(0.74); C308(1.10)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C143(0.82); C146(0.82); C308(1.07)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C143(0.85); C146(0.85); C308(1.15)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C143(0.86); C146(0.86); C308(0.96)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C143(0.74); C146(0.74); C308(0.75)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C143(0.72); C146(0.72); C308(0.91)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C143(1.33); C146(1.07); C186(2.53); C189(2.53)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C143(0.66); C146(0.66); C308(0.68)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C143(0.65); C146(0.65); C308(0.68)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C143(0.99); C146(0.99); C308(0.97)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C143(1.07); C146(1.07); C186(0.96); C189(0.96)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C308(0.71); C189(0.87); C186(0.89); C146(1.05)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C186(0.78); C189(0.82); C308(0.83); C146(1.10)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C308(0.77); C186(0.93); C146(1.00); C189(1.02)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C308(0.64); C146(0.87); C189(0.92); C143(0.93)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C146(0.58); C143(0.64); C308(0.69); C186(0.86)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C146(0.84); C308(0.86); C186(0.88); C143(0.91)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C146(1.10); C308(1.30); C143(1.32); C186(1.80)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C308(0.79); C186(0.89); C189(0.93); C146(0.98)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C186(0.78); C308(0.79); C189(0.83); C146(0.95)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C308(0.70); C146(0.75); C143(0.85); C186(0.97)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C146(0.55); C143(0.57); C308(0.84); C186(0.86)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C143(1.03); C146(0.97); C186(0.97); C189(1.01)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C143(0.92); C146(0.90); C186(0.82); C189(0.91)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C143(1.12); C146(1.00); C186(0.98); C189(1.04)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C143(1.02); C146(0.96); C186(0.95); C189(1.03)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C186(0.85); C189(0.85); C146(0.96); C143(0.97)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C143(0.73); C146(0.76); C186(0.87); C189(0.87)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C186(0.88); C189(0.88); C143(1.01); C146(1.01)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C186(1.04); C189(1.04); C143(1.06); C146(1.06)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C186(0.44); C189(0.44); C146(1.01); C143(1.03)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C186(0.71); C189(0.71); C143(0.89); C146(0.90)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C186(0.53); C189(0.53); C146(0.94); C143(0.94)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C186(0.59); C189(0.59); C143(0.86); C146(0.87)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C186(0.88); C189(0.88); C143(0.88); C146(0.89)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C186(0.88); C189(0.88); C143(0.95); C146(0.95)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C186(0.72); C189(0.72); C308(0.79); C143(0.89)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C186(0.87); C189(0.87); C308(0.87); C143(0.95)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C308(0.78); C143(0.80); C146(0.80); C186(0.87)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C186(0.70); C189(0.70); C308(0.74); C143(0.85)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C143(0.99); C146(0.99); C186(1.16); C189(1.16)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C308(0.71); C143(0.76); C146(0.76); C186(0.97)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C308(0.83); C143(0.85); C146(0.85); C186(0.90)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C308(0.64); C143(0.77); C146(0.77); C186(0.84)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C308(0.70); C143(0.85); C146(0.85); C186(1.06)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C308(0.68); C186(0.82); C189(0.82); C143(0.83)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C143(1.02); C146(1.03); C308(1.17)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C146(0.97); C143(0.98); C308(1.13)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C308(1.20); C146(1.30); C143(1.31)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C146(0.93); C143(0.96); C308(1.09)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C308(1.09); C146(1.10); C143(1.11)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C186(0.94); C189(0.94); C143(0.94); C146(0.94)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C143(0.87); C146(0.88); C308(0.91)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C143(0.97); C146(1.00); C308(1.05)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C146(0.80); C143(0.81); C308(0.84)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C146(0.82); C143(0.83); C308(1.05)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C146(0.84); C143(0.86); C308(0.93)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C308(0.90); C146(0.94); C143(0.95)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C308(0.86); C143(0.94); C146(0.95)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C143(0.94); C146(0.95); C308(0.98)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C308(0.97); C143(1.04); C146(1.06)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C308(0.57); C146(0.75); C143(0.83)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C143(1.02); C146(1.02); C186(1.28); C189(1.28)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C308(0.64); C146(0.81); C143(0.85)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C143(0.99); C146(1.03); C308(1.06)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C308(0.96); C146(0.96); C143(0.98)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C146(0.85); C143(0.94); C308(0.97)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C308(0.89); C146(0.95); C143(1.07)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C146(0.79); C308(0.87); C143(0.88)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C146(0.59); C308(0.60); C143(0.64)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C186(0.89); C189(0.89); C146(0.89); C143(0.90)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C146(0.83); C143(0.84); C308(0.89); C186(1.03)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C308(0.94); C143(0.96); C146(1.00); C186(1.01)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C143(0.90); C146(0.95); C308(0.99); C186(1.21)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C143(0.76); C146(0.78); C308(0.80); C186(0.88)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C186(0.90); C189(0.90); C308(1.06); C143(1.20)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C186(0.76); C189(0.76); C308(0.78); C143(0.80)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C186(0.72); C189(0.72); C143(0.95); C146(0.97)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C143(0.76); C186(0.77); C189(0.77); C308(0.79)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C308(0.81); C186(0.83); C189(0.83); C143(0.88)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C143(0.87); C186(0.87); C189(0.87); C146(0.94)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C143(0.54); C146(0.59); C308(0.70); C186(0.91)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C146(0.93); C308(0.98); C143(0.98); C186(1.06)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C146(0.87); C143(0.90); C186(1.04); C189(1.04)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C146(0.99); C143(1.02); C308(1.26); C186(1.58)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C146(0.64); C143(0.67); C186(0.77); C189(0.77)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C186(0.80); C189(0.80); C146(0.83); C143(0.88)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C146(0.74); C143(0.78); C186(0.95); C189(0.95)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C146(0.53); C143(0.62); C186(0.82); C189(0.82)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C146(0.51); C143(0.61); C186(0.79); C189(0.79)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C146(0.44); C143(0.51); C186(0.70); C189(0.70)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C146(0.66); C143(0.74); C308(0.91); C186(0.93)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C146(0.77); C308(0.79); C143(0.83); C186(0.95)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C186(0.93); C189(0.93); C308(1.01); C143(1.07)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C146(0.88); C186(0.92); C189(0.92); C143(0.92)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C146(0.91); C143(0.95); C308(1.22); C186(1.62)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C146(0.86); C308(0.89); C143(0.90); C186(0.93)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C146(0.69); C143(0.75); C186(0.94); C189(0.94)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C146(0.44); C143(0.49); C186(0.57); C189(0.57)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C308(0.64); C186(0.84); C189(0.84); C143(0.86)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C308(0.70); C143(0.82); C146(0.82); C186(0.83)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C308(0.82); C143(0.92); C146(0.92); C186(0.96)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C308(0.86); C143(0.96); C146(0.96); C186(0.99)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C186(0.93); C189(0.93); C143(0.99); C146(0.99)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C308(0.88); C186(0.93); C189(0.93); C143(1.03)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C308(0.77); C143(0.97); C146(0.97); C186(0.99)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C186(0.88); C189(0.88); C143(0.96); C146(0.96)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C308(0.71); C186(0.90); C189(0.90); C143(1.17)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C308(0.70); C186(0.91); C189(0.91); C143(0.92)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C308(0.88); C143(0.98); C146(0.98); C186(0.99)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C308(0.81); C186(0.87); C189(0.87); C143(1.14)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C186(0.91); C189(0.91); C308(0.95); C143(1.07)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C308(0.69); C186(0.89); C189(0.89); C143(0.98)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C308(0.70); C186(1.01); C189(1.01); C143(1.04)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C146(0.30); C143(0.31); C308(0.91)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C146(0.63); C143(0.63); C308(0.99)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C308(0.57)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C308(0.90); C146(1.13)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C143(1.05); C146(1.06); C186(1.43); C189(1.43)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C146(1.03); C143(1.10); C308(1.31); C186(1.32)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C308(1.04); C146(1.09); C143(1.17); C186(1.53)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C308(0.88)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C308(0.69)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C186(0.80); C189(0.80); C308(1.17); C143(1.21)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C186(0.84); C189(0.84); C143(1.06); C146(1.07)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C186(0.81); C189(0.81); C143(0.91); C146(0.91)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C146(1.03); C308(1.21); C143(1.38); C186(2.74)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C146(1.01); C143(1.12); C308(1.19); C186(1.78)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C146(1.16); C308(1.34); C143(1.63); C186(2.74)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C146(1.07); C143(1.33); C308(1.44); C186(1.96)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C186(0.77); C189(0.77); C146(0.81); C143(0.82)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C146(0.71); C143(0.73); C186(0.78); C189(0.78)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C186(0.72); C189(0.72); C146(0.78); C143(0.78)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C146(0.64); C143(0.65); C186(1.01); C189(1.01)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C186(0.71); C189(0.71); C146(0.80); C143(0.80)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C146(0.96); C186(0.98); C189(0.98); C143(1.00)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C146(0.66); C186(0.66); C189(0.66); C143(0.67)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C143(0.71); C146(0.72); C186(0.95); C189(0.95)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C186(0.72); C189(0.72); C143(0.79); C146(0.79)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C143(0.69); C146(0.69); C308(0.70); C186(0.90)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C143(0.72); C146(0.72); C186(0.84); C189(0.84)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C143(0.77); C146(0.77); C308(0.78); C186(0.81)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C186(0.77); C189(0.77); C143(0.91); C146(0.91)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C146(0.62); C143(0.65); C308(0.70)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C146(0.96); C143(0.97); C308(1.01)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C143(0.95); C146(0.96); C308(1.14)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C146(0.97); C186(1.02); C189(1.02); C308(1.03)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C146(0.96); C143(0.97); C308(1.21)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C308(0.92); C143(1.22); C146(1.72)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C308(0.81); C146(0.91); C143(0.93)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C146(0.71); C308(0.85); C143(0.88)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C146(0.74); C308(0.78); C143(0.84)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C186(0.87); C189(0.87); C143(1.06); C146(1.09)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C186(0.84); C189(0.84); C146(0.90); C143(0.95)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C186(0.88); C189(0.88); C308(1.01); C146(1.01)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C143(0.92); C186(0.93); C189(0.93); C146(0.96)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C186(0.93); C189(0.93); C146(1.05); C143(1.13)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C186(0.81); C189(0.81); C146(1.07); C143(1.11)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C143(0.91); C146(1.00); C308(1.13); C186(1.19)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C143(0.80); C146(0.87); C186(1.00); C189(1.00)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C186(1.03); C189(1.03); C143(1.04); C146(1.12)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C146(1.13); C143(1.16); C186(1.34); C189(1.34)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C143(0.98); C146(1.02); C186(1.11); C189(1.11)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C186(0.79); C189(0.79); C308(1.26); C146(1.44)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C143(1.00); C146(1.12); C308(1.22); C186(1.34)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C143(0.91); C146(1.01); C186(1.16); C189(1.16)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C143(0.80); C146(0.92); C186(1.17); C189(1.17)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C146(0.99); C143(1.00); C308(1.03); C186(1.10)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C143(0.91); C146(0.98); C186(1.17); C189(1.17)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C143(0.89); C146(0.99); C186(1.09); C189(1.09)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C143(0.79); C146(0.90); C186(0.96); C189(0.96)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C143(1.18); C146(1.18); C186(1.27); C189(1.27)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C143(0.97); C146(1.04); C186(1.05); C189(1.05)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C143(1.07); C146(1.17); C186(1.30); C189(1.30)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C143(1.24); C146(1.32); C186(0.90); C189(0.90)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C143(1.01); C146(1.04); C186(1.10); C189(1.10)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C143(0.83); C146(0.86); C186(1.08); C189(1.08)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C143(0.92); C146(0.91); C186(1.33); C189(1.33)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C143(0.77); C146(0.78); C186(0.76); C189(0.76)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C143(0.66); C146(0.66); C186(0.93); C189(0.93)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C143(0.65); C146(0.67); C186(1.49); C189(1.49)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C143(0.73); C146(0.73); C186(1.12); C189(1.12)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C143(0.72); C146(0.72); C186(1.12); C189(1.12)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C143(0.72); C146(0.73); C186(1.01); C189(1.01)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C143(1.45); C146(1.71); C186(1.01); C189(1.01)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C143(0.78); C146(0.77); C186(0.98); C189(0.98)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C143(0.85); C146(0.85); C186(1.10); C189(1.10)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C143(0.61); C146(0.59); C186(1.00); C189(1.00)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C143(0.68); C146(0.66); C186(1.06); C189(1.06)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C143(0.83); C146(0.81); C186(1.02); C189(1.02)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C143(0.69); C146(0.67); C186(0.89); C189(0.89)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C143(1.28); C146(1.13); C308(0.89)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C143(1.25); C146(1.11); C308(0.96)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C143(1.17); C146(1.04); C308(0.95)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C143(1.18); C146(1.11); C308(0.96)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C143(1.32); C146(1.32); C186(0.90); C189(0.90)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C143(1.34); C146(1.19); C308(0.97)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C143(1.28); C146(1.18); C308(1.04)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C143(1.29); C146(1.17); C308(0.93)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C143(1.18); C146(1.08); C308(0.94)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C143(1.43); C146(1.20); C308(1.00)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C143(1.39); C146(1.20); C308(0.98)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C143(1.16); C146(1.09); C308(0.91)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C143(1.26); C146(1.18); C308(0.87)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C143(1.37); C146(1.23); C308(0.81)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C143(1.24); C146(1.17); C308(0.93)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C143(1.18); C146(1.11); C186(0.88); C189(0.88)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C143(1.23); C146(1.15); C308(1.08)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C143(1.17); C146(1.22); C186(0.94); C189(0.94)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C143(1.16); C146(1.21); C186(0.82); C189(0.82)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C143(1.04); C146(1.08); C186(0.81); C189(0.81)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C143(1.08); C146(1.13); C186(0.97); C189(0.97)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C143(1.12); C146(1.15); C186(0.67); C189(0.67)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C143(1.08); C146(1.17); C186(1.53); C189(1.53)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C143(1.16); C146(1.23); C186(1.01); C189(1.01)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C143(1.11); C146(1.16); C186(1.19); C189(1.19)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C143(1.24); C146(1.23); C186(0.89); C189(0.89)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C143(1.04); C146(0.97); C186(0.90); C189(0.90)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C143(1.09); C146(1.10); C186(1.41); C189(1.41)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C143(0.95); C146(0.99); C186(0.92); C189(0.92)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C143(1.09); C146(1.09); C186(0.94); C189(0.94)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C143(1.09); C146(1.14); C186(1.10); C189(1.10)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C143(1.11); C146(1.20); C186(0.94); C189(0.94)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C143(1.01); C146(1.01); C186(1.10); C189(1.10)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C143(0.78); C146(0.78); C186(1.19); C189(1.19)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C143(0.84); C146(0.84); C186(1.14); C189(1.14)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C143(0.87); C146(0.87); C186(1.18); C189(1.18)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C143(0.86); C146(0.77); C186(0.93); C189(0.93)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C143(1.06); C146(1.06); C186(1.25); C189(1.25)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C143(0.89); C146(0.89); C186(0.92); C189(0.92)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C143(0.76); C146(0.76); C186(1.47); C189(1.47)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C143(0.74); C146(0.74); C186(0.97); C189(0.97)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C143(0.68); C146(0.68); C186(1.14); C189(1.14)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C143(0.83); C146(0.83); C186(1.12); C189(1.12)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C143(0.83); C146(0.83); C186(1.02); C189(1.02)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C143(0.94); C146(0.94); C186(0.93); C189(0.93)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C143(0.78); C146(0.78); C186(1.54); C189(1.54)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C143(0.69); C146(0.69); C186(1.10); C189(1.10)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C143(1.09); C146(1.03); C186(0.90); C189(0.90)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C143(0.83); C146(0.83); C186(0.62); C189(0.62)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C143(0.93); C146(0.93); C186(0.93); C189(0.93)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C143(1.09); C146(1.09); C186(1.02); C189(1.02)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C143(1.04); C146(1.04); C186(1.07); C189(1.07)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C143(1.12); C146(1.12); C186(1.09); C189(1.09)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C143(1.01); C146(1.01); C186(1.02); C189(1.02)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C143(1.14); C146(1.14); C186(1.23); C189(1.23)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C143(1.09); C146(1.09); C186(1.15); C189(1.15)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C143(0.91); C146(0.91); C186(0.92); C189(0.92)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C143(0.99); C146(0.99); C186(1.00); C189(1.00)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C308(0.87); C280(0.90)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C308(1.23); C146(1.02)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C143(1.18); C146(1.22); C186(0.87); C189(0.87)  LDD0785  [11]
 LDCM0427  Fragment51 HCT 116 C143(0.64); C146(0.64); C186(1.30); C189(1.30)  LDD0744  [11]
 LDCM0116  HHS-0101 DM93 Y69(0.91); Y35(0.99); Y54(2.48)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y69(0.74); Y35(1.48); Y54(2.31)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y69(0.76); Y35(0.83); Y54(3.16)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y69(0.87); Y35(1.76); Y54(3.70)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y69(1.32); Y35(1.72); Y54(2.91)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0123  JWB131 DM93 Y69(1.38)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y69(1.25)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y69(1.00)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y69(4.86)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y69(1.73)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y69(0.94)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y69(1.31)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y69(4.01)  LDD0292  [7]
 LDCM0022  KB02 HCT 116 C186(1.71); C189(1.71); C143(1.74); C146(1.74)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C186(2.61); C189(2.61); C143(1.90); C146(1.90)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C186(2.57); C189(2.57); C143(1.59); C146(1.59)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C308(1.00)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C308(0.74)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0227  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C308(0.66)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C308(1.14)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C308(0.99); C146(1.18)  LDD2093  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C308(1.15); C146(0.91)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C308(0.86); C146(1.10); C143(0.68)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C308(0.84); C143(1.13)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C308(0.31)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C308(0.94)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C308(0.50)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C308(1.04); C146(1.07)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C308(0.38)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C308(0.48); C146(0.70); C143(0.53)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C308(0.67)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C308(0.97); C146(1.01); C143(1.13)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C308(0.52)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C308(0.55)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C308(1.38); C146(2.06)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C308(0.96)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C308(0.87); C146(0.85)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C308(0.80); C143(0.80)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C308(1.02); C146(0.77); C143(0.78)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C308(1.06)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C308(1.01); C146(1.14); C143(0.97)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C308(0.96)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C308(0.43)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C308(1.23); C146(1.36)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C308(0.98); C146(1.11); C143(0.87)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C308(0.92); C146(1.07); C143(0.88)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C143(1.70); C146(1.61); C308(1.48)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C308(0.65); C146(1.05)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C308(0.42)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C308(1.00)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C308(2.73); C146(2.94); C143(2.25)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C308(0.22)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C308(0.80)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C308(0.44); C146(0.47); C143(0.53)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C308(0.55)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C308(1.88)  LDD2153  [5]
 LDCM0014  Panhematin HEK-293T 3.19  LDD0062  [6]
 LDCM0131  RA190 MM1.R C280(1.21)  LDD0304  [27]
 LDCM0021  THZ1 HCT 116 C186(1.98); C189(1.98); C143(1.90); C146(1.90)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Single-stranded DNA cytosine deaminase (AICDA) Cytidine and deoxycytidylate deaminase family Q9GZX7
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172
Nuclear migration protein nudC (NUDC) NudC family Q9Y266
DnaJ homolog subfamily A member 4 (DNAJA4) . Q8WW22

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.